{"id":13637,"date":"2017-09-04T13:26:49","date_gmt":"2017-09-04T05:26:49","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=13637"},"modified":"2022-07-21T10:44:55","modified_gmt":"2022-07-21T02:44:55","slug":"gzd824-bcr-abl%e6%8a%91%e5%88%b6%e5%8a%91-angiogenesis%e8%a1%80%e7%ae%a1%e7%94%9f%e6%88%90%e6%8a%91%e5%88%b6%e5%8a%91%e8%b2%a8%e8%99%9fcc7350","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=13637","title":{"rendered":"GZD824-Bcr-Abl\u6291\u5236\u5291 | Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291\u8ca8\u865fCC7350"},"content":{"rendered":"

GZD824 \u00a0\u00a0\/ Angiogenesis<\/strong>\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 |<\/strong> \u8ca8\u865fCC7350<\/strong><\/a><\/span><\/p>\n

Chemcatch\u63d0\u4f9b\u4e00\u7cfb\u5217\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5291\uff0c\u7522\u54c1\u5305\u62ecSrc<\/a> HIF<\/a> FLT3<\/a> Bcr-Abl<\/a> VDA<\/a> FGFR<\/a> Syk<\/a> FAK<\/a> BTK<\/a>\u7b49\u8840\u7ba1\u751f\u6210\u5316\u5408\u7269\uff0c\u5177\u6709\u4e0d\u540c\u5305\u88dd\u7d44\u5408\u3002GZD824\u662f\u7528\u65bcBcr-Abl\uff08WT\uff09\u548cBcr-Abl\uff08T315I\uff09\u7684\u65b0\u578b\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528Bcr-Abl\u6291\u5236\u5291\uff0cIC50\u5206\u5225\u70ba0.34nM\u548c0.68nM\u3002(\u7814\u7a76\u7528\u7b49\u7d1a)<\/p>\n\n\n\n\n\n\n\n\n
\u5206\u5b50\u91cf<\/strong>Molecular Weight (MW)<\/strong><\/td>\n724.77<\/td>\n<\/tr>\n
\u5316\u5b78\u5f0f<\/strong>Formula<\/strong><\/td>\n\n

 <\/p>\n

C29<\/sub>H27<\/sub>F3<\/sub>N6<\/sub>O.2CH4<\/sub>O3<\/sub>S<\/p>\n

 <\/td>\n<\/tr>\n

CAS<\/strong>\u865f<\/strong>CAS No.<\/strong><\/td>\n1421783-64-3<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/strong>Solubility (25\u00b0C)\u00a0*<\/em><\/strong><\/td>\n\u00a0<\/strong>\u4e8c\u7532\u57fa\u4e9e\u78b8<\/strong>DMSO<\/strong><\/td>\n100mg\/mL<\/td>\n<\/tr>\n
\u6c34<\/strong>Water<\/strong><\/td>\n<1mg\/mL<\/td>\n<\/tr>\n
\u4e59\u9187<\/strong>Alcohol<\/strong><\/td>\n100mg\/mL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5546\u54c1<\/strong><\/span>\u00a0Src\u6291\u5236\u5291<\/a>\u00a0|\u00a0HIF\u6291\u5236\u5291<\/a>\u00a0|\u00a0FLT3\u6291\u5236\u5291<\/a>\u00a0|\u00a0Bcr-Abl\u6291\u5236<\/a>\u00a0|\u00a0VDA\u6291\u5236\u5291<\/a>\u00a0|\u00a0FGFR\u6291\u5236\u5291<\/a>\u00a0|\u00a0SYK\u6291\u5236\u5291<\/a>\u00a0|\u00a0FAK\u6291\u5236\u5291<\/a>\u00a0|\u00a0BTK\u6291\u5236\u5291<\/a><\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

GZD824 \u00a0\u00a0\/ Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 | \u8ca8\u865fCC7350 Chemcatch\u63d0\u4f9b\u4e00\u7cfb […]<\/p>\n","protected":false},"author":3,"featured_media":13638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[3236],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13637"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13637"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13637\/revisions"}],"predecessor-version":[{"id":13670,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13637\/revisions\/13670"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/13638"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}