{"id":41826,"date":"2023-04-27T14:23:14","date_gmt":"2023-04-27T06:23:14","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41826"},"modified":"2025-09-03T11:35:07","modified_gmt":"2025-09-03T03:35:07","slug":"%e8%81%9a%e5%87%9d%e8%83%bapolybrene-%e9%99%bd%e9%9b%a2%e5%ad%90%e8%81%9a%e5%90%88%e7%89%a9-cas28728-55-4-mce%e8%b2%a8%e8%99%9fhy-112735","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=41826","title":{"rendered":"\u805a\u51dd\u80fa(Polybrene) | \u967d\u96e2\u5b50\u805a\u5408\u7269 CAS#28728-55-4 MCE\u8ca8\u865fHY-112735"},"content":{"rendered":"

MCE (MedChem Express)<\/span> -Polybrene\u00a0\u00a0<\/span><\/span><\/span><\/strong><\/span><\/p>\n

(Synonyms:Hexadimethrine bromide ; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide)<\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

<\/p>\n

Polybrene | CAS#28728-55-4 MCE\u8ca8\u865fHY-112735<\/a>\u00a0<\/span><\/p>\n

\u805a\u51dd\u80fa(Polybrene; Hexadimethrine bromide)\uff0c\u6216\u7a31\u70bahexadimethrine bromide\u3002\u4e00\u7a2e\u967d\u96e2\u5b50\u805a\u5408\u7269(cationic polymer)\uff0c\u5e38\u7528\u65bc\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u4e4bDNA\u611f\u67d3\u5be6\u9a57\uff0c\u53ef\u589e\u5f37\u8102\u8cea\u9ad4\u7684\u611f\u67d3\u6548\u7387\u3002\u5ee3\u6cdb\u7528\u65bc\u53cd\u8f49\u9304\u75c5\u6bd2\u4ecb\u5c0e((retrovirus vector-mediated))\u7684\u57fa\u56e0\u611f\u67d3\uff0c\u6162\u75c5\u6bd2\u4ecb\u5c0e\u7684\u57fa\u56e0\u611f\u67d3\uff0c\u4f5c\u7528\u6a5f\u5236\u53ef\u80fd\u662f\u901a\u904e\u4e2d\u548c\u7d30\u80de\u8868\u9762\u553e\u6db2\u9178\u8207\u75c5\u6bd2\u9846\u7c92\u4e4b\u9593\u7684\u975c\u96fb\u6392\u65a5((neutralizing the charge repulsion))\u5f9e\u800c\u4fc3\u9032\u5438\u9644\u4f5c\u7528\u3002\u5176\u4e5f\u662f\u4e00\u7a2e\u6709\u540d\u7684\u6297\u809d\u7d20\u5291\uff08\u809d\u7d20\u62ee\u6297\u5291\uff09\uff0c\u5e38\u7528\u4f86\u751f\u7522\u975e\u7279\u7570\u6027\u51dd\u96c6\u7684\u7d05\u7d30\u80de\u3002\u53e6\u5916\u4e5f\u591a\u7528\u65bc\u86cb\u767d\u6e2c\u5e8f(protein sequencing)\uff0c\u56e0\u70ba\u5c0f\u5291\u91cf\u7684\u805a\u51dd\u80fa\u5728\u81ea\u52d5\u6e2c\u5e8f\u5206\u6790\u53ef\u660e\u986f\u6539\u5584\u591a\u80dc\u80bd\u7684\u964d\u89e3\u73fe\u8c61\u3002<\/p>\n

\u805a\u51dd\u80fa(Polybrene;\u00a0Hexadimethrine bromide)\u5728\u6162\u75c5\u6bd2\u8f49\u5c0e\u904e\u7a0b\u4e2d\u6291\u5236\u4eba\u9593\u5145\u8cea\u5e79\u7d30\u80de(\u00a0mesenchymal stem cell )\u589e\u6b96(cell proliferation)\u3002 \u805a\u51dd\u80fa(Polybrene;\u00a0Hexadimethrine bromide)\u5728\u4f4e\u6fc3\u5ea6\u4e0b\u88ab\u8a8d\u70ba\u662f\u7121\u6bd2\u7684\uff0c\u4f46\u5df2\u767c\u73fe\u5728\u6fc3\u5ea6\u5927\u65bc 10 \u00b5g\/mL \u6642\u6703\u5c0d\u67d0\u4e9b\u7d30\u80de\u985e\u578b\u7684\u7d30\u80de\u589e\u6b96\u7522\u751f\u8ca0\u9762\u5f71\u97ff\u3002\u5728\u986f\u5fae\u93e1\u4e0b\u89c0\u5bdf\u6642\uff0c\u66b4\u9732\u65bc\u805a\u51dd\u80fa(Polybrene;\u00a0Hexadimethrine bromide)\u7684\u80f0\u86cb\u767d\u9176\u5316\u7d30\u80de(Trypsinized cells )\u660e\u986f\u8b8a\u5927 \u3002<\/p>\n

\u5efa\u8b70\u7528\u91cf\u70ba8 \u00b5g\/ml\u00a0polybrene (\u8996\u4e0d\u540c\u8a66\u9a57\u9700\u8abf\u6574\u6fc3\u5ea6)\u00a0<\/span><\/p>\n

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 <\/p>\n\n\n\n\n\n\n\n\n\n\n
Description<\/th>\n\n
\n

Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer[1]<\/a><\/sup>[2]<\/a><\/sup>.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

In Vitro<\/th>\n\n
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Hexadimethrine bromide inhibits human mesenchymal stem cell proliferation during lentiviral transduction. Hexadimethrine bromide is considered non-toxic at low concentrations, but has been found to negatively affect cell proliferation in some cell types at concentrations greater than 10 \u00b5g\/mL. Trypsinized cells exposed to Hexadimethrine bromide are visibly larger in size when viewed under the microscope[1]<\/a><\/sup>.<\/p>\n

MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/b><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
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Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Formula<\/th>\n\n
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(C13<\/sub>H30<\/sub>N2<\/sub>)n.Br2<\/sub><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
SMILES<\/th>\n\n
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C[N+](CCCCCCC)(C)CCC[N+](C)(C)C.[Br-].[Br-].[n]<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
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Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Storage<\/th>\n\n
\n

4\u00b0C, stored under nitrogen, away from moisture<\/p>\n

*In solvent : -80\u00b0C, 6 months; -20\u00b0C, 1 month (stored under nitrogen, away from moisture)<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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15 Publications Citing Use of MCE Hexadimethrine bromide<\/span><\/h2>\n<\/div>\n
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