{"id":6980,"date":"2016-10-06T11:59:21","date_gmt":"2016-10-06T03:59:21","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=6980"},"modified":"2022-07-25T16:41:59","modified_gmt":"2022-07-25T08:41:59","slug":"anti-dnarna-g-quadruplex-%e6%8a%97%e9%ab%94-absoluted-antibody-%e8%b2%a8%e8%99%9fab00174-1-1","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=6980","title":{"rendered":"Anti-DNA\/RNA G-quadruplex \u6297\u9ad4 | Absoluted Antibody \u8ca8\u865fAb00174-1.1"},"content":{"rendered":"

Fc Silent\u2122 Antibodies: Turning down the background noise<\/strong><\/p>\n

Fc Silent| <\/strong>\u6297\u9ad4<\/strong> | <\/strong>\u53ea\u8981<\/strong>\u8a0a<\/strong>\u865f\u4e0d\u8981\u96dc<\/strong>\u8a0a (Engineered Fc Domain)<\/strong><\/p>\n

Absoluted Antibody \u63d0\u4f9b\u4e00\u7cfb\u5217\u6297\u9ad4\u5546\u54c1\uff0c\u5176\u4e2dFc Silent\u2122 Antibodies\u7cfb\u5217\uff1b\u80fd\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027Fc\u7d50\u5408\u3002Fc Silent\u2122\u6280\u8853\uff0c\u70ba\u61c9\u7528\u751f\u7269\u5de5\u7a0b\u6280\u8853\uff0c\u5c07Fc receptors (Fc\u03b3R, FcR)\u9ede\u7a81\u8b8a\uff0c\u9032\u800c\u4e2d\u6b62\u6297\u9ad4\u8207ADCC\u7684\u529f\u80fd\uff1b\u6709\u6548\u964d\u4f4eFc\u6240\u9020\u6210\u7684\u80cc\u666f\u8a0a\u865f\u3002Fc Silent\u2122\u6297\u9ad4\u61c9\u7528\u65bc\u514d\u75ab\u7d30\u80de\u6642flow cytometry\u3001immunohistochemistry (IHC)\u8cc7\u6599\u986f\u793a\uff0c\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027\u4e4bFc\u7d50\u5408\uff0c\u6240\u9020\u6210\u7684\u80cc\u666f\u503c\u3002(\u8a02\u8cfc\u6297\u9ad4\u524d\uff0c\u8acb\u78ba\u8a8d\u9078\u64c7\u6297\u9ad4\u662f\u5426\u6709Fc Silent\u2122\u4fee\u98fe\u6a19\u8a8c)<\/p>\n

\"f480_silent_post\"<\/p>\n

Anti-DNA\/RNA G-quadruplex (and related small molecules) [BG4] \u6297\u9ad4 | \u7522\u54c1\u63cf\u8ff0: \u8ca8\u865fAb00174-1.1<\/p>\n

Recombinant monoclonal antibody to DNA\/RNA G-quadruplex (and related small molecules). Manufactured using AbAb\u2019s Recombinant Platform with variable regions (i.e. specificity) from the phage display derived scfv BG4.<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n
\u6297\u9ad4\u540d\u7a31<\/td>\nAnti-DNA\/RNA G-quadruplex (and related small molecules) [BG4]<\/td>\n<\/td>\n<\/tr>\n
\u6297\u9ad4\u8ca8\u865f<\/td>\nAb00174-1.1<\/td>\n\u7279\u7570\u6027Specificity: Binds with high selectivity and low nanomolar affinity to DNA and RNA G-quadruplex structures.<\/td>\n<\/tr>\n
\u514d\u75ab\u539f<\/td>\nImmunogen: DNA\/RNA G-quadruplex.<\/td>\n<\/tr>\n
\u61c9\u7528\u6ce8\u610f<\/td>\nApplication Notes: This antibody has been shown (by ELISA) to bind selectively to G-quadruplex forming DNA and RNA structures. Please note that unlike the original scFv reported by Biffi et al. , this antibody does not have FLAG-tag.<\/td>\n<\/tr>\n
\u5176\u5b83\u76f8\u95dc\u9023\u7d50<\/td>\nBiffi G,\u00a0Tannahill D,\u00a0McCafferty J,\u00a0Balasubramanian S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem.\u00a02013 Mar;5(3):182-6 PMID:23422559<\/a> pAbmAbs<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n
Product<\/a><\/strong><\/td>\nExpected Species Reactivity<\/a><\/strong><\/td>\nIsotype\/Format<\/a><\/strong><\/td>\nModification<\/a><\/strong><\/td>\n<\/tr>\n<\/thead>\n
Ab00174-1.1 Anti-DNA\/RNA G-quadruplex (and related small molecules) [BG4]<\/a><\/td>\nHuman<\/td>\nMouse IgG1<\/td>\n<\/td>\n<\/tr>\n
Ab00174-10.6 Anti-DNA\/RNA G-quadruplex (and related small molecules) [BG4]<\/a><\/td>\nHuman<\/td>\nHuman Fab fragment<\/td>\nHis-Tagged<\/td>\n<\/tr>\n
Ab00174-24.1 Anti-DNA\/RNA G-quadruplex (and related small molecules) [BG4]<\/a><\/td>\nHuman<\/td>\nGoat IgG<\/td>\n<\/td>\n<\/tr>\n
Ab00174-1.6 Anti-DNA\/RNA G-quadruplex (and related small molecules) [BG4]<\/a><\/td>\nHuman<\/td>\nMouse Fab fragment<\/td>\nHis-Tagged<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Fc Silent\u2122 Antibodies: Turning down the background nois […]<\/p>\n","protected":false},"author":3,"featured_media":6981,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[136],"tags":[4382],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6980"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6980"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6980\/revisions"}],"predecessor-version":[{"id":6983,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6980\/revisions\/6983"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6981"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6980"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}