{"id":15489,"date":"2018-02-04T10:37:15","date_gmt":"2018-02-04T02:37:15","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=15489"},"modified":"2022-07-20T17:48:19","modified_gmt":"2022-07-20T09:48:19","slug":"crt-inhibitor-icrt5%e6%8a%91%e5%88%b6%e5%8a%91-biovision-cas%e8%b2%a8%e8%99%9f1896-25","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=15489","title":{"rendered":"CRT Inhibitor, iCRT5\u6291\u5236\u5291 | Biovision CAS#\u8ca8\u865f1896-25\u00a0\u00a0"},"content":{"rendered":"

Wnt Signaling Inhibitors\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1<\/span><\/p>\n

Wnt\u86cb\u767d\uff08\u4f86\u6e90\u65bc\u679c\u8805\u7121\u7ffc\u8868\u578b\u7684Wnt\u540d\u7a31\uff09\u662f\u9ad8\u5ea6\u4fdd\u5b88\u7684\u5206\u6ccc\u7cd6\u86cb\u767d\uff0c\u5176\u4f5c\u70ba\u4e3b\u8981\u5728\u80da\u80ce\u9aee\u751f\u4e2d\u8d77\u4f5c\u7528\u7684\u77ed\u7a0b\u6216\u9577\u7a0b\u4fe1\u865f\u5206\u5b50\u3002Wnt\u86cb\u767d\u89f8\u767c\u4e26\u50b3\u905e\u5efa\u7acb\u8eab\u9ad4\u8ef8\uff0c\u5668\u5b98\u4f4d\u7f6e\u7b49\u7684\u7d30\u80de\u53cd\u61c9\u3002\u4fe1\u606f\u7684\u50b3\u905e\u662f\u901a\u904e\u7cbe\u78ba\u5b9a\u6642\u6fc0\u6d3b\u4e00\u7d44\u8907\u96dc\u7684\u76f8\u4e92\u9023\u63a5\u7684\u7d30\u80de\u5167\u4fe1\u865f\u8f49\u5c0e\u7db2\u7d61\u9032\u884c\u7684\uff0c\u5f9eWnt\u86cb\u767d\u8207\u6372\u66f2\u86cb\u767d\u5bb6\u65cf\u7684\u53d7\u9ad4\u7d50\u5408\u958b\u59cb\u3002\u5728\u4eba\u985e\u4e2d\uff0c\u5df2\u77e519\u500bWnt\u5bb6\u65cf\u6210\u54e1\u548c10\u500b\u6372\u66f2\u86cb\u767d\u53d7\u9ad4\u3002 Wnt\u4fe1\u4ee4\u5df2\u7d93\u6709\u4e09\u7a2e\u4e3b\u8981\u7684\u65b9\u5f0f\u9032\u884c\u3002\u5728\u898f\u7bc4\u9014\u5f91\u4e2d\uff0cWnt\u7d50\u5408\u5c0e\u81f4\u8f49\u9304\u56e0\u5b50\u03b2-\u9023\u74b0\u86cb\u767d\u7684\u7a69\u5b9a\u5316\uff0c\u5176\u9032\u5165\u7d30\u80de\u6838\u4ee5\u8abf\u7bc0\u4e00\u7d44\u9776\u57fa\u56e0\u3002\u7136\u800c\uff0cWnt\u7d50\u5408\u9084\u901a\u904e\u4e0d\u4f9d\u8cf4\u03b2-\u9023\u74b0\u86cb\u767d\u7684\u975e\u7d93\u5178\u9014\u5f91\u5982\u5e73\u9762\u7d30\u80de\u6975\u6027\uff08PCP\uff09\u9014\u5f91\u548c\u6d89\u53caCa 2+\u4fe1\u865f\u50b3\u5c0e\u7684\u9014\u5f91\u8d77\u4f5c\u7528\u3002 Wnt\u5728\u5e79\u7d30\u80de\u751f\u7269\u5b78\uff0c\u5668\u5b98\u767c\u80b2\uff0c\u7d30\u80de\u5206\u5316\uff0c\u7d30\u80de\u9077\u79fb\uff0c\u8840\u7ba1\u751f\u6210\u548c\u8001\u5316\u7b49\u65b9\u9762\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u7531\u65bc\u7a81\u8b8a\u9020\u6210\u7684Wnt\u4fe1\u865f\u7684\u904e\u5ea6\u6d3b\u5316\u662f\u4eba\u985e\u7d50\u8178\uff0c\u809d\u81df\uff0c\u76ae\u819a\uff0c\u524d\u5217\u817a\uff0c\u4e73\u623f\u548c\u5176\u4ed6\u7d44\u7e54\u4e2d\u7684\u764c\u767c\u751f\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u7531\u65bc\u5176\u80fd\u5920\u5f71\u97ff\u57fa\u672c\u7684\u7d30\u80de\u884c\u70ba\uff0c\u5176\u4e2d\u7684\u5931\u8abf\u751a\u81f3\u53ef\u80fd\u5c0e\u81f4\u767c\u80b2\u4e2d\u80da\u80ce\u7684\u201c\u4e0d\u53ef\u884c\u201d\u7684\u547d\u904b\uff0c\u6240\u4ee5Wnt\u4fe1\u865f\u7d1a\u806f\u4f5c\u70ba\u6cbb\u7642\u8af8\u5982\u764c\u75c7\u548c\u5404\u7a2e\u767c\u80b2\u7684\u4eba\u985e\u75be\u75c5\u7684\u6cbb\u7642\u9776\u6a19\u5177\u6709\u6975\u597d\u7684\u6f5b\u529b\u7570\u5e38\u3002<\/p>\n

