{"id":39821,"date":"2023-03-10T17:04:38","date_gmt":"2023-03-10T09:04:38","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=39821"},"modified":"2025-09-03T19:12:12","modified_gmt":"2025-09-03T11:12:12","slug":"olaparib-cas763113-22-0-medchemexpressmce%e8%b2%a8%e8%99%9fhy-10162","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=39821","title":{"rendered":"Olaparib | CAS#763113-22-0 MedChemExpress(MCE)\u8ca8\u865fHY-10162"},"content":{"rendered":"

MCE (MedChem Express)<\/span> Olaparib\u00a0<\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%<\/p>\n

<\/p>\n

CAS No. :\u00a0763113-22-0<\/a><\/p>\n

Olaparib (AZD2281; KU0059436) | CAS#763113-22-0 MedChemExpress(MCE)\u8ca8\u865fHY-10162 <\/a><\/span><\/p>\n

AZD2281; KU0059436<\/p>\n

Olaparib (AZD2281; KU0059436) \u662f\u4e00\u7a2e\u6709\u6548\u7684\u53e3\u670d\u6d3b\u6027 PARP \u6291\u5236\u5291\uff0c\u5c0d PARP1 \u548c PARP2 \u7684 IC50 \u5206\u5225\u70ba 5 \u548c 1 nM\u3002 Olaparib \u662f\u4e00\u7a2e\u81ea\u566c(autophagy )\u548c\u7dda\u7c92\u9ad4\u81ea\u566c\u6fc0\u6d3b\u5291(mitophagy activator)\u3002<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

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 <\/p>\n

Olaparib<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Oncogene<\/cite>. 2018 Jan 18;37(3):341-351. \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

PTEN-deficient endometrioid endometrial cancer cell lines are treated with drugs as indicated for 24\u2009h. Phosphorylated AKT, S6RP and 4EBP1 proteins and cleaved PARP are detected by western blot. Vinculin served as a loading control.<\/p>\n

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 <\/p>\n

Olaparib<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Gynecol Oncol<\/cite>. 2019 Jan;152(1):157-165. \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

Immunohistochemistry of RAD51 and \u03b3-H2AX in samples of SKOV3 tumors. Representative sections are taken from tumor tissue of control, scrambled shRNA treated, Olaparib + scrambled shRNA treated, or Olaparib + CCND1-shRNA treated mice.<\/p>\n

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 <\/p>\n

Olaparib<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0J Biomed Sci<\/cite>.\u00a02019 Feb 4;26(1):14.\u00a0 \u00a0<\/a>[Abstract]<\/b><\/a><\/span><\/p>\n

Inhibition of NFBD1 results in defective \u03b3-H2AX foci formation after Olaparib exposure, cells are exposed to Olaparib for 24 h, and the \u03b3-H2AX positive cells are determined by FCM<\/p>\n

