{"id":7743,"date":"2016-11-16T16:45:48","date_gmt":"2016-11-16T08:45:48","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=7743"},"modified":"2023-08-04T13:33:56","modified_gmt":"2023-08-04T05:33:56","slug":"mouse-anti-human-cd107a-biot%e6%8a%97%e9%ab%94-southernbiotech%e8%b2%a8%e8%99%9f9835-08","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=7743","title":{"rendered":"Human CD107a-BIOT\u6297\u9ad4(LAMP-1) | \u55ae\u682aClone H4A3 SouthernBiotech\u8ca8\u865f9835-08"},"content":{"rendered":"

\u6297<\/strong>Mouse Anti-Human CD107a-BIOT<\/strong>\u6297\u9ad4<\/strong> | <\/strong>\u8ca8\u865f<\/strong>9835-08<\/strong> |<\/strong> \u898f\u683c<\/strong>100<\/strong> TEST (<\/strong>\u5177<\/strong>Biotin<\/strong>\u6a19\u8a8c<\/strong>)<\/strong><\/a><\/span><\/p>\n

\u7d30\u80de\u514d\u75ab\u5c08\u5bb6<\/strong>\u6975\u529b\u63a8\u85a6<\/strong>SouthernBiotech<\/strong>\u9ad8\u54c1\u8cea\u4e8c\u7d1a\u6297\u9ad4<\/strong><\/p>\n

\u7f8e\u570b\u6297\u9ad4\u751f\u7522\u5546Southern Biotech\u65bc1982\u5e74\uff0c\u7531UAB\u7d30\u80de\u514d\u75ab\u5c08\u5bb6Dr. Max Cooper\u8207\u5be6\u9a57\u5ba4\u6210\u54e1\u5171\u540c\u5275\u7acb\u3002SouthernBiotech\u81f4\u529b\u65bc\u751f\u7522\u9ad8\u54c1\u8cea\u4e8c\u7d1a\u6297\u9ad4\u3002\u7269\u7a2e\u7a2e\u985e\u9f4a\u5168\uff0c\u5305\u62ec\u6709Bovine\u3001Canine\u3001Chicken\u3001Cynomolgus\u3001Donkey\u3001Equine\u3001Feline\u3001Goat\u3001Guinea Pig\u3001Hamster\u3001Human\u3001Monkey\u3001Mouse\u3001Porcine\u3001Rabbit\u3001Rat\u3001Rhesus\u3001Sheep\u3001Turkey\u3002\u5177\u6709\u87a2\u5149\u7269\u8cea\uff08FITC\u3001PE\u3001APC\u3001SPRD\u3001PE\/CY5.5\u3001APC\/CY5.5\u3001Spectral Red\u3001Alexa 488\u3001Alexa 647\u3001Pacific Blue\uff09\u5404\u7a2e\u87a2\u5149\u6a19\u8a8c\u3001\u53e6\u5177\u9175\u7d20\uff08HRP\u3001AP\uff09\u3001\u6216\u672a\u6a19\u8a8c\u53caLow Endotoxin\/Azide Free\uff08LE\/AF\uff09\u7b49\u6a19\u5b9a\u3002<\/p>\n

