{"id":36827,"date":"2022-12-05T17:27:40","date_gmt":"2022-12-05T09:27:40","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=36827"},"modified":"2023-11-24T16:05:58","modified_gmt":"2023-11-24T08:05:58","slug":"discoveryprobe-fda-approved-drug-library-apexbio-%e8%b2%a8%e8%99%9fl1021","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=36827","title":{"rendered":"DiscoveryProbe\u2122 FDA-approved Drug Library APExBIO \u8ca8\u865fL1021"},"content":{"rendered":"

\u85e5\u54c1\u5eab (Drug Library) FDA \u6838\u51c6\u7684\u85e5\u7269\u5eab(drug library)<\/span>
\n<\/span><\/span><\/span><\/strong><\/span><\/p>\n

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https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

DiscoveryProbe\u00a0 Drug Library<\/strong>\u7cfb\u5217\u7522\u54c1<\/strong><\/span><\/p>\n

\u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(Bioactive Screening Libraries)\u662f\u5373\u7528\u578b\u5316\u5b78\u5eab(chemical libraries)\uff0c\u7528\u65bc\u85e5\u7269\u767c\u73fe(drug discovery)\u3001\u5be6\u9a57\u5ba4\u85e5\u7269\u7be9\u9078(lab drug screening)\u3001\u85e5\u7269\u9776\u6a19\u8b58\u5225(drug target identification)\u548c\u5176\u4ed6\u88fd\u85e5\u76f8\u95dc\u61c9\u7528(pharmaceutical-related applications)\u3002\u5b83\u5011\u53ef\u7528\u65bc\u9ad8\u901a\u91cf\u7be9\u9078 (high-throughput screening , HTS) \u548c\u9ad8\u5167\u6db5\u7be9\u9078 (high-content screening , HCS)\u3002libraries\u5305\u542b\u8d85\u904e 5,000 \u500b\u5177\u6709\u7d93\u904e\u9a57\u8b49\u7684\u751f\u7269\u5b78(validated biological)\u548c\u85e5\u7406\u5b78\u6d3b\u6027(pharmacological activities)\u7684\u5c0f\u5206\u5b50(small molecules)\u3002\u9084\u8b49\u660e\u4e86\u5316\u5408\u7269\u7684\u6eb6\u89e3\u6027(solubility)\u3001\u7d14\u5ea6(purity)\u548c\u7a69\u5b9a\u6027(stability)\u3002\u9019\u4e9b\u5316\u5408\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5df2\u901a\u904e\u6587\u737b(literature)\u3001\u81e8\u5e8a\u524d(preclinical)\u548c\u81e8\u5e8a\u7814\u7a76(clinical research)\u5f97\u5230\u8b49\u660e\uff0c\u8a31\u591a\u5316\u5408\u7269\u5df2\u7372\u5f97 FDA \u6279\u51c6(FDA-approved)\u3002\u7368\u7279\u5c0f\u5206\u5b50\u7684\u96c6\u5408\uff0c\u5305\u62ec\u6291\u5236\u5291(inhibitors)\u3001\u62ee\u6297\u5291(antagonists)\u548c\u6fc0\u52d5\u5291(agonists)\u3002\u9019\u4e9b\u5316\u5408\u7269\u5c08\u6ce8\u65bc\u6578\u767e\u500b\u76ee\u6a19\uff0c\u9019\u4e9b\u76ee\u6a19\u662f 20 \u591a\u500b\u4fe1\u865f\u901a\u8def(signaling pathways)\u6216\u7814\u7a76\u9818\u57df(research areas)\u7684\u4e00\u90e8\u5206\uff0c\u5305\u62ec DNA \u640d\u50b7(DNA Damage )\/DNA \u4fee\u5fa9(DNA Repair)\u3001\u7d30\u80de\u9031\u671f(Cell Cycle )\/\u6aa2\u67e5\u9ede(Checkpoint)\u3001JAK\/STAT \u4fe1\u865f\u901a\u8def(Signaling Pathway)\u3001MAPK \u4fe1\u865f\u901a\u8def(MAPK Signaling Pathway)\u3001GPCR\/G \u86cb\u767d(GPCR\/G protein)\u3001\u8840\u7ba1\u751f\u6210(Angiogenesis)\u3001\u514d\u75ab\u5b78\/\u708e\u75c7(Immunology\/Inflammation )\u3001\u5167\u5206\u6ccc\u5b78\u548c\u6fc0\u7d20(Endocrinology and Hormones)\u3001\u764c\u75c7\u751f\u7269\u5b78(Cancer Biology)\u3001\u65b0\u9673\u4ee3\u8b1d(Metabolism)\u3001\u5e79\u7d30\u80de(Stem Cell)\u7b49\u3002\u63d0\u4f9b\u5b9a\u5236\u7684\u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(customized bioactive screening libraries)\uff0c\u60a8\u53ef\u4ee5\u5728\u5eab\u4e2d\u9078\u64c7\u6240\u9700\u7684\u5316\u5408\u7269\u3001\u5927\u5c0f\u3001\u6578\u91cf\u3001\u5f62\u5f0f\uff08\u7c89\u672b\u6216\u6eb6\u6db2\uff09\u548cplate\u3002<\/p>\n

