{"id":19378,"date":"2019-04-03T11:31:49","date_gmt":"2019-04-03T03:31:49","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=19378"},"modified":"2022-07-20T14:05:28","modified_gmt":"2022-07-20T06:05:28","slug":"recombinant-human-pdgfa%e9%87%8d%e7%b5%84%e8%9b%8b%e7%99%bd-%e8%b2%a8%e8%99%9fz100367-z100368","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=19378","title":{"rendered":"Recombinant Human PDGFA\u91cd\u7d44\u86cb\u767d |\u8ca8\u865fZ100367 \/ Z100368"},"content":{"rendered":"

Recombinant Human PDGFA<\/strong>\u91cd\u7d44<\/strong>\u86cb\u767d<\/strong> |<\/strong>\u8ca8\u865f<\/strong>Z100367\u00a0<\/strong><\/a><\/span><\/p>\n

PDGF\u4e9e\u57faA\uff0cPDGF-1\uff0c\u8840\u5c0f\u677f\u884d\u751f\u751f\u9577\u56e0\u5b50A\u93c8\uff0c\u8840\u5c0f\u677f\u884d\u751f\u751f\u9577\u56e0\u5b50\u03b1\u591a\u80bd\uff0cPDGFA\uff0cPDGF-AA\uff0cPDGF1<\/p>\n

\"\"<\/p>\n

\u91cd\u7d44\u4eba\u8840\u5c0f\u677f\u884d\u751f\u751f\u9577\u56e0\u5b50\u4e9e\u57faA\uff08PDGFA\uff09<\/p>\n

PDGFA<\/strong>\u91cd\u7d44<\/strong>\u86cb\u767d\u4ecb\u7d39<\/strong>:<\/strong>\u00a0 <\/strong>PDGF\u5bb6\u65cf (PDGF family) \u7531\u56db\u7a2e\u4e0d\u540c\u591a\u80bd\u93c8\u7684\u4e94\u7a2e\u4e0d\u540c\u7684\u4e8c\u786b\u9375\u9023\u63a5\u7684\u4e8c\u805a\u9ad4\u7d44\u6210\uff1aA\uff0cB\uff0cC\u548cD \uff08PDGF-AA\uff0cPDGF-BB\uff0cPDGF-AB\uff0cPDGF-CC\u548cPDGF-DD\uff09\u3002\u4e3b\u8981\u7531\u5de8\u6838\u7d30\u80de\u5408\u6210 (megakaryocytes) \uff0cPDGF\u5b58\u5132\u5728\u8840\u5c0f\u677f(platelets)\u7684\u03b1\u9846\u7c92\u4e2d(alpha granules)\uff0c\u8840\u5c0f\u677f\u6d3b\u5316\u5f8c\u5b83\u5011\u5f9e\u8840\u5c0f\u677f\u4e2d\u91cb\u653e\u3002 PDGF\u53d7\u9ad4(PDGF receptors)\u5728\u6210\u7e96\u7dad\u7d30\u80de(fibroblasts)\uff0c\u6210\u9aa8\u7d30\u80de(osteoblasts)\uff0c\u6210\u8edf\u9aa8\u7d30\u80de(chondroblasts)\uff0c\u5e73\u6ed1\u808c\u7d30\u80de(smooth muscle cells)\uff0c\u795e\u7d93\u81a0\u8cea\u7d30\u80de(glial cells)\u548c\u5167\u76ae\u7d30\u80de(endothelial cells)\u4e2d\u8868\u9054\u3002 PDGF\u4f5c\u70ba\u81ea\u5206\u6ccc(autocrine)\u548c\u65c1\u5206\u6ccc\u751f\u9577\u56e0\u5b50(paracrine growth factor)\u8d77\u4f5c\u7528\uff0c\u53c3\u8207\u8a31\u591a\u751f\u7269\u904e\u7a0b\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u589e\u751f(hyperplasia)\uff0c\u8da8\u5316\u6027(chemotaxis)\uff0c\u80da\u80ce\u795e\u7d93\u5143\u767c\u80b2(embryonic neuron development)\uff0c\u50b7\u53e3\u7652\u5408(wound healing )\u548c\u547c\u5438\u5c0f\u7ba1\u4e0a\u76ae\u7d30\u80de\u767c\u80b2\u3002\u5728\u8840\u7ba1\u589e\u751f\u6027\u75be\u75c5(vascular proliferative diseases)\u5982\u52d5\u8108\u7ca5\u6a23\u786c\u5316(atherosclerosis)\u4e2d\u89c0\u5bdf\u5230PDGF\u7684\u7570\u5e38\u8868\u9054\u3002 PDGF\u8abf\u7bc0\u5176\u81ea\u8eab\u53d7\u9ad4\u7684\u5408\u6210\uff0c\u4e26\u4e14\u9084\u5f71\u97ffIL1\uff0cEGF\uff0c5-\u7fa5\u8272\u80fa(5-Hydroxytryptamine)\uff0cLDL\u548c\u8f49\u9435\u86cb\u767d(transferrin)\u7684\u819c\u53d7\u9ad4\u7684\u8868\u9054\u3002\u91cd\u7d44\u4ebaPDGFA\u662f\u5169\u689dA\u93c8\u7684\u4e8c\u786b\u9375\u9023\u63a5\u7684\u540c\u578b\u4e8c\u805a\u9ad4\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Gene Symbol<\/strong><\/td>\nPDGFA<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n5154<\/td>\n<\/tr>\n
Accession No.<\/strong><\/td>\nP04085<\/td>\n<\/tr>\n
Source<\/strong><\/td>\nE. coli<\/em><\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nLyophilized Powder<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n14.5 kDa<\/td>\n<\/tr>\n
Endotoxin Level<\/strong><\/td>\n<1.0 EU\/\u03bcg of recombinant protein as determined by the LAL method<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n>95% as determined by SDS-PAGE<\/td>\n<\/tr>\n
Bioactivity<\/strong><\/td>\nThe ED50 as determined by the dose-dependent proliferation of mouse embryonic fibroblast cells was found to be \u2264 5.0 ng\/mL<\/td>\n<\/tr>\n
Formulation<\/strong><\/td>\nLyophilized from a 0.2 \u03bcm filtered solution in Tris and NaCl<\/td>\n<\/tr>\n
Reconstitution<\/strong><\/td>\nA quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg\/mL. This solution can then be diluted into other buffers.<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nThe lyophilized protein is stable for at least one year from date of receipt at -70\u00b0C. Upon reconstitution, this cytokine can be stored in working aliquots at 2\u00b0 – 8\u00b0C for one month, or at -20\u00b0C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze\/thaw cycles.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Recombinant Human PDGFA\u91cd\u7d44\u86cb\u767d |\u8ca8\u865fZ100367\u00a0 PDGF\u4e9e\u57faA\uff0cPDGF-1\uff0c […]<\/p>\n","protected":false},"author":3,"featured_media":19379,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[461],"tags":[2279],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/19378"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19378"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/19378\/revisions"}],"predecessor-version":[{"id":19380,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/19378\/revisions\/19380"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/19379"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}