{"id":13657,"date":"2017-09-04T14:44:41","date_gmt":"2017-09-04T06:44:41","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=13657"},"modified":"2022-07-21T10:44:42","modified_gmt":"2022-07-21T02:44:42","slug":"entospletinib-gs-9973-%e9%81%b8%e6%93%87%e6%80%a7syk%e6%8a%91%e5%88%b6%e5%8a%91-angiogenesis%e8%a1%80%e7%ae%a1%e7%94%9f%e6%88%90%e6%8a%91%e5%88%b6%e5%8a%91%e8%b2%a8%e8%99%9fcc1332","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=13657","title":{"rendered":"Entospletinib (GS-9973) \u9078\u64c7\u6027Syk\u6291\u5236\u5291 | Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291CAS#1229208-44-9\u8ca8\u865fCC1332"},"content":{"rendered":"

Entospletinib (GS-9973) \u00a0\/ Angiogenesis<\/strong>\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 |<\/strong> \u8ca8\u865fCC1332<\/strong><\/a><\/span><\/p>\n

Chemcatch\u63d0\u4f9b\u4e00\u7cfb\u5217\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5291\uff0c\u7522\u54c1\u5305\u62ecSrc<\/a> HIF<\/a> FLT3<\/a> Bcr-Abl<\/a> VDA<\/a> FGFR<\/a> Syk<\/a> FAK<\/a> BTK<\/a>\u7b49\u8840\u7ba1\u751f\u6210\u5316\u5408\u7269\uff0c\u5177\u6709\u4e0d\u540c\u5305\u88dd\u7d44\u5408\u3002Entospletinib (GS-9973))\u662f\u4e00\u7a2e\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528\u7684\u9078\u64c7\u6027Syk\u6291\u5236\u5291\uff0c\u5728\u7121\u7d30\u80de\u6e2c\u5b9a\u4e2dIC50\u70ba7.7 nM\u3002 \u968e\u6bb52\u3002(\u7814\u7a76\u7528\u8a66\u5291)<\/p>\n\n\n\n\n\n\n\n\n
\u5206\u5b50\u91cf<\/strong>Molecular Weight (MW)<\/strong><\/td>\n411.46<\/td>\n<\/tr>\n
\u5316\u5b78\u5f0f<\/strong>Formula<\/strong><\/td>\n\n

 <\/p>\n

C23<\/sub>H21<\/sub>N7<\/sub>O<\/p>\n

 <\/td>\n<\/tr>\n

CAS<\/strong>\u865f<\/strong>CAS No.<\/strong><\/td>\n1229208-44-9<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/strong>Solubility (25\u00b0C)\u00a0*<\/em><\/strong><\/td>\n\u00a0<\/strong>\u4e8c\u7532\u57fa\u4e9e\u78b8<\/strong>DMSO<\/strong><\/td>\n82mg\/mLwarmed<\/td>\n<\/tr>\n
\u6c34<\/strong>Water<\/strong><\/td>\n<1mg\/mL<\/td>\n<\/tr>\n
\u4e59\u9187<\/strong>Alcohol<\/strong><\/td>\n<1mg\/mL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5546\u54c1<\/strong><\/span>\u00a0Src\u6291\u5236\u5291<\/a>\u00a0|\u00a0HIF\u6291\u5236\u5291<\/a>\u00a0|\u00a0FLT3\u6291\u5236\u5291<\/a>\u00a0|\u00a0Bcr-Abl\u6291\u5236<\/a>\u00a0|\u00a0VDA\u6291\u5236\u5291<\/a>\u00a0|\u00a0FGFR\u6291\u5236\u5291<\/a>\u00a0|\u00a0SYK\u6291\u5236\u5291<\/a>\u00a0|\u00a0FAK\u6291\u5236\u5291<\/a>\u00a0|\u00a0BTK\u6291\u5236\u5291<\/a><\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Entospletinib (GS-9973) \u00a0\/ Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 | \u8ca8\u865fCC13 […]<\/p>\n","protected":false},"author":3,"featured_media":13658,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[3233],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13657"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13657"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13657\/revisions"}],"predecessor-version":[{"id":13715,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13657\/revisions\/13715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/13658"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}