{"id":42228,"date":"2023-05-05T11:24:24","date_gmt":"2023-05-05T03:24:24","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=42228"},"modified":"2025-09-02T15:37:36","modified_gmt":"2025-09-02T07:37:36","slug":"%e7%a3%b7%e9%85%b8%e6%b0%af%e5%96%b9-chloroquine-phosphate-cas50-63-5-mce%e8%b2%a8%e8%99%9fhy-17589","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=42228","title":{"rendered":"\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate | CAS#50-63-5 MCE\u8ca8\u865fHY-17589"},"content":{"rendered":"

MCE (MedChem Express)<\/span> -Chloroquine phosphate <\/span><\/span><\/span><\/strong><\/span><\/p>\n

CAS #50-63-5<\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

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Chloroquine phosphate<\/em>\u00a0Chemical Structure<\/p>\n

CAS No. :\u00a050-63-5<\/a><\/p>\n

\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate | CAS#50-63-5 MCE\u8ca8\u865fHY-17589<\/a><\/span><\/p>\n

\u78f7\u9178\u6c2f\u55b9(Chloroquine phosphate )\u662f\u4e00\u7a2e\u6297\u7627\u85e5\u548c\u6297\u708e\u85e5\uff0c\u5ee3\u6cdb\u7528\u65bc\u6cbb\u7642\u7627\u75be\u548c\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3002 \u78f7\u9178\u6c2f\u55b9(Chloroquine phosphate ) \u662f\u4e00\u7a2e\u81ea\u566c\u548c Toll \u6a23\u53d7\u9ad4 (TLR) \u6291\u5236\u5291\u3002\u6c2f\u55b9(Chloroquine\u00a0 )\u5728\u9ad4\u5916\u63a7\u5236 SARS-CoV-2 (COVID-19) \u611f\u67d3\u65b9\u9762\u975e\u5e38\u6709\u6548 (EC50=1.13 \u03bcM)\u3002\u6c2f\u55b9(Chloroquine\u00a0 )(CHQ, 20 \u03bcM) \u6291\u5236 IL-12p70 \u91cb\u653e\u4e26\u964d\u4f4e\u6d3b\u5316\u7684\u4eba\u55ae\u6838\u7d30\u80de\u884d\u751f\u7684\u6717\u683c\u6f22\u65af\u6a23\u7d30\u80de (MoLC) \u7684 Th1 \u555f\u52d5\u80fd\u529b\u3002\u6c2f\u55b9(Chloroquine\u00a0 ) (CHQ, 20 \u03bcM) \u53ef\u589e\u5f37 MoLC \u4e2d IL-1 \u8a98\u5c0e\u7684 IL-23 \u5206\u6ccc\uff0c\u96a8\u5f8c\u589e\u52a0\u81f4\u654f CD4+ T \u7d30\u80de\u91cb\u653e\u7684 IL-17A[1]\u3002\u6c2f\u55b9(Chloroquine\u00a0 ) (25 \u03bcM) \u5728\u89aa\u672c MDA-MB-231 \u7d30\u80de\u4e2d\u6291\u5236\u5e38\u6c27\u548c\u7f3a\u6c27\u689d\u4ef6\u4e0b\u7684 MMP-9 mRNA \u8868\u9054\u3002\u6c2f\u55b9(Chloroquine\u00a0 )\u5c0d MMP-2\u3001MMP-9 \u548c MMP-13 mRNA \u8868\u9054\u5177\u6709\u7d30\u80de\u3001\u5291\u91cf\u548c\u7f3a\u6c27\u4f9d\u8cf4\u6027\u4f5c\u7528[2]\u3002\u4f7f\u7528 IRS-954 \u6216\u6c2f\u55b9(Chloroquine\u00a0 )\u6291\u5236 TLR7 \u548c TLR9 \u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u5916 HuH7 \u7d30\u80de\u589e\u6b96[3]\u3002\u6c2f\u55b9(Chloroquine\u00a0 )\uff080.01-100 \u03bcM\uff1b48\u5c0f\u6642\uff09\u5728\u4f4e\u5fae\u6469\u723e\u6fc3\u5ea6\uff08EC50= 1.13\u03bcM\uff09\u4e0b\u6709\u6548\u963b\u65b7\u75c5\u6bd2\u611f\u67d3\uff08\u611f\u67d3SARS-CoV-2\u7684vero E6\u7d30\u80de\uff09\u3002\u6c2f\u55b9(Chloroquine\u00a0 )\u901a\u904e\u589e\u52a0\u75c5\u6bd2\/\u7d30\u80de\u878d\u5408\u6240\u9700\u7684\u5167\u9ad4 pH \u503c\u4ee5\u53ca\u5e72\u64fe SARS-CoV \u7d30\u80de\u53d7\u9ad4\u7684\u7cd6\u57fa\u5316\u4f86\u963b\u65b7\u75c5\u6bd2\u611f\u67d3 [4]\u3002\u6c2f\u55b9 (80 mg\/kg, i.p.) \u4e0d\u6703\u963b\u6b62\u539f\u4f4d\u5c0f\u9f20\u6a21\u578b\u4e2d\u5177\u6709\u9ad8\u6216\u4f4e TLR9 \u8868\u9054\u6c34\u5e73\u7684\u4e09\u9670\u6027 MDA-MB-231 \u7d30\u80de\u7684\u751f\u9577 [2]\u3002\u4f7f\u7528 IRS-954 \u6216\u6c2f\u55b9\u6291\u5236 TLR7 \u548c TLR9 \u53ef\u986f\u8457\u6291\u5236\u5c0f\u9f20\u7570\u7a2e\u79fb\u690d\u6a21\u578b\u4e2d\u7684\u816b\u7624\u751f\u9577\u3002 DEN\/NMOR \u5927\u9f20\u6a21\u578b\u4e2d\u7684 HCC \u767c\u5c55\u4e5f\u88ab\u6c2f\u55b9\u986f\u8457\u6291\u5236[3]<\/p>\n

