{"id":41203,"date":"2023-04-18T17:57:32","date_gmt":"2023-04-18T09:57:32","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41203"},"modified":"2025-09-03T11:51:05","modified_gmt":"2025-09-03T03:51:05","slug":"y-27632-dihydrochloride-cas129830-38-2-mce%e8%b2%a8%e8%99%9fhy-10583","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=41203","title":{"rendered":"Y-27632 dihydrochloride | CAS#129830-38-2 MCE\u8ca8\u865fHY-10583"},"content":{"rendered":"

MCE (MedChem Express)<\/span> – ROCK\uff08Rho \u6fc0\u9176\uff09\u6291\u5236\u5291<\/span><\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

Y-27632 dihydrochloride | CAS#129830-38-2 MCE\u8ca8\u865fHY-10583<\/a><\/span><\/p>\n

Y-27632 dihydrochloride \u662f\u4e00\u7a2e\u5177\u6709\u53e3\u670d\u6d3b\u6027\u548c ATP \u7af6\u722d\u6027\u7684 ROCK\uff08Rho \u6fc0\u9176\uff09\u6291\u5236\u5291\uff08ROCK-I Ki=220 nM\uff1bROCK-II Ki=300 nM\uff09\u3002 Y-27632 \u4e8c\u9e7d\u9178\u9e7d\u5177\u6709\u6297\u7672\u7647\u4f5c\u7528\u3002Y-27632\uff081-5 \u03bcM\uff1b0-60 \u5206\u9418\uff09\u4fc3\u9032\u8102\u80aa\u7d44\u7e54\u4f86\u6e90\u7684\u5e79\u7d30\u80de (adipose tissue-derived stem cells, ADSC) \u7684\u795e\u7d93\u5143\u5206\u5316(neuronal differentiation) [3]; \u8a98\u5c0e ADSC \u4e2d NSE\u3001MAP-2 \u548cnestin\u7684\u8868\u9054 [3]\u3002Y-27632\uff08\u53e3\u670d\u704c\u80c3\uff1b30 mg\/kg\uff1b\u6bcf\u5929\u4e00\u6b21\uff1b4 \u9031\uff09\u9810\u9632\u4e8c\u7532\u57fa\u4e9e\u785d\u80fa\u8a98\u5c0e\u7684\u5927\u9f20\u809d\u7e96\u7dad\u5316[1]Y-27632\uff08\u53e3\u670d\u704c\u80c3\uff1b5-10 mg\/kg\uff1b\u4e00\u6b21\uff09\u5728 PTZ \u548c MES \u8a98\u767c\u7684\u7672\u7647\u4e2d\u8868\u73fe\u51fa\u6297\u7672\u7647\u4f5c\u7528[2]<\/p>\n

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Y-27632 dihydrochloride<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Adv Sci (Weinh)<\/cite>. 2020 Jun 17;7(15):1903583. \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

Immunofluorescence imaging of LNCaP cells treated with the Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl). After the cells are cultured on different substrates for 3 days, inhibitors are added and incubated for 24 h.<\/p>\n

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Y-27632 dihydrochloride<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Adv Sci (Weinh)<\/cite>. 2020 Jun 17;7(15):1903583. \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

Expression of CTC cluster-related (plakoglobin and CD44) and EMT-related (vimentin and E-cadherin, 4 days) proteins in LNCaP cells grown on different substrates after treatment with different inhibitors (Cytoskeleton B (CB), Nocodazole (NO), PF-573288 (PF), Y-27632 (Y), and (-)-Blebbistatin ((-) Bl)).<\/p>\n

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Y-27632 dihydrochloride<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Oncotarget<\/cite>. 2017 Jul 31;8(47):82506-82530. \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) cells were either untreated (-) or treated (+) with 10mM Y27632 over a period of 48 hr. SKOV3 mock-transfected control (Ctrl) and shRNA-Hic-5 knockdown (KD) (sh-S1 and sh-S2) clones were either untreated (-) or treated (+) with 10 mM Y27632 followed by stimulation without (-) or with (+) 5 ng\/mL of TGF\u03b21 for 48 hr.<\/p>\n

<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n
Molecular Weight<\/th>\n\n
\n

320.26<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
\n

Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Formula<\/th>\n\n
\n

C14<\/sub>H23<\/sub>Cl2<\/sub>N3<\/sub>O<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
SMILES<\/th>\n\n
\n

O=C([C@@H]1CC[C@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
\n

Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n

\u2022Anti-infection<\/a><\/span><\/strong><\/h4>\n

\u2022Antibody-drug Conjugate\/ADC Related<\/a><\/span><\/strong><\/h4>\n

\u2022Apoptosis<\/a><\/span><\/strong><\/h4>\n

\u2022Autophagy<\/a><\/span><\/strong><\/h4>\n

\u2022Cell Cycle\/DNA Damage<\/a><\/span><\/strong><\/h4>\n

\u2022Cytoskeleton<\/a><\/span><\/strong><\/h4>\n

\u2022Epigenetics<\/a><\/span><\/strong><\/h4>\n

\u2022GPCR\/G Protein<\/a><\/span><\/strong><\/h4>\n

\u2022Immunology\/Inflammation<\/a><\/span><\/strong><\/h4>\n

\u2022JAK\/STAT Signaling<\/a>\u2022MAPK\/ERK Pathway<\/a><\/span><\/strong><\/h4>\n

\u2022Membrane Transporter\/Ion Channel<\/a><\/span><\/strong><\/h4>\n

\u2022Metabolic Enzyme\/Protease<\/a><\/span><\/strong><\/h4>\n

\u2022Neuronal Signaling<\/a><\/span><\/strong><\/h4>\n

\u2022NF-\u03baB<\/a><\/span><\/strong><\/h4>\n

\u2022PI3K\/Akt\/mTOR<\/a><\/span><\/strong><\/h4>\n

\u2022PROTAC<\/a><\/span><\/strong><\/h4>\n

\u2022Protein Tyrosine Kinase\/RTK<\/a>\u2022Stem Cell\/Wnt<\/a><\/span><\/strong><\/h4>\n

\u2022TGF-beta\/Smad<\/a><\/span><\/strong><\/h4>\n

\u2022Vitamin D Related<\/a><\/span><\/strong><\/h4>\n

\u2022Others<\/a><\/span><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"

MCE (MedChem Express) – ROCK\uff08Rho \u6fc0\u9176\uff09\u6291\u5236\u5291 MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b […]<\/p>\n","protected":false},"author":3,"featured_media":52867,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[6867,6866,5564,6869,6865,6868],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41203"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41203"}],"version-history":[{"count":7,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41203\/revisions"}],"predecessor-version":[{"id":52868,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41203\/revisions\/52868"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52867"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}