{"id":54088,"date":"2025-12-10T17:23:50","date_gmt":"2025-12-10T09:23:50","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=54088"},"modified":"2025-12-26T11:09:39","modified_gmt":"2025-12-26T03:09:39","slug":"brefeldin-a-cas20350-15-6-apexbio%e8%b2%a8%e8%99%9fb1400","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=54088","title":{"rendered":"Brefeldin A | CAS#20350-15-6 APExBIO\u8ca8\u865fB1400"},"content":{"rendered":"

\u00a0Inhibitor\u7cfb\u5217\u5546\u54c1->>Brefeldin A<\/span>
\n<\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Brefeldin A | CAS#20350-15-6 APExBIO\u8ca8\u865fB1400<\/span><\/strong><\/span><\/a><\/span><\/p>\n

(Synonyms: BFA; Cyanein; Decumbin)<\/span><\/p>\n

\u5e03\u96f7\u83f2\u5fb7\u83cc\u7d20A\uff08Brefeldin A, CAS#20350-15-6\uff09\uff0c\u901a\u5e38\u7e2e\u5beb\u70baBFA\uff0c\u662f\u4e00\u7a2e\u9776\u5411ATPase\u6d3b\u6027\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u5176IC50\u503c\u7d04\u70ba0.2 \u03bcM\u3002\u5176\u4e3b\u8981\u4f5c\u7528\u6a5f\u8f49\u662f\u900f\u904e\u963b\u65b7\u86cb\u767d\u8cea\u5f9e\u5167\u8cea\u7db2\uff08ER\uff09\u5230\u9ad8\u723e\u57fa\u9ad4\u7684\u904b\u8f38\u4ee5\u53ca\u6291\u5236GTP\/GDP\u4ea4\u63db\uff0c\u5f9e\u800c\u7834\u58de\u7d30\u80de\u5167\u56ca\u6ce1\u904b\u8f38\u3002\u900f\u904e\u9019\u4e9b\u4f5c\u7528\uff0c\u5e03\u96f7\u83f2\u5fb7\u83cc\u7d20A\uff08Brefeldin A, CAS#20350-15-6\uff09\u53ef\u6e1b\u5c11ATP\u4ecb\u5c0e\u7684\u56ca\u6ce1\u80de\u5410\uff0c\u9032\u800c\u6e1b\u8f15\u523a\u6fc0\u4f9d\u8cf4\u6027\u75db\u89ba\u904e\u654f\u3002\u6b64\u5916\uff0c\u5b83\u9084\u80fd\u8a98\u5c0e\u5167\u8cea\u7db2\u61c9\u6fc0\uff0c\u4e26\u4fc3\u9032MCF-7\u548cHeLa\u7b49\u816b\u7624\u7d30\u80de\u6a21\u578b\u4e2dp53\u7684\u8868\u9054\uff0c\u6700\u7d42\u589e\u5f37\u7d50\u76f4\u8178\u764c\u7d30\u80de\uff08HCT116\uff09\u7684\u51cb\u4ea1\u3002\u5e03\u96f7\u83f2\u5fb7\u83cc\u7d20A\uff08Brefeldin A, CAS#20350-15-6\uff09\u4f5c\u70ba\u4e00\u7a2e\u85e5\u7406\u5de5\u5177\uff0c\u88ab\u5ee3\u6cdb\u7528\u65bc\u7d30\u80de\u751f\u7269\u5b78\u7814\u7a76\u4e2d\uff0c\u4ee5\u7814\u7a76\u86cb\u767d\u8cea\u5206\u6ccc\u3001\u56ca\u6ce1\u904b\u8f38\u52d5\u529b\u5b78\u548c\u5167\u8cea\u7db2\u58d3\u529b\u8def\u5f91\u3002<\/p>\n

\u61c9\u7528:\u00a0BFA \u8655\u7406\u6b63\u5e38\u5927\u9f20\u814e\u7d30\u80de (NRK) 15 \u5c0f\u6642\u6216 40 \u5c0f\u6642\u5f8c\uff0c\u5167\u8cea\u7db2 (ER) \u986f\u8457\u816b\u8139\uff0c\u4e26\u5411\u7d30\u80de\u9031\u908a\u8f49\u79fb\u3002 BFA \u5f71\u97ff\u9ad8\u723e\u57fa\u9ad4\u7d50\u69cb\u4ee5\u53ca\u5fae\u7ba1\u548c\u808c\u52d5\u86cb\u767d\u7684\u7d44\u7e54\u3002 BFA \u512a\u5148\u8a98\u5c0e MDA-MB-231 \u61f8\u6d6e\u57f9\u990a\u7d30\u80de\u6b7b\u4ea1\uff0cEC50 \u70ba 0.016 \u03bcg\/mL\u3002 BFA \u900f\u904e\u4e0b\u8abf\u4e73\u764c\u5e79\u7d30\u80de\u6a19\u8a18 CD44 \u548c\u6297\u51cb\u4ea1\u86cb\u767d Bcl-2 \u548c Mcl-1\uff0c\u4ee5\u53ca\u9006\u8f49\u4e0a\u76ae-\u9593\u8cea\u8f49\u5316\uff0c\u6709\u6548\u6291\u5236 MDA-MB-231 \u7d30\u80de\u7684\u514b\u9686\u5f62\u6210\u80fd\u529b\u3001\u9077\u79fb\u80fd\u529b\u548c\u57fa\u8cea\u91d1\u5c6c\u86cb\u767d\u9176-9 (MMP-9) \u6d3b\u6027\u3002 BFA (1 \u03bcg\/mL) \u8655\u7406\u53ef\u8a98\u5c0e MCF-7 \u7d30\u80de\u548c Hela \u7d30\u80de\u4e2d p53 \u7684\u8868\u9054\u3002\u5728\u5927\u8178\u76f4\u8178\u764c\u7d30\u80de\u7cfbHCT116\u7d30\u80de\u4e2d\uff0cBFA\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u3002<\/p>\n

For research use only. We do not sell to patients.<\/span><\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n280.36<\/td>\n<\/tr>\n
Cas No.<\/td>\n20350-15-6<\/td>\n<\/tr>\n
Formula<\/td>\nC16<\/sub>H24<\/sub>O4<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226511.73 mg\/mL in EtOH with ultrasonic; \u22654.67 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC[C@@H](CCC\/C=C\/[C@H](C[C@@H](C1)O)[C@@H]1[C@@H](\/C=C1)O)OC\\1=O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

\"APExBIO_logo\"<\/a><\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/h2>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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