{"id":39756,"date":"2023-03-09T18:57:30","date_gmt":"2023-03-09T10:57:30","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=39756"},"modified":"2025-11-15T13:30:09","modified_gmt":"2025-11-15T05:30:09","slug":"%e5%a5%a7%e6%8b%89%e5%b8%95%e5%b0%bcolaparib-azd2281-ku-0059436-cas763113-22-0-apexbio-%e8%b2%a8%e8%99%9f-a4154","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=39756","title":{"rendered":"\u5967\u62c9\u5e15\u5c3c(Olaparib (AZD2281, Ku-0059436)| PARP\u6291\u5236\u5291CAS#763113-22-0 APExBIO \u8ca8\u865f A4154"},"content":{"rendered":"

\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>\u5967\u62c9\u5e15\u5c3c(Olaparib (AZD2281, Ku-0059436)<\/span>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

\u5967\u62c9\u5e15\u5c3c(Olaparib (AZD2281, Ku-0059436)| CAS#763113-22-0 APExBIO\u00a0 \u8ca8\u865f A4154<\/a><\/span><\/strong><\/p>\n

Potent PARP1\/PARP2 inhibitor, PARP\u6291\u5236\u5291<\/span><\/p>\n

Olaparib (4-(3-4-fluorophenyl) methyl-1(2H)-one)\uff0c\u7a31\u70ba AZD2281 \u6216 KU0059436\uff0c\u662f\u4e00\u7a2e\u65b0\u578b\u3001\u9078\u64c7\u6027\u548c\u6709\u6548\u7684\u6291\u5236\u5291\uff0c\u53ef\u6291\u5236\u805a\u817a\u82f7\u4e8c\u78f7\u9178-\u6838\u7cd6\u591a\u805a\u9ad4-1 (poly adenosine diphosphate-ribose polymeras-1 , PARP-1) ) \u548c\u805a\u817a\u82f7\u4e8c\u78f7\u9178-\u6838\u7cd6\u591a\u805a\u9ad4-2 (poly adenosine diphosphate-ribose polymeras-2, PARP-2)\u3002\u5967\u62c9\u5e15\u5c3c(Olaparib)\u5df2\u6210\u529f\u7528\u65bc\u6cbb\u7642\u651c\u5e36 BRCA \u7a81\u8b8a\u7684\u816b\u7624\uff0c\u53ef\u5f37\u70c8\u6291\u5236 BRCA2 \u7f3a\u9677\u5c0f\u9f20\u4e8c\u5143\u816b\u7624\u7d30\u80de\u7cfb\u7684\u751f\u9577\uff0c\u8868\u73fe\u51fa\u7d30\u80de\u6bd2\u6027\u3002\u5728\u4e4b\u524d\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c (non-small cell lung carcinoma , NSCLC) \u7684\u7814\u7a76\u4e2d\uff0c\u5967\u62c9\u5e15\u5c3c(Olaparib)\u589e\u52a0\u4e86 NSCLC \u7d30\u80de\u7684\u8f3b\u5c04\u654f\u611f\u6027\uff0c\u9019\u4e9b\u7d30\u80de\u5728\u8f3b\u5c04\u5f8c\u5728\u88f8\u9f20\u4e2d\u4f5c\u70ba\u7570\u7a2e\u79fb\u690d\u7269\u751f\u9577\uff0c\u4e26\u589e\u52a0\u4e86dorsal window chamber\u00a0 (dorsal window chamber , DWC) \u4e2d\u5efa\u7acb\u7684 Calu-6 \u816b\u7624\u4e2d\u7684vascular perfusion\u3002<\/p>\n

\"\"<\/p>\n

\u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09<\/a>|\u00a0Romidepsin (FK228, depsipeptide)<\/a>\u00a0|\u00a0Daptomycin\u00a0<\/a>|\u00a0G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291)<\/a><\/span><\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n434.46<\/td>\n<\/tr>\n
Cas No.<\/td>\n763113-22-0<\/td>\n<\/tr>\n
Formula<\/td>\nC24<\/sub>H23<\/sub>FN4<\/sub>O3<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nAZD 2281,AZD-2281<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226521.72 mg\/mL in DMSO; insoluble in EtOH; insoluble in H2O<\/td>\n<\/tr>\n
Chemical Name<\/td>\n4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

