{"id":41522,"date":"2023-04-23T13:23:52","date_gmt":"2023-04-23T05:23:52","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41522"},"modified":"2025-09-03T11:47:02","modified_gmt":"2025-09-03T03:47:02","slug":"egta-%e9%88%a3%e9%9b%a2%e5%ad%90%e8%9e%af%e5%90%88%e5%8a%91-cas67-42-5-mce%e8%b2%a8%e8%99%9fhy-d0861","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=41522","title":{"rendered":"EGTA-\u9223\u96e2\u5b50\u87af\u5408\u5291 | CAS#67-42-5 MCE\u8ca8\u865fHY-D0861"},"content":{"rendered":"

MCE (MedChem Express)<\/span> -EGTA-\u9223\u96e2\u5b50\u87af\u5408\u5291<\/span><\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

<\/p>\n

EGTA| CAS#67-42-5 MCE\u8ca8\u865fHY-D0861\u00a0<\/a> Ethylene glycol-bis-(beta-aminoethyl ether)-N,N,N’,N’-tetraacetic acid (EGTA) <\/span><\/p>\n

\u226598.0%, Calcium Ion Chelator<\/p>\n

Synonym(s):<\/div>\n
EGTA, Egtazic acid, Ethylene-bis(oxyethylenenitrilo)tetraacetic acid, Glycol ether diamine tetraacetic acid<\/div>\n
<\/div>\n
\u4e59\u4e8c\u9187-\u96d9(2-\u6c28\u57fa\u4e59\u919a)-N,N,N’,N’-\u56db\u4e59\u9178 (EGTA) \u5728 Dulbecco \u7684\u78f7\u9178\u9e7d\u7de9\u885d\u9e7d\u6c34 (DPBS) \u4e2d\u8a98\u5c0e\u7d30\u80de\u9593\u9023\u63a5\u7684\u5f31\u5316\uff0c\u4f5c\u70ba\u7d30\u80de\u5916\u9223\u87af\u5408\u5291\u7814\u7a76\u9223\u5728\u8ef8\u7a81\u7dda\u7c92\u9ad4\u8b8a\u6027\u4e2d\u7684\u4f5c\u7528\u3002\u4f5c\u70ba\u88c2\u89e3\u7de9\u885d\u6db2\u4e2d\u7684\u4e00\u7a2e\u6210\u5206\uff0c\u7528\u65bc\u88c2\u89e3\u5c0f\u9f20\u7c98\u819c\u7d30\u80de\u4ee5\u9032\u884c\u86cb\u767d\u8cea\u5370\u8de1\u5206\u6790\u3002EGTA \u662f\u4e00\u7a2e\u7279\u6b8a\u7684\u9223\u96e2\u5b50\u87af\u5408\u5291(calcium ion chelator)\u3002 EGTA \u5728\u751f\u7406 pH (7.4) \u4e0b\u7684\u8868\u89c0\u9223\u89e3\u96e2\u5e38\u6578 (Kd) \u70ba 60.5 nM\uff0c\u4e26\u4e14\u5c0d Ca2+ \u7684\u7279\u7570\u6027\u9ad8\u65bc Mg2+\uff08Mg2+ Kd 1-10 mM\uff09\u3002 EGTA\u986f\u8457\u6291\u5236\u708e\u6027\u5de8\u566c\u7d30\u80de\u7684\u5e95\u7269\u7c98\u9644\u80fd\u529b\u3002EGTA \u88ab\u63d0\u8b70\u4f5c\u70ba\u7259\u9ad3\u6c96\u6d17\u5291(endodontic irrigant)\uff0c\u4ee5\u6642\u9593\u548c\u5291\u91cf\u4f9d\u8cf4\u7684\u65b9\u5f0f\u964d\u4f4e\u708e\u6027\u5de8\u566c\u7d30\u80de(inflammatory macrophages)\u7684\u5e95\u7269\u7c98\u9644\u80fd\u529b(\u00a0substrate adherence capacity)\u3002\u5c0e\u81f4 IC50 \u7684 EGTA \u6fc3\u5ea6\u70ba 202 mM\u3002\u87af\u5408\u5291(Chelators)\u8207\u7fa5\u57fa\u78f7\u7070\u77f3\u6676\u9ad4(\u00a0hydroxyapatite crystals )\u4e2d\u7684\u9223\u96e2\u5b50\u53cd\u61c9\u751f\u6210\u91d1\u5c6c\u87af\u5408\u7269(metallic chelate)\u3002\u7259\u672c\u8cea\u4e2d\u9223\u96e2\u5b50(calcium ions )\u7684\u53bb\u9664\u4f7f\u7259\u672c\u8cea\u7d44\u7e54\u8b8a\u8edf(dentinal tissue softer)\uff0c\u5c24\u5176\u662f\u5bcc\u542b\u7fa5\u57fa\u78f7\u7070\u77f3(hydroxyapatite-rich)\u7684\u7ba1\u9031\u7259\u672c\u8cea\uff0c\u4e26\u589e\u52a0\u66b4\u9732\u7684\u7259\u672c\u8cea\u5c0f\u7ba1(dentinal tubules)\u7684\u76f4\u5f91\u3002<\/div>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n
Molecular Weight<\/th>\n\n
\n

