{"id":35213,"date":"2022-10-22T21:02:39","date_gmt":"2022-10-22T13:02:39","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35213"},"modified":"2025-11-15T16:02:54","modified_gmt":"2025-11-15T08:02:54","slug":"rhps4n-cas390362-78-4-apexbio%e8%b2%a8%e8%99%9fb6186-dna-damagedna-repair","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=35213","title":{"rendered":"RHPS4n | CAS#390362-78-4 APExBIO\u8ca8\u865fB6186 (DNA Damage\/DNA Repair)"},"content":{"rendered":"

DNA\u640d\u50b7\/DNA\u4fee\u5fa9\u7cfb\u5217\u5546\u54c1->>RHPS4n<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

APExBIO –<\/strong>DNA Damage\/DNA Repair<\/strong>\u7cfb\u5217\u7522\u54c1<\/strong>+236<\/strong><\/span><\/p>\n

\"\"<\/p>\n

\u7531\u65bc\u5916\u90e8\uff08exogenous, \u5916\u6e90\u6027\uff09\u548c\u5167\u90e8\uff08endogenous, \u5167\u6e90\u6027\uff09\u58d3\u529b\uff0c\u4eba\u9ad4\u7d30\u80de\u4e2d\u7684 DNA \u6bcf\u5929\u6703\u53d7\u5230\u6578\u4ee5\u842c\u8a08\u7684\u640d\u5bb3(damages)\u3002\u5916\u6e90\u6027\u640d\u5bb3(exogenous damages)\u662f\u7531\u5316\u5b78\u6c61\u67d3(chemical contamination)\u3001\u7d2b\u5916\u7dda(UV light)\u3001\u96fb\u96e2\u8f3b\u5c04(ionizing radiation)\u548c\u70f7\u57fa\u5316\/\u7532\u57fa\u5316(alkylation\/methylation)\u7b49\u5f15\u8d77\u7684\uff0c\u800c\u5167\u6e90\u6027\u640d\u5bb3(endogenous damages)\u662f\u7531\u9e7c\u7684\u6c27\u5316(oxidation)\u3001\u70f7\u57fa\u5316(alkylation)\u548c\u6c34\u89e3(hydrolysis)\u7b49\u5f15\u8d77\u7684\u3002\u7531\u65bcDNA\u640d\u50b7(double strand breaks)\u5f8c\u6703\u767c\u751f\u55ae\u934a(single strand)\u548c\u96d9\u93c8\u65b7\u88c2(double strand breaks)\uff0c\u672a\u4fee\u5fa9\u7684DNA\u640d\u50b7\u5c0e\u81f4\u7d30\u80de\u8870\u8001(cell senescent)\u3001\u51cb\u4ea1(apoptosis)\u548c\u60e1\u6027\u816b\u7624(malignancies)\u7b49\u3002\u70ba\u4e86\u514b\u670d\u9019\u7a2e\u5a01\u8105\uff0c\u7d30\u80de\u7522\u751f\u4e86 DNA \u640d\u50b7\u53cd\u61c9(DNA damage response)\uff0c\u4ee5\u6aa2\u6e2c DNA \u640d\u50b7\u4e26\u4ecb\u5c0e\u5176\u4fee\u5fa9(repair)\u3002DNA\u4fee\u5fa9\u6d89\u53ca\u932f\u914d\u3001\u9e7c\u57fa\u5207\u9664\u3001\u6838\u82f7\u9178\u5207\u9664\u4fee\u5fa9\u7b49\u591a\u7a2e\u6a5f\u5236\u3002\u4e00\u7d44\u86cb\u767d\u8cea\u548c\u9014\u5f91\u53c3\u8207\u4e86\u9019\u4e9b\u904e\u7a0b\u3002 ATM\/ATR \u6fc0\u9176\u548c DNA-PK \u5c0d\u65bc\u6aa2\u6e2c DNA \u640d\u50b7\u81f3\u95dc\u91cd\u8981\u3002\u67d3\u8272\u8cea\u91cd\u5851\u5291\u8abf\u7bc0 DNA \u4fee\u5fa9\u56e0\u5b50\u767c\u63ee\u4f5c\u7528\u7684\u67d3\u8272\u8cea\u53ef\u53ca\u6027\u3002 RPA\u3001Rad51 \u548c\u7bc4\u53ef\u5c3c\u8ca7\u8840\u86cb\u767d\u76f4\u63a5\u4f5c\u7528\u65bc\u4fee\u5fa9 DNA \u640d\u50b7\u3002 p53 \u7db2\u7d61\u3001RAS GTPase \u8d85\u5bb6\u65cf\u548c\u6cdb\u7d20\u7cfb\u7d71\u4e5f\u5728 DNA \u640d\u50b7\u53cd\u61c9\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002\u7570\u5e38\u7684 DNA \u640d\u50b7\u53cd\u61c9\u8207\u8870\u8001\u3001\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u6709\u95dc\u3002<\/p>\n

RHPS4n | CAS#390362-78-4 APExBIO\u8ca8\u865fB6186<\/a><\/span><\/p>\n

Telomerase inhibitor<\/p>\n

\"RHPS4\"<\/p>\n

 <\/p>\n

 <\/p>\n

IC50\uff1aM14 \u7d30\u80de\u5728 5 \u5929\u751f\u9577\u6291\u5236\u8a66\u9a57(growth inhibition assay)\u4e2d\u7d04\u70ba 3 \u03bcM<\/p>\n