FDA \u6838\u51c6\u7684\u85e5\u7269\u5eab(drug library) L1021<\/strong><\/span><\/p>\n

DiscoveryProbe\u2122 FDA-approved Drug Library APExBIO\u00a0 \u8ca8\u865fL1021<\/span><\/span><\/span><\/strong><\/a><\/span><\/p>\n

DiscoveryProbe\u2122 FDA \u6279\u51c6\u7684\u85e5\u7269\u5eab(drug library)\u5305\u62ec 2320 \u7a2e FDA \u6279\u51c6\u7684\u7528\u65bc\u9ad8\u901a\u91cf\u7be9\u9078 (high throughput screening ,HTS) \u548c\u9ad8\u5167\u6db5\u7be9\u9078 (high content screening ,HCS) \u7684\u85e5\u7269\u3002\u5b83\u53ef\u4ee5\u7528\u4f86\u70ba\u820a\u85e5\u5c0b\u627e\u65b0\u9776\u9ede\u3002\u9019\u4e9b\u85e5\u7269\u7684\u751f\u7269\u6d3b\u6027\u548c\u5b89\u5168\u6027\u5df2\u901a\u904e\u81e8\u5e8a\u8a66\u9a57\u5f97\u5230\u8b49\u5be6\u3002\u7531\u65bc\u90fd\u662fFDA\u6279\u51c6\u7684\u85e5\u7269\uff0c\u7be9\u9078\u51fa\u4f86\u7684\u85e5\u7269\u53ef\u4ee5\u76f4\u63a5\u7528\u65bc\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n

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\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Catalog No.<\/strong><\/td>\nProduct Name<\/strong><\/td>\nSummary<\/strong><\/td>\nTargets<\/strong><\/td>\nCAS Number<\/strong><\/td>\n<\/tr>\n
A3298<\/td>\nCetirizine<\/td>\nAntihistamine<\/td>\nNeuroscience|Histamine Receptor<\/td>\n83881-51-0<\/td>\n<\/tr>\n
A3789<\/td>\nSalmeterol xinafoate<\/td>\n\u03b22-adrenergic receptor agonist<\/td>\nGPCR\/G protein|Adrenergic Receptor<\/td>\n94749-08-3<\/td>\n<\/tr>\n
A4363<\/td>\nFluvastatin Sodium<\/td>\nHMG-CoA reductase inhibitor<\/td>\nMetabolism|HMG-CoA Reductase<\/td>\n93957-55-2<\/td>\n<\/tr>\n
A4370<\/td>\nMoclobemide (Ro 111163)<\/td>\nReversible inhibitor of MAO-A<\/td>\nMetabolism|MAO<\/td>\n71320-77-9<\/td>\n<\/tr>\n
A8252<\/td>\nNintedanib(BIBF 1120)<\/td>\nVEGFR\/PDGFR\/FGFR inhibitor<\/td>\nTyrosine Kinase\/Adaptors|PDGFR<\/td>\n928326-83-4<\/td>\n<\/tr>\n
B1792<\/td>\nMontelukast Sodium<\/td>\nLeukotriene receptor antagonist<\/td>\nGPCR\/G protein|CysLT1 receptor<\/td>\n151767-02-1<\/td>\n<\/tr>\n
N1674<\/td>\nPiperine<\/td>\nMAPK inhibitor<\/td>\nNatural Products<\/td>\n94-62-2<\/td>\n<\/tr>\n
N1707<\/td>\nCoumarin<\/td>\nPrecursor in chemical reaction<\/td>\nNatural Products<\/td>\n91-64-5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong>James M. Havrilla, Cong Liu, et al. “PhenCards: a data resource linking human phenotype information to biomedical knowledge.” Genome Med. 2021 May 25;13(1):91.PMID:34034817<\/a><\/p>\n

    \n
  1. Gur D, Chitlaru T, Mamroud E, et al. “Screening of an FDA-Approved Library for Novel Drugs against Y. pestis.” Antibiotics (Basel). 2021 Jan 3;10(1):40.PMID:33401634<\/a><\/li>\n
  2. Moore JA, Meakin M, et al. “Effects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin.” J Glob Antimicrob Resist. 2020;S2213-7165(20)30078-3.PMID:32247076<\/a><\/li>\n
  3. Turner TH, Alzubi MA, et al. “Identification of synergistic drug combinations using breast cancer patient-derived xenografts.” Sci Rep. 2020 Jan 30;10(1):1493.PMID:32001757<\/a><\/li>\n
  4. Yang JJ, Han Y, et al. “Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction.” Anal Chim Acta. 2020;1100:88\u201396.PMID:31987156<\/a><\/li>\n<\/ol>\n