380.35<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
\n

Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Formula<\/th>\n\n
\n

C14<\/sub>H24<\/sub>N2<\/sub>O10<\/sub><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
SMILES<\/th>\n\n
\n

O=C(O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
\n

Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n

\u2022Anti-infection<\/a><\/span><\/strong><\/h4>\n

\u2022Antibody-drug Conjugate\/ADC Related<\/a><\/span><\/strong><\/h4>\n

\u2022Apoptosis<\/a><\/span><\/strong><\/h4>\n

\u2022Autophagy<\/a><\/span><\/strong><\/h4>\n

\u2022Cell Cycle\/DNA Damage<\/a><\/span><\/strong><\/h4>\n

\u2022Cytoskeleton<\/a><\/span><\/strong><\/h4>\n

\u2022Epigenetics<\/a><\/span><\/strong><\/h4>\n

\u2022GPCR\/G Protein<\/a><\/span><\/strong><\/h4>\n

\u2022Immunology\/Inflammation<\/a><\/span><\/strong><\/h4>\n

\u2022JAK\/STAT Signaling<\/a>\u2022MAPK\/ERK Pathway<\/a><\/span><\/strong><\/h4>\n

\u2022Membrane Transporter\/Ion Channel<\/a><\/span><\/strong><\/h4>\n

\u2022Metabolic Enzyme\/Protease<\/a><\/span><\/strong><\/h4>\n

\u2022Neuronal Signaling<\/a><\/span><\/strong><\/h4>\n

\u2022NF-\u03baB<\/a><\/span><\/strong><\/h4>\n

\u2022PI3K\/Akt\/mTOR<\/a><\/span><\/strong><\/h4>\n

\u2022PROTAC<\/a><\/span><\/strong><\/h4>\n

\u2022Protein Tyrosine Kinase\/RTK<\/a>\u2022Stem Cell\/Wnt<\/a><\/span><\/strong><\/h4>\n

\u2022TGF-beta\/Smad<\/a><\/span><\/strong><\/h4>\n

\u2022Vitamin D Related<\/a><\/span><\/strong><\/h4>\n

\u2022Others<\/a><\/span><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"

MCE (MedChem Express) -EGTA-\u9223\u96e2\u5b50\u87af\u5408\u5291 MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684 […]<\/p>\n","protected":false},"author":3,"featured_media":52862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[5613,6867,6866,6869,6865,6868],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41522"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41522"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41522\/revisions"}],"predecessor-version":[{"id":52863,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41522\/revisions\/52863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52862"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}