{"id":33999,"date":"2022-09-06T12:10:10","date_gmt":"2022-09-06T04:10:10","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=33999"},"modified":"2025-11-15T16:42:23","modified_gmt":"2025-11-15T08:42:23","slug":"mg-149-tip60-hat-inhibitor-%e9%81%b8%e6%93%87%e6%80%a7%e6%8a%91%e5%88%b6%e5%8a%91-cas-1243583-85-8-apexbio%e8%b2%a8%e8%99%9f-b3276","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=33999","title":{"rendered":"MG 149  (Tip60 HAT inhibitor) \u9078\u64c7\u6027\u6291\u5236\u5291 | CAS# 1243583-85-8 APExBIO\u8ca8\u865f B3276"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">Tip60 HAT\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1-&gt;&gt;<span style=\"color: #ff6600;\">MG 149 \u00a0<\/span><\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=33999\"><span style=\"color: #33cccc;\"><strong><span style=\"font-size: 12pt;\">MG 149 \u00a0(Tip60 HAT inhibitor) \u9078\u64c7\u6027\u6291\u5236\u5291 | CAS# 1243583-85-8 APExBIO\u8ca8\u865f B3276<\/span><\/strong><\/span><\/a><\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.apexbt.com\/media\/diy\/images\/pathway\/epigenetics.png\" alt=\"\" width=\"808\" height=\"562\" \/><\/p>\n<p>\u8868\u89c0\u907a\u50b3\u5b78(Epigenetics)\u662f\u57fa\u56e0\u8868\u9054\u7684\u53ef\u907a\u50b3\u4fee\u98fe(heritable modifications)\uff0c\u8207 DNA \u5e8f\u5217(DNA sequence)\u7684\u8b8a\u5316\u7121\u95dc\u3002\u8868\u89c0\u907a\u50b3\u4fee\u98fe(Epigenetic modifications)\u4e3b\u8981\u767c\u751f\u5728 DNA \u6216\u7d44\u86cb\u767d\u516b\u805a\u9ad4(histone octamer)\u4e0a\u3002\u6709\u5e7e\u7a2e\u985e\u578b\u7684\u8868\u89c0\u907a\u50b3\u5b78\u4fee\u98fe(epigenetics modifications)\uff0cDNA-\u7532\u57fa\u8f49\u79fb\u9176 (DNMT) \u7684 DNA \u7532\u57fa\u5316\u548c\u7d44\u86cb\u767d\u7684\u5171\u50f9\u4fee\u98fe\uff0c\u4f8b\u5982\u4e59\u91af\u5316(acetylation)\u3001\u7532\u57fa\u5316(methylation)\u3001\u78f7\u9178\u5316(phosphorylation)\u548c\u6cdb\u7d20\u5316(ubiquitination)\u3002\u7d44\u86cb\u767d\u4e59\u91af\u8f49\u79fb\u9176 (HAT) \u7684\u7d44\u86cb\u767d\u4e59\u91af\u5316\u53c3\u8207\u8f49\u9304\u6fc0\u6d3b\uff0c\u800c\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u9176 (HDAC) \u7684\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u8207\u8f49\u9304\u6291\u5236(transcriptional repression)\u6709\u95dc\u3002\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316(Histone demethylation)\u8207\u8cf4\u6c28\u9178\u7279\u7570\u6027\u53bb\u7532\u57fa\u5316\u9176 (lysine-specific demethylase , LSD) \u548c\u542b\u6709\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176 (JHDM) \u7684 JmjC \u7d50\u69cb\u57df(JmjC domain)\u6709\u95dc\u3002<\/p>\n<p>\u6838\u5c0f\u9ad4(nucleosome)\u7531\u56db\u7a2e\u7d44\u86cb\u767d\uff08H2A\u3001H2B\u3001H3 \u548c H4\uff09\u7d44\u6210\uff0c\u5b83\u5011\u662f\u67d3\u8272\u8cea(chromatin)\u7684\u4e3b\u8981\u7d44\u6210\u90e8\u5206\u3002\u7279\u5b9a\u5316\u5b78\u57fa\u5718\u7684\u6dfb\u52a0\u548c\u53bb\u9664\u7a31\u70ba\u8868\u89c0\u907a\u50b3\u6a19\u8a18(epigenetic marks)\uff0c\u5b83\u8abf\u7bc0\u67d3\u8272\u8cea\u7d50\u69cb\u4e26\u5f71\u97ff\u57fa\u56e0\u8868\u9054\u3002\u6b64\u5916\uff0cRNA \u8207\u6291\u5236\u6027\u67d3\u8272\u8cea\u72c0\u614b(repressive chromatin state)\u7684\u5f62\u6210\u5bc6\u5207\u76f8\u95dc\u3002<\/p>\n<p>\u8868\u89c0\u907a\u50b3(Epigenetic)\u6a5f\u5236\u5728\u7d30\u80de\u6c34\u5e73\u4e0a\u97ff\u61c9\u74b0\u5883\u8b8a\u5316\uff0c\u5f9e\u800c\u5f71\u97ff\u7d30\u80de\u53ef\u5851\u6027(plasticity)\u3002\u67d3\u8272\u8cea(Chromatin)\u548c\u8868\u89c0\u907a\u50b3\u8abf\u63a7(epigenetic