{"id":34842,"date":"2022-10-15T21:47:03","date_gmt":"2022-10-15T13:47:03","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34842"},"modified":"2025-06-30T17:23:16","modified_gmt":"2025-06-30T09:23:16","slug":"dna-damagedna-repair%e7%b3%bb%e5%88%97%e7%94%a2%e5%93%81-%e5%8f%b0%e7%81%a3apexbio","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=34842","title":{"rendered":"DNA Damage\/DNA Repair\u7cfb\u5217\u7522\u54c1 | \u53f0\u7063APExBIO"},"content":{"rendered":"

DNA\u640d\u50b7\/DNA\u4fee\u5fa9\u7cfb\u5217\u5546\u54c1->>DNA Damage\/DNA Repair<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

APExBIO –<\/strong>DNA Damage\/DNA Repair<\/strong>\u7cfb\u5217\u7522\u54c1<\/strong>+236<\/strong><\/p>\n

\u7531\u65bc\u5916\u90e8\uff08exogenous, \u5916\u6e90\u6027\uff09\u548c\u5167\u90e8\uff08endogenous, \u5167\u6e90\u6027\uff09\u58d3\u529b\uff0c\u4eba\u9ad4\u7d30\u80de\u4e2d\u7684 DNA \u6bcf\u5929\u6703\u53d7\u5230\u6578\u4ee5\u842c\u8a08\u7684\u640d\u5bb3(damages)\u3002\u5916\u6e90\u6027\u640d\u5bb3(exogenous damages)\u662f\u7531\u5316\u5b78\u6c61\u67d3(chemical contamination)\u3001\u7d2b\u5916\u7dda(UV light)\u3001\u96fb\u96e2\u8f3b\u5c04(ionizing radiation)\u548c\u70f7\u57fa\u5316\/\u7532\u57fa\u5316(alkylation\/methylation)\u7b49\u5f15\u8d77\u7684\uff0c\u800c\u5167\u6e90\u6027\u640d\u5bb3(endogenous damages)\u662f\u7531\u9e7c\u7684\u6c27\u5316(oxidation)\u3001\u70f7\u57fa\u5316(alkylation)\u548c\u6c34\u89e3(hydrolysis)\u7b49\u5f15\u8d77\u7684\u3002\u7531\u65bcDNA\u640d\u50b7(double strand breaks)\u5f8c\u6703\u767c\u751f\u55ae\u934a(single strand)\u548c\u96d9\u93c8\u65b7\u88c2(double strand breaks)\uff0c\u672a\u4fee\u5fa9\u7684DNA\u640d\u50b7\u5c0e\u81f4\u7d30\u80de\u8870\u8001(cell senescent)\u3001\u51cb\u4ea1(apoptosis)\u548c\u60e1\u6027\u816b\u7624(malignancies)\u7b49\u3002\u70ba\u4e86\u514b\u670d\u9019\u7a2e\u5a01\u8105\uff0c\u7d30\u80de\u7522\u751f\u4e86 DNA \u640d\u50b7\u53cd\u61c9(DNA damage response)\uff0c\u4ee5\u6aa2\u6e2c DNA \u640d\u50b7\u4e26\u4ecb\u5c0e\u5176\u4fee\u5fa9(repair)\u3002DNA\u4fee\u5fa9\u6d89\u53ca\u932f\u914d\u3001\u9e7c\u57fa\u5207\u9664\u3001\u6838\u82f7\u9178\u5207\u9664\u4fee\u5fa9\u7b49\u591a\u7a2e\u6a5f\u5236\u3002\u4e00\u7d44\u86cb\u767d\u8cea\u548c\u9014\u5f91\u53c3\u8207\u4e86\u9019\u4e9b\u904e\u7a0b\u3002 ATM\/ATR \u6fc0\u9176\u548c DNA-PK \u5c0d\u65bc\u6aa2\u6e2c DNA \u640d\u50b7\u81f3\u95dc\u91cd\u8981\u3002\u67d3\u8272\u8cea\u91cd\u5851\u5291\u8abf\u7bc0 DNA \u4fee\u5fa9\u56e0\u5b50\u767c\u63ee\u4f5c\u7528\u7684\u67d3\u8272\u8cea\u53ef\u53ca\u6027\u3002 RPA\u3001Rad51 \u548c\u7bc4\u53ef\u5c3c\u8ca7\u8840\u86cb\u767d\u76f4\u63a5\u4f5c\u7528\u65bc\u4fee\u5fa9 DNA \u640d\u50b7\u3002 p53 \u7db2\u7d61\u3001RAS GTPase \u8d85\u5bb6\u65cf\u548c\u6cdb\u7d20\u7cfb\u7d71\u4e5f\u5728 DNA \u640d\u50b7\u53cd\u61c9\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002\u7570\u5e38\u7684 DNA \u640d\u50b7\u53cd\u61c9\u8207\u8870\u8001\u3001\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u6709\u95dc\u3002<\/p>\n

