{"id":41390,"date":"2023-04-20T17:49:46","date_gmt":"2023-04-20T09:49:46","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41390"},"modified":"2025-09-03T11:48:41","modified_gmt":"2025-09-03T03:48:41","slug":"alisporivir-debio-025-cas254435-95-5-mce%e8%b2%a8%e8%99%9fhy-12559","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=41390","title":{"rendered":"Alisporivir (Debio-025) | CAS#254435-95-5 MCE\u8ca8\u865fHY-12559"},"content":{"rendered":"

MCE (MedChem Express)<\/span> – Cyclophilin \u6291\u5236\u5291<\/span><\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

<\/p>\n

Alisporivir (Debio-025)| CAS#254435-95-5 MCE\u8ca8\u865fHY-12559\u00a0 (Synonyms: Debio-025; DEB-025) <\/a><\/span><\/p>\n

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.<\/span><\/p>\n

DEB025 \u8207 CypA \u7d50\u5408\uff0cCypA \u662f\u4e00\u7a2e\u80bd\u57fa-\u812f\u6c28\u9170\u9806\u53cd\u7570\u69cb\u9176(peptidyl-prolyl cis-trans isomerase )\uff0c\u662f HCV \u8907\u88fd\u7684\u95dc\u9375\u8f14\u52a9\u56e0\u5b50\u3002 Alisporivir (Debio-025) \u4ee3\u8868\u4e86\u4e00\u985e\u65b0\u578b\u975e\u514d\u75ab\u6291\u5236\u6027\u89aa\u74b0\u86cb\u767d\u6291\u5236\u5291(non-immunosuppressive cyclophilin inhibitors)\u7684\u539f\u578b\u3002\u00a0Alisporivir\u00a0\u53ef\u9632\u6b62 HCV \u86cb\u767d\u4ecb\u5c0e(HCV protein-mediated )\u7684\u547c\u5438\u9a45\u52d5\u7dda\u7c92\u9ad4\u819c\u96fb\u4f4d(\u00a0respiration-driven mitochondrial membrane potential) collapse\u00a0\u3002\u5728\u7d30\u80de\u51cb\u4ea1(apoptosis)\u3001\u9223\u904e\u8f09(calcium overload)\u3001ROS \u7522\u751f\u3001\u529f\u80fd\u969c\u7919(dysfunction)\u7684\u60c5\u6cc1\u4e0b\uff0cAlisporivir\u00a0\u53ef\u9810\u9632 HCV \u86cb\u767d\u4ecb\u5c0e\u7684\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u3002\u5728\u7d30\u80de\u57f9\u990a\u6a21\u578b\u4e2d\uff0c\u4f4e\u5fae\u6469\u723e\u5291\u91cf\u7684Alisporivir\u00a0\u53ef\u963b\u65b7 SARS-CoV \u548c MERS-CoV \u7684\u8907\u88fd(replication)\u3002Alisporivir\u00a0\u548c ICN-1229 \u806f\u5408\u6cbb\u7642\u53ef\u63d0\u9ad8\u7d30\u80de\u57f9\u990a\u7269\u4e2d\u7684\u6297 MERS-CoV \u6d3b\u6027\u3002Alisporivir\u00a0\u9810\u8655\u7406\u523a\u6fc0\u809d\u764c\u9776\u7d30\u80de\u7684\u6297\u539f\u5448\u905e(antigen presentation)\uff0c\u5c0e\u81f4\u6297\u539f\u7279\u7570\u6027 CD8+ T \u7d30\u80de\u6d3b\u5316(antigen-specific CD8+ T cell activation )\u589e\u5f37 40%\u3002Alisporivir\u00a0\u8a98\u5c0e\u591a\u7a2e\u7d30\u80de\u682a\u8868\u9762\u7684 MHC-I \u548c \u03b2-2 \u5fae\u7403\u86cb\u767d(\u00a0beta-2 microglobulin)\u589e\u52a0 \u3002<\/p>\n

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 <\/p>\n

MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n
Molecular Weight<\/th>\n\n
\n

1216.64<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
\n

Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Formula<\/th>\n\n
\n

C63<\/sub>H113<\/sub>N11<\/sub>O12<\/sub><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
Shipping<\/th>\n\n
\n

Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n

\u2022Anti-infection<\/a><\/span><\/strong><\/h4>\n

\u2022Antibody-drug Conjugate\/ADC Related<\/a><\/span><\/strong><\/h4>\n

\u2022Apoptosis<\/a><\/span><\/strong><\/h4>\n

\u2022Autophagy<\/a><\/span><\/strong><\/h4>\n

\u2022Cell Cycle\/DNA Damage<\/a><\/span><\/strong><\/h4>\n

\u2022Cytoskeleton<\/a><\/span><\/strong><\/h4>\n

\u2022Epigenetics<\/a><\/span><\/strong><\/h4>\n

\u2022GPCR\/G Protein<\/a><\/span><\/strong><\/h4>\n

\u2022Immunology\/Inflammation<\/a><\/span><\/strong><\/h4>\n

\u2022JAK\/STAT Signaling<\/a>\u2022MAPK\/ERK Pathway<\/a><\/span><\/strong><\/h4>\n

\u2022Membrane Transporter\/Ion Channel<\/a><\/span><\/strong><\/h4>\n

\u2022Metabolic Enzyme\/Protease<\/a><\/span><\/strong><\/h4>\n

\u2022Neuronal Signaling<\/a><\/span><\/strong><\/h4>\n

\u2022NF-\u03baB<\/a><\/span><\/strong><\/h4>\n

\u2022PI3K\/Akt\/mTOR<\/a><\/span><\/strong><\/h4>\n

\u2022PROTAC<\/a><\/span><\/strong><\/h4>\n

\u2022Protein Tyrosine Kinase\/RTK<\/a>\u2022Stem Cell\/Wnt<\/a><\/span><\/strong><\/h4>\n

\u2022TGF-beta\/Smad<\/a><\/span><\/strong><\/h4>\n

\u2022Vitamin D Related<\/a><\/span><\/strong><\/h4>\n

\u2022Others<\/a><\/span><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"

MCE (MedChem Express) – Cyclophilin \u6291\u5236\u5291 MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b […]<\/p>\n","protected":false},"author":3,"featured_media":52864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[5608,6867,6866,6869,6865,6868],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41390"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41390"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41390\/revisions"}],"predecessor-version":[{"id":52865,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41390\/revisions\/52865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52864"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}