RHPS4 \u662f\u4e00\u7a2e\u7aef\u7c92\u9176\u6291\u5236\u5291(telomerase inhibitor)\u3002\u67d3\u8272\u9ad4\u672b\u7aef(chromosome termini)\u7684\u4fdd\u8b77\u3001\u964d\u89e3(degradation)\u548c\u91cd\u7d44(recombination)\u53d7\u7aef\u7c92(telomeres)\u8abf\u63a7\u3002\u6700\u8fd1\u7684\u4e00\u500b\u6a21\u578b\u63d0\u51fa\u7aef\u7c92(telomeres)\u53ef\u4ee5\u5728\u67d3\u8272\u9ad4\u672b\u7aef(chromosome end)\u5f62\u6210\u4e00\u500bcap\u3002\u56e0\u6b64\uff0c\u7aef\u7c92\u5e3d\u7684\u5b8c\u6574\u6027(telomere cap integrity)\u61c9\u8a72\u662f\u5b8c\u6574\u7684\uff0c\u4ee5\u5141\u8a31\u7d30\u80de\u5206\u88c2(cell division)\u7e7c\u7e8c\u9032\u884c\u3002\u9ad4\u5916\u8a66\u9a57\uff1a\u767c\u73fe RHPS4 \u5c0d UXF1138L \u7d30\u80de\u7684\u8655\u7406\u5c0e\u81f4\u7aef\u7c92\u9176\u50ac\u5316\u4e9e\u57fa (telomerase catalytic subunit, hTERT) \u5f9e\u7d30\u80de\u6838\u4e2d\u7f6e\u63db\u51fa\u4f86\uff0c\u8a98\u5c0e\u7aef\u7c92\u555f\u52d5\u7684 DNA \u640d\u50b7\u4fe1\u865f\u50b3\u5c0e(f telomere-initiated DNA-damage signaling)\u4ee5\u53ca\u67d3\u8272\u9ad4\u878d\u5408(chromosome fusions)\u3002\u9032\u4e00\u6b65\u5831\u5c0e\u4e86 RHPS4 \u5c0d\u4ee5\u96c6\u843d\u5f62\u5f0f(colonies)\u751f\u9577\u7684\u764c\u7d30\u80de\u6bd4\u4ee5\u55ae\u5c64\u5f62\u5f0f(monolayers)\u751f\u9577\u7684\u7d30\u80de\u66f4\u6709\u6548\u3002\u6b64\u5916\uff0c\u4eba\u81cd\u5e36\u8840(human cord blood)\u548cHEK293T\u80da\u80ce\u814e\u7d30\u80de(HEK293T embryonic kidney cell)\u96c6\u843d\u7684\u5f62\u6210\u55ae\u4f4d\u5c0dRHPS4\u7684\u62b5\u6297\u529b\u66f4\u5f37[1]\u3002\u9ad4\u5167\u8a66\u9a57\uff1a\u52d5\u7269\u7814\u7a76\u767c\u73fe\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u7d93 RHPS4 \u8655\u7406\u7684 UXF1138L \u7570\u7a2e\u79fb\u690d\u7269\u7684\u514b\u9686\u5f62\u6210\u6027\u964d\u4f4e\u3001\u6838 hTERT \u8868\u9054\u7f3a\u5931\u548c\u6709\u7d72\u5206\u88c2\u7570\u5e38\u7684\u8a98\u5c0e\u3002\u5118\u7ba1\u55ae\u7368\u7684 RHPS4 \u986f\u793a\u51fa\u6709\u9650\u7684\u9ad4\u5167\u529f\u6548\uff0c\u4f46\u8207\u6709\u7d72\u5206\u88c2\u7d21\u9318\u9ad4\u6bd2\u7269\u7d2b\u6749\u9187\u7684\u806f\u5408\u6cbb\u7642\u53ef\u5c0e\u81f4\u816b\u7624\u7de9\u89e3\u4e26\u9032\u4e00\u6b65\u589e\u5f37\u7aef\u7c92\u529f\u80fd\u969c\u7919 [1]\u3002<\/p>\n

\"\"<\/p>\n

    \n
  1. Chen H, Sun H, et al. “Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures.” Chem Commun (Camb). 2019 Apr 25;55(35):5060-5063.PMID:30907894<\/a><\/li>\n
  2. SugeZhang, HongxiaSun, et al. “Evaluation of the selectivity of G-quadruplex ligands in living cells with a small molecule fluorescent probe.” Analytica Chimica Acta: X. Available online 23 April 2019, 100017.<\/li>\n<\/ol>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n458.48<\/td>\n<\/tr>\n
    Cas No.<\/td>\n390362-78-4<\/td>\n<\/tr>\n
    Formula<\/td>\nC23<\/sub>H20<\/sub>F2<\/sub>N2<\/sub>O4<\/sub>S<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in EtOH; \u226510.54 mg\/mL in DMSO; \u22652.51 mg\/mL in H2O with ultrasonic<\/td>\n<\/tr>\n
    Chemical Name<\/td>\n3,11-difluoro-6,8,13-trimethyl-8H-quinolino[4,3,2-kl]acridin-13-ium methyl sulfate<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nFC1=CC=C(N(C)C2=C3C4=[N+](C)C5=C(C=C(F)C=C5)C3=CC(C)=C2)C4=C1.COS(=O)([O-])=O<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
    SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
    RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
    AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
    \n

    ORY-1001<\/a><\/span><\/p>\n

     <\/td>\n

    		CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
    RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
    Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
    (S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

    \u8ca8\u865fA8802<\/span><\/p>\n

     <\/td>\n

    		Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
    Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    DNA\u640d\u50b7\/DNA\u4fee\u5fa9\u7cfb\u5217\u5546\u54c1->>RHPS4n APExBIO Technology LLC \u662f […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,5368,3],"tags":[5015],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35213"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35213"}],"version-history":[{"count":7,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35213\/revisions"}],"predecessor-version":[{"id":53779,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35213\/revisions\/53779"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}