{"id":42212,"date":"2023-05-04T18:56:36","date_gmt":"2023-05-04T10:56:36","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=42212"},"modified":"2025-11-15T15:50:52","modified_gmt":"2025-11-15T07:50:52","slug":"%e7%a3%b7%e9%85%b8%e6%b0%af%e5%96%b9-chloroquine-diphosphate-cas50-63-5-apexbio%e8%b2%a8%e8%99%9fa8628","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=42212","title":{"rendered":"\u78f7\u9178\u6c2f\u55b9 | Chloroquine diphosphate CAS#50-63-5 APExBIO\u8ca8\u865fA8628"},"content":{"rendered":"

\u78f7\u9178\u6c2f\u55b9Chloroquine diphosphate CAS#50-63-5 APExBIO\u8ca8\u865fA8628<\/strong><\/span><\/a><\/span><\/p>\n

Chloroquine diphosphate, apoptosis and autophagy inhibitor<\/span><\/p>\n

\u78f7\u9178\u6c2f\u55b9Chloroquine diphosphate\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u6297\u7627\u5291(Antimalarial agent)\u3002\u5728\u9ad4\u5916\u6291\u5236\u816b\u7624\u7d30\u80de\u7684\u751f\u9577(tumor cell growth)\u548c\u8f49\u79fb(metastasis )\u4e26\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1(apoptosis )\u3002\u8207 Fe(II)-\u539f\u535f\u5549 IX (FP) \u7d50\u5408\u5f62\u6210 FP-\u6c2f\u55b9\u8907\u5408\u7269\uff0c\u5c0e\u81f4\u7d30\u80de\u88c2\u89e3( cell lysis)\u548c\u5bc4\u751f\u87f2\u7d30\u80de\u81ea\u6d88\u5316(parasite cell autodigestion)\u3002<\/p>\n

\u4e8c\u78f7\u9178\u6c2f\u55b9(Chloroquine diphosphate)\u7528\u4f5c\u6297\u7627\u85e5(antimalarial drug)\uff0c\u9084\u53ef\u4ee5\u901a\u904e\u8a98\u5c0e\u81ea\u566c( autophagy)\u4f86\u63d0\u9ad8\u816b\u7624\u7d30\u80de\u5c0d\u653e\u7642( radiation )\u548c\u5316\u7642(chemotherapy)\u7684\u654f\u611f\u6027( sensitivity)\u3002\u5df2\u5831\u5c0e\u4e8c\u78f7\u9178\u6c2f\u55b9(Chloroquine diphosphate)\u4f5c\u70ba\u653e\u7642\u548c\u5316\u7642\u7684\u4f50\u5291\uff0c\u7528\u65bc\u8a98\u5c0e\u7d30\u80de\u81ea\u566c\u4ee5\u6297\u764c\u7d30\u80de\u589e\u6b96\u6216\u8f49\u79fb\u3002\u4e8c\u78f7\u9178\u6c2f\u55b9(Chloroquine diphosphate)\u8a98\u5c0e\u7d30\u80de\u81ea\u566c\u7684\u6a5f\u5236\u662f\u5c07\u7d30\u80de\u963b\u6eef\u5728G1\u671f\uff0c\u4e0a\u8abfp27\u548cp53\u7684\u8868\u9054\uff0c\u4e0b\u8abfCDK2\u548ccyclin D1\u7684\u8868\u9054[3]\u3002\u9664\u6297\u7627\u75be\u5916\uff0c\u9577\u671f\u4ee5\u4f86\u4e00\u76f4\u88ab\u5831\u5c0e\u5728\u7d30\u80de\u51cb\u4ea1\u4e2d\u767c\u63ee\u4f5c\u7528\u3002\u7528\u9810\u8655\u7406 CNE-2 \u4eba\u9f3b\u54bd\u764c\u7d30\u80de\uff0c\u901a\u904e\u589e\u52a0\u7d30\u80de\u81ea\u566c\u7387\u589e\u5f37\u96fb\u96e2\u8f3b\u5c04\u8a98\u5c0e\u7684\u7d30\u80de\u51cb\u4ea1 [4]\u3002\u7576\u7528\u5c0f\u9f20\u4e73\u817a\u764c 4T1 \u7d30\u80de\u8655\u7406\u6642\uff0c\u8655\u7406\u6703\u6291\u5236\u7d30\u80de\u589e\u6b96\u548c\u6d3b\u529b\uff0c\u5f9e\u800c\u4ee5\u6642\u9593\u548c\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1 [2]\u3002\u5728\u4eba\u7d50\u8178\u764c DLD-1 \u7d30\u80de\u4e2d\uff0c5-FU \u548c\u7684\u7d44\u5408\u53ef\u901a\u904e\u8a98\u5c0e\u81ea\u566c\u6291\u5236\u7d30\u80de\u589e\u6b96 [3]\u3002\u5728 4T1 \u7d30\u80de\u76ae\u4e0b\u7570\u7a2e\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u4e8c\u78f7\u9178\u6c2f\u55b9(Chloroquine diphosphate)\u6cbb\u7642\u986f\u8457\u6291\u5236\u4e86\u816b\u7624\u751f\u9577\u548c\u816b\u7624\u7d30\u80de\u5411\u80ba\u90e8\u7684\u8f49\u79fb\uff0c\u5f9e\u800c\u63d0\u9ad8\u4e86\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387 [2]\u3002\u5728\u76ae\u4e0b\u6ce8\u5c04colon26\u7d30\u80de\u7684BALB\/c\u5c0f\u9f20\u4e2d\uff0c\u4e8c\u78f7\u9178\u6c2f\u55b9(Chloroquine diphosphate)\u82075-FU\u5354\u540c\u4f5c\u7528\uff0c\u901a\u904e\u589e\u52a0\u51cb\u4ea1\u7d30\u80de\u7684\u6bd4\u4f8b\uff0c\u986f\u8457\u589e\u5f37\u4e86\u5c0d5-FU\u8a98\u5c0e\u7684\u816b\u7624\u751f\u9577\u7684\u6291\u5236\u4f5c\u7528[5]\u3002<\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n

\"COA\u6587\u4ef6_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nDesiccate at RT<\/td>\n<\/tr>\n
M.Wt<\/td>\n515.86<\/td>\n<\/tr>\n
Cas No.<\/td>\n50-63-5<\/td>\n<\/tr>\n
Formula<\/td>\nC18<\/sub>H26<\/sub>ClN3<\/sub>\u00b72H3<\/sub>PO4<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in DMSO; insoluble in EtOH; \u2265106.06 mg\/mL in H2O<\/td>\n<\/tr>\n
Chemical Name<\/td>\n4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u78f7\u9178\u6c2f\u55b9Chloroquine diphosphate CAS#50-63-5 APExBIO\u8ca8\u865fA8628 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5720],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42212"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42212"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42212\/revisions"}],"predecessor-version":[{"id":53761,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42212\/revisions\/53761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}