{"id":14997,"date":"2017-10-31T11:13:35","date_gmt":"2017-10-31T03:13:35","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=14997"},"modified":"2022-07-21T10:12:38","modified_gmt":"2022-07-21T02:12:38","slug":"anti-egfr-domain-iii%e6%8a%97%e9%ab%94-%e8%b2%a8%e8%99%9fab00723-10-0","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=14997","title":{"rendered":"Anti-EGFR domain III\u6297\u9ad4 | \u8ca8\u865fAb00723-10.0"},"content":{"rendered":"<p><strong>Fc Silent\u2122 Antibodies: Turning down the background noise<\/strong> <strong>\u53ea\u8981<\/strong><strong>\u8a0a<\/strong><strong>\u865f\u4e0d\u8981\u96dc<\/strong><strong>\u8a0a (Engineered Fc Domain)<\/strong><\/p>\n<p>Absoluted Antibody \u63d0\u4f9b\u4e00\u7cfb\u5217\u6297\u9ad4\u5546\u54c1\uff0c\u5176\u4e2dFc Silent\u2122 Antibodies\u7cfb\u5217\uff1b\u80fd\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027Fc\u7d50\u5408\u3002Fc Silent\u2122\u6280\u8853\uff0c\u70ba\u61c9\u7528\u751f\u7269\u5de5\u7a0b\u6280\u8853\uff0c\u5c07Fc receptors (Fc\u03b3R, FcR)\u9ede\u7a81\u8b8a\uff0c\u9032\u800c\u4e2d\u6b62\u6297\u9ad4\u8207ADCC\u7684\u529f\u80fd\uff1b\u6709\u6548\u964d\u4f4eFc\u6240\u9020\u6210\u7684\u80cc\u666f\u8a0a\u865f\u3002Fc Silent\u2122\u6297\u9ad4\u61c9\u7528\u65bc\u514d\u75ab\u7d30\u80de\u6642flow cytometry\u3001immunohistochemistry (IHC)\u8cc7\u6599\u986f\u793a\uff0c\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027\u4e4bFc\u7d50\u5408\uff0c\u6240\u9020\u6210\u7684\u80cc\u666f\u503c\u3002(\u8a02\u8cfc\u6297\u9ad4\u524d\uff0c\u8acb\u78ba\u8a8d\u9078\u64c7\u6297\u9ad4\u662f\u5426\u6709Fc Silent\u2122\u4fee\u98fe\u6a19\u8a8c)<\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=14997\"><strong>\u7522\u54c1\u4ecb\u7d39<\/strong> Anti-EGFR domain III<strong>\u6297\u9ad4<\/strong> <strong>| <\/strong><strong>\u8ca8\u865fAb00723-10.0<\/strong><\/a><\/span><\/p>\n<p>Ab00723-10.0 Anti-EGFR domain III [h-R3 (Nimotuzumab)]<\/p>\n<p><strong>Description:\u00a0<\/strong>Recombinant monoclonal antibody to EGFR domain III. Manufactured using AbAb\u2019s Recombinant Platform with variable regions (i.e. specificity) from the therapeutic antibody h-R3 (Nimotuzumab).<br \/>\n<strong>Species and Isotype:\u00a0<\/strong>Human IgG1, kappa<br \/>\n<strong>Clone Number:\u00a0<\/strong>h-R3 (Nimotuzumab)<br \/>\n<strong>UniProt Accession Number of Target Protein:\u00a0<\/strong><br \/>\n<strong>Published Application(s):\u00a0<\/strong>block; FC; IHC<br \/>\n<strong>Published Species Reactivity:\u00a0<\/strong>human<br \/>\n<strong>Immunogen:\u00a0<\/strong>This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.<br \/>\n<strong>Specificity:\u00a0<\/strong>Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)<br \/>\n<strong>Application Notes:\u00a0<\/strong>This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fc Silent\u2122 Antibodies: Turning down the background nois [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":12266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[136],"tags":[3062],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14997"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14997"}],"version-history":[{"count":2,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14997\/revisions"}],"predecessor-version":[{"id":14999,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14997\/revisions\/14999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/12266"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}