{"id":12768,"date":"2017-08-14T11:36:08","date_gmt":"2017-08-14T03:36:08","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=12768"},"modified":"2022-07-21T11:24:27","modified_gmt":"2022-07-21T03:24:27","slug":"mdr1-p-gp%e9%85%8d%e9%ab%94%e7%af%a9%e9%81%b8%ef%bd%9cmultidrug-efflux-transporter-mdr1p-gp-ligand-screening-kit%e8%b2%a8%e8%99%9fk507","status":"publish","type":"post","link":"https:\/\/biopioneer.com.tw\/?p=12768","title":{"rendered":"MDR1 \/ P-gp\u914d\u9ad4\u7be9\u9078\uff5cMultidrug Efflux Transporter (MDR1\/P-gp) Ligand Screening Kit\u8ca8\u865fK507"},"content":{"rendered":"

\u85e5\u7269\u4ee3\u8b1d<\/strong>\u7cfb\u5217\u5546\u54c1<\/strong><\/span><\/p>\n

\u6d3b\u9ad4\u5167\u7684\u85e5\u7269\u6216\u7570\u751f\u7269\uff08\u4efb\u4f55\u5916\u4f86\u5316\u5b78\u7269\u8cea\uff09\u5305\u62ec\u5206\u5b50\u7684\u5438\u6536\uff0c\u5206\u4f48\uff0c\u4ee3\u8b1d\u548c\u6392\u6cc4\uff08ADME\uff09\u6240\u6709\u53cd\u61c9\/\u751f\u7406\u6a5f\u5236\u3002\u5206\u5b50\u4e4bMetabolism and Excretion , ADME\u5f71\u97ff\u66b4\u9732\u65bc\u7d44\u7e54\u4e4b\u6fc3\u5ea6\u548c\u52d5\u529b\u5b78\uff0c\u6c7a\u5b9a\u7d66\u4e88\u5316\u5408\u7269\u7684\u4f5c\u7528\u3002 Xenobiotics\u53ef\u4ee5\u901a\u904e\u5404\u7a2e\u751f\u7269\u5316\u5b78\u4fee\u98fe\u5982\u6c27\u5316\u9084\u539f\uff0c\u6c34\u89e3\uff0c\u6c34\u5408\uff0c\u7db4\u5408\uff0c\u7e2e\u5408\u6216\u7570\u69cb\u5316\u800c\u4ee3\u8b1d\uff0c\u76ee\u6a19\u662f\u4f7f\u5206\u5b50\u66f4\u89aa\u6c34\uff0c\u56e0\u6b64\u66f4\u5bb9\u6613\u6392\u6cc4\u3002\u5305\u62ec\u7d30\u80de\u8272\u7d20P450\u9176\uff0c\u651d\u53d6\u548c\u6d41\u51fa\u8f49\u904b\u86cb\u767d\uff08P-\u7cd6\u86cb\u767d\uff0cMDR\u8f49\u904b\u86cb\u767d\uff09\u3002BIOVISION\u63d0\u4f9b\u4e86\u4e00\u7cfb\u5217\u5de5\u5177\uff08\u751f\u7269\u5316\u5b78\uff0c\u86cb\u767d\u8cea\uff0c\u6297\u9ad4\uff0c\u6e2c\u5b9a\u8a66\u5291\u76d2\uff09\uff0c\u7528\u65bc\u7814\u7a76\u9069\u7528\u65bc\u85e5\u7269\u8a2d\u8a08\uff0c\u85e5\u7269\u4ee3\u8b1d\/\u8f49\u904b\uff0c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u85e5\u7269\u4ee3\u8b1d\u9176\u548c\u8f49\u904b\u86cb\u767d\u8868\u9054\u7684\u8868\u9054\/\u8abf\u63a7ADME\u7684\u5404\u500b\u65b9\u9762\uff0c\u9776\u86cb\u767d\u7684\u7d50\u69cb – \u529f\u80fd\u95dc\u4fc2\u7b49\u5546\u54c1<\/p>\n

