{"id":54862,"date":"2026-06-18T11:49:54","date_gmt":"2026-06-18T03:49:54","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=54862"},"modified":"2026-06-18T11:49:54","modified_gmt":"2026-06-18T03:49:54","slug":"tunicamycin-cas11089-65-9-apexbio%e8%b2%a8%e8%99%9fb7417","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=54862","title":{"rendered":"Tunicamycin | CAS#11089-65-9 APExBIO\u8ca8\u865fB7417"},"content":{"rendered":"

APExBIO\u7cfb\u5217\u5546\u54c1-\u7d30\u83cc\u6297\u751f\u7d20\u00a0->>Tunicamycin<\/span><\/span><\/span><\/span><\/strong>
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APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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Tunicamycin | CAS#11089-65-9 APExBIO\u8ca8\u865fB7417<\/a><\/span><\/p>\n

antibiotic,inhibits GlcNAc phosphotransferase (GPT)<\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

\u8863\u9ef4\u7d20\uff08Tunicamycin, CAS#11089-65-9\uff09\u662f\u4e00\u7a2e\u5e38\u7528\u7684\u6297\u751f\u7d20\uff0c\u53ef\u4f5c\u70ba\u86cb\u767d\u8ceaN-\u7cd6\u57fa\u5316\u6291\u5236\u5291( protein N-glycosylation)\u3002\u5176\u4f5c\u7528\u6a5f\u5236\u662f\u900f\u904e\u963b\u65b7UDP-N-\u4e59\u91af\u6c28\u57fa\u8461\u8404\u7cd6(UDP-N-acetylglucosamine )\u8207\u805a\u7570\u620a\u4e8c\u70ef\u9187\u78f7\u9178(polyisoprenol phosphate)\u4e4b\u9593\u7684\u521d\u59cb\u8f49\u79fb\u53cd\u61c9\uff0c\u5f9e\u800c\u963b\u6b62N-\u9023\u63a5\u7cd6\u86cb\u767d\u5408\u6210\u6240\u5fc5\u9700\u7684\u591a\u841c\u9187\u7126\u78f7\u9178-N-\u4e59\u91af\u6c28\u57fa\u8461\u8404\u7cd6\u4e2d\u9593\u9ad4( N-acetylglucosamine intermediates)\u7684\u5f62\u6210\u3002\u9019\u7a2e\u5e72\u64fe\u6703\u8a98\u5c0e\u53d7\u5f71\u97ff\u7d30\u80de\u7684\u5167\u8cea\u7db2\uff08endoplasmic reticulum, ER\uff09\u58d3\u529b\u3002\u5be6\u9a57\u8868\u660e\uff0c\u8863\u9ef4\u7d20\u80fd\u6709\u6548\u6291\u5236\u8102\u591a\u91a3\u523a\u6fc0\u7684RAW264.7\u5de8\u566c\u7d30\u80de\u7684\u767c\u708e\u53cd\u61c9\uff0c\u964d\u4f4eCOX-2\u548ciNOS\u7b49\u767c\u708e\u4ecb\u8cea\u7684\u8868\u9054\u548c\u91cb\u653e\u3002\u6b64\u5916\uff0c\u5b83\u9084\u80fd\u8abf\u7bc0\u5c0f\u9f20\u8178\u9053\u548c\u809d\u81df\u7d44\u7e54\u4e2d\u58d3\u529b\u76f8\u95dc\u57fa\u56e0\u7684\u8868\u9054\uff0c\u4f7f\u5176\u5728\u5167\u8cea\u7db2\u58d3\u529b\u3001\u7cd6\u57fa\u5316\u9014\u5f91(glycosylation pathways)\u548c\u767c\u708e(inflammation)\u7684\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u50f9\u503c\u3002<\/p>\n

Tunicamycin (CAS 11089-65-9) is an antibiotic commonly utilized as an inhibitor of protein N-glycosylation. It acts by blocking the initial transfer reaction between UDP-N-acetylglucosamine and polyisoprenol phosphate, thus preventing formation of dolichol pyrophosphate N-acetylglucosamine intermediates essential for N-linked glycoprotein synthesis. This interference induces endoplasmic reticulum (ER) stress within affected cells. Experimentally, tunicamycin effectively suppresses inflammatory responses in RAW264.7 macrophages stimulated by lipopolysaccharide, reducing expression and release of inflammatory mediators such as COX-2 and iNOS. Additionally, it modulates stress-related gene expression in murine intestinal and hepatic tissues, making it valuable for studies of ER stress, glycosylation pathways, and inflammation.<\/p>\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n844.95<\/td>\n<\/tr>\n
Cas No.<\/td>\n11089-65-9<\/td>\n<\/tr>\n
Formula<\/td>\nC39<\/sub>H64<\/sub>N4<\/sub>O16<\/sub>\u00a0(tunicamycin C, n=10)<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226525 mg\/mL in DMSO<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/div>\n
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APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n

https:\/\/www.apexbt.com<\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\"\u86cb\u767d\u6291\u5236\u5291\/\u7de9\u885d\u6db2\u6210\u5206<\/span><\/strong><\/span><\/p>\n