{"id":35423,"date":"2022-10-26T15:01:07","date_gmt":"2022-10-26T07:01:07","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35423"},"modified":"2025-11-15T15:57:05","modified_gmt":"2025-11-15T07:57:05","slug":"rgfp966-cas1357389-11-71396841-57-8-apexbio-%e8%b2%a8%e8%99%9fa8803-2","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=35423","title":{"rendered":"RGFP966 | CAS#1357389-11-7;1396841-57-8 APExBIO \u8ca8\u865fA8803"},"content":{"rendered":"

HDAC \u7cfb\u5217\u5546\u54c1->>RGFP966<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

RGFP966 | CAS#1357389-11-7;1396841-57-8 APExBIO\u00a0 \u8ca8\u865fA8803<\/a><\/span><\/p>\n

Specific HDAC3 inhibitor.<\/p>\n

RGFP966 is a selective inhibitor of HDAC3 with IC50 value of 80 nM [1].<\/p>\n

\"\"<\/p>\n

RGFP966 \u662f HDAC3 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291\uff0cIC50 \u503c\u70ba 80 nM [1]\u3002HDAC3\uff08histone deacetylase 3, \u7d44\u86cb\u767d\u812b\u4e59\u91af\u9176 3\uff09\u662f HDACs \u5bb6\u65cf\u7684\u4e00\u7a2e\u7570\u69cb\u9ad4\uff0c\u5728 DNA \u8f49\u9304\u8abf\u63a7(DNA transcriptional regulation)\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u5df2\u7d93\u8868\u660e\uff0cHDACs \u6d89\u53ca\u591a\u7a2e\u751f\u7269\u904e\u7a0b\uff0c\u5982 DNA \u4fee\u5fa9(DNA repair)\u3001\u8907\u88fd(replication)\u3001\u8f49\u9304(transcription)\u548c\u67d3\u8272\u8cea\u7d50\u69cb(chromatin structure)\u3002\u8a31\u591a\u7814\u7a76\u8868\u660e\uff0cHDACs \u662f\u5927\u8166\u4e2d\u8868\u9054\u6700\u9ad8\u7684 I \u985e HDAC\uff0c\u8ca0\u5411\u53c3\u8207\u5b78\u7fd2(learning)\u548c\u8a18\u61b6\u904e\u7a0b(memory process) [2]\u3002RGFP966 \u662f\u4e00\u7a2e\u6709\u6548\u7684 HDAC3 \u6291\u5236\u5291(HDAC3 inhibitor)\uff0c\u5728\u6fc3\u5ea6\u9ad8\u9054 15 \u03bcM \u6642\u5c0d\u5176\u4ed6 HDAC \u6c92\u6709\u6291\u5236\u4f5c\u7528\u3002\u4f7f\u7528\u5e95\u7269\u4f9d\u8cf4\u6027\u751f\u5316\u8a66\u9a57\u7814\u7a76RGFP966\u5c0dHDACs\u7684\u6291\u5236\u4f5c\u7528\uff0c\u7d50\u679c\u8868\u660e\u5b83\u6291\u5236HDAC3\u7684IC50\u503c\u70ba80 nM\uff0c\u800c\u5c0d\u5176\u4ed6HDACs\u6c92\u6709\u6709\u6548\u6291\u5236\u4f5c\u7528[1]\u3002\u7576\u7528 RGFP966 \u5c0d\u76ae\u819a T \u7d30\u80de\u6dcb\u5df4\u7624 (T cell lymphoma , CTCL) \u7d30\u80de\u7cfb\u9032\u884c\u6e2c\u8a66\u6642\uff0c\u901a\u904e\u6291\u5236\u589e\u52a0\u7d30\u80de\u51cb\u4ea1\u7684 HDAC3\uff0c\u7d30\u80de\u751f\u9577(cell apoptosis)\u986f\u8457\u964d\u4f4e [3]\u3002\u5728\u96c4\u6027 C57BL\/6J \u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5728\u7d66\u4e88 RGFP966 \u5f8c\u5728\u4e9e\u95be\u503c\u671f\u9593\u5c0d\u5b83\u5011\u9032\u884c\u7269\u9ad4\u8b58\u5225 (ORM) \u548c\u4f4d\u7f6e\u4f9d\u8cf4\u6027\u7269\u9ad4\u8b58\u5225 (OLM) \u8a13\u7df4\uff0c\u986f\u8457\u589e\u52a0\u4e86\u65b0\u7684\u7269\u9ad4\u504f\u597d\u4e26\u589e\u5f37\u4e86\u9577\u671f OLM \u7684\u5291\u91cf-\u4f9d\u8cf4\u65b9\u5f0f[1]\u3002<\/p>\n

\"\"<\/p>\n

    \n
  1. Zhang M, Urabe G, et al. “HDAC6 Regulates the MRTF-A\/SRF Axis and Vascular Smooth Muscle Cell Plasticity.” JACC Basic Transl Sci. 2018 Dec 31;3(6):782-795.PMID:30623138<\/a><\/li>\n
  2. Huang L, Lai WH, et al. “Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.” ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.PMID:29541372<\/a><\/li>\n
  3. Topper MJ, Vaz M, et al. “Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.” Cell. 2017 Nov 30;171(6):1284-1300.e21.PMID:29195073<\/a><\/li>\n
  4. Sun XY, Qu Y, et al. “Novel histone deacetylase inhibitor N25 exerts anti-tumor effects and induces autophagy in human glioma cells by inhibiting HDAC3.”Oncotarget. 2017 Sep 8;8(43):75232-75242.PMID:29088860<\/a><\/li>\n<\/ol>\n

     <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n362.4<\/td>\n<\/tr>\n
    Cas No.<\/td>\n1357389-11-7;1396841-57-8<\/td>\n<\/tr>\n
    Formula<\/td>\nC21<\/sub>H19<\/sub>FN4<\/sub>O<\/td>\n<\/tr>\n
    Synonyms<\/td>\nRGFP 966;RGFP-966<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in H2O; \u226518.12 mg\/mL in DMSO; \u22652.94 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nC1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
    SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
    RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
    AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
    \n

    ORY-1001<\/a><\/span><\/p>\n

     <\/td>\n

    		CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
    RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
    Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
    (S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

    \u8ca8\u865fA8802<\/span><\/p>\n

     <\/td>\n

    		Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
    Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    HDAC \u7cfb\u5217\u5546\u54c1->>RGFP966 APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5018],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35423"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35423"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35423\/revisions"}],"predecessor-version":[{"id":53771,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35423\/revisions\/53771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}