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MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5316\u5408\u7269\u54c1\u724c<\/td>\n\u5316\u5408\u7269CAS\u865f<\/td>\n\u5316\u5408\u7269\u540d\u7a31<\/td>\n\u5316\u5408\u7269\u8ca8\u865f<\/td>\n\u5316\u5408\u7269\u4ecb\u7d39<\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#108321-42-2<\/td>\nG-418 disulfat<\/td>\nMCE\u8ca8\u865fHY-17561<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#68528-80-3<\/td>\nDSS Crosslinker (disuccinimidyl suberate)<\/td>\nMCE\u8ca8\u865fHY-W019543<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1380723-44-3<\/td>\nAtezolizumab<\/td>\nMCE\u8ca8\u865fHY-P9904<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1207456-01-6<\/td>\nTalazoparib (BMN-673; LT-673)<\/td>\nMCE\u8ca8\u865fHY-16106<\/span><\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#763113-22-0<\/td>\nOlaparib<\/td>\nMCE\u8ca8\u865fHY-10162<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1382764-52-4<\/td>\nLipidGreen 2\u8102\u8cea\u6210\u50cf\u5c0f\u5206\u5b50\u63a2\u91dd<\/td>\nMCE\u8ca8\u865fHY-D1353<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#103404-75-7<\/td>\nD-\u87a2\u5149\u7d20(D-luciferin) \u6c34\u6eb6\u6027\u9209\u9e7d<\/td>\nMCE\u8ca8\u865fHY-12591<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#15144-35-9<\/td>\nD-\u87a2\u5149\u7d20(D-Luciferin potassium)<\/td>\nMCE\u8ca8\u865fHY-12591B<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#186689-07-6<\/td>\n2-NBDG\u6d3b\u7d30\u80de\u548c\u7d44\u7e54\u8461\u8404\u7cd6\u7684\u651d\u53d6<\/td>\nMCE\u8ca8\u865fHY-116215<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\n<\/td>\nIPTG\u00a0 ( Isopropyl \u03b2-D-thiogalactoside)<\/td>\nMCE\u8ca8\u865fHY-15921<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#10121-91-2<\/td>\n\u81ea\u566c\u6ce1(autophagic vacuoles)\u87a2\u5149\u6a19\u8a8c<\/td>\nMCE\u8ca8\u865fHY-D1027<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#28728-55-4<\/td>\n\u805a\u51dd\u80fa(Polybrene) \u967d\u96e2\u5b50\u805a\u5408\u7269<\/td>\nMCE\u8ca8\u865fHY-112735<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#288250-47-5<\/td>\nY-320 \u514d\u75ab\u8abf\u7bc0\u5291<\/td>\nMCE\u8ca8\u865fHY-15898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#30931-67-0<\/td>\nABTS diammonium salt<\/td>\nMCE\u8ca8\u865fHY-15902<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#16561-29-8<\/td>\nPhorbol 12-myristate 13-acetate, PMA<\/td>\nMCE\u8ca8\u865fHY-18739<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#50-63-5<\/td>\n\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate<\/td>\nMCE\u8ca8\u865fHY-17589<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9003-11-6<\/td>\nPoloxamer 407<\/td>\nMCE\u8ca8\u865fHY-D1005<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#150347-59-4<\/td>\nCFSE\u87a2\u5149\u67d3\u6599<\/td>\nMCE\u8ca8\u865fHY-D0938<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9025-71-2<\/td>\n\u55ae\u5be7\u9176(Tannase)<\/td>\nMCE\u8ca8\u865fHY-P2877<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 941678-49-5<\/td>\nRuxolitinib<\/td>\nMCE\u8ca8\u865fHY-50856<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#9002-92-0<\/td>\nPolidocanol<\/td>\nMCE\u8ca8\u865fHY-B2106<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#HY-100579<\/td>\nFerrostatin-1 (Synonyms: Fer-1)<\/td>\nMCE\u8ca8\u865f HY-100579<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#154-23-4<\/td>\n\u5152\u8336\u7d20(Catechin)<\/td>\nMCE\u8ca8\u865f HY-N0898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nFT895\u5f37\u6548\u9078\u64c7\u6027 HDAC11 \u6291\u5236\u5291<\/td>\nMCE\u8ca8\u865f HY-112285<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 5471-63-6<\/td>\n1,3-\u4e8c\u82ef\u57fa\u7570\u82ef\u4e26\u544b\u5583 (DPBF)<\/td>\nMCE\u8ca8\u865f HY-W011664<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nAkaLumine hydrochloride<\/td>\nMCE\u8ca8\u865fHY-112641A<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#203115-63-3<\/td>\nWRN \u89e3\u65cb\u9176\u6291\u5236\u5291NSC 617145<\/td>\nMCE\u8ca8\u865f \u00a0HY-110185<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#2244-11-3<\/td>\nAlloxan hydrate<\/td>\nMCE\u8ca8\u865fHY-W017227<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#23491-44-3<\/td>\nHoechst 33258<\/td>\nMCE\u8ca8\u865fHY-15558<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#18883-66-4<\/td>\nStreptozotocin<\/td>\nMCE\u8ca8\u865fHY-13753<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#554435-83-5<\/td>\nDeferasirox (Fe3+ chelate)<\/td>\nMCE\u8ca8\u865f\u00a0HY-16564<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

MCE (MedChem Express) Olaparib\u00a0 MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca […]<\/p>\n","protected":false},"author":3,"featured_media":52894,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[6867,5471,6866,6869,6865,6868],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39821"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39821"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39821\/revisions"}],"predecessor-version":[{"id":52895,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39821\/revisions\/52895"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52894"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}