CRT Inhibitor, iCRT5\u6291\u5236\u5291 | Biovision CAS#\u8ca8\u865f1896-25\u00a0\u00a0<\/a><\/span><\/p>\n

A \u03b2-catenin-responsive transcription (CRT) inhibitor<\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39\uff1aCRT Inhibitor\u70ba\u7d30\u80de\u6ef2\u900f\u6027, \u6838\u5167\u03b2-catenin\u53cd\u61c9\u8f49\u9304\uff08CRT\uff09\u7684\u6709\u6548\u6291\u5236\u5291\u3002 iCRT5\u6291\u5236IC 50\u70ba18nM\u7684Wnt\u53cd\u61c9\u6027STF16\u87a2\u5149\u7d20\u9176\uff08STF16-Luc\uff09\u3002 \u5b83\u901a\u904e\u7834\u58de\u03b2-\u9023\u74b0\u86cb\u767d\u548cTCF4\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u80fd\u901a\u904e\u76f4\u63a5\u7d50\u5408\u03b2-\u9023\u74b0\u86cb\u767d\u4f86\u8d77\u4f5c\u7528\u3002 \u7136\u800c\uff0c\u5b83\u5c0d\u975e\u7d93\u5178Wnt\u4fe1\u865f\u50b3\u5c0e\u548c\u5176\u4ed6\u9014\u5f91\u5982Hh\uff0cJAK \/ STAT\u548cNotch\u4fe1\u865f\u50b3\u5c0e\u986f\u793a\u6700\u5c0f\u6216\u8f03\u5c0f\u7684\u986f\u8457\u5f71\u97ff\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/td>\n(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid<\/td>\n<\/tr>\n
Appearance<\/td>\nYellow solid<\/td>\n<\/tr>\n
Molecular Formula<\/td>\nC\u2081\u2086H\u2081\u2087NO\u2085S\u2082<\/td>\n<\/tr>\n
Molecular Weight<\/td>\n367.44<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/td>\nDMSO<\/td>\n<\/tr>\n
PubChem CID<\/td>\n<\/td>\n<\/tr>\n
Handling<\/td>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u66f4\u591a\u9175\u7d20\u578b\u6291\u5236\u5291\u5546\u54c1: ACE\u6291\u5236\u5291\u985e<\/a> | AR\u6291\u5236\u5291\u985e<\/a> | AKR\u6291\u5236\u5291\u985e<\/a> | adenylyl cyclase \u6291\u5236\u5291\u985e<\/a> | AAC\u6291\u5236\u5291<\/a> | ACAT\u6291\u5236\u5291<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Wnt Signaling Inhibitors\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1 Wnt\u86cb\u767d\uff08\u4f86\u6e90\u65bc\u679c\u8805\u7121\u7ffc\u8868\u578b\u7684Wnt\u540d\u7a31\uff09\u662f […]<\/p>\n","protected":false},"author":3,"featured_media":15490,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[2938,2939],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15489"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15489"}],"version-history":[{"count":1,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15489\/revisions"}],"predecessor-version":[{"id":15491,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15489\/revisions\/15491"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/15490"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}