regulation)\u5728\u767c\u80b2\u548c\u61c9\u6fc0\u53cd\u61c9\u671f\u9593\u7684\u57fa\u56e0\u7d44\u7de8\u7a0b\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\uff0c\u8868\u89c0\u907a\u50b3\u5b78\u7f3a\u9677(defects in epigenetics)\u53ef\u5c0e\u81f4\u764c\u75c7(cancer)\u3001\u708e\u75c7(inflammation)\u548c\u4ee3\u8b1d\u7d0a\u4e82(metabolic disorders)\u7b49\u3002MG 149 \u662f\u4e00\u7a2e\u7d44\u86cb\u767d\u4e59\u9170\u8f49\u79fb\u9176 (HAT) \u6291\u88fd\u5291\uff0c\u5c0d Tip60 \u548c MOF \u7684 IC50 \u503c\u5206\u5225\u70ba 74\u03bcM \u548c 47\u03bcM [1]\u3002<\/p>\n<p>MG 149 \u662f\u6f06\u6a39\u9178\u884d\u751f\u7269(anacardic acid derivative)\u3002\u5b83\u986f\u793a\u5c0d MYST \u985e\u578b\u7684 HAT(histone acetyltransferases)\uff1aTip60 \u548c MOF \u7684\u9078\u64c7\u6027\u6291\u5236(selective inhibition)\uff0cIC50 \u503c\u5206\u5225\u70ba 74\u03bcM \u548c 47\u03bcM\u3002\u5c0d\u63a5\u7814\u7a76\u8868\u660e\uff0cMG 149 \u5c0d Tip60 \u7684\u6291\u5236\u4f5c\u7528\u76f8\u5c0d\u65bc Tip60 \u7684 Ac-CoA \u7d50\u5408\u53e3\u888b\u4e2d\u7684 Ac-CoA \u5177\u6709\u7af6\u722d\u6027\u3002 MG 149 \u9084\u4f7f\u7528\u751f\u7269\u7d20\u5316\u7d44\u86cb\u767d H3 \u6216\u7d44\u86cb\u767d H4 \u80bd\u4f5c\u70ba\u5e95\u7269\u6291\u5236 HeLa \u7d30\u80de\u6838\u63d0\u53d6\u7269\u4e2d HAT \u7684\u6d3b\u6027\u3002\u8207\u7d44\u86cb\u767d H4 \u76f8\u6bd4\uff0c\u5b83\u88ab\u767c\u73fe\u5c0d\u7d44\u86cb\u767d H3 \u66f4\u6709\u6548\u3002\u6b64\u5916\uff0cDNA \u5fae\u9663\u5217(DNA microarrays) , \u986f\u793a MG149 \u6291\u5236 p53 \u548c NF-kB \u901a\u8def\u4ee5\u53ca\u6578\u91cf\u975e\u5e38\u6709\u9650\u7684\u5176\u4ed6\u901a\u8def [1, 2]\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/09\/B3276_1-1.jpg\" alt=\"\" \/><\/p>\n<ul>\n<li>1. Zichong Li. &#8220;Functional characterization of transcription elongation machinery in HIV transcription and latency.&#8221; University of California. 2019.<\/li>\n<li>2. Li Z, Mbonye U, et al. &#8220;The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency.&#8221; PLoS Pathog. 2018 Apr 23;14(4):e1007012.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29684085\">PMID:29684085<\/a><\/li>\n<\/ul>\n<table width=\"1128\">\n<tbody>\n<tr>\n<td>Storage<\/td>\n<td>Store at RT<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>340.46<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>1243583-85-8<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>22<\/sub>H<sub>28<\/sub>O<sub>3<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u2265114 mg\/mL in DMSO; \u226530.5 mg\/mL in EtOH; insoluble in H2O<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>2-(4-heptylphenethyl)-6-hydroxybenzoic acid<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/B3276.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>CCCCCCCC1=CC=C(CCC2=C(C(O)=O)C(O)=CC=C2)C=C1<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Ship with blue ice, or upon other requests.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4><\/h4>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%93%81%E7%89%8C%E7%B9%AA%E5%9C%96-Apexbio_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x300.jpg\" width=\"203\" height=\"225\" \/><\/p>\n<p><a href=\"http:\/\/www.apexbt.com\/\"><span style=\"font-size: 14pt; color: #ff6600;\"><strong><span style=\"color: #800080;\"><span style=\"font-size: 14pt;\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a><span style=\"font-size: 14pt;\"><a href=\"https:\/\/www.apexbt.com\/\"><span style=\"color: #ff99cc;\"><span style=\"color: #ff6600;\">https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2024\/09\/line-2_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1.jpg\" width=\"302\" height=\"230\" \/><\/p>\n<table