    \u00a0\"\"<\/strong><\/p>\n

    DiscoveryProbe\u00a0 Drug Library<\/strong>\u7cfb\u5217\u7522\u54c1<\/strong><\/span><\/p>\n

    \u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(Bioactive Screening Libraries)\u662f\u5373\u7528\u578b\u5316\u5b78\u5eab(chemical libraries)\uff0c\u7528\u65bc\u85e5\u7269\u767c\u73fe(drug discovery)\u3001\u5be6\u9a57\u5ba4\u85e5\u7269\u7be9\u9078(lab drug screening)\u3001\u85e5\u7269\u9776\u6a19\u8b58\u5225(drug target identification)\u548c\u5176\u4ed6\u88fd\u85e5\u76f8\u95dc\u61c9\u7528(pharmaceutical-related applications)\u3002\u5b83\u5011\u53ef\u7528\u65bc\u9ad8\u901a\u91cf\u7be9\u9078 (high-throughput screening , HTS) \u548c\u9ad8\u5167\u6db5\u7be9\u9078 (high-content screening , HCS)\u3002<\/p>\n

    libraries\u5305\u542b\u8d85\u904e 5,000 \u500b\u5177\u6709\u7d93\u904e\u9a57\u8b49\u7684\u751f\u7269\u5b78(validated biological)\u548c\u85e5\u7406\u5b78\u6d3b\u6027(pharmacological activities)\u7684\u5c0f\u5206\u5b50(small molecules)\u3002\u9084\u8b49\u660e\u4e86\u5316\u5408\u7269\u7684\u6eb6\u89e3\u6027(solubility)\u3001\u7d14\u5ea6(purity)\u548c\u7a69\u5b9a\u6027(stability)\u3002\u9019\u4e9b\u5316\u5408\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5df2\u901a\u904e\u6587\u737b(literature)\u3001\u81e8\u5e8a\u524d(preclinical)\u548c\u81e8\u5e8a\u7814\u7a76(clinical research)\u5f97\u5230\u8b49\u660e\uff0c\u8a31\u591a\u5316\u5408\u7269\u5df2\u7372\u5f97 FDA \u6279\u51c6(FDA-approved)\u3002<\/p>\n

    \u7368\u7279\u5c0f\u5206\u5b50\u7684\u96c6\u5408\uff0c\u5305\u62ec\u6291\u5236\u5291(inhibitors)\u3001\u62ee\u6297\u5291(antagonists)\u548c\u6fc0\u52d5\u5291(agonists)\u3002\u9019\u4e9b\u5316\u5408\u7269\u5c08\u6ce8\u65bc\u6578\u767e\u500b\u76ee\u6a19\uff0c\u9019\u4e9b\u76ee\u6a19\u662f 20 \u591a\u500b\u4fe1\u865f\u901a\u8def(signaling pathways)\u6216\u7814\u7a76\u9818\u57df(research areas)\u7684\u4e00\u90e8\u5206\uff0c\u5305\u62ec DNA \u640d\u50b7(DNA Damage )\/DNA \u4fee\u5fa9(DNA Repair)\u3001\u7d30\u80de\u9031\u671f(Cell Cycle )\/\u6aa2\u67e5\u9ede(Checkpoint)\u3001JAK\/STAT \u4fe1\u865f\u901a\u8def(Signaling Pathway)\u3001MAPK \u4fe1\u865f\u901a\u8def(MAPK Signaling Pathway)\u3001GPCR\/G \u86cb\u767d(GPCR\/G protein)\u3001\u8840\u7ba1\u751f\u6210(Angiogenesis)\u3001\u514d\u75ab\u5b78\/\u708e\u75c7(Immunology\/Inflammation )\u3001\u5167\u5206\u6ccc\u5b78\u548c\u6fc0\u7d20(Endocrinology and Hormones)\u3001\u764c\u75c7\u751f\u7269\u5b78(Cancer Biology)\u3001\u65b0\u9673\u4ee3\u8b1d(Metabolism)\u3001\u5e79\u7d30\u80de(Stem Cell)\u7b49\u3002<\/p>\n

    \u63d0\u4f9b\u5b9a\u5236\u7684\u751f\u7269\u6d3b\u6027\u7be9\u9078\u5eab(customized bioactive screening libraries)\uff0c\u60a8\u53ef\u4ee5\u5728\u5eab\u4e2d\u9078\u64c7\u6240\u9700\u7684\u5316\u5408\u7269\u3001\u5927\u5c0f\u3001\u6578\u91cf\u3001\u5f62\u5f0f\uff08\u7c89\u672b\u6216\u6eb6\u6db2\uff09\u548cplate\u3002<\/p>\n

    \"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/p>\n

    https:\/\/www.apexbt.com\/<\/a><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u52dd\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u85e5\u54c1\u5eab (Drug Library) FDA \u6838\u51c6\u7684\u85e5\u7269\u5eab(drug library) https:\/\/www […]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5083],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/36827"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36827"}],"version-history":[{"count":14,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/36827\/revisions"}],"predecessor-version":[{"id":47349,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/36827\/revisions\/47349"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}