{"id":6193,"date":"2016-08-31T18:49:32","date_gmt":"2016-08-31T10:49:32","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=6193"},"modified":"2022-07-26T14:40:46","modified_gmt":"2022-07-26T06:40:46","slug":"jc-1-%e7%b2%92%e7%b7%9a%e9%ab%94%e6%9f%93%e5%8a%91-%e6%b8%ac%e9%87%8f%e7%b2%92%e7%b7%9a%e9%ab%94%e8%86%9c%e9%9b%bb%e4%bd%8d%ef%bc%8c%e6%9f%93%e5%87%ba%e7%b2%92%e7%b7%9a%e9%ab%94%e8%86%9c%e9%9b%bb","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=6193","title":{"rendered":"JC-1 \u7c92\u7dda\u9ad4\u67d3\u5291 |mitochondrial dye\u6e2c\u91cf\u7c92\u7dda\u9ad4\u819c\u96fb\u4f4dCAS #3520-43-2 \u8ca8\u865f1130-5"},"content":{"rendered":"

JC-1 \u7c92\u817a\u9ad4\u67d3\u5291 | \u8ca8\u865f1130-5<\/a> <\/span>\u00a0(<\/strong> 5, 5\u2019 ,6, 6\u2019 -tetrachloro-1, 1\u2019 ,3, 3\u2019 -tetraethyl-benzimidazolylcarbocyanine Iodide_Catalog#:\u00a01130-5\u00a0\u00a0| Size: 5 mg<\/p>\n

JC-1 \u67d3\u5291\u662f\u4e00\u7a2e\u7c92\u7dda\u9ad4\u67d3\u5291(mitochondrial dye)\u3002JC-1\u67d3\u5291\u53ef\u4ee5\u6e2c\u91cf\u7c92\u7dda\u9ad4\u819c\u96fb\u4f4d\uff0c\u67d3\u51fa\u7c92\u7dda\u9ad4\u819c\u96fb\u4f4d\u5931\u8861\u73fe\u8c61\u3002\u5176\u539f\u7406\u70ba: \u7576\u5e36\u6b63\u96fb\u7684JC-1\u67d3\u5291\u9032\u5165\u7d30\u80de\u4e2d\uff0c\u6703\u88ab\u7c92\u7dda\u9ad4\u819c\u4e0a\u7684\u8ca0\u6027\u96fb\u5834\u6240\u5438\u5f15\u4e26\u805a\u96c6\u5f62\u6210\u4e8c\u805a\u9ad4\uff0c\u5728\u87a2\u5149\u986f\u5fae\u93e1\u4e0b\u767c\u51fa\u6a58\u7d44\u8272\u87a2\u5149\uff1b\u82e5\u662f\u7c92\u7dda\u9ad4\u4e0a\u819c\u96fb\u4f4d\u6d88\u5931\uff0c\u4f7fJC-1\u67d3\u5291\u7121\u6cd5\u88ab\u819c\u4e0a\u96fb\u5834\u6240\u5438\u5f15\uff0c\u800c\u6563\u4f48\u5728\u7d30\u80de\u4e2d\uff0c\u4e26\u5448\u73fe\u55ae\u9ad4\u72c0\u614b\uff0c\u5728\u87a2\u5149\u986f\u5fae\u93e1\u4e0b\u767c\u51fa\u7da0\u8272\u87a2\u5149\u3002JC-1\u67d3\u5291\u53ef\u4ee5\u7528\u4f86\u89c0\u5bdf\u7d30\u80de\u51cb\u4ea1\u73fe\u8c61\uff0c\u5728\u5065\u5eb7\u7684\u7d30\u80de\u4e2d\uff0c\u767c\u51fa\u7d05\u8272\u87a2\u5149\uff1b\u7576\u7d30\u80de\u80de\u51cb\u4ea1\u767c\u751f\u6642\uff0c\u767c\u51fa\u7da0\u8272\u67d3\u5149\u3002<\/p>\n

