{"id":52153,"date":"2025-08-05T13:14:25","date_gmt":"2025-08-05T05:14:25","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=52153"},"modified":"2025-08-11T18:01:58","modified_gmt":"2025-08-11T10:01:58","slug":"pmsf-cas329-98-6-apexbio%e8%b2%a8%e8%99%9fa2587","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=52153","title":{"rendered":"PMSF | CAS#329-98-6 APExBIO\u8ca8\u865fA2587"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">APExBIO\u7cfb\u5217\u5546\u54c1-&gt;&gt;<span style=\"color: #ff6600;\">PMSF<\/span><\/span><\/span><span style=\"font-size: 14pt;\"><span style=\"color: #ff6600;\"> <span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=52131\">CAS#329-98-6 <\/a><\/span><\/span><\/span><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\"><br \/>\n<\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291 (Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #33cccc;\"><a style=\"color: #33cccc;\" href=\"https:\/\/biopioneer.com.tw\/?p=52153&amp;preview=true\"><span style=\"font-size: 12pt;\">PMSF| CAS#329-98-6 APExBIO\u8ca8\u865fA2587<\/span><\/a><\/span><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n<p>PMSF \u53ef\u7528\u65bc\u5f9e\u7d44\u7e54\u548c\u7d30\u80de\u88c2\u89e3\u7269\u4e2d\u88fd\u5099\u86cb\u767d\u8cea\u8403\u53d6\u7269\u3002\u82ef\u7532\u78fa\u9170\u6c1f (<span class=\"Y2IQFc\" lang=\"zh-TW\">Phenylmethanesulfonyl fluoride, <\/span>PMSF; CAS 329-98-6) \u662f\u4e00\u7a2e\u4e0d\u53ef\u9006\u7d72\u6c28\u9178\u86cb\u767d\u9176\u6291\u5236\u5291(<span class=\"Y2IQFc\" lang=\"zh-TW\"> irreversible serine protease inhibitor)<\/span>\uff0c\u5ee3\u6cdb\u61c9\u7528\u65bc\u751f\u7269\u91ab\u5b78\u7814\u7a76\u3002\u5b83\u5171\u50f9\u4fee\u98fe\u76ee\u6a19\u9176\u6d3b\u6027\u4f4d\u9ede\u5167\u7684\u7d72\u80fa\u9178\u6b98\u57fa\uff0c\u6709\u6548\u6291\u5236\u5176\u50ac\u5316\u529f\u80fd\u3002 PMSF \u53ef\u4ee5\u6291\u5236\u7d72\u80fa\u9178\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">serine proteases)<\/span>\uff0c\u4f8b\u5982\u7cdc\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">chymotrypsin)<\/span>\u3001\u80f0\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">trypsin)<\/span>\u548c\u51dd\u8840\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">thrombin)<\/span>\u3002\u5b83\u4e0d\u6291\u5236\u91d1\u5c6c\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">metalloproteases)<\/span>\u3001\u5927\u591a\u6578\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">cysteine proteases)<\/span>\u6216\u5929\u9580\u51ac\u80fa\u9178\u86cb\u767d\u9176(<span class=\"Y2IQFc\" lang=\"zh-TW\">aspartic proteases)<\/span>\u3002 PMSF \u53ef\u7528\u65bc\u5728\u86cb\u767d\u8cea\u5370\u8de1\u6cd5 (Western blotting) \u524d\u88fd\u5099\u7d44\u7e54\u548c\u7d30\u80de\u7684\u86cb\u767d\u8cea\u8403\u53d6\u7269\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/08\/3-PMSF-CAS329-98-6-APExBIO%E8%B2%A8%E8%99%9FA2587.jpg\" \/><\/p>\n<p>Thomas Baker, Herbert E. Lowndes, Martin K. Johnson, Irene C. Sandborg. The effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy. Archives of Toxicology. 1980; 46(3-4): 305 \u2013 311.<\/p>\n<p>Marcello Lotti, Stefano Caroldi, Eugenio Capodicasa, Angelo Moretto. Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride. Toxicology and Applied Pharmacology. 1991; 108(2): 234 \u2013 241.<\/p>\n<p>Masayasu Inoue, Seikoh Horiuchi, Yoshimasa Morino. Inactivation of \u03b3-glutamyl transpeptidase by phenylmethanesulfonyl fluoride, a specific inactivator of serine enzymes. Biochemical and Biophysical Research Communications. 1978; 82(4): 1183 \u2013 1188.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/08\/2-PMSF-CAS329-98-6-APExBIO%E8%B2%A8%E8%99%9FA2587.jpg\" \/><\/p>\n<p><em class=\"hyphenate\">PMSF<\/em>\u00a0Chemical Structure<\/p>\n<p>CAS No. :\u00a0329-98-6<\/p>\n<table>\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>174.2<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>329-98-6<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>7<\/sub>H<sub>7<\/sub>FO<sub>2<\/sub>S<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>insoluble in H2O; \u226517.4 mg\/mL in DMSO; \u226528.3 mg\/mL in EtOH<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>phenylmethanesulfonyl fluoride<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A2587.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>C1=CC=C(C=C1)CS(=O)(=O)F<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div><\/div>\n<div>\n<ul id=\"artul\">\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41598-025-94868-4\" target=\"_blank\" rel=\"noopener\">1. Qiqi Gao, Mengjia Zhang, et al. &#8220;Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.&#8221; Scientific Reports.15, Article number: 10132 (2025) PMID: 40128377<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41598-025-94868-4\" target=\"_blank\" rel=\"noopener\">2. Qiqi Gao, Mengjia Zhang, et al. &#8220;Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.&#8221; Sci Rep 15, 10132 (2025)<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02205\" target=\"_blank\" rel=\"noopener\">3. Hui Shen, Hongrui Xu, et al. &#8220;Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer.&#8221; J Med Chem. 2025 Jan 23;68(2):1553-1571. PMID: 39746330<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1101\/2024.12.24.630260\" target=\"_blank\" rel=\"noopener\">4. Cadence Lee, Rachel Khan, et al. &#8220;IL-1\u03b2-driven NF-\u03baB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2.&#8221; bioRxiv. 2025 Feb 13:2024.12.24.630260. PMID: 39763770<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41419-024-06915-z\" target=\"_blank\" rel=\"noopener\">5. Lan Shao, Haoran Yu, et al. &#8220;DKK1-SE recruits AP1 to activate the target gene\u00a0DKK1\u00a0thereby promoting pancreatic cancer progression.&#8221; Cell Death Dis. 2024 Aug 6;15(8):566 PMID: 39107271<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1002\/mco2.553\" target=\"_blank\" rel=\"noopener\">6. Yuxuan Zhang, Qingxin Shi, et al. &#8220;iPSC\u2010derived NK cells with site\u2010specific integration of CAR19 and IL24 at the multi\u2010copy rDNA locus enhanced antitumor activity and proliferation.&