1. Leonie Sch\u00fcrmann, Lena Schumacher, et al. “Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways.” Cancer Lett. 2021 Nov 1;520:361-373.<\/a>\u00a0PMID:34389435<\/a><\/p>\n

2. Asha Sinha, Sachin Katyal, et al. “PARP-DNA trapping ability of PARP inhibitors jeopardizes astrocyte viability: Implications for CNS disease therapeutics.” Neuropharmacology. 2021 Apr 1;187:108502.<\/a>\u00a0PMID:33631119<\/a><\/p>\n

3. Phoebe McCrorie, Jatin Mistry, et al. “Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.” Eur J Pharm Biopharm. 2020 Oct 14;S0939-6411(20)30305-2.<\/a>\u00a0PMID:33068736<\/a><\/p>\n

4. Kim DS, Camacho CV, et al. “Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21.” Mol Cell. 2019 Jul 9. pii: S1097-2765(19)30476-9.<\/a>\u00a0PMID:31351877<\/a><\/p>\n

5. Singatulina AS, Hamon L, et al. “PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA.” Cell Rep. 2019 May 7;27(6):1809-1821.e5.<\/a>\u00a0PMID:31067465<\/a><\/p>\n

6. Kong X, Cruz GMS, et al. “Biphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repair.” J Cell Sci. 2018 Dec 5;131(23). pii: jcs219311.<\/a>\u00a0PMID:30404833<\/a><\/p>\n

\"\u54c1\u724c\u4ecb\u7d39_\u5de5\u4f5c\u5340\u57df<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/p>\n

https:\/\/www.apexbt.com\/<\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
APExBIO\u7522\u54c1\u7dda<\/span><\/td>\n\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n<\/tr>\n
Proteases<\/span><\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n<\/tr>\n
Proteinase K<\/span><\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/span><\/td>\nCAS#39450-01-6<\/span><\/td>\n\u8ca8\u865fK1037<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Romidepsin (FK228, depsipeptide)<\/a><\/span><\/td>\n\n

CAS#128517-07-7<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fA8173<\/span><\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n
Pirarubicin<\/a><\/span><\/td>\nCAS#72496-41-4<\/span><\/td>\n\u8ca8\u865fB2295<\/span><\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/span><\/td>\n<\/tr>\n
Tunicamycin<\/a><\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\n

\u8ca8\u865fA8321<\/span><\/p>\n

 <\/td>\n

\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
Azithromycin<\/a><\/span><\/td>\nCAS#83905-01-5<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
Bleomycin Sulfate<\/a><\/span><\/td>\n\n

CAS# 9041-93-4<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fB1398<\/span><\/td>\nAntibiotic by inhibiting protein synthesis<\/span><\/td>\n<\/tr>\n
Nystatin (Fungicidin)<\/a><\/span><\/td>\nCAS#1400-61-9<\/span><\/td>\n\u8ca8\u865fB1993<\/span><\/td>\nantifungal antibiotic<\/span><\/td>\n<\/tr>\n
Rapamycin<\/a><\/span><\/td>\nCAS#53123-88-9<\/span><\/td>\n\u8ca8\u865fA8167<\/span><\/td>\nOriginal antifungal antibiotic<\/span><\/td>\n<\/tr>\n
Daptomycin<\/a><\/span><\/td>\nCAS#103060-53-3<\/span><\/td>\n\u8ca8\u865fA1206<\/span><\/td>\nCalcium-dependent antibiotic<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Z-VAD-FMK \u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

ICE-like proteases<\/span><\/td>\n<\/tr>\n

TAPI-1 \u00a0<\/a><\/span><\/td>\nCAS#171235-71-5<\/span><\/td>\n\u8ca8\u865f\u00a0B4686<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

TACE\/ADAM17 inhibitor Product Citation+3<\/span><\/td>\n<\/tr>\n

Talabostat mesylate<\/a><\/span><\/td>\nCAS# 150080-09-4<\/span><\/td>\n\u8ca8\u865fB3941<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n