<\/p>\n

CD107a\uff0c\u4e5f\u7a31\u70ba\u6eb6\u9176\u9ad4\u76f8\u95dc\u819c\u86cb\u767d 1 (lysosomal-associated membrane protein 1, LAMP-1)\uff0c\u662f\u4e00\u7a2e\u9ad8\u5ea6\u7cd6\u57fa\u5316\u7684 I \u578b\u8de8\u819c\u86cb\u767d(glycosylated type I transmembrane protein)\uff0c\u69cb\u6210\u6eb6\u9176\u9ad4\u819c( lysosomal membranes)\u4e0a\u7684\u4e3b\u8981\u553e\u6db2\u9178\u7cd6\u86cb\u767d(sialoglycoproteins)\u3002\u5b83\u662f Galaptin\uff08\u4e00\u7a2e\u5b58\u5728\u65bc\u7d30\u80de\u5916\u57fa\u8cea\u4e2d\u7684 S \u578b\u51dd\u96c6\u7d20\uff09\u7684\u914d\u9ad4\uff0c\u901a\u904e\u8b58\u5225\u4e59\u91af\u57fa\u4e73\u7cd6\u80fa\u5be1\u7cd6\u93c8\uff0c\u4e26\u4e14\u662f E-\u9078\u64c7\u7d20\u4ecb\u5c0e( E-selectin-mediated )\u7684\u7d30\u80de\u7c98\u9644(cell adhesion)\u7684\u914d\u9ad4\u3002 CD107a \u7531\u6d3b\u5316\u7684 T \u7d30\u80de( T cells)\u3001\u5de8\u566c\u7d30\u80de(macrophages)\u3001\u6a39\u7a81\u72c0\u7d30\u80de(dendritic cells)\u3001\u6d3b\u5316\u7684\u8840\u5c0f\u677f( activated platelets)\u3001\u6241\u6843\u9ad4\u4e0a\u76ae\u548c\u4e00\u4e9b\u816b\u7624\u7d30\u80de\u7cfb\uff08\u5305\u62ec U937 \u548c KG1a\uff09\u8868\u9054\u3002\u5b83\u4e5f\u662f\u4e00\u7a2e\u5ee3\u6cdb\u8868\u9054\u7684\u7d30\u80de\u5167\u6297\u539f\u3002 LAMP-1 (lysosomal-associated membrane protein 1, LAMP-1)\u53ef\u80fd\u901a\u904e\u5f62\u6210\u6eb6\u9176\u9ad4\u6c34\u89e3\u9176( lysosomal hydrolases)\u5c4f\u969c\u4f86\u4fdd\u8b77\u6eb6\u9176\u9ad4\u819c\u7684\u5167\u8868\u9762\u3002\u816b\u7624\u7d30\u80de\u7cfb\u8868\u9762\u4e0a CD107a \u548c CD107b \u7684\u4e0a\u8abf\u8207\u5176\u589e\u5f37\u7684\u8f49\u79fb\u6f5b\u529b\u76f8\u95dc\uff0c\u5176\u4e2d\u5b83\u5011\u53ef\u80fd\u589e\u52a0\u8207\u7d30\u80de\u5916\u57fa\u8cea(extracellular matrix)\u548c\u5167\u76ae( endothelium)\u7684\u7c98\u9644\u3002<\/p>\n

Mouse Anti-Human CD107a-BIOT<\/strong>\u6297\u9ad4\u7522\u54c1\u8cc7\u6599<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Clone<\/strong><\/td>\nH4A3<\/td>\n<\/tr>\n
Isotype<\/strong><\/td>\nMouse (BALB\/c) IgG1<\/sub>\u03ba<\/td>\n<\/tr>\n
Isotype Control<\/strong><\/td>\nMouse IgG1<\/sub>-BIOT<\/a><\/td>\n<\/tr>\n
Immunogen<\/strong><\/td>\nHuman adherent peripheral blood cells<\/td>\n<\/tr>\n
Specificity<\/strong><\/td>\nHuman\/Rhesus\/African Green Monkey\/Pigtail Macaque\/Sooty Mangabey CD107a<\/td>\n<\/tr>\n
Alternalte Name(s)<\/strong><\/td>\nLAMP-1, lysosome-associated membrane protein 1<\/td>\n<\/tr>\n
Description<\/strong><\/td>\nCD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.<\/td>\n<\/tr>\n
Format\/Conjugate<\/strong><\/td>\nBIOT (Biotin)<\/td>\n<\/tr>\n
Buffer Formulation<\/strong><\/td>\nSupplied in PBS\/NaN3<\/sub><\/td>\n<\/tr>\n
Volume<\/strong><\/td>\n1.0 mL<\/td>\n<\/tr>\n
Storage & Handling<\/strong><\/td>\nStore at 2-8\u00b0C
\nPlease refer to product specific\u00a0(M)SDS<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u5546\u54c1\u00a0<\/span>Isotype control \u5206\u578b\u5c0d\u7167\u7d44<\/a> |\u5206\u578b\u5c0d\u7167\u7d44\u5957\u7d44<\/a> | \u6297\u9ad4\u5206\u578bELISA \u5957\u7d44<\/a> | anti-rabbit \u4e8c\u7d1a\u6297\u9ad4<\/a> | anti-mouse\u4e8c\u7d1a\u6297\u9ad4<\/a> |<\/span><\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u6297Mouse Anti-Human CD107a-BIOT\u6297\u9ad4 | \u8ca8\u865f9835-08 | \u898f\u683c100 TES […]<\/p>\n","protected":false},"author":3,"featured_media":6176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[198],"tags":[4189],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/7743"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7743"}],"version-history":[{"count":7,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/7743\/revisions"}],"predecessor-version":[{"id":44834,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/7743\/revisions\/44834"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6176"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7743"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}