{"id":40590,"date":"2023-03-27T18:11:37","date_gmt":"2023-03-27T10:11:37","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=40590"},"modified":"2025-11-15T15:20:15","modified_gmt":"2025-11-15T07:20:15","slug":"nitrocefin-%e9%a1%af%e8%89%b2%e9%a0%ad%e5%ad%a2%e8%8f%8c%e7%b4%a0%e5%ba%95%e7%89%a9-cas41906-86-9-apexbio%e8%b2%a8%e8%99%9f-b6052","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=40590","title":{"rendered":"Nitrocefin | \u986f\u8272\u982d\u5b62\u83cc\u7d20\u5e95\u7269 CAS#41906-86-9 APExBIO\u8ca8\u865f B6052"},"content":{"rendered":"<p><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"http:\/\/biopioneer.com.tw\/?p=40461\"><span style=\"font-size: 12pt;\"><strong>Nitrocefin | \u986f\u8272\u982d\u5b62\u83cc\u7d20\u5e95\u7269(chromogenic\u00a0cephalosporin\u00a0substrate) CAS#41906-86-9 APExBIO\u8ca8\u865f B6052<\/strong><\/span><\/a><\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/03\/APEXBIO-%E8%B2%A8%E8%99%9FB6052.png\" alt=\"\" width=\"314\" height=\"266\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n<p>Nitrocefin \u662f\u4e00\u7a2e\u986f\u8272\u982d\u5b62\u83cc\u7d20\u5e95\u7269(chromogenic\u00a0cephalosporin\u00a0substrate)\uff0c\u7528\u65bc\u6aa2\u6e2c \u03b2-\u5167\u91af\u80fa\u9176(\u03b2-lactamases)\u3002 \u03b2-\u5167\u91af\u80fa\u9176(\u03b2-lactamases)\u662f\u7531\u5404\u7a2e\u5fae\u751f\u7269\u7522\u751f\u7684\u9176\uff0c\u53ef\u4ecb\u5c0e\u5c0d \u03b2-\u5167\u91af\u80fa\u985e\u6297\u751f\u7d20(\u03b2-lactam\u00a0antibiotics )\uff0c\u5982\u9752\u9ef4\u7d20(penicillins) \u548c\u982d\u9ef4\u7d20(cephamycins)\u7684\u8010\u85e5\u6027\u3002\u8207\u5176\u4ed6\u6aa2\u6e2c\u03b2-\u5167\u91af\u80fa\u9176(\u00a0\u03b2-lactamases )\u7684\u65b9\u6cd5\u76f8\u6bd4\uff0c\u982d\u5b62\u785d\u5511(\u00a0nitrocefin )\u66f4\u70ba\u9748\u654f\uff0c\u800c\u4e14\u4f7f\u7528\u7684\u6750\u6599\u5c11\uff0c\u8a2d\u5099\u4fbf\u5b9c\u3002\u53ef\u4ee5\u901a\u904e\u6e2c\u91cf 380 \u81f3 500 nm \u5340\u57df\u4e4b\u9593\u7684\u5438\u6536\u8b8a\u5316\u4f86\u5b9a\u91cf\u8ddf\u8e2a\u982d\u5b62\u785d\u5511(nitrocefin)\u7684\u984f\u8272\u8b8a\u5316 [1]\u3002<strong>\u00a0<\/strong><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/03\/Nitrocefin-%E9%A1%AF%E8%89%B2%E9%A0%AD%E5%AD%A2%E8%8F%8C%E7%B4%A0%E5%BA%95%E7%89%A9chromogenic-cephalosporin-substrate-CAS41906-86-9-APExBIO%E8%B2%A8%E8%99%9F-B6052.jpg\" alt=\"\" \/><\/p>\n<p>Nitrocefin\u00a0is a\u00a0chromogenic\u00a0cephalosporin\u00a0substrate which is used for detection of \u03b2-lactamases. \u03b2-lactamases are enzymes produced by various microbes that mediate resistance to\u00a0\u03b2-lactam\u00a0antibiotics such as\u00a0penicillins and \u00a0cephamycins. Comparing to other methods for \u03b2-lactamases detection, nitrocefin is more sensitive while using few materials and inexpensive equipment. The color change by nitrocefin can be followed quantitatively by measuring changes in absorption between 380 to 500 nm region[1].<\/p>\n<div id=\"cite\" class=\"tbar\">\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Product Citation<\/span><\/strong><\/span><\/h2>\n<\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<ul id=\"artul\">\n<li><a>1. Liu X, Ma L, et al. &#8220;Synergistic antibacterial mechanism of Bi(2)Te(3) nanoparticles combined with the ineffective \u03b2-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus.&#8221; J Inorg Biochem. 2019 Jul;196:110687.&#8221;<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31004991\" target=\"_blank\" rel=\"noopener\">PMID:31004991<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"chemical_property\" class=\"tbar\">\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Chemical Properties<\/span><\/strong><\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A crystalline solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>516.50<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>41906-86-9<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>21<\/sub>H<sub>16<\/sub>N<sub>4<\/sub>O<sub>8<\/sub>S<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>insoluble in EtOH; insoluble in H2O; \u226520.24 mg\/mL in DMSO<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>(6R,7R)-3-((E)-2,4-dinitrostyryl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/B6052.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>[H][C@]1([C@@H]2NC(CC3=CC=CS3)=O)SCC(\/C=C\/C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=C(C(O)=O)N1C2=O<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nitrocefin | \u986f\u8272\u982d\u5b62\u83cc\u7d20\u5e95\u7269(chromogenic\u00a0cephalosporin\u00a0substra [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":34299,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5386],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/40590"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=40590"}],"version-history":[{"count":4,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/40590\/revisions"}],"predecessor-version":[{"id":53703,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/40590\/revisions\/53703"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34299"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=40590"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=40590"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=40590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}