{"id":29277,"date":"2021-09-09T13:33:29","date_gmt":"2021-09-09T05:33:29","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=29277"},"modified":"2022-07-19T13:41:55","modified_gmt":"2022-07-19T05:41:55","slug":"rsl3%e5%8c%96%e5%90%88%e7%89%a9-cas1219810-16-8%e8%b2%a8%e8%99%9fb2303","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=29277","title":{"rendered":"RSL3\u5316\u5408\u7269 | CAS#1219810-16-8\u8ca8\u865fB2303"},"content":{"rendered":"

RSL3\u5316\u5408\u7269 |\u00a0 CAS#1219810-16-8\u8ca8\u865f<\/strong>B2303<\/a><\/span><\/p>\n

\"\"<\/p>\n

A glutathione peroxidase 4 (GPX4) inhibitor and an inducer of ferroptosis<\/em><\/strong><\/p>\n

\"\u00e5\u008e\u009f\u00e7\u0090\u0086\u00e4\u00bb\u008b\u00e7\u00b4\u00b9\"RSL3 \u662f\u4e00\u7a2e\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176 4 (gl, utathione peroxidase 4 GPX4) \u6291\u5236\u5291\u548cferroptosis\u7684\u8a98\u5c0e\u5291\u3002 RSL3 \u5728\u9ad4\u5916\u589e\u52a0\u8102\u8cea\u904e\u6c27\u5316\u7269\u9176(lipid peroxidase)\u6c34\u5e73\u4e26\u5728\u9ad4\u5167\u6291\u5236\u816b\u7624\u5f62\u6210\u548c\u9032\u5c55\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/th>\n(1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester<\/td>\n<\/tr>\n
Appearance<\/th>\nYellow solid<\/td>\n<\/tr>\n
CAS #<\/th>\n1219810-16-8<\/td>\n<\/tr>\n
Molecular Formula<\/th>\nC\u2082\u2083H\u2082\u2081ClN\u2082O\u2085<\/td>\n<\/tr>\n
Molecular Weight<\/th>\n440.88<\/td>\n<\/tr>\n
Purity<\/th>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/th>\nDMSO (>35 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/th>\nCOC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24<\/td>\n<\/tr>\n
InChi<\/th>\nInChI=1S\/C23H21ClN2O5\/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24\/h3-10,18,21,25H,11-12H2,1-2H3\/t18-,21+\/m1\/s1<\/td>\n<\/tr>\n
InChi Key<\/th>\nTXJZRSRTYPUYRW-NQIIRXRSSA-N<\/td>\n<\/tr>\n
PubChem CID<\/th>\n1750826<\/td>\n<\/tr>\n
MDL Number<\/th>\nMFCD30187526<\/td>\n<\/tr>\n
Handling<\/th>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/th>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/th>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/th>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"b2303\"<\/a><\/strong><\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n
 <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

RSL3\u5316\u5408\u7269 |\u00a0 CAS#1219810-16-8\u8ca8\u865fB2303 A glutathione peroxi […]<\/p>\n","protected":false},"author":3,"featured_media":28510,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1020],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/29277"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29277"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/29277\/revisions"}],"predecessor-version":[{"id":29279,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/29277\/revisions\/29279"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/28510"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}