{"id":23291,"date":"2020-01-31T12:02:15","date_gmt":"2020-01-31T04:02:15","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23291"},"modified":"2022-07-19T17:36:27","modified_gmt":"2022-07-19T09:36:27","slug":"%e5%a5%a7%e8%b2%9d%e8%86%bd%e9%85%b8-obeticholic-acid-%e8%b2%a8%e8%99%9fb1898","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=23291","title":{"rendered":"\u5967\u8c9d\u81bd\u9178 (Obeticholic acid) | \u8ca8\u865fB1898"},"content":{"rendered":"

\u5967\u8c9d\u81bd\u9178 (Obeticholic acid) | <\/strong>\u8ca8\u865f<\/strong>B1898<\/a><\/span><\/p>\n

Obeticholic Acid-<\/em>A potent and selective FXR (Farnesoid X receptor) agonist<\/em>\u00a0<\/em><\/p>\n

\u7522\u54c1\u63cf\u8ff0\uff1a<\/strong>\u5967\u8c9d\u81bd\u9178(Obeticholic acid)\u662f\u81bd\u9178(cholic acid)\u7684\u884d\u751f\u7269(derivative)\uff0c\u5728\u9ad4\u5167\u81bd\u6c41\u6de4\u7a4d\u5927\u9f20\u6a21\u578b\u4e2d\uff0c\u81bd\u753e\u9178\u662f\u4e00\u7a2e\u6709\u6548\u7684\uff0c\u9078\u64c7\u6027\u7684FXR\uff08Farnesoid X\u53d7\u9ad4\uff09\u6fc0\u52d5\u5291\uff08EC 50 = 99 nM\uff09\uff0c\u5177\u6709\u6297\u81bd\u6c41\u6d3b\u6027(anticholeretic activity)\u3002 \u5967\u8c9d\u81bd\u9178(Obeticholic acid)\u7684\u6548\u529b\u6bd4\u5167\u6e90\u6027\u914d\u9ad4\u9d5d\u53bb\u6c27\u81bd\u9178\uff08endogenous ligand chenodeoxycholic acid , CDCA\uff09\uff08\u8ca8\u865f2831\uff09\u9ad8100\u500d\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 6-ECDCA; 6-Ethylchenodeoxycholic acid); INT-747<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n459789-99-2<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2086H\u2084\u2084O\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n420.63<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C26H44O4\/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30\/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)\/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-\/m1\/s1<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nZXERDUOLZKYMJM-ZWECCWDJSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n447715<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e7e\u6d74\u52a0\u71b1\u6c34\u6d74\u69fd<\/strong><\/a>\u00a0|\u00a0 <\/strong>Finnpipette F3 <\/strong>\u5fae\u91cf\u5206\u6ce8\u5668<\/strong><\/a>\u00a0| \u00a0<\/strong>\u8a66\u7ba1\u632f\u76ea\u5668 Vortex Mixer\u00a0<\/strong><\/a>\u00a0|\u00a0 <\/strong>Genereach<\/strong>\u8ff7\u4f60\u578b\u5fae\u91cf\u96e2\u5fc3\u6a5f<\/strong><\/a>\u00a0 |\u00a0\u00a0 <\/strong>ELISA<\/strong>\u5100\u5668<\/strong><\/a><\/span><\/p>\n

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\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u5967\u8c9d\u81bd\u9178 (Obeticholic acid) | \u8ca8\u865fB1898 Obeticholic Acid-A po […]<\/p>\n","protected":false},"author":3,"featured_media":23292,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1713],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23291"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23291"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23291\/revisions"}],"predecessor-version":[{"id":23293,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23291\/revisions\/23293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/23292"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}