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\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

\"\"<\/p>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5316\u5408\u7269\u54c1\u724c<\/td>\n\u5316\u5408\u7269CAS\u865f<\/td>\n\u5316\u5408\u7269\u540d\u7a31<\/td>\n\u5316\u5408\u7269\u8ca8\u865f<\/td>\n\u5316\u5408\u7269\u4ecb\u7d39<\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#108321-42-2<\/td>\nG-418 disulfat<\/td>\nMCE\u8ca8\u865fHY-17561<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#68528-80-3<\/td>\nDSS Crosslinker (disuccinimidyl suberate)<\/td>\nMCE\u8ca8\u865fHY-W019543<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1380723-44-3<\/td>\nAtezolizumab<\/td>\nMCE\u8ca8\u865fHY-P9904<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1207456-01-6<\/td>\nTalazoparib (BMN-673; LT-673)<\/td>\nMCE\u8ca8\u865fHY-16106<\/span><\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#763113-22-0<\/td>\nOlaparib<\/td>\nMCE\u8ca8\u865fHY-10162<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1382764-52-4<\/td>\nLipidGreen 2\u8102\u8cea\u6210\u50cf\u5c0f\u5206\u5b50\u63a2\u91dd<\/td>\nMCE\u8ca8\u865fHY-D1353<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#103404-75-7<\/td>\nD-\u87a2\u5149\u7d20(D-luciferin) \u6c34\u6eb6\u6027\u9209\u9e7d<\/td>\nMCE\u8ca8\u865fHY-12591<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#15144-35-9<\/td>\nD-\u87a2\u5149\u7d20(D-Luciferin potassium)<\/td>\nMCE\u8ca8\u865fHY-12591B<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#186689-07-6<\/td>\n2-NBDG\u6d3b\u7d30\u80de\u548c\u7d44\u7e54\u8461\u8404\u7cd6\u7684\u651d\u53d6<\/td>\nMCE\u8ca8\u865fHY-116215<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\n<\/td>\nIPTG\u00a0 ( Isopropyl \u03b2-D-thiogalactoside)<\/td>\nMCE\u8ca8\u865fHY-15921<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#10121-91-2<\/td>\n\u81ea\u566c\u6ce1(autophagic vacuoles)\u87a2\u5149\u6a19\u8a8c<\/td>\nMCE\u8ca8\u865fHY-D1027<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#28728-55-4<\/td>\n\u805a\u51dd\u80fa(Polybrene) \u967d\u96e2\u5b50\u805a\u5408\u7269<\/td>\nMCE\u8ca8\u865fHY-112735<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#288250-47-5<\/td>\nY-320 \u514d\u75ab\u8abf\u7bc0\u5291<\/td>\nMCE\u8ca8\u865fHY-15898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#30931-67-0<\/td>\nABTS diammonium salt<\/td>\nMCE\u8ca8\u865fHY-15902<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#16561-29-8<\/td>\nPhorbol 12-myristate 13-acetate, PMA<\/td>\nMCE\u8ca8\u865fHY-18739<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#50-63-5<\/td>\n\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate<\/td>\nMCE\u8ca8\u865fHY-17589<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9003-11-6<\/td>\nPoloxamer 407<\/td>\nMCE\u8ca8\u865fHY-D1005<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#150347-59-4<\/td>\nCFSE\u87a2\u5149\u67d3\u6599<\/td>\nMCE\u8ca8\u865fHY-D0938<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9025-71-2<\/td>\n\u55ae\u5be7\u9176(Tannase)<\/td>\nMCE\u8ca8\u865fHY-P2877<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 941678-49-5<\/td>\nRuxolitinib<\/td>\nMCE\u8ca8\u865fHY-50856<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#9002-92-0<\/td>\nPolidocanol<\/td>\nMCE\u8ca8\u865fHY-B2106<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#HY-100579<\/td>\nFerrostatin-1 (Synonyms: Fer-1)<\/td>\nMCE\u8ca8\u865f HY-100579<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#154-23-4<\/td>\n\u5152\u8336\u7d20(Catechin)<\/td>\nMCE\u8ca8\u865f HY-N0898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nFT895\u5f37\u6548\u9078\u64c7\u6027 HDAC11 \u6291\u5236\u5291<\/td>\nMCE\u8ca8\u865f HY-112285<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 5471-63-6<\/td>\n1,3-\u4e8c\u82ef\u57fa\u7570\u82ef\u4e26\u544b\u5583 (DPBF)<\/td>\nMCE\u8ca8\u865f HY-W011664<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nAkaLumine hydrochloride<\/td>\nMCE\u8ca8\u865fHY-112641A<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#203115-63-3<\/td>\nWRN \u89e3\u65cb\u9176\u6291\u5236\u5291NSC 617145<\/td>\nMCE\u8ca8\u865f \u00a0HY-110185<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#2244-11-3<\/td>\nAlloxan hydrate<\/td>\nMCE\u8ca8\u865fHY-W017227<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#23491-44-3<\/td>\nHoechst 33258<\/td>\nMCE\u8ca8\u865fHY-15558<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#18883-66-4<\/td>\nStreptozotocin<\/td>\nMCE\u8ca8\u865fHY-13753<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#554435-83-5<\/td>\nDeferasirox (Fe3+ chelate)<\/td>\nMCE\u8ca8\u865f\u00a0HY-16564<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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