{"id":34289,"date":"2022-09-20T14:31:24","date_gmt":"2022-09-20T06:31:24","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34289"},"modified":"2025-11-15T15:29:26","modified_gmt":"2025-11-15T07:29:26","slug":"gentamycin-sulfate-cas1405-41-0-apexbio-%e8%b2%a8%e8%99%9fa2514","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=34289","title":{"rendered":"Gentamycin Sulfate | CAS#1405-41-0 APExBIO  \u8ca8\u865fA2514"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">\u6c28\u57fa\u7cd6\u82f7\u985e\u6297\u751f\u7d20\u7cfb\u5217\u5546\u54c1-&gt;&gt;<span style=\"color: #ff6600;\">Gentamycin Sulfate<\/span><\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=34289\"><strong><span style=\"color: #33cccc; font-size: 12pt;\">Gentamycin Sulfate | CAS#1405-41-0 APExBIO\u00a0 \u8ca8\u865fA2514<\/span><\/strong><\/a><\/span><\/p>\n<p>Aminoglycoside antibiotic<\/p>\n<p>\u6176\u5927\u9709\u7d20\u662f\u4e00\u7a2e\u6c28\u57fa\u7cd6\u82f7\u985e\u6297\u751f\u7d20(aminoglycoside antibiotic)\uff0c\u4e00\u76f4\u4f7f\u7528\u786b\u9178\u9e7d\u5f62\u5f0f\uff0c\u7531\u76f8\u95dc\u6176\u5927\u9709\u7d20\u6210\u5206\u548c\u7d1a\u5206\u7684\u6df7\u5408\u7269\u7d44\u6210\uff0c\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u7d30\u83cc\u611f\u67d3\uff0c\u7279\u5225\u662f\u7531\u9769\u862d\u6c0f\u9670\u6027\u83cc(Gram-negative organisms) \u5f15\u8d77\u7684\u611f\u67d3\u3002 [1]\u6176\u5927\u9709\u7d20(Gentamicin)\u662f\u4e00\u7a2e\u6bba\u83cc\u6297\u751f\u7d20(bactericidal antibiotic)\uff0c\u901a\u904e\u4e0d\u53ef\u9006\u5730\u7d50\u5408\u7d30\u83cc\u6838\u91a3\u9ad4\u7684 30S \u4e9e\u57fa\u548c 16S rRNA \u767c\u63ee\u4f5c\u7528\uff0c\u5f9e\u800c\u4e2d\u65b7\u86cb\u767d\u8cea\u5408\u6210(interrupting protein synthesis)\u3002\u9019\u7a2e\u4f5c\u7528\u6a5f\u5236\u8207\u5176\u4ed6\u6c28\u57fa\u7cd6\u82f7\u985e(aminoglycosides)\u76f8\u4f3c\u3002\u6838\u91a3\u9ad4(ribosome)\u662f\u4e00\u7a2e\u5927\u578b\u800c\u5fa9\u96dc\u7684\u5206\u5b50\u6a5f\u5668\uff0c\u5b58\u5728\u65bc\u6240\u6709\u6d3b\u7d30\u80de\u4e2d\uff0c\u7528\u4f5c\u751f\u7269\u86cb\u767d\u8cea\u5408\u6210\uff08translation\uff09\u7684\u5834\u6240\u3002\u6838\u91a3\u9ad4\u6309\u7167\u4fe1\u4f7f RNA (mRNA) \u5206\u5b50\u6307\u5b9a\u7684\u9806\u5e8f\u5c07\u6c28\u57fa\u9178\u9023\u63a5\u5728\u4e00\u8d77\u3002 [2] \u6838\u91a3\u9ad4(ribosome)\u7531\u5169\u500b\u4e3b\u8981\u6210\u5206\u7d44\u6210\uff0c\u4e00\u500b\u662f\u8b80\u53d6 RNA \u7684\u5c0f\u6838\u91a3\u9ad4\u4e9e\u57fa(small ribosomal subunit)\uff0c\u53e6\u4e00\u500b\u662f\u9023\u63a5\u6c28\u57fa\u9178\u5f62\u6210\u591a\u80bd\u93c8(polypeptide chain)\u7684\u5927\u4e9e\u57fa\u3002\u6bcf\u500b\u4e9e\u57fa\u7531\u4e00\u500b\u6216\u591a\u500b\u6838\u91a3\u9ad4 RNA (ribosomal RNA , rRNA) \u5206\u5b50\u548c\u591a\u7a2e\u86cb\u767d\u8cea\u7d44\u6210\u3002\u6838\u91a3\u9ad4(ribosome)\u7684\u5927\u5c0f\u3001\u5e8f\u5217\u3001\u7d50\u69cb\u4ee5\u53ca\u4f86\u81ea\u7d30\u83cc(bacteria)\u3001\u53e4\u7d30\u83cc(archaea)\u548c\u771f\u6838\u751f\u7269(eukaryotes)\uff08\u5730\u7403\u4e0a\u751f\u547d\u7684\u4e09\u500b\u9818\u57df\uff09\u7684\u86cb\u767d\u8cea\u8207 RNA \u7684\u6bd4\u4f8b\u4e0d\u540c\u3002 [3]\u7d50\u69cb\u4e0a\u7684\u5dee\u7570\u4f7f\u4e00\u4e9b\u6297\u751f\u7d20\u53ef\u4ee5\u901a\u904e\u6291\u5236\u6838\u91a3\u9ad4(ribosome)\u4f86\u6bba\u6b7b\u7d30\u83cc\uff0c\u540c\u6642\u4e0d\u5f71\u97ff\u4eba\u985e\u6838\u91a3\u9ad4(ribosome)\u3002\u6176\u5927\u9709\u7d20(Gentamicin)\u8207 16S rRNA \u7684\u56db\u500b\u6838\u82f7\u9178\u548c\u86cb\u767d\u8cea S12 \u7684\u55ae\u500b\u6c28\u57fa\u9178\u7d50\u5408\uff0c\u5e72\u64fe 30S \u4e9e\u57fa\u7684 16S rRNA \u4e2d\u6838\u82f7\u9178 1400 \u9644\u8fd1\u7684\u89e3\u78bc\u4f4d\u9ede\u3002\u8207 tRNA \u53cd\u5bc6\u78bc\u5b50\u4e2d\u7684\u64fa\u52d5\u9e7c\u57fa\u7684\u76f8\u4e92\u4f5c\u7528\u6703\u5e72\u64fe\u8d77\u59cb\u5fa9\u5408\u7269\u7684\u8aa4\u8b80\uff0c\u56e0\u6b64\u5c07\u932f\u8aa4\u7684\u6c28\u57fa\u9178\u63d2\u5165\u5230\u591a\u80bd\u4e2d\uff0c\u5f9e\u800c\u5c0e\u81f4\u7121\u529f\u80fd\u6216\u6709\u6bd2\u7684\u80bd\uff0c\u4ee5\u53ca\u591a\u6838\u91a3\u9ad4\u5206\u89e3\u6210\u7121\u529f\u80fd\u7684\u55ae\u6838\u91a3\u9ad4(nonfunctional monosomes)\u3002 [4]<\/p>\n<p>\u6176\u5927\u9709\u7d20(Gentamicin)\u662f\u4e00\u7a2e\u5ee3\u8b5c(broad spectrum)\u6c28\u57fa\u7cd6\u82f7\u985e\u6297\u751f\u7d20(aminoglycoside antibiotic)\u3002\u6c28\u57fa\u7cd6\u82f7\u985e(Aminoglycosides)\u4e3b\u8981\u7528\u65bc\u611f\u67d3\u6027\u75be\u75c5(infection diease)\uff0c\u5305\u62ec\u9700\u6c27\u7684\u9769\u862d\u6c0f\u9670\u6027\u7d30\u83cc(Gram-negative bacteria)\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u5206\u679d\u687f\u83cc(tuberculosis)\uff0c\u5305\u62ec\u5f15\u8d77\u7d50\u6838\u75c5\u7684\u7d30\u83cc\uff0c\u5c0d\u6c28\u57fa\u7cd6\u82f7\u985e(aminoglycoside)\u654f\u611f\u3002\u7531\u9769\u862d\u6c0f\u967d\u6027\u83cc(Gram-positive bacteria)\u5f15\u8d77\u7684\u611f\u67d3\u4e5f\u53ef\u4ee5\u7528\u6c28\u57fa\u7cd6\u82f7\u985e(aminoglycosides)\u85e5\u7269\u6cbb\u7642\uff0c\u4f46\u5176\u4ed6\u985e\u578b\u7684\u6297\u751f\u7d20\u66f4\u6709\u6548\uff0c\u5c0d\u5bbf\u4e3b\u7684\u50b7\u5bb3\u66f4\u5c0f\u3002\u6176\u5927\u9709\u7d20\u4e2d\u6bd2(gentamicin toxicity)\u7684\u75c7\u72c0\u5305\u62ec\uff1a\u5e73\u8861\u56f0\u96e3\u3001\u5f48\u8df3\u3001\u8996\u529b\u4e0d\u7a69\u5b9a\u3001\u8033\u9cf4\uff08\u8033\u9cf4\uff09\u3001\u591a\u4efb\u52d9\u8655\u7406\u56f0\u96e3\uff0c\u5c24\u5176\u662f\u7ad9\u7acb\u6642\u3002 [5]\u6176\u5927\u9709\u7d20(Gentamicin)\u53e3\u670d\u5438\u6536\u975e\u5e38\u5dee\u3002\u6ce8\u5c04\u5c0e\u81f4\u8840\u6e05\u6fc3\u5ea6\u5728 30-60 \u5206\u9418\u5167\u9054\u5230\u5cf0\u503c\u3002\u9ad4\u5167\u5c0f\u9f20\u7570\u7a2e\u79fb\u690d\u7814\u7a76\u8868\u660e\uff0c(S)-\u514b\u5511\u66ff\u5c3c\uff0c\u800c\u4e0d\u662f (R)-\u5c0d\u6620\u7570\u69cb\u9ad4\uff0c\u80fd\u5920\u640d\u5bb3\u6574\u9ad4\u816b\u7624\u9032\u5c55\uff0c\u4e26\u7279\u5225\u6e1b\u5c11\u816b\u7624\u9ad4\u7a4d\u8d85\u904e 50%\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.apexbt.com\/media\/diy\/images\/struct\/A2514.png\" alt=\"Gentamycin Sulfate\" width=\"514\" height=\"258\" \/><\/p>\n<table width=\"1128\">\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>1506.80<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>1405-41-0<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>60<\/sub>H<sub>127<\/sub>N<sub>15<\/sub>O<sub>26<\/sub>S<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u226551.1 mg\/mL in H2O; insoluble in DMSO; insoluble in EtOH<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>sulfuric acid compound with (2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-diamino-3-(((2R,3R,6R)-3-amino-6-((R)-1-(methylamino)ethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol and (2R,3R,4R,5R)-2-(<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A2514.