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 <\/p>\n

The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation\/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.<\/p>\n

DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM\/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.<\/p>\n

https:\/\/www.apexbt.com\/<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
APExBIO\u7522\u54c1\u7dda<\/td>\n\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n<\/tr>\n
Proteases<\/td>\nZ-VAD-FMK | CAS# 187389-52-2 APExBIO\u00a0 <\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n<\/tr>\n
Proteinase K<\/td>\n\u86cb\u767d\u9176 K (Proteinase K) | CAS#39450-01-6 APExBIO\u00a0 \u8ca8\u865fK1037<\/a><\/td>\nCAS#39450-01-6<\/td>\n\u8ca8\u865fK1037<\/td>\n<\/tr>\n
\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
Romidepsin (FK228, depsipeptide)<\/a><\/td>\n\n

CAS#128517-07-7<\/p>\n

 <\/td>\n

\u8ca8\u865fA8173<\/td>\nHDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n
Pirarubicin<\/a><\/td>\nCAS#72496-41-4<\/td>\n\u8ca8\u865fB2295<\/td>\n\u00a0anthracycline anti-neoplastic doxorubicin<\/td>\n<\/tr>\n
Tunicamycin<\/a><\/td>\nCAS# 15663-27-1<\/td>\n\n

\u8ca8\u865fA8321<\/p>\n

 <\/td>\n

\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
Azithromycin<\/a><\/td>\nCAS#83905-01-5<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
Bleomycin Sulfate<\/a><\/td>\n\n

CAS# 9041-93-4<\/p>\n

 <\/td>\n

\u8ca8\u865fB1398<\/td>\nAntibiotic by inhibiting protein synthesis<\/td>\n<\/tr>\n
Nystatin (Fungicidin)<\/a><\/td>\nCAS#1400-61-9<\/td>\n\u8ca8\u865fB1993<\/td>\nantifungal antibiotic<\/td>\n<\/tr>\n
Rapamycin<\/a><\/td>\nCAS#53123-88-9<\/td>\n\u8ca8\u865fA8167<\/td>\nOriginal antifungal antibiotic<\/td>\n<\/tr>\n
Daptomycin<\/a><\/td>\nCAS#103060-53-3<\/td>\n\u8ca8\u865fA1206<\/td>\nCalcium-dependent antibiotic<\/td>\n<\/tr>\n
\u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
Z-VAD-FMK \u00a0<\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n\n

Proteases<\/p>\n

ICE-like proteases<\/td>\n<\/tr>\n

TAPI-1 \u00a0<\/a><\/td>\nCAS#171235-71-5<\/td>\n\u8ca8\u865f\u00a0B4686<\/td>\n\n

Proteases<\/p>\n

TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n

Talabostat mesylate<\/a><\/td>\nCAS# 150080-09-4<\/td>\n\u8ca8\u865fB3941<\/td>\n\n

Proteases<\/p>\n

DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n

Z-IETD-FMK<\/a><\/td>\nCAS# 210344-98-2<\/td>\n\u8ca8\u865fB3232<\/td>\ninhibitor of caspase 8<\/td>\n<\/tr>\n
Cisplatin<\/td>\nCAS# 15663-27-1<\/td>\n\u8ca8\u865fA8321<\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
17-DMAG (Alvespimycin) HCl<\/a><\/td>\nCAS#467214-21-7<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
CA-074 Me\u00a0<\/a><\/td>\nCAS# 147859-80-1<\/td>\n\u8ca8\u865fA8239<\/td>\nCathepsin B inhibitor<\/td>\n<\/tr>\n
VX-765<\/a><\/td>\nCAS# 273404-37-8<\/td>\n\u8ca8\u865fA8238<\/td>\nCaspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

DNA\u640d\u50b7\/DNA\u4fee\u5fa9\u7cfb\u5217\u5546\u54c1->>DNA Damage\/DNA Repair APExBIO T […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[760,5368],"tags":[4995],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34842"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34842"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34842\/revisions"}],"predecessor-version":[{"id":51839,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34842\/revisions\/51839"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}