\u85e5\u7269\u6392\u51fa\uff08MDR1 \/ P-gp\uff09\u914d\u9ad4\u7be9\u9078\u8a66\u5291\u76d2\uff5c\u8ca8\u865fK507<\/strong><\/a><\/span><\/p>\n

Multidrug Efflux Transporter (MDR1\/P-gp) Ligand Screening Kit<\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u63cf\u8ff0: P-\u7cd6\u86cb\u767d\uff08P-gp\uff0c\u591a\u85e5\u8010\u85e5\u86cb\u767d1\uff08MDR1\uff09\uff0cEC 3.6.3.44\uff09\u662f\u8de8\u819c\u8f49\u904b\u86cb\u767d\u7684ATP\u7d50\u5408\u76d2\uff08ABC\uff09ATP\u9176\u8d85\u5bb6\u65cf\u7684\u6210\u54e1\u3002 P-gp\u5177\u6709\u975e\u5e38\u5ee3\u7684\u5e95\u7269\u7279\u7570\u6027\uff0c\u4e26\u4e14\u80fd\u5920\u8f38\u9001\u5927\u91cf\u7684\u4e2d\u6027\u548c\u9670\u96e2\u5b50\u89aa\u8102\u6027\u5206\u5b50\u3002 P-gp\u5f37\u70c8\u5f71\u97ff\u8a31\u591a\u85e5\u7269\u7684\u53e3\u670d\u5438\u6536\uff0c\u7d44\u7e54\u5206\u4f48\u548c\u6392\u6cc4\uff0c\u4e26\u9632\u6b62\u67d0\u4e9b\u89aa\u8102\u6027\u85e5\u7269\u6ef2\u900f\u8840\u8166\u5c4f\u969c\u3002 P-gp\u7684\u904e\u5ea6\u8868\u9054\u901a\u904e\u4e3b\u52d5\u5730\u5c07\u5176\u5f9e\u7d30\u80de\u4e2d\u62bd\u51fa\u4f86\u8ce6\u4e88\u816b\u7624\u7d30\u80de\u5c0d\u5316\u5b78\u548c\u85e5\u7406\u5b78\u4e0a\u4e0d\u540c\u7684\u5316\u5b78\u6cbb\u7642\u85e5\u7269\uff08\u4f8b\u5982\u591a\u67d4\u6bd4\u661f\uff0c\u9577\u6625\u65b0\u9e7c\u548c\u7d2b\u6749\u9187\uff09\u7684\u6297\u6027\u3002 P-gp\u8868\u9054\u7684\u8a98\u5c0e\u662f\u5c0e\u81f4\u5931\u6557\u7684\u5e38\u898b\u539f\u56e0\uff0c\u6b63\u5728\u7814\u7a76P-gp\u6291\u5236\u5291\u7684\u816b\u7624\u9776\u5411\u905e\u9001\u4f5c\u70ba\u514b\u670d\u5316\u7642\u6297\u6027\u7684\u7b56\u7565\u3002 BioVision\u7684MDR1 \/ P-gp\u914d\u9ad4\u7be9\u9078\u8a66\u5291\u76d2\u65e8\u5728\u5feb\u901f\u7be9\u9078\u6e2c\u8a66\u5316\u5408\u7269\uff0c\u4ee5\u8abf\u63a7MDR1\u8868\u9054\u7d30\u80de\u7cfb\u4e2d\u7684\u5916\u6392\u8f49\u904b\u86cb\u767d\u6d3b\u6027\u3002<\/p>\n

