{"id":39754,"date":"2023-03-09T18:38:22","date_gmt":"2023-03-09T10:38:22","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=39754"},"modified":"2025-11-15T15:52:54","modified_gmt":"2025-11-15T07:52:54","slug":"%e8%84%ab%e6%b0%ab%e8%a1%a8%e9%9b%84%e9%85%aedehydroepiandrosterone-dhea-cas-53-43-0-apexbio-%e8%b2%a8%e8%99%9f-b1375","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=39754","title":{"rendered":"\u812b\u6c2b\u8868\u96c4\u916e(Dehydroepiandrosterone (DHEA) | CAS# 53-43-0 APExBIO \u8ca8\u865f B1375"},"content":{"rendered":"

\u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09<\/a>|\u00a0Romidepsin (FK228, depsipeptide)<\/a>\u00a0|\u00a0Daptomycin\u00a0<\/a>|\u00a0G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291)<\/a><\/p>\n

\"Dehydroepiandrosterone<\/p>\n

\u812b\u6c2b\u8868\u96c4\u916e(Dehydroepiandrosterone (DHEA) | CAS# 53-43-0 APExBIO\u00a0 \u8ca8\u865f B1375<\/a><\/span><\/strong><\/p>\n

\u812b\u6c2b\u8868\u96c4\u916e(Dehydroepiandrosterone, DHEA)\u662f\u4e00\u7a2e\u91cd\u8981\u7684\u5167\u6e90\u6027\u985e\u56fa\u9187\u6fc0\u7d20[1]\u3002DHEA \u662f\u4e00\u7a2e\u91cd\u8981\u7684\u5167\u6e90\u6027\u985e\u56fa\u9187\u6fc0\u7d20(androgen)\uff0c\u5728\u96cc\u6fc0\u7d20(estrogen)\u548c\u96c4\u6fc0\u7d20(androgen)\u7684\u751f\u7269\u5408\u6210\u4e2d\u8d77\u8457\u4ee3\u8b1d\u4e2d\u9593\u9ad4\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0cDHEA \u901a\u904e\u8207\u6838\u548c\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\u4f75\u5145\u7576\u795e\u7d93\u985e\u56fa\u9187(neurosteroid)\uff0c\u5177\u6709\u591a\u7a2e\u6f5b\u5728\u7684\u751f\u7269\u5b78\u6548\u61c9\u3002\u5728\u6e90\u81ea\u80ce\u5152\u76ae\u5c64\u7684\u4eba\u985e\u795e\u7d93\u5e79\u7d30\u80de\u4e2d\uff0c\u7576\u8207\u767d\u8840\u75c5\u6291\u5236\u56e0\u5b50 (\u00a0leukemia inhibitory factor , LIF) \u548c\u8868\u76ae\u751f\u9577\u56e0\u5b50 (epidermal growth factor, EGF) \u4e00\u8d77\u751f\u9577\u6642\uff0cDHEA \u6703\u986f\u8457\u4fc3\u9032\u7d30\u80de\u751f\u9577\u3002\u6b64\u5916\uff0cDHEA \u4f7f\u795e\u7d93\u5143\u751f\u6210\u589e\u52a0\u4e86 29%\u3002\u5728\u81a0\u8cea\u7e96\u7dad\u9178\u6027\u86cb\u767d\u967d\u6027\u7d30\u80de(glial fibrillary acidic protein-positive cells)\u4e2d\uff0cDHEA\u986f\u8457\u589e\u52a0\u7d30\u80de\u751f\u9577\u3001\u9178\u6027\u86cb\u767d(acidic protein)\u7684mRNA\u548c\u86cb\u767d[2]\u3002\u5728\u5927\u9f20\u55dc\u927b\u7d30\u80de(chromaffin cells)\u548c\u55dc\u927b\u7d30\u80de\u7624 PC12 \u7d30\u80de\u682a (pheochromocytoma PC12 cell line) \u4e2d\uff0cDHEA \u4fdd\u8b77\u7d30\u80de\u514d\u53d7\u8840\u6e05\u525d\u596a\u8a98\u5c0e\u7684\u7d30\u80de\u51cb\u4ea1\uff0cEC50 \u503c\u70ba 1.8 nM\u3002 DHEA \u589e\u52a0\u4e86 NF-\u03baB \u548c cAMP \u53cd\u61c9\u5143\u4ef6\u7d50\u5408\u86cb\u767d\u7684\u8868\u9054\uff0c\u5b83\u5011\u662f\u6297\u51cb\u4ea1 Bcl-2 \u86cb\u767d\u7684\u4e0a\u6e38\u6548\u61c9\u5b50\u3002 DHEA \u9084\u6fc0\u6d3b\u4e86 PKC \u0251\/\u03b2\uff0c\u4e00\u7a2e Bcl-2 \u7684\u7ffb\u8b6f\u5f8c\u6fc0\u6d3b\u5291 [3]\u3002\u5728\u96c4\u6027 Lister \u8499\u9762\u5927\u9f20\u4e2d\uff0cs.c. DHEA \u9846\u7c92\u4fdd\u8b77\u6d77\u99ac CA1\/2 \u795e\u7d93\u5143\u514d\u53d7 N-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178 (NMDA)\uff085 \u6216 10 nM\uff09\u7684\u4fb5\u5bb3 [1]\u3002<\/p>\n

