{"id":24613,"date":"2020-05-09T16:39:45","date_gmt":"2020-05-09T08:39:45","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=24613"},"modified":"2022-07-19T17:18:24","modified_gmt":"2022-07-19T09:18:24","slug":"tace%e6%8a%91%e5%88%b6%e5%8a%91%e7%af%a9%e9%81%b8%e6%b8%ac%e5%ae%9a-tace-inhibitor-screening-assay-kit%e8%b2%a8%e8%99%9fk366","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=24613","title":{"rendered":"TACE\u6291\u5236\u5291\u7be9\u9078\u6e2c\u5b9a| TACE Inhibitor Screening Assay Kit\u8ca8\u865fK366"},"content":{"rendered":"

TACE\u6291\u5236\u5291\u7be9\u9078\u6e2c\u5b9a\u8a66\u5291\u76d2(\u87a2\u5149\u5b78) | TACE Inhibitor Screening Assay Kit ( Fluorometric)\u8ca8\u865f<\/strong>K366<\/a><\/span>\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39: TACE(tumor necrosis factor-\u03b1-converting enzyme, \u816b\u7624\u58de\u6b7b\u56e0\u6578-\u03b2-\u8f49\u5316\u9176),\u4e5f\u7a31\u70baADAM\u91d1\u5c6c\u80bd\u9176\u57df17(ADAM metallopeptidase domain 17, ADAM17),\u662f\u4e00\u7a2e70kDa\u9176,\u5c6c\u65bcADAM\u86cb\u767d\u7cfb\u5217(ADAM protein family),\u5305\u62ec\u812b\u9ec3\u9176(disintegrins)\u548c\u91d1\u5c6c\u86cb\u767d\u9176(metalloproteases)\u3002TACE\u88ab\u8a8d\u70ba\u53c3\u8207\u8655\u7406\u816b\u7624\u58de\u6b7b\u56e0\u6578\u03b1(tumor necrosis factor alpha , TNF-\u03b1)\u5728\u7d30\u80de\u8868\u9762,\u4e26\u5f9e\u7d30\u80de\u5167\u819c\u7684\u8de8Golgi network.\u3002\u9019\u500b\u904e\u7a0b,\u4e5f\u7a31\u70ba” shedding “,\u6d89\u53ca\u5f9e\u819c\u7d50\u5408\u7684\u89aa\u86cb\u767d(\u5982\u89aaTNF-+)\u4e2d\u5206\u96e2\u548c\u91cb\u653e\u53ef\u6eb6\u6027\u7570\u4f4d,\u4e26\u4e14\u5177\u6709\u5df2\u77e5\u7684\u751f\u7406\u91cd\u8981\u6027\u3002\u5728 BioVision \u7684 TACE \u6291\u5236\u5291\u7be9\u9078\u8a66\u5291\u76d2\u4e2d,TACE \u6703\u6c34\u89e3\u7279\u5b9a\u7684 FRET \u57fa\u677f\u4ee5\u91cb\u653e\u6dec\u706b\u87a2\u5149\u7d44,\u53ef\u5728 Ex\/Em = 318\/449 nm \u4e0a\u4ee5\u87a2\u5149\u6aa2\u6e2c\u3002\u5728\u5f37\u6027TACE\u6291\u5236\u5291\u7684\u5b58\u5728\u4e0b,\u57fa\u8cea\u7684\u6c34\u89e3\u5c07\u53d7\u5230\u963b\u7919\u3002\u8a72\u8a66\u5291\u76d2\u63d0\u4f9b\u5feb\u901f\u3001\u7c21\u55ae\u3001\u9748\u654f\u548c\u53ef\u9760\u7684\u6e2c\u8a66,\u9069\u7528\u65bcTACE\u6291\u5236\u5291\u7684\u9ad8\u901a\u91cf\u7be9\u9078,\u4e26\u53ef\u5c0d\u5176\u9032\u884c\u4fee\u6539\u4ee5\u6aa2\u67e5\u76f8\u95dc\u7684TACE\u6d3b\u6027\u3002\u5305\u62ec\u6291\u5236\u5291\u63a7\u5236GM6001\u7528\u65bc\u6bd4\u8f03\u6e2c\u8a66\u6291\u5236\u5291\u7684\u7642\u6548\u3002<\/p>\n\n\n\n\n\n\n\n\n\n
Cat # +Size<\/strong><\/td>\nK366-100<\/td>\n<\/tr>\n
Size<\/strong><\/td>\n100 assays<\/td>\n<\/tr>\n
Detection Method<\/strong><\/td>\nFluorescence (Ex\/Em 318\/449 nm)<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nMammalian<\/td>\n<\/tr>\n
Applications<\/strong><\/td>\nProvides a rapid, simple, sensitive and reliable test suitable for high-throughput screening of TACE inhibitors and can be modified to check the relative TACE activity. Inhibitor control GM6001 is included to compare the efficiency of test inhibitors.<\/td>\n<\/tr>\n
Features & Benefits<\/strong><\/td>\n\u2022 Simple procedure \u2022 Fast and convenient \u2022 The assay is sensitive, simple, and high-throughput adaptable.<\/td>\n<\/tr>\n
Kit Components<\/strong><\/td>\n\u2022 TACE Assay Buffer \u2022 TACE Substrate \u2022 TACE Enzyme (20 \u03bcg) \u2022 Inhibitor Control (0.1 mM GM6001)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/strong>\u6aa2\u6e2c<\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

TACE\u6291\u5236\u5291\u7be9\u9078\u6e2c\u5b9a\u8a66\u5291\u76d2(\u87a2\u5149\u5b78) | TACE Inhibitor Screening Assay Ki […]<\/p>\n","protected":false},"author":3,"featured_media":459,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1568],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/24613"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24613"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/24613\/revisions"}],"predecessor-version":[{"id":24614,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/24613\/revisions\/24614"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/459"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}