{"id":35163,"date":"2022-10-21T12:51:44","date_gmt":"2022-10-21T04:51:44","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35163"},"modified":"2025-11-15T16:05:55","modified_gmt":"2025-11-15T08:05:55","slug":"gap-27-cas198284-64-9-apexbio-%e8%b2%a8%e8%99%9fa1045","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=35163","title":{"rendered":"Gap 27 | CAS#198284-64-9 APExBIO \u8ca8\u865fA1045"},"content":{"rendered":"

\u9593\u9699\u9023\u63a5\u86cb\u767d\u7cfb\u5217\u5546\u54c1->>Gap 27<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u7d30\u80de\u53cd\u61c9(Cellular responses)\u7531\u8207\u7279\u5b9a\u53d7\u9ad4\u7d50\u5408\u7684\u86cb\u767d\u8cea(proteins)\u3001\u85e5\u7269(drugs)\u6216\u75c5\u539f\u9ad4(pathogens)\u89f8\u767c\u3002\u53d7\u9ad4\u4ecb\u5c0e(Receptor mediated signaling)\u7684\u4fe1\u865f\u50b3\u5c0e\u662f\u653e\u5927\u4fe1\u865f\u7684\u9176\u4fc3\u53cd\u61c9\u7d1a\u806f\u3002\u8abf\u7bc0\u53d7\u9ad4\u529f\u80fd\u7684\u6fc0\u52d5\u5291(agonists)\u548c\u62ee\u6297\u5291(antagonists)\u662f\u7814\u7a76\u548c\u91ab\u7642\u5be6\u8e10\u7684\u91cd\u8981\u5de5\u5177\u3002<\/p>\n

\"\"<\/p>\n

Gap 27 | CAS#198284-64-9 APExBIO\u00a0 \u8ca8\u865fA1045<\/a><\/span><\/p>\n

Selective gap junction blocker.<\/p>\n

\u9023\u63a5\u86cb\u767d(Connexins)\u6216\u9593\u9699\u9023\u63a5(gap junctions)\u662f\u7d50\u69cb\u76f8\u95dc\u7684\u8de8\u819c\u86cb\u767d(structurally-related transmembrane proteins)\u5bb6\u65cf\u3002\u9593\u9699\u9023\u63a5(Gap junctions)\u5305\u542b\u5141\u8a31\u96e2\u5b50\u548c\u5c0f\u5206\u5b50\u5728\u76f8\u9130\u7d30\u80de\u4e4b\u9593\u901a\u904e\u7684\u901a\u9053\u3002\u9019\u7a2e\u7d30\u80de\u9593\u901a\u8a0a(intercellular communication)\u8207\u7d30\u80de\u5c0d\u7d30\u80de\u5167\u4fe1\u865f\u5206\u5b50\u7684\u53cd\u61c9\u7684\u5354\u8abf\u6709\u95dc\u3002\u9223(Calcium)\u548c\u808c\u9187\u78f7\u9178\u9e7d(inositol phosphates)\u662f\u53ef\u4ee5\u901a\u904e\u9593\u9699\u9023\u63a5\u901a\u9053\u7684\u7b2c\u4e8c\u4fe1\u4f7f\u3002\u9019\u7a2e\u5408\u6210\u7684\u9023\u63a5\u86cb\u767d\u6a21\u64ec\u80bd(connexin-mimetic peptide) Gap 27 \u7528\u65bc\u8a55\u4f30\u9593\u9699\u9023\u63a5\u901a\u8a0a(gap-junctional communication)\u5c0d\u7834\u9aa8\u7d30\u80de(osteoclastic bone)\u9aa8\u5438\u6536(bone resorption)\u7684\u8ca2\u737b\u3002\u5f97\u51fa\u7684\u7d50\u8ad6\u662f\uff0c\u9593\u9699\u9023\u63a5\u901a\u8a0a\u5c0d\u65bc\u9069\u7576\u7684\u9aa8\u91cd\u5851(bone remodeling)\u662f\u5fc5\u8981\u7684\u3002<\/p>\n

\"\"<\/p>\n

    \n
  1. Fan J, Chen Y, et al. “Multi-walled carbon nanotubes induce IL-1\u03b2 secretion by activating hemichannels-mediated ATP release in THP-1 macrophages.” Nanotoxicology. 2020;1-18.PMID:32538272<\/a><\/li>\n
  2. Ni X, Li XZ, et al. “Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats.” Cell Mol Biol Lett. 2018 Aug 20;23:40.PMID:30151015<\/a><\/li>\n
  3. HAI-CHAO ZHANG, ZHONG-SHUANG ZHANG, et al.”Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+ CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation.” INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2017 October 20.<\/li>\n
  4. Ni X, Wang A, et al. “Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.” PLoS One. 2017 Sep 14;12(9):e0184773.PMID:28910394<\/a><\/li>\n
  5. 5. Koenen, Anna, et al. “Effects of renal denervation on renal pelvic contractions and connexin expression in rats.” Acta Physiologica (2015).\u00a0PMID:26436542<\/a><\/li>\n<\/ol>\n

