{"id":25425,"date":"2020-06-17T16:55:39","date_gmt":"2020-06-17T08:55:39","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=25425"},"modified":"2022-07-19T16:55:50","modified_gmt":"2022-07-19T08:55:50","slug":"phospho-limk1-2%ef%bc%88thr508-505%ef%bc%89%e6%8a%97%e9%ab%94-biovision%e8%b2%a8%e8%99%9fa1965","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=25425","title":{"rendered":"Phospho LIMK1 \/ 2\uff08Thr508 \/ 505\uff09\u6297\u9ad4 | Biovision\u8ca8\u865fA1965"},"content":{"rendered":"

Home<\/strong><\/a> \u00a0 \u00a0<\/strong>Literature<\/strong><\/a>\u00a0 \u00a0<\/strong>Promotions<\/strong><\/a>\u00a0\u00a0<\/strong>Product Citations<\/strong><\/a><\/p>\n

Phospho LIMK1 \/ 2\uff08Thr508 \/ 505\uff09\u6297\u9ad4 | <\/strong>\u8ca8\u865f<\/strong>A1965<\/a><\/span><\/p>\n

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\u00a0<\/em><\/strong>\u7522\u54c1\u63cf\u8ff0:<\/strong> \u5927\u7d04\u670940\u7a2e\u5df2\u77e5\u7684\u771f\u6838LIM\u86cb\u767d(eukaryotic LIM proteins)\uff0c\u4ee5\u5b83\u5011\u6240\u5305\u542b\u7684LIM\u57df(LIM domains)\u547d\u540d\u3002 LIM\u7d50\u69cb\u57df(. LIM domains)\u662f\u9ad8\u5ea6\u4fdd\u5b88\u7684\u5bcc\u542b\u534a\u80f1\u6c28\u9178(cysteine-rich)\u7684\u7d50\u69cb\uff0c\u5305\u542b2\u500b\u92c5\u6307(zinc fingers)\u3002\u5118\u7ba1\u92c5\u6307(zinc fingers)\u901a\u5e38\u901a\u904e\u7d50\u5408DNA\u6216RNA\u8d77\u4f5c\u7528\uff0c\u4f46LIM\u57fa\u5e8f(LIM motif)\u53ef\u80fd\u4ecb\u5c0e\u4e86\u86cb\u767d\u8cea\u8207\u86cb\u767d\u8cea\u7684\u76f8\u4e92\u4f5c\u7528(protein-protein interactions)\u3002 LIM\u6fc0\u91761(LIM kinase-1)\u548cLIM\u6fc0\u91762(LIM kinase-2)\u5c6c\u65bc\u4e00\u500b\u5c0f\u4e9e\u79d1(small subfamily)\uff0c\u5177\u67092\u500bN\u7aefLIM\u57fa\u5e8f(2 N-terminal LIM motifs)\u548c\u4e00\u500bC\u7aef\u86cb\u767d\u6fc0\u9176\u7d50\u69cb\u57df(C-terminal protein kinase domain)\u7684\u7368\u7279\u7d44\u5408\u3002 LIMK1\u662f\u4e00\u7a2e\u7d72\u6c28\u9178\/\u8607\u6c28\u9178\u6fc0\u9176(serine\/threonine kinase)\uff0c\u53ef\u901a\u904e\u808c\u52d5\u86cb\u767d\u7d50\u5408\u56e0\u5b50cofilin\u7684\u78f7\u9178\u5316\u548c\u5931\u6d3b\u4f86\u8abf\u7bc0\u808c\u52d5\u86cb\u767d\u7684\u805a\u5408\u53cd\u61c9\u3002\u8a72\u86cb\u767d\u5728\u767c\u80b2\u904e\u7a0b\u4e2d\u666e\u904d\u8868\u9054\uff0c\u4e26\u5728\u8a31\u591a\u8207\u7d30\u80de\u9aa8\u67b6\u7d50\u69cb(cytoskeletal structure)\u76f8\u95dc\u7684\u7d30\u80de\u904e\u7a0b\u4e2d\u767c\u63ee\u4f5c\u7528\u3002\u8a72\u86cb\u767d\u9084\u523a\u6fc0\u8ef8\u7a81\u751f\u9577(axon growth)\uff0c\u4e26\u53ef\u80fd\u5728\u5927\u8166\u767c\u80b2(brain development)\u4e2d\u8d77\u4f5c\u7528\u3002 LIMK1\u534a\u5408\u5b50\u6027(LIMK1 hemizygosity) \u8207Williams\u7d9c\u5408\u5fb5\u7684\u8996\u89ba\u7a7a\u9593\u5efa\u8a2d\u6027\u8a8d\u77e5\u53d7\u640d\u6709\u95dc\u3002\u9078\u64c7\u6027\u526a\u63a5(Alternative splicing)\u5c0e\u81f4\u7de8\u78bc\u4e0d\u540c\u540c\u5de5\u578b\u7684\u591a\u500b\u8f49\u9304\u8b8a\u9ad4\u3002<\/p>\n

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\u4e7e\u6d74\u52a0\u71b1\u6c34\u6d74\u69fd<\/strong><\/a>\u00a0|\u00a0 <\/strong>Finnpipette F3 <\/strong>\u5fae\u91cf\u5206\u6ce8\u5668<\/strong><\/a>\u00a0| \u00a0<\/strong>\u8a66\u7ba1\u632f\u76ea\u5668 Vortex Mixer\u00a0<\/strong><\/a>\u00a0|\u00a0 <\/strong>Genereach<\/strong>\u8ff7\u4f60\u578b\u5fae\u91cf\u96e2\u5fc3\u6a5f<\/strong><\/a>\u00a0 |\u00a0\u00a0 <\/strong>ELISA<\/strong>\u5100\u5668<\/strong><\/a><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Size<\/strong><\/td>\n100 \u00b5l<\/td>\n<\/tr>\n
Antibody Target<\/strong><\/td>\nPhospho LIMK1\/2 (Thr508\/505)<\/td>\n<\/tr>\n
Alternate Name<\/strong><\/td>\nLIMK; LIM domain kinase 1; LIMK-1<\/td>\n<\/tr>\n
Host<\/strong><\/td>\nRabbit<\/td>\n<\/tr>\n
Antibody Type<\/strong><\/td>\nPolyclonal<\/td>\n<\/tr>\n
Isotype<\/strong><\/td>\nIgG<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\nP53667<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n3984<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nColorless liquid<\/td>\n<\/tr>\n
Formulation<\/strong><\/td>\nIn 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide<\/td>\n<\/tr>\n
Purification<\/strong><\/td>\nAffinity purified<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nBovine, Rat, Chicken, Human<\/td>\n<\/tr>\n
Application<\/strong><\/td>\nImmunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting<\/td>\n<\/tr>\n
Application & Usage<\/strong><\/td>\nWB 1:500 – 1:1000, IHC 1:100 – 1:200, IF 1:100 – 1:500<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nThe antibody solution should be gently mixed before use.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/span><\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

Home \u00a0 \u00a0Literature\u00a0 \u00a0Promotions\u00a0\u00a0Product Citations Phos […]<\/p>\n","protected":false},"author":3,"featured_media":25426,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1475],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/25425"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25425"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/25425\/revisions"}],"predecessor-version":[{"id":25427,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/25425\/revisions\/25427"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/25426"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25425"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}