{"id":6838,"date":"2016-09-27T10:18:18","date_gmt":"2016-09-27T02:18:18","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=6838"},"modified":"2022-07-25T17:32:10","modified_gmt":"2022-07-25T09:32:10","slug":"tmp-153-acat-inhibitors%e6%8a%91%e5%88%b6%e5%8a%91-biovision%e8%b2%a8%e8%99%9f-b1181-50","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=6838","title":{"rendered":"TMP-153, ACAT Inhibitors\u6291\u5236\u5291 | Biovision\u8ca8\u865f: B1181-50"},"content":{"rendered":"

\"New\u00a0:\u00a0ACC2ACAT Inhibitors\u6291\u5236\u5291 | TMP-153 | \u8ca8\u865f: B1181-50<\/p>\n

TMP-153 , selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT)<\/p>\n

\"TMP-153\"<\/a><\/p>\n

TMP-153\u662facyl-CoA ACAT\u7684\u9078\u64c7\u6027\u6291\u88fd\u5291\uff1aIC 50\uff085\u81f310Nm\uff09\u7684IC 50\u3002\u5927\u9f20\u548c\u5009\u9f20\u4e2d\uff0c\u6709\u6548\u529b\u6291\u5236\u81bd\u56fa\u9187\u916f\u5316\uff0c\u4e26\u6e1b\u5c11\u6d41\u5165\u8840\u6f3f\u4e2d\u3002TMP-153\u986f\u793a\u51fa\u6bd2\u6027\u670a\u75c5\u6bd2\u611f\u67d3\u7684\u795e\u7d93\u5143\uff08ScGT1\uff09\u7d30\u80de\u3002\u5b83\u53ef\u80fd\u5177\u6709\u6f5b\u5728\u589e\u52a0ScGT1\u7d30\u80decaspase-3\u7684\u6d3b\u6027\u548c\u524d\u5217\u817a\u7d20E2\u7684\u751f\u7522\u3002<\/p>\n

TMP-153 is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC\u2085\u2080 of 5 to 10 nM. It has potency to inhibit cholesterol esterification and reduces its influx into the plasma of rats and hamsters. TMP-153 is shown toxicity to prion infected neuronal (ScGT1) cells. It might have potential to increase caspase-3 activity and prostaglandin E2 production in ScGT1 Cells.<\/p>\n

 <\/p>\n

Molecular Formula: C\u2082\u2084H\u2081\u2088ClF\u2082N\u2083O<\/p>\n

Molecular Weight: 437.88<\/p>\n

Purity: \u226598% by TLC<\/p>\n

Solubility: DMSO (~25 mg\/ml)<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0Catalog #<\/a><\/td>\n\u00a0Product Name+<\/a><\/td>\n\u00a0Size<\/a><\/td>\n<\/tr>\n
\u00a09506-5<\/td>\n\u00a0Avasimibe<\/a><\/strong><\/td>\n\u00a05 mg<\/td>\n<\/tr>\n
\u00a09506-25<\/td>\n\u00a0Avasimibe<\/a><\/strong><\/td>\n\u00a025 mg<\/td>\n<\/tr>\n
\u00a02053-1<\/td>\n\u00a0Pellitorine<\/a><\/strong><\/td>\n\u00a01 mg<\/td>\n<\/tr>\n
\u00a02053-5<\/td>\n\u00a0Pellitorine<\/a><\/strong><\/td>\n\u00a05 mg<\/td>\n<\/tr>\n
\u00a02214-250<\/td>\n\u00a0Terpendole C<\/a><\/strong><\/td>\n\u00a0250 \u00b5g<\/td>\n<\/tr>\n
\u00a02214-1000<\/td>\n\u00a0Terpendole C<\/a><\/strong><\/td>\n\u00a01 mg<\/td>\n<\/tr>\n
\u00a0B1181-10<\/td>\n\u00a0TMP-153\u00a0<\/a><\/strong><\/td>\n\u00a010 mg<\/td>\n<\/tr>\n
\u00a0B1181-50<\/td>\n\u00a0TMP-153\u00a0<\/a><\/strong><\/td>\n\u00a050 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u66f4\u591a\u9175\u7d20\u578b\u6291\u5236\u5291\u5546\u54c1:<\/span> ACE\u6291\u5236\u5291\u985e<\/a> | AR\u6291\u5236\u5291\u985e<\/a> | AKR\u6291\u5236\u5291\u985e<\/a> | adenylyl cyclase \u6291\u5236\u5291\u985e<\/a> | AAC\u6291\u5236\u5291<\/a> | ACAT\u6291\u5236\u5291<\/a><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

ACAT Inhibitors\u6291\u5236\u5291 | TMP-153 | \u8ca8\u865f: B1181-50 TMP-153 , s […]<\/p>\n","protected":false},"author":3,"featured_media":6676,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486,451],"tags":[4416,4415],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6838"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6838"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6838\/revisions"}],"predecessor-version":[{"id":6861,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6838\/revisions\/6861"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6676"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6838"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}