{"id":34109,"date":"2022-09-13T12:26:30","date_gmt":"2022-09-13T04:26:30","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34109"},"modified":"2025-11-15T15:33:49","modified_gmt":"2025-11-15T07:33:49","slug":"g-418-80-s-%e6%a0%b8%e9%86%a3%e9%ab%94%e5%bb%b6%e4%bc%b8%e6%8a%91%e5%88%b6%e5%8a%91-cas-108321-42-2-apexbio%e8%b2%a8%e8%99%9fa2513","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=34109","title":{"rendered":"G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291) | CAS# 108321-42-2 APExBIO\u8ca8\u865fA2513"},"content":{"rendered":"

80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>G-418<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291) | CAS# 108321-42-2 APExBIO\u8ca8\u865fA2513<\/span><\/strong><\/span><\/a><\/span><\/p>\n

\"G-418<\/p>\n

G-418 is an elongation inhibitor of 80 S ribosomes [1].<\/p>\n

G-418 \u662f 80 S \u6838\u91a3\u9ad4(80 S ribosomes)\u7684\u5ef6\u4f38\u6291\u5236\u5291(elongation inhibitor)\u3002<\/p>\n

\u7522\u54c1\u4ecb\u7d39G418\u662f\u4e00\u7a2e\u6c28\u57fa\u7cd6\u82f7\u985e\u6297\u751f\u7d20(aminoglycoside antibiotic)\uff0c\u5177\u6709\u5ee3\u8b5c\u6d3b\u6027(wide spectrum of activity)\uff0c\u5c0d\u7d30\u83cc(bacteria)\u3001\u9175\u6bcd\u83cc(yeasts)\u3001\u771f\u83cc(fungi)\u3001\u85fb\u985e(algae)\u3001\u690d\u7269(plant)\u751a\u81f3\u52d5\u7269\u7d30\u80de(animal cells)\u90fd\u6709\u6d3b\u6027\u3002 G418 \u901a\u5e38\u7528\u4f5c\u539f\u6838\u548c\u771f\u6838\u751f\u7269(eukaryotes)\u4e2d\u7684\u514b\u9686(cloning selection)\u9078\u64c7\uff0c\u6fc3\u5ea6\u70ba 1 \u81f3 300ug\/ml\u3002\u5728\u7d30\u83cc\u81e8\u5e8a\u5206\u96e2\u682a\u7684\u6297\u751f\u7d20\u8010\u85e5\u6027\u7814\u7a76\u4e2d\uff0c\u767c\u73fe\u6240\u6709\u651c\u5e363′-O-\u6c28\u57fa\u7cd6\u82f7\u78f7\u9178\u8f49\u79fb\u9176()\u7684\u83cc\u682a\u5747\u5c0dG418\u8010\u85e5\u3002\u5728\u9019\u4e9b\u78f7\u9178\u8f49\u79fb\u9176()\u4e2d\uff0cI \u578b\u548c II \u578b\u5206\u5225\u7531\u8f49\u5ea7\u56e0\u5b50 TnS \u548c Tn601 \u7de8\u78bc [2]\u3002<\/p>\n

\u9664\u4e86\u9078\u64c7\u529f\u80fd(selector function)\u5916\uff0c\u9084\u767c\u73fe G418 \u5c0d\u725b\u75c5\u6bd2\u6027\u8179\u7009\u75c5\u6bd2 (bovine viral diarrhea virus , BVDV) \u5177\u6709\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 G418 \u4ee5\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f\u9632\u6b62 DENV-2 \u611f\u67d3 BHK \u7d30\u80de\u5f15\u8d77\u7684\u7d30\u80de\u75c5\u8b8a\u6548\u61c9 (CPE)\uff0cEC50 \u503c\u70ba 3\u00b10.4 \uf06dg\/ml [3]\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n692.71<\/td>\n<\/tr>\n
Cas No.<\/td>\n108321-42-2<\/td>\n<\/tr>\n
Formula<\/td>\nC20<\/sub>H40<\/sub>N4<\/sub>O10<\/sub>\u00b72H2<\/sub>SO4<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nAntibiotic G418<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in EtOH; insoluble in DMSO; \u226564.6 mg\/mL in H2O<\/td>\n<\/tr>\n
Chemical Name<\/td>\n2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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