{"id":8161,"date":"2016-12-19T11:02:43","date_gmt":"2016-12-19T03:02:43","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=8161"},"modified":"2022-07-22T16:53:36","modified_gmt":"2022-07-22T08:53:36","slug":"tp-0903%e6%8a%91%e5%88%b6%e5%8a%91-biovision%e8%b2%a8%e8%99%9f9590-25","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=8161","title":{"rendered":"TP-0903\u6291\u5236\u5291 | CAS#1341200-45-0Biovision\u8ca8\u865f9590-25"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

TP-0903<\/strong>\u6291<\/strong>\u5236<\/strong>\u5291 |\u00a0<\/strong>\u8ca8\u865f<\/strong>9590-25<\/strong><\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: TP-0903\u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027AXLkinase Inhibitor\u6291\u5236\u5291\uff08IC 50 = 27nM\uff09\u3002 TP-0903\u8a98\u5c0eCLL B\u7d30\u80de\u7684\u5927\u91cf\u51cb\u4ea1\uff0cLD50\u503c\u70bananomolar\u7bc4\u570d\u3002 \u7528TP-0903\u6cbb\u7642\u764c\u7d30\u80de\u5728\u591a\u500b\u6a21\u578b\u4e2d\u9006\u8f49\u9593\u5145\u8cea\u8868\u578b\uff0c\u4e26\u4f7f\u764c\u7d30\u80de\u5c0d\u7528\u5176\u5b83\u9776\u5411\u85e5\u7269\u7684\u6cbb\u7642\u654f\u611f\u3002TP-0903 is a potent and selective AXL Inhibitor (IC\u2085\u2080 = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD\u2085\u2080 values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.<\/p>\n\n\n\n\n\n\n
\u5206\u5b50\u91cf<\/strong><\/td>\n516.06<\/td>\n\u5132\u5b58\u689d\u4ef6<\/strong><\/td>\n\u53c3\u8003CoA\u4e2d\u63a8\u85a6\u7684\u689d\u4ef6\u9032\u884c\u5132\u5b58\u3002<\/td>\n<\/tr>\n
\u5206\u5b50\u5f0f<\/strong><\/td>\nC<\/strong>\u2082\u2084<\/strong>H<\/strong>\u2083\u2080<\/strong>ClN<\/strong>\u2087<\/strong>O<\/strong>\u2082<\/strong>S<\/strong><\/td>\n<\/tr>\n
CAS<\/strong>\u865f<\/strong><\/td>\n1341200-45-0<\/td>\n<\/tr>\n
\u6eb6\u5291<\/strong>\/<\/strong>\u6eb6\u89e3\u5ea6<\/strong><\/td>\nDMSO (>5 mg\/ml)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/th>\n2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide<\/td>\n<\/tr>\n
Appearance<\/th>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/th>\n1341200-45-0<\/td>\n<\/tr>\n
Molecular Formula<\/th>\nC\u2082\u2084H\u2083\u2080ClN\u2087O\u2082S<\/td>\n<\/tr>\n
Molecular Weight<\/th>\n516.06<\/td>\n<\/tr>\n
Purity<\/th>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/th>\nDMSO (>5 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/th>\nCN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl<\/td>\n<\/tr>\n
InChi<\/th>\nInChI=1S\/C24H30ClN7O2S\/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32\/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)<\/td>\n<\/tr>\n
InChi Key<\/th>\nYUAALFPUEOYPNX-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/th>\n56839178<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

TP-0903\u6291\u5236\u5291 |\u00a0\u8ca8\u865f9590-25 \u7522\u54c1\u4ecb\u7d39: TP-0903\u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027AXLkinase […]<\/p>\n","protected":false},"author":3,"featured_media":6898,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486,451],"tags":[4087],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/8161"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8161"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/8161\/revisions"}],"predecessor-version":[{"id":32487,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/8161\/revisions\/32487"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6898"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8161"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}