{"id":15485,"date":"2018-02-04T10:25:33","date_gmt":"2018-02-04T02:25:33","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=15485"},"modified":"2022-07-20T17:48:27","modified_gmt":"2022-07-20T09:48:27","slug":"tmp-153%e6%8a%91%e5%88%b6%e5%8a%91-biovision-cas128831-46-9%e8%b2%a8%e8%99%9fb1181-10","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=15485","title":{"rendered":"TMP-153\u6291\u5236\u5291 | Biovision CAS#128831-46-9\u8ca8\u865fB1181-10\u00a0\u00a0"},"content":{"rendered":"

ACAT Inhibitors\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1<\/span><\/p>\n

TMP-153\u6291\u5236\u5291 | Biovision CAS#128831-46-9\u8ca8\u865fB1181-10\u00a0\u00a0<\/a><\/span><\/p>\n

\"\"<\/p>\n

selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT)<\/p>\n

\u7522\u54c1\u4ecb\u7d39\uff1aTMP-153\u662f\u91af\u57fa\u8f14\u9176A\uff1a\u81bd\u56fa\u9187\u91af\u57fa\u8f49\u79fb\u9176\uff08ACAT\uff09\u7684\u9078\u64c7\u6027\u6291\u5236\u5291\uff0c\u5176IC 50\u70ba5\u81f310nM\u3002\u5177\u6709\u6291\u5236\u81bd\u56fa\u9187\u916f\u5316\u4e26\u6e1b\u5c11\u5176\u6d41\u5165\u5927\u9f20\u548c\u5009\u9f20\u8840\u6f3f\u7684\u6548\u529b\u3002 \u5c0d\u670a\u75c5\u6bd2\u611f\u67d3\u7684\u795e\u7d93\u5143\uff08ScGT1\uff09\u7d30\u80de\u986f\u793a\u51faTMP-153\u6bd2\u6027\u3002\u53ef\u80fd\u6709\u6f5b\u529b\u589e\u52a0ScGT1\u7d30\u80de\u4e2dcaspase-3\u7684\u6d3b\u6027\u548c\u524d\u5217\u817a\u7d20E2\u7684\u7522\u751f\u3002(\u7814\u7a76\u5c08\u7528)<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/td>\nN-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N’-(2,4-difluorophenyl)-urea<\/td>\n<\/tr>\n
Appearance<\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/td>\n128831-46-9<\/td>\n<\/tr>\n
Molecular Formula<\/td>\nC\u2082\u2084H\u2081\u2088ClF\u2082N\u2083O<\/td>\n<\/tr>\n
Molecular Weight<\/td>\n437.88<\/td>\n<\/tr>\n
Purity<\/td>\n\u226598% by TLC<\/td>\n<\/tr>\n
Solubility<\/td>\nDMSO (~25 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/td>\nCC1=C(C=C2C(=C1)C(=C(C=N2)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl)C<\/td>\n<\/tr>\n
InChi<\/td>\nInChI=1S\/C24H18ClF2N3O\/c1-13-9-17-21(10-14(13)2)28-12-22(23(17)16-5-3-4-6-18(16)25)30-24(31)29-20-8-7-15(26)11-19(20)27\/h3-12H,1-2H3,(H2,29,30,31)<\/td>\n<\/tr>\n
InChi Key<\/td>\nFFKNNBNIAHVVCU-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/td>\n125289<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u66f4\u591a\u9175\u7d20\u578b\u6291\u5236\u5291\u5546\u54c1: ACE\u6291\u5236\u5291\u985e<\/a> | AR\u6291\u5236\u5291\u985e<\/a> | AKR\u6291\u5236\u5291\u985e<\/a> | adenylyl cyclase \u6291\u5236\u5291\u985e<\/a> | AAC\u6291\u5236\u5291<\/a> | ACAT\u6291\u5236\u5291<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

ACAT Inhibitors\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1 TMP-153\u6291\u5236\u5291 | Biovision CAS#12883 […]<\/p>\n","protected":false},"author":3,"featured_media":15487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486,451],"tags":[2940],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15485"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15485"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15485\/revisions"}],"predecessor-version":[{"id":15488,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15485\/revisions\/15488"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/15487"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}