{"id":35192,"date":"2022-10-21T15:30:52","date_gmt":"2022-10-21T07:30:52","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35192"},"modified":"2025-11-15T16:04:06","modified_gmt":"2025-11-15T08:04:06","slug":"scr7-cas1533426-72-0-apexbio-%e8%b2%a8%e8%99%9fa8705","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=35192","title":{"rendered":"SCR7 | CAS#1533426-72-0 APExBIO \u8ca8\u865fA8705"},"content":{"rendered":"

DNA\u9023\u63a5\u9176IV\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>SCR7<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u7d30\u80de\u53cd\u61c9(Cellular responses)\u7531\u8207\u7279\u5b9a\u53d7\u9ad4\u7d50\u5408\u7684\u86cb\u767d\u8cea(proteins)\u3001\u85e5\u7269(drugs)\u6216\u75c5\u539f\u9ad4(pathogens)\u89f8\u767c\u3002\u53d7\u9ad4\u4ecb\u5c0e(Receptor mediated signaling)\u7684\u4fe1\u865f\u50b3\u5c0e\u662f\u653e\u5927\u4fe1\u865f\u7684\u9176\u4fc3\u53cd\u61c9\u7d1a\u806f\u3002\u8abf\u7bc0\u53d7\u9ad4\u529f\u80fd\u7684\u6fc0\u52d5\u5291(agonists)\u548c\u62ee\u6297\u5291(antagonists)\u662f\u7814\u7a76\u548c\u91ab\u7642\u5be6\u8e10\u7684\u91cd\u8981\u5de5\u5177\u3002<\/p>\n

SCR7 | CAS#1533426-72-0 APExBIO\u00a0 \u8ca8\u865fA8705<\/a><\/span><\/p>\n

DNA ligase IV inhibitor<\/p>\n

Scr7 \u662f\u4e00\u7a2e DNA \u9023\u63a5\u9176 IV \u6291\u5236\u5291(DNA ligase IV inhibitor)\uff0c\u6700\u521d\u88ab\u78ba\u5b9a\u70ba\u4e00\u7a2e\u6297\u764c\u5291 (anti-cancer agent)\u3002Scr7 \u9776\u5411 DNA \u9023\u63a5\u9176 IV \u7684 DNA \u7d50\u5408\u57df(DNA binding domain)\uff0c\u964d\u4f4e\u5176\u5c0d\u96d9\u93c8\u65b7\u88c2 (double strand breaks , DSB) \u7684\u89aa\u548c\u529b\u4e26\u6291\u5236\u5176\u529f\u80fd\u3002 Scr7 \u9084\u6291\u5236 DNA \u9023\u63a5\u9176 III\uff08\u4f46\u4e0d\u6291\u5236 DNA \u9023\u63a5\u9176 I\uff09\uff0c\u5118\u7ba1\u6548\u7387\u8f03\u4f4e\u3002\u7528\u5f37\u529b\u9ef4\u7d20\u8655\u7406\u7d30\u80de\u4ee5\u8a98\u5c0e Cas9 \u8868\u9054\uff0c\u7528\u4e0d\u540c\u6fc3\u5ea6\u7684 Scr7 \u8655\u7406 24 \u5c0f\u6642\u3002 Scr7 \u7dad\u6301\u7684\u7d30\u80de\u80fd\u5920\u9032\u5165 S\/G2 \u671f\uff0c\u9019\u662f HDR \u6240\u5fc5\u9700\u7684 [1]\u3002\u7528 Scr7 \u6cbb\u7642\u5c0f\u9f20\u6703\u5f71\u97ff\u6dcb\u5df4\u7d30\u80de\u767c\u80b2\uff0c\u56e0\u70ba DNA \u9023\u63a5\u9176 IV(DNA ligase IV) \u5728\u901a\u904e C-NHEJ16 \u9032\u884c V(D)J \u91cd\u7d44\u904e\u7a0b\u4e2d\u7de8\u78bc\u672b\u7aef\u7684\u9023\u63a5\u4e2d\u8d77\u95dc\u9375\u4f5c\u7528\u3002\u7531\u65bc Scr7 \u7684\u975e\u5171\u50f9\u7d50\u5408\u6a21\u5f0f\uff0cScr7 \u6cbb\u7642\u5f8c\u6dcb\u5df4\u7d30\u80de\u767c\u80b2\u7684\u7f3a\u9677\u662f\u77ed\u66ab\u7684\u548c\u53ef\u9006\u7684\u3002 Scr7 \u901a\u904e\u77ac\u6642\u963b\u65b7 NHEJ\uff08\u4f9d\u8cf4 DNA \u9023\u63a5\u9176 I \u7684 alt-NHEJ \u9664\u5916\uff09\u589e\u5f37 HDR \u7684\u983b\u7387\uff0c\u5f9e\u800c\u5728\u57f9\u990a\u7d30\u80de\u548c\u5c0f\u9f20\u4e2d\u901a\u904e CRISPR-Cas9 \u9032\u884c\u7cbe\u78ba\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f(genome editing) [2]\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n334.39<\/td>\n<\/tr>\n
Cas No.<\/td>\n1533426-72-0<\/td>\n<\/tr>\n
Formula<\/td>\nC18<\/sub>H14<\/sub>N4<\/sub>OS<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226516.72 mg\/mL in DMSO; \u22652.6 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
Chemical Name<\/td>\n5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nS=C(NC(\/N=C\/C1=CC=CC=C1)=C2\/N=C\/C3=CC=CC=C3)NC2=O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
RHPS4n <\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
AZD6738 <\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
\n