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>C[C@]1(O)CO[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@@]([H])([C@@H](C)NC)CC[C@H]3N)[C@@H]2O)[C@H](O)[C@H]1NC.C[C@]4(O)CO[C@H](O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@H](CN)CC[C@H]6N)[C@@H]5O)[C@H](O)[C@H]4NC.C[C@]7(O)CO[C@H](O[C@H]8[C@H](N)C[C@H](<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Ship with blue ice, or upon other requests.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<ul id=\"selectqc_2\" class=\"select-list\">\n<li><span style=\"color: #993300;\"><a style=\"color: #993300;\" href=\"https:\/\/www.apexbt.com\/downloader\/document\/A2514\/COA-2.pdf\" target=\"_blank\" rel=\"nofollow noopener\">COA (Certificate Of Analysis)<\/a><\/span><\/li>\n<li><span style=\"color: #993300;\"><a style=\"color: #993300;\" href=\"https:\/\/www.apexbt.com\/downloader\/document\/A2514\/NMR-2.pdf\" target=\"_blank\" rel=\"nofollow noopener\">NMR (Nuclear Magnetic Resonance)<\/a><\/span><\/li>\n<li><span style=\"color: #993300;\"><a style=\"color: #993300;\" href=\"https:\/\/www.apexbt.com\/downloader\/document\/A2514\/MSDS.pdf\" target=\"_blank\" rel=\"nofollow noopener\">MSDS (Material Safety Data Sheet)<\/a><\/span><\/li>\n<li><span style=\"color: #993300;\"><a style=\"color: #993300;\" href=\"https:\/\/www.apexbt.com\/downloader\/document\/A2514\/Datasheet.pdf\" target=\"_blank\" rel=\"nofollow noopener\">Datasheet<\/a><\/span><\/li>\n<\/ul>\n<h4><\/h4>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%93%81%E7%89%8C%E7%B9%AA%E5%9C%96-Apexbio_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x300.jpg\" width=\"203\" height=\"225\" \/><\/p>\n<p><a href=\"http:\/\/www.apexbt.com\/\"><span style=\"font-size: 14pt; color: #ff6600;\"><strong><span style=\"color: #800080;\"><span style=\"font-size: 14pt;\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a><span style=\"font-size: 14pt;\"><a href=\"https:\/\/www.apexbt.com\/\"><span style=\"color: #ff99cc;\"><span style=\"color: #ff6600;\">https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2024\/09\/line-2_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1.jpg\" width=\"302\" height=\"230\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6c28\u57fa\u7cd6\u82f7\u985e\u6297\u751f\u7d20\u7cfb\u5217\u5546\u54c1-&gt;&gt;Gentamycin Sulfate APExBIO Technol [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":45049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486],"tags":[4955],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34289"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34289"}],"version-history":[{"count":6,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34289\/revisions"}],"predecessor-version":[{"id":53714,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34289\/revisions\/53714"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/45049"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}