{"id":34475,"date":"2022-10-04T11:31:15","date_gmt":"2022-10-04T03:31:15","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34475"},"modified":"2025-11-15T16:10:43","modified_gmt":"2025-11-15T08:10:43","slug":"jnj-26854165-serdemetan-cas-881202-45-5-apexbio-%e8%b2%a8%e8%99%9fa4204","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=34475","title":{"rendered":"JNJ-26854165 (Serdemetan) | CAS# 881202-45-5 APExBIO \u8ca8\u865fA4204"},"content":{"rendered":"

P53\u6d3b\u5316\u5291\u7cfb\u5217\u5546\u54c1->>JNJ-26854165 (Serdemetan)<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

JNJ-26854165 (Serdemetan) | CAS# 881202-45-5 APExBIO\u00a0 \u8ca8\u865fA4204<\/span><\/strong><\/span><\/a><\/span><\/p>\n

P53 activator, blocking Mdm2-p53 interaction<\/p>\n

JNJ-26854165\uff0c\u4e5f\u7a31\u70ba Serdemetan\uff0c\u6700\u521d\u662f\u4f5c\u70ba p53 \u7684\u6fc0\u6d3b\u5291(activator)\u958b\u767c\u7684\uff0c\u73fe\u5728\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d Human Double Minute-2 (HDM-2) \u6cdb\u7d20\u9023\u63a5\u9176\u62ee\u6297\u5291(ubiquitin ligase antagonist)\u3002\u5b83\u53ef\u4ee5\u901a\u904e\u6291\u5236 HDM-2-\u5ba2\u6236\u86cb\u767d\u8907\u5408\u7269(HDM-2-client protein complex)\u8207\u86cb\u767d\u9176\u9ad4\u7684\u7d50\u5408\u4f86\u589e\u52a0 HDM-2 client proteins\u7684\u6c34\u5e73\uff0c\u4f8b\u5982 p53\u3002\u5728\u5ee3\u6cdb\u7684 p53 \u91ce\u751f\u578b\u548c\u7a81\u8b8a\u578b\u816b\u7624\u6a21\u578b\u4e2d\uff0cJNJ-26854165 \u986f\u793a\u51fa\u6709\u6548\u7684\u6297\u589e\u6b96\u548c\u51cb\u4ea1\u8a98\u5c0e\u6d3b\u6027\u3002\u5728\u9ad4\u5167\uff0c\u8207\u5c0d\u7167\u76f8\u6bd4\uff0cJNJ-26854165 \u5728 37 \u500b\u5be6\u9ad4\u7624\u4e2d\u7684 18 \u500b\u548c\u53ef\u8a55\u4f30\u7684 ALL \u7570\u7a2e\u79fb\u690d\u7269(xenografts)\u4e2d\u7684 7 \u500b\u4e2d\u7684 5 \u500b\u4e2d\u53ef\u80fd\u5f15\u8d77 EFS \u5206\u4f48\u7684\u91cd\u8981\u5dee\u7570\u3002<\/p>\n

    \n
  1. Chen R, Zhou J, et al. “A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors.” Biochemistry. 2017 Jun 27;56(25):3273-3282.PMID:28581721<\/a><\/li>\n<\/ol>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n328.41<\/td>\n<\/tr>\n
    Cas No.<\/td>\n881202-45-5<\/td>\n<\/tr>\n
    Formula<\/td>\nC21<\/sub>H20<\/sub>N4<\/sub><\/td>\n<\/tr>\n
    Synonyms<\/td>\nJNJ 26854165<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in EtOH; insoluble in H2O; \u226514.8 mg\/mL in DMSO<\/td>\n<\/tr>\n
    Chemical Name<\/td>\n1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nC1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/h4>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

    <\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    P53\u6d3b\u5316\u5291\u7cfb\u5217\u5546\u54c1->>JNJ-26854165 (Serdemetan) APExBIO Te […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486,3],"tags":[4976],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34475"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34475"}],"version-history":[{"count":5,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34475\/revisions"}],"predecessor-version":[{"id":53793,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34475\/revisions\/53793"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}