\"biovision01\"<\/p>\n

\"1130\"<\/a><\/p>\n

\"\"<\/p>\n

Description: <\/strong>JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (lem = 527 nm), while the J-aggregates have red fluorescence (lem = 590 nm). Therefore, it has been possible to use fluorescence ratioing technique to study mitochondrial membrane potential. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green, while in healthy cells, the dye aggregates in the mitochondria and fluoresces red.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Cat # +Size<\/th>\n1130-5<\/td>\n<\/tr>\n
Size<\/th>\n5 mg<\/td>\n<\/tr>\n
Alternate Name<\/th>\n5,5\u2019,6,6\u2019-tetrachloro-1,1\u2019,3,3\u2019-tetraethyl-benzimidazolylcarbocyanine Iodide<\/td>\n<\/tr>\n
Appearance<\/th>\nBrown red solid<\/td>\n<\/tr>\n
CAS #<\/th>\n3520-43-2<\/td>\n<\/tr>\n
Molecular Formula<\/th>\nC\u2082\u2085H\u2082\u2087Cl\u2084IN\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/th>\n652.23<\/td>\n<\/tr>\n
Purity<\/th>\n>98% by HPLC<\/td>\n<\/tr>\n
Solubility<\/th>\nDMSO and DMF<\/td>\n<\/tr>\n
SMILES<\/th>\nCCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]<\/td>\n<\/tr>\n
InChi<\/th>\nInChI=1S\/C25H27Cl4N4.HI\/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;\/h9-15H,5-8H2,1-4H3;1H\/q+1;\/p-1<\/td>\n<\/tr>\n
InChi Key<\/th>\nFYNNIUVBDKICAX-UHFFFAOYSA-M<\/td>\n<\/tr>\n
PubChem CID<\/th>\n5492929<\/a><\/td>\n<\/tr>\n
MDL Number<\/th>\nMFCD00188475<\/td>\n<\/tr>\n
Handling<\/th>\nProtect from light and moisture<\/td>\n<\/tr>\n
Storage Conditions<\/th>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/th>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n
<\/div>\n
\"\u00e5\u00bc\u0095\u00e7\u0094\u00a8\u00e6\u0096\u0087\u00e7\u008d\u00bb\"<\/div>\n
Yi-Huan Chen, MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells.\u00a0Biosci Rep., Apr. 2020;\u00a0\u00a032255176.<\/a><\/div>\n<\/div>\n
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Hai-Yan Hou, Evidence that growth hormone can improve mitochondrial function in oocytes from aged mice.\u00a0Reproduction., Jan. 2019;\u00a0\u00a030668522<\/a><\/div>\n<\/div>\n
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Hung et al., Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin.\u00a0Toxicol. Sci., May 2015; 145: 59 – 67.<\/a><\/div>\n<\/div>\n
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Trondl et al., Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells.\u00a0Mol. Pharmacol., Jan 2014; 85: 451 – 459.<\/a><\/div>\n<\/div>\n
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Ling-Yi Chen et al., Taiwanofungus camphoratus (Syn Antrodia camphorata) Extract and Amphotericin B Exert Adjuvant Effects via Mitochondrial Apoptotic Pathway.\u00a0Integr Cancer Ther, Mar 2013; 12: 153 – 164.<\/a><\/div>\n
<\/div>\n<\/div>\n\n\n\n\n\n\n
\u00a0Catalog#<\/a><\/td>\n\u00a0Product Name<\/a><\/td>\n\u00a0Size<\/a><\/td>\n<\/tr>\n
\u00a01130-5<\/td>\n\u00a0JC-1<\/a><\/td>\n\u00a05 mg<\/td>\n<\/tr>\n
\u00a0K250-100<\/td>\n\u00a0MitoCapture\u2122 Mitochondrial Apoptosis Detection Fluorometric Kit<\/a><\/td>\n\u00a0100 assays<\/td>\n<\/tr>\n
\u00a0K250-25<\/td>\n\u00a0MitoCapture\u2122 Mitochondrial Apoptosis Detection Fluorometric Kit<\/a><\/td>\n\u00a025 assays<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"smart\"<\/a>\"Spectrumlab<\/a><\/p>\n

\"\u5be6\u9a57\u8a2d\u50992\"<\/a>\"\u00e7\u008e\u00bb\u00e7\u0089\u0087\u00e6\u008e\u0083\u00e6\u008f\u008f\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

JC-1 \u7c92\u817a\u9ad4\u67d3\u5291 | \u8ca8\u865f1130-5 \u00a0( 5, 5\u2019 ,6, 6\u2019 -tetrachloro-1, 1 […]<\/p>\n","protected":false},"author":3,"featured_media":6194,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[84,129],"tags":[4559],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6193"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6193"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6193\/revisions"}],"predecessor-version":[{"id":29870,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/6193\/revisions\/29870"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6194"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6193"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}