\"\"<\/p>\n

\u8a72\u6e2c\u5b9a\u4f7f\u7528\u5bb9\u6613\u64f4\u6563\u901a\u904e\u8cea\u819c\u7684\u89aa\u8102\u6027\u975e\u87a2\u5149P-gp\u5e95\u7269\uff0c\u5176\u4e2d\u901a\u904e\u80de\u8cea\u916f\u9176\u5c07\u5176\u6c34\u89e3\u6210\u6d3b\u6027\u87a2\u5149\u5718\u3002\u6240\u5f97\u5230\u7684\u89aa\u6c34\u6027\u87a2\u5149\u5718\u65e2\u975e\u819c\u53ef\u6ef2\u900f\u7684\uff0c\u4e5f\u4e0d\u662fP-gp\u7684\u5e95\u7269\uff0c\u56e0\u6b64\u5b83\u4ecd\u7136\u88ab\u6355\u7372\u5728\u7d30\u80de\u5167\u3002\u5728\u8868\u9054MDR1\u7684\u7d30\u80de\u7cfb\u4e2d\uff0c\u89aa\u8102\u6027\u524d\u87a2\u5149\u5718\u901a\u904eP-gp\u5f9e\u7d30\u80de\u8cea\u6eb6\u6db2\u4e2d\u9023\u7e8c\u64e0\u51fa\uff0c\u5c0e\u81f4\u4f4e\u7d30\u80de\u5167\u87a2\u5149\u3002\u901a\u904e\u6e2c\u8a66\u5316\u5408\u7269\u6291\u5236P-gp\u4ecb\u5c0e\u7684\u5916\u6392\u5c0e\u81f4\u7d30\u80de\u5167\u87a2\u5149\u589e\u52a0\u3002\u901a\u904e\u8207\u5b58\u5728\u548c\u4e0d\u5b58\u5728\u6240\u9078\u9078\u64c7\u6027P-gp\u6291\u5236\u5291\u7684\u98fd\u548c\u6fc3\u5ea6\u7684\u7a4d\u7d2f\u7684\u87a2\u5149\u9032\u884c\u6bd4\u8f03\u4f86\u5b9a\u91cf\u7279\u7570\u6027\u8f49\u904b\u86cb\u767d\u6d3b\u6027\u3002\u8a72\u6e2c\u5b9a\u662f\u9ad8\u5ea6\u654f\u611f\u7684\uff0c\u7121\u9700\u6d17\u6ecc\uff0c\u9ad8\u901a\u91cf\u9069\u61c9\u6027\u3002\u8a72\u8a66\u5291\u76d2\u542b\u6709\u4e00\u5957\u5b8c\u6574\u7684\u8a66\u5291\uff0c\u8db3\u4ee5\u572896\u5b54\u677f\u4e2d\u9032\u884c100\u6b21\u53cd\u61c9\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n
Cat # +Size<\/td>\nK507-100<\/td>\n<\/tr>\n
Size<\/td>\n100 Assays<\/td>\n<\/tr>\n
Detection Method<\/td>\nFluorescence (Ex\/Em = 488\/532 nm)<\/td>\n<\/tr>\n
Applications<\/td>\nScreening\/studying\/characterizing MDR1\/P-gp Inhibitors<\/td>\n<\/tr>\n
Features & Benefits<\/td>\n\u2022 Simple method to screen Pg-p inhibitors \u2022 High-throughput adaptable \u2022 Includes Inhibitor Control, Verapamil<\/td>\n<\/tr>\n
Kit Components<\/td>\n\u2022 Efflux Assay Buffer \u2022 Fluorogenic P-gp Substrate \u2022 P-gp Inhibitor (Verapamil)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u5546\u54c1<\/span> \uff08MDR1 \/ P-gp\uff09\u914d\u9ad4\u7be9\u9078<\/u> | \u9ec3\u9eb4\u9709\u6bd2\u7d20\u5206\u6790<\/a><\/strong>\u00a0| P-glycoprotein\u591a\u682a\u6297\u9ad4<\/a>\u00a0|\u78fa\u91af\u80fa\u6b98\u7559ELISA\u8a66\u5291<\/a>\u00a0| \u6c1f\u55b9\u8afe\u916e\u985e\u85e5\u7269ELISA<\/a>\u00a0|MK-571 sodium\uff5c<\/strong><\/a> D2HGDH\u91cd\u7d44\u6d3b\u6027\u86cb\u767d<\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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