Z-IETD-FMK<\/a><\/span><\/td>\nCAS# 210344-98-2<\/span><\/td>\n\u8ca8\u865fB3232<\/span><\/td>\ninhibitor of caspase 8<\/span><\/td>\n<\/tr>\n
Cisplatin<\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\u8ca8\u865fA8321<\/span><\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
17-DMAG (Alvespimycin) HCl<\/a><\/span><\/td>\nCAS#467214-21-7<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
CA-074 Me\u00a0<\/a><\/span><\/td>\nCAS# 147859-80-1<\/span><\/td>\n\u8ca8\u865fA8239<\/span><\/td>\nCathepsin B inhibitor<\/span><\/td>\n<\/tr>\n
VX-765<\/a><\/span><\/td>\nCAS# 273404-37-8<\/span><\/td>\n\u8ca8\u865fA8238<\/span><\/td>\nCaspase-1 inhibitor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u54c1\u724c\u4ecb\u7d39_\u5de5\u4f5c\u5340\u57df<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/p>\n

https:\/\/www.apexbt.com\/<\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
APExBIO\u7522\u54c1\u7dda<\/span><\/td>\n\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n<\/tr>\n
Proteases<\/span><\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n<\/tr>\n
Proteinase K<\/span><\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/span><\/td>\nCAS#39450-01-6<\/span><\/td>\n\u8ca8\u865fK1037<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Romidepsin (FK228, depsipeptide)<\/a><\/span><\/td>\n\n

CAS#128517-07-7<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fA8173<\/span><\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n
Pirarubicin<\/a><\/span><\/td>\nCAS#72496-41-4<\/span><\/td>\n\u8ca8\u865fB2295<\/span><\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/span><\/td>\n<\/tr>\n
Tunicamycin<\/a><\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\n

\u8ca8\u865fA8321<\/span><\/p>\n

 <\/td>\n

\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
Azithromycin<\/a><\/span><\/td>\nCAS#83905-01-5<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
Bleomycin Sulfate<\/a><\/span><\/td>\n\n

CAS# 9041-93-4<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fB1398<\/span><\/td>\nAntibiotic by inhibiting protein synthesis<\/span><\/td>\n<\/tr>\n
Nystatin (Fungicidin)<\/a><\/span><\/td>\nCAS#1400-61-9<\/span><\/td>\n\u8ca8\u865fB1993<\/span><\/td>\nantifungal antibiotic<\/span><\/td>\n<\/tr>\n
Rapamycin<\/a><\/span><\/td>\nCAS#53123-88-9<\/span><\/td>\n\u8ca8\u865fA8167<\/span><\/td>\nOriginal antifungal antibiotic<\/span><\/td>\n<\/tr>\n
Daptomycin<\/a><\/span><\/td>\nCAS#103060-53-3<\/span><\/td>\n\u8ca8\u865fA1206<\/span><\/td>\nCalcium-dependent antibiotic<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Z-VAD-FMK \u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

ICE-like proteases<\/span><\/td>\n<\/tr>\n

TAPI-1 \u00a0<\/a><\/span><\/td>\nCAS#171235-71-5<\/span><\/td>\n\u8ca8\u865f\u00a0B4686<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

TACE\/ADAM17 inhibitor Product Citation+3<\/span><\/td>\n<\/tr>\n

Talabostat mesylate<\/a><\/span><\/td>\nCAS# 150080-09-4<\/span><\/td>\n\u8ca8\u865fB3941<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n

Z-IETD-FMK<\/a><\/span><\/td>\nCAS# 210344-98-2<\/span><\/td>\n\u8ca8\u865fB3232<\/span><\/td>\ninhibitor of caspase 8<\/span><\/td>\n<\/tr>\n
Cisplatin<\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\u8ca8\u865fA8321<\/span><\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
17-DMAG (Alvespimycin) HCl<\/a><\/span><\/td>\nCAS#467214-21-7<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
CA-074 Me\u00a0<\/a><\/span><\/td>\nCAS# 147859-80-1<\/span><\/td>\n\u8ca8\u865fA8239<\/span><\/td>\nCathepsin B inhibitor<\/span><\/td>\n<\/tr>\n
VX-765<\/a><\/span><\/td>\nCAS# 273404-37-8<\/span><\/td>\n\u8ca8\u865fA8238<\/span><\/td>\nCaspase-1 inhibitor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>\u5967\u62c9\u5e15\u5c3c(Olaparib (AZD2281, Ku-0059436) APE […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5480,5479],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39756"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39756"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39756\/revisions"}],"predecessor-version":[{"id":53628,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39756\/revisions\/53628"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39756"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39756"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}