\"\"<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n288.42<\/td>\n<\/tr>\n
Cas No.<\/td>\n53-43-0<\/td>\n<\/tr>\n
Formula<\/td>\nC19<\/sub>H28<\/sub>O2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226513.7 mg\/mL in DMSO; \u226558.6 mg\/mL in ETOH<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nO=C1[C@]2(C)[C@@H](CC1)[C@H]3[C@H](CC2)[C@](CC[C@@H]4O)(C)C(C4)=CC3<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u54c1\u724c\u4ecb\u7d39_\u5de5\u4f5c\u5340\u57df<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/p>\n

https:\/\/www.apexbt.com\/<\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
APExBIO\u7522\u54c1\u7dda<\/span><\/td>\n\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n<\/tr>\n
Proteases<\/span><\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n<\/tr>\n
Proteinase K<\/span><\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/span><\/td>\nCAS#39450-01-6<\/span><\/td>\n\u8ca8\u865fK1037<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Romidepsin (FK228, depsipeptide)<\/a><\/span><\/td>\n\n

CAS#128517-07-7<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fA8173<\/span><\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n
Pirarubicin<\/a><\/span><\/td>\nCAS#72496-41-4<\/span><\/td>\n\u8ca8\u865fB2295<\/span><\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/span><\/td>\n<\/tr>\n
Tunicamycin<\/a><\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\n

\u8ca8\u865fA8321<\/span><\/p>\n

 <\/td>\n

\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
Azithromycin<\/a><\/span><\/td>\nCAS#83905-01-5<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
Bleomycin Sulfate<\/a><\/span><\/td>\n\n

CAS# 9041-93-4<\/span><\/p>\n

 <\/td>\n

\u8ca8\u865fB1398<\/span><\/td>\nAntibiotic by inhibiting protein synthesis<\/span><\/td>\n<\/tr>\n
Nystatin (Fungicidin)<\/a><\/span><\/td>\nCAS#1400-61-9<\/span><\/td>\n\u8ca8\u865fB1993<\/span><\/td>\nantifungal antibiotic<\/span><\/td>\n<\/tr>\n
Rapamycin<\/a><\/span><\/td>\nCAS#53123-88-9<\/span><\/td>\n\u8ca8\u865fA8167<\/span><\/td>\nOriginal antifungal antibiotic<\/span><\/td>\n<\/tr>\n
Daptomycin<\/a><\/span><\/td>\nCAS#103060-53-3<\/span><\/td>\n\u8ca8\u865fA1206<\/span><\/td>\nCalcium-dependent antibiotic<\/span><\/td>\n<\/tr>\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
Z-VAD-FMK \u00a0<\/a><\/span><\/td>\nCAS# 187389-52-2<\/span><\/td>\n\u8ca8\u865f\u00a0A1902<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

ICE-like proteases<\/span><\/td>\n<\/tr>\n

TAPI-1 \u00a0<\/a><\/span><\/td>\nCAS#171235-71-5<\/span><\/td>\n\u8ca8\u865f\u00a0B4686<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

TACE\/ADAM17 inhibitor Product Citation+3<\/span><\/td>\n<\/tr>\n

Talabostat mesylate<\/a><\/span><\/td>\nCAS# 150080-09-4<\/span><\/td>\n\u8ca8\u865fB3941<\/span><\/td>\n\n

Proteases<\/span><\/p>\n

DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n

Z-IETD-FMK<\/a><\/span><\/td>\nCAS# 210344-98-2<\/span><\/td>\n\u8ca8\u865fB3232<\/span><\/td>\ninhibitor of caspase 8<\/span><\/td>\n<\/tr>\n
Cisplatin<\/span><\/td>\nCAS# 15663-27-1<\/span><\/td>\n\u8ca8\u865fA8321<\/span><\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/span><\/td>\n<\/tr>\n
17-DMAG (Alvespimycin) HCl<\/a><\/span><\/td>\nCAS#467214-21-7<\/span><\/td>\n\u00a0\u8ca8\u865fA2213<\/span><\/td>\nHsp90 inhibitor<\/span><\/td>\n<\/tr>\n
CA-074 Me\u00a0<\/a><\/span><\/td>\nCAS# 147859-80-1<\/span><\/td>\n\u8ca8\u865fA8239<\/span><\/td>\nCathepsin B inhibitor<\/span><\/td>\n<\/tr>\n
VX-765<\/a><\/span><\/td>\nCAS# 273404-37-8<\/span><\/td>\n\u8ca8\u865fA8238<\/span><\/td>\nCaspase-1 inhibitor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09|\u00a0Romidepsin (FK228, depsipeptide)\u00a0|\u00a0Dap […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[5481],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39754"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39754"}],"version-history":[{"count":4,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39754\/revisions"}],"predecessor-version":[{"id":53765,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39754\/revisions\/53765"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}