{"id":6236,"date":"2016-09-01T15:00:54","date_gmt":"2016-09-01T07:00:54","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=6236"},"modified":"2022-07-26T14:38:38","modified_gmt":"2022-07-26T06:38:38","slug":"anti-vaccinia-a33-glycoprotein%e6%8a%97%e9%ab%94-fc-silent-antibodies%e7%b3%bb%e5%88%97%e6%9c%89%e6%95%88%e9%99%8d%e4%bd%8e%e9%9d%9e%e7%89%b9%e7%95%b0%e6%80%a7fc%e7%b5%90%e5%90%88%e3%80%82","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=6236","title":{"rendered":"Anti-Vaccinia A33 glycoprotein\u6297\u9ad4 | Fc Silent\u2122 Antibodies\u7cfb\u5217\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027Fc\u7d50\u5408\u3002"},"content":{"rendered":"

Fc Silent\u2122 Antibodies: Turning down the background noise<\/strong><\/p>\n

Fc Silent\u00a0<\/strong>\u6297\u9ad4<\/strong> | <\/strong>\u53ea\u8981<\/strong>\u8a0a<\/strong>\u865f\u4e0d\u8981\u96dc<\/strong>\u8a0a (Engineered Fc Domain)<\/strong><\/span><\/p>\n

Absolute Antibody \u63d0\u4f9b\u4e00\u7cfb\u5217\u6297\u9ad4\u5546\u54c1\uff0c\u5176\u4e2dFc Silent\u2122 Antibodies\u7cfb\u5217\uff1b\u80fd\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027Fc\u7d50\u5408\u3002Fc Silent\u2122\u6280\u8853\uff0c\u70ba\u61c9\u7528\u751f\u7269\u5de5\u7a0b\u6280\u8853\uff0c\u5c07Fc receptors (Fc\u03b3R, FcR)\u9ede\u7a81\u8b8a\uff0c\u9032\u800c\u4e2d\u6b62\u6297\u9ad4\u8207ADCC\u7684\u529f\u80fd\uff1b\u6709\u6548\u964d\u4f4eFc\u6240\u9020\u6210\u7684\u80cc\u666f\u8a0a\u865f\u3002<\/p>\n

Fc Silent\u2122\u6297\u9ad4\u61c9\u7528\u65bc\u514d\u75ab\u7d30\u80de\u6642flow cytometry\u3001immunohistochemistry (IHC)\u8cc7\u6599\u986f\u793a\uff0c\u6709\u6548\u964d\u4f4e\u975e\u7279\u7570\u6027\u4e4bFc\u7d50\u5408\uff0c\u6240\u9020\u6210\u7684\u80cc\u666f\u503c\u3002(\u8a02\u8cfc\u6297\u9ad4\u524d\uff0c\u8acb\u78ba\u8a8d\u9078\u64c7\u6297\u9ad4\u662f\u5426\u6709Fc Silent\u2122\u4fee\u98fe\u6a19\u8a8c)<\/p>\n

\"f480_silent_post\"<\/p>\n

\n

Anti-Vaccinia A33 glycoprotein\u6297\u9ad4 | \u7522\u54c1\u63cf\u8ff0:<\/p>\n

Recombinant monoclonal antibody to Vaccinia A33 glycoprotein. Manufactured using AbAb\u2019s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma A2C7.<\/p>\n\n\n\n\n\n\n\n
\u6297\u9ad4\u540d\u7a31<\/td>\nAnti-Vaccinia A33 glycoprotein [A2C7]<\/td>\n<\/tr>\n
\u6297\u9ad4\u8ca8\u865f<\/td>\n <\/td>\n\u7279\u7570\u6027This antibody is specific for the VACV antigen A33, a viral glycoprotein associated with the outer membrane of extracellular enveloped viruses. A33 is known to elicit protective antibody responses.<\/td>\n<\/tr>\n
This antibody was prepared by intranasally infecting BALB\/c mice with an attenuated vaccinia virus (VACV) mutant, followed by a boost with an intravenous injection of UV-inactivated WT VACV.<\/td>\n<\/tr>\n
\u514d\u75ab\u539f<\/td>\nThis antibody is specific for the VACV antigen A33, a viral glycoprotein associated with the outer membrane of extracellular enveloped viruses. A33 is known to elicit protective antibody responses.<\/td>\n<\/tr>\n
\u61c9\u7528\u6ce8\u610f<\/td>\nThe specificity of this antibody for VACV has been confirmed by IF assays (Meng, 2011). This antibody exhibited strong complement-mediated neutralization of the extracellular enveloped form of vaccinia virus in the presence of complement, and was able to protect mice against weight loss and death following an in vivo VACV challenge (Matho, 2015).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u66f4\u591a\u76f8\u95dc\u6297\u9ad4Primary Antibodies<\/p>\n

\n
\n
\n
\n
\n
\n\n\n\n\n\n\n\n
Product Name page<\/a><\/th>\nExpected Species Reactivity<\/a><\/th>\nApplications<\/a><\/th>\n<\/tr>\n<\/thead>\n
Anti-A14 [BB5.2]<\/a><\/td>\nVaccinia virus<\/td>\nWB; IP; IF<\/td>\n<\/tr>\n
Anti-Vaccinia A33 glycoprotein [A2C7]<\/a><\/td>\nVaccinia virus<\/td>\nIF; neutralization<\/td>\n<\/tr>\n
Anti-Vaccinia L1 protein [M12b9 Fab]<\/a><\/td>\nVaccinia virus<\/td>\ncrystallization; BLI binding assay<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Fc Silent\u2122 Antibodies: Turning down the background nois […]<\/p>\n","protected":false},"author":3,"featured_media":6231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[136],"tags":[4553],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6236"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6236"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6236\/revisions"}],"predecessor-version":[{"id":6237,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6236\/revisions\/6237"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6231"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6236"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}