{"id":15696,"date":"2018-02-21T16:00:46","date_gmt":"2018-02-21T08:00:46","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=15696"},"modified":"2022-07-20T17:42:19","modified_gmt":"2022-07-20T09:42:19","slug":"%e7%94%b2%e7%8b%80%e6%97%81%e8%85%ba%e6%bf%80%e7%b4%a0%e7%9b%b8%e9%97%9c%e8%9b%8b%e7%99%bd%e5%96%ae%e6%a0%aa%e6%8a%97%e9%ab%94-%e8%b2%a8%e8%99%9fab00795-1-1","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=15696","title":{"rendered":"\u7532\u72c0\u65c1\u817a\u6fc0\u7d20\u76f8\u95dc\u86cb\u767d\u55ae\u682a\u6297\u9ad4 | \u8ca8\u865fAb00795-1.1"},"content":{"rendered":"<p><strong>Fc Silent\u2122 Antibodies: Turning down the background noise<\/strong> <strong>\u53ea\u8981<\/strong><strong>\u8a0a<\/strong><strong>\u865f\u4e0d\u8981\u96dc<\/strong><strong>\u8a0a (Engineered Fc Domain)<\/strong><\/p>\n<p><strong>Anti-Parathyroid Hormone-related Protein<\/strong><\/p>\n<p>Absoluted Antibody \u63d0\u4f9b\u4e00\u7cfb\u5217\u6297\u9ad4\u5546\u54c1\uff0c\u5176\u4e2dFc Silent\u2122 Antibodies\u7cfb\u5217\uff1b\u80fd\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027Fc\u7d50\u5408\u3002Fc Silent\u2122\u6280\u8853\uff0c\u70ba\u61c9\u7528\u751f\u7269\u5de5\u7a0b\u6280\u8853\uff0c\u5c07Fc receptors (Fc\u03b3R, FcR)\u9ede\u7a81\u8b8a\uff0c\u9032\u800c\u4e2d\u6b62\u6297\u9ad4\u8207ADCC\u7684\u529f\u80fd\uff1b\u6709\u6548\u964d\u4f4eFc\u6240\u9020\u6210\u7684\u80cc\u666f\u8a0a\u865f\u3002Fc Silent\u2122\u6297\u9ad4\u61c9\u7528\u65bc\u514d\u75ab\u7d30\u80de\u6642flow cytometry\u3001immunohistochemistry (IHC)\u8cc7\u6599\u986f\u793a\uff0c\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027\u4e4bFc\u7d50\u5408\uff0c\u6240\u9020\u6210\u7684\u80cc\u666f\u503c\u3002(\u8a02\u8cfc\u6297\u9ad4\u524d\uff0c\u8acb\u78ba\u8a8d\u9078\u64c7\u6297\u9ad4\u662f\u5426\u6709Fc Silent\u2122\u4fee\u98fe\u6a19\u8a8c)<\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=15696\"><strong>\u7532\u72c0\u65c1\u817a\u6fc0\u7d20\u76f8\u95dc\u86cb\u767d<\/strong><strong>\u55ae\u682a\u6297\u9ad4<\/strong> <strong>| <\/strong><strong>\u8ca8\u865f<\/strong><strong>Ab00795-1.1<\/strong><\/a><\/span><\/p>\n<p><strong>Species and Isotype:\u00a0<\/strong>Mouse IgG1, kappa<br \/>\n<strong>Clone Number:\u00a0<\/strong>23-57-137-1<br \/>\n<strong>UniProt Accession Number of Target Protein:\u00a0<\/strong><br \/>\n<strong>Published Application(s):\u00a0<\/strong>neutralize; crystallize<br \/>\n<strong>Published Species Reactivity:\u00a0<\/strong>Human<br \/>\n<strong>Immunogen:\u00a0<\/strong>The anti-PTHrP antibody was prepared by immunizing mice with synthetic human bovine thyroglobulin-conjugated PTHrP (aa 1-34) and generating the hybridoma cell line #23-57-137-1<br \/>\n<strong>Specificity:\u00a0<\/strong>The anitbody binds to human PTHrP (The KD ~ 0.1 nM) at a site closely overlapping with the GPCR parathyroid hormone receptor 1 binding site &#8211; the epitope is between residues 20 and 30, with some contribution from residues 15-20 (aa 14-34 are important for receptor binding and aa1-34 are important for full signal tranduction). PTHrP is known to be a causative factor of humoural hypercalcemia of malignancy (HHM), which is frequently found at advanced stages of cancer. The protein binds to PTHR1, which is expressed on the surface of cells of the osteoblast lineage and of the kidney tubule; this interaction actively promotes bone resorption, in a manner identical to that of PTH.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fc Silent\u2122 Antibodies: Turning down the background nois [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":6981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[89],"tags":[2896],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15696"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15696"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15696\/revisions"}],"predecessor-version":[{"id":15697,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15696\/revisions\/15697"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6981"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}