    \"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
    Storage<\/td>\nDesiccate at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n1304.55<\/td>\n<\/tr>\n
    Cas No.<\/td>\n198284-64-9<\/td>\n<\/tr>\n
    Formula<\/td>\nC60<\/sub>H101<\/sub>N15<\/sub>O17<\/sub><\/td>\n<\/tr>\n
    Synonyms<\/td>\nSer-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in EtOH; \u22655 mg\/mL in H2O; \u226565.25 mg\/mL in DMSO<\/td>\n<\/tr>\n
    Chemical Name<\/td>\nGap 27<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nCCC(C)C(C(=O)NC(C(C)CC)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)CC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CO)N<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    APExBIO\u7522\u54c1\u7dda<\/td>\n\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n<\/tr>\n
    Proteases<\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0 <\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n<\/tr>\n
    Proteinase K<\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/td>\nCAS#39450-01-6<\/td>\n\u8ca8\u865fK1037<\/td>\n<\/tr>\n
    \u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
    Romidepsin (FK228, depsipeptide)<\/a><\/td>\n\n

    CAS#128517-07-7<\/p>\n

     <\/td>\n

    		\u8ca8\u865fA8173<\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n
    Pirarubicin<\/a><\/td>\nCAS#72496-41-4<\/td>\n\u8ca8\u865fB2295<\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/td>\n<\/tr>\n
    Tunicamycin<\/a><\/td>\nCAS# 15663-27-1<\/td>\n\n

    \u8ca8\u865fA8321<\/p>\n

     <\/td>\n

    		\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
    Azithromycin<\/a><\/td>\nCAS#83905-01-5<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
    Bleomycin Sulfate<\/a><\/td>\n\n

    CAS# 9041-93-4<\/p>\n

     <\/td>\n

    		\u8ca8\u865fB1398<\/td>\nAntibiotic by inhibiting protein synthesis<\/td>\n<\/tr>\n
    Nystatin (Fungicidin)<\/a><\/td>\nCAS#1400-61-9<\/td>\n\u8ca8\u865fB1993<\/td>\nantifungal antibiotic<\/td>\n<\/tr>\n
    Rapamycin<\/a><\/td>\nCAS#53123-88-9<\/td>\n\u8ca8\u865fA8167<\/td>\nOriginal antifungal antibiotic<\/td>\n<\/tr>\n
    Daptomycin<\/a><\/td>\nCAS#103060-53-3<\/td>\n\u8ca8\u865fA1206<\/td>\nCalcium-dependent antibiotic<\/td>\n<\/tr>\n
    \u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
    Z-VAD-FMK \u00a0<\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n\n

    Proteases<\/p>\n

    ICE-like proteases<\/td>\n<\/tr>\n

    TAPI-1 \u00a0<\/a><\/td>\nCAS#171235-71-5<\/td>\n\u8ca8\u865f\u00a0B4686<\/td>\n\n

    Proteases<\/p>\n

    TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n

    Talabostat mesylate<\/a><\/td>\nCAS# 150080-09-4<\/td>\n\u8ca8\u865fB3941<\/td>\n\n

    Proteases<\/p>\n

    DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n

    Z-IETD-FMK<\/a><\/td>\nCAS# 210344-98-2<\/td>\n\u8ca8\u865fB3232<\/td>\ninhibitor of caspase 8<\/td>\n<\/tr>\n
    Cisplatin<\/td>\nCAS# 15663-27-1<\/td>\n\u8ca8\u865fA8321<\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
    17-DMAG (Alvespimycin) HCl<\/a><\/td>\nCAS#467214-21-7<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
    CA-074 Me\u00a0<\/a><\/td>\nCAS# 147859-80-1<\/td>\n\u8ca8\u865fA8239<\/td>\nCathepsin B inhibitor<\/td>\n<\/tr>\n
    VX-765<\/a><\/td>\nCAS# 273404-37-8<\/td>\n\u8ca8\u865fA8238<\/td>\nCaspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u9593\u9699\u9023\u63a5\u86cb\u767d\u7cfb\u5217\u5546\u54c1->>Gap 27 APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5012],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35163"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35163"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35163\/revisions"}],"predecessor-version":[{"id":53786,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35163\/revisions\/53786"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}