ORY-1001 <\/a><\/span><\/p>\n

 <\/td>\n

CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
Oxaliplatin <\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
(S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

\u8ca8\u865fA8802<\/span><\/p>\n

 <\/td>\n

Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
Tubastatin A <\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
APExBIO\u7522\u54c1\u7dda<\/td>\n\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n<\/tr>\n
Proteases<\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0 <\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n<\/tr>\n
Proteinase K<\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/td>\nCAS#39450-01-6<\/td>\n\u8ca8\u865fK1037<\/td>\n<\/tr>\n
\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
Romidepsin (FK228, depsipeptide)<\/a><\/td>\n\n

CAS#128517-07-7<\/p>\n

 <\/td>\n

\u8ca8\u865fA8173<\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n
Pirarubicin<\/a><\/td>\nCAS#72496-41-4<\/td>\n\u8ca8\u865fB2295<\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/td>\n<\/tr>\n
Tunicamycin<\/a><\/td>\nCAS# 15663-27-1<\/td>\n\n

\u8ca8\u865fA8321<\/p>\n

 <\/td>\n

\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
Azithromycin<\/a><\/td>\nCAS#83905-01-5<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
Bleomycin Sulfate<\/a><\/td>\n\n

CAS# 9041-93-4<\/p>\n

 <\/td>\n

\u8ca8\u865fB1398<\/td>\nAntibiotic by inhibiting protein synthesis<\/td>\n<\/tr>\n
Nystatin (Fungicidin)<\/a><\/td>\nCAS#1400-61-9<\/td>\n\u8ca8\u865fB1993<\/td>\nantifungal antibiotic<\/td>\n<\/tr>\n
Rapamycin<\/a><\/td>\nCAS#53123-88-9<\/td>\n\u8ca8\u865fA8167<\/td>\nOriginal antifungal antibiotic<\/td>\n<\/tr>\n
Daptomycin<\/a><\/td>\nCAS#103060-53-3<\/td>\n\u8ca8\u865fA1206<\/td>\nCalcium-dependent antibiotic<\/td>\n<\/tr>\n
\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
Z-VAD-FMK \u00a0<\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n\n

Proteases<\/p>\n

ICE-like proteases<\/td>\n<\/tr>\n

TAPI-1 \u00a0<\/a><\/td>\nCAS#171235-71-5<\/td>\n\u8ca8\u865f\u00a0B4686<\/td>\n\n

Proteases<\/p>\n

TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n

Talabostat mesylate<\/a><\/td>\nCAS# 150080-09-4<\/td>\n\u8ca8\u865fB3941<\/td>\n\n

Proteases<\/p>\n

DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n

Z-IETD-FMK<\/a><\/td>\nCAS# 210344-98-2<\/td>\n\u8ca8\u865fB3232<\/td>\ninhibitor of caspase 8<\/td>\n<\/tr>\n
Cisplatin<\/td>\nCAS# 15663-27-1<\/td>\n\u8ca8\u865fA8321<\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
17-DMAG (Alvespimycin) HCl<\/a><\/td>\nCAS#467214-21-7<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
CA-074 Me\u00a0<\/a><\/td>\nCAS# 147859-80-1<\/td>\n\u8ca8\u865fA8239<\/td>\nCathepsin B inhibitor<\/td>\n<\/tr>\n
VX-765<\/a><\/td>\nCAS# 273404-37-8<\/td>\n\u8ca8\u865fA8238<\/td>\nCaspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

DNA\u9023\u63a5\u9176IV\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>SCR7 APExBIO Technology LLC \u662f\u4e00\u5bb6 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5014],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35192"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35192"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35192\/revisions"}],"predecessor-version":[{"id":53782,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35192\/revisions\/53782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}