width=\"553\">\n<tbody>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\">\u54c1\u9805<\/span><\/td>\n<td width=\"139\"><span style=\"color: #008080;\">CAS#<\/span><\/td>\n<td width=\"138\"><span style=\"color: #008080;\">#\u8ca8\u865f<\/span><\/td>\n<td width=\"138\"><span style=\"color: #008080;\">\u61c9\u7528<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=33999\">MG 149 \u00a0(Tip60 HAT inhibitor) \u9078\u64c7\u6027\u6291\u5236\u5291<strong><u>\u00a0<\/u><\/strong><\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS#\u00a01243583-85-8<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865f\u00a0B3276<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">HAT inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=34002\">4&#8242;-bromo-Resveratrol<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\"><a style=\"color: #000080;\" href=\"http:\/\/biopioneer.com.tw\/?p=34002\">CAS# 1224713-90-9\u00a0<\/a><\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865f C3552<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">Sirt1 \u548c Sirt3 \u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=34010\">MS023<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS# 1831110-54-3<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865f B6183<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">type I PRMTs inhibitor\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=34348\">CHZ868<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">N\/O<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865fB5980<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">Type II JAK2 inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=35251\">Chidamide<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS#743420-02-2<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865fB5916<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">Novel HDAC inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=35254\">RGFP966<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS#1357389-11-7\/1396841-57-8<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865fA8803<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">Specific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=35260\">EPZ-6438<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS#1403254-99-8<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865fA8221<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">EZH2 inhibitor, potent and selective<\/span><\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><span style=\"color: #008080;\"><a style=\"color: #008080;\" href=\"http:\/\/biopioneer.com.tw\/?p=35291\">Bromodomain Inhibitor, (+)-JQ1<\/a><\/span><\/td>\n<td width=\"139\"><span style=\"color: #000080;\">CAS# 1268524-70-4<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">\u8ca8\u865fA1910<\/span><\/td>\n<td width=\"138\"><span style=\"color: #000080;\">BET bromodomain inhibitor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tip60 HAT\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1-&gt;&gt;MG 149 \u00a0 APExBIO Technology LL [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":34000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[4928],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/33999"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33999"}],"version-history":[{"count":7,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/33999\/revisions"}],"predecessor-version":[{"id":53849,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/33999\/revisions\/53849"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34000"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}