{"id":13603,"date":"2017-09-01T15:22:57","date_gmt":"2017-09-01T07:22:57","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=13603"},"modified":"2022-07-21T10:45:22","modified_gmt":"2022-07-21T02:45:22","slug":"%e8%a1%80%e7%ae%a1%e7%94%9f%e6%88%90%e6%8a%91%e5%88%b6%e5%8a%91azd3759-cns%e6%bb%b2%e9%80%8f%e6%80%a7egfr%e6%8a%91%e5%88%b6%e5%8a%91%e8%b2%a8%e8%99%9f-cc8127","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=13603","title":{"rendered":"AZD3759-EGFR\u6291\u5236\u5291 | CNS\u6ef2\u900f\u6027EGFR\u6291\u5236\u5291\u8ca8\u865f CC8127"},"content":{"rendered":"

Angiogenesis<\/strong>\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291AZD3759 \u00a0| \u8ca8\u865f\u00a0<\/strong>CC8127<\/a><\/span><\/p>\n

Src<\/a> HIF<\/a> FLT3<\/a> Bcr-Abl<\/a> VDA<\/a> FGFR<\/a> Syk<\/a> FAK<\/a> BTK<\/a>\u8840\u7ba1\u751f\u6210\u5316\u5408\u7269\u3002\u00a0<\/strong>AZD3759\u662f\u4e00\u7a2e\u6709\u6548\u7684\u53e3\u670d\u6d3b\u6027CNS\u6ef2\u900f\u6027EGFR\u6291\u5236\u5291\uff0cIC 50\u968e\u6bb51\u5206\u5225\u5177\u6709EGFR\uff08WT\uff09\uff0cEGFR\uff08L858R\uff09\u548cEGFR\uff08\u5916\u986f\u5b5019Del\uff090.3nM\uff0c0.2nM\u548c0.2nM\u3002<\/p>\n\n\n\n\n\n\n\n\n
\u5206\u5b50\u91cfMolecular Weight (MW)<\/strong><\/td>\n459.90<\/td>\n<\/tr>\n
\u5316\u5b78\u5f0fFormula<\/strong><\/td>\nC22<\/sub>H23<\/sub>ClFN5<\/sub>O3<\/sub><\/td>\n<\/tr>\n
CAS<\/strong>\u865fCAS No.<\/strong><\/td>\n1626387-80-1<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027Solubility (25\u00b0C)\u00a0*<\/em><\/strong><\/td>\n\u00a0<\/strong>\u4e8c\u7532\u57fa\u4e9e\u78b8DMSO<\/strong><\/td>\n92mg\/mL<\/td>\n<\/tr>\n
\u6c34Water<\/strong><\/td>\n<1mg\/mL<\/td>\n<\/tr>\n
\u4e59\u9187Alcohol<\/strong><\/td>\n44mg\/mLwarmed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5546\u54c1<\/strong><\/span>\u00a0Src\u6291\u5236\u5291<\/a>\u00a0|\u00a0HIF\u6291\u5236\u5291<\/a>\u00a0|\u00a0FLT3\u6291\u5236\u5291<\/a>\u00a0|\u00a0Bcr-Abl\u6291\u5236<\/a>\u00a0|\u00a0VDA\u6291\u5236\u5291<\/a>\u00a0|\u00a0FGFR\u6291\u5236\u5291<\/a>\u00a0|\u00a0SYK\u6291\u5236\u5291<\/a>\u00a0|\u00a0FAK\u6291\u5236\u5291<\/a>\u00a0|\u00a0BTK\u6291\u5236\u5291<\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291AZD3759 \u00a0| \u8ca8\u865f\u00a0CC8127 Src HIF FLT3 Bc […]<\/p>\n","protected":false},"author":3,"featured_media":13604,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[3242],"_links":{"self":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13603"}],"collection":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13603"}],"version-history":[{"count":3,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13603\/revisions"}],"predecessor-version":[{"id":13666,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13603\/revisions\/13666"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/13604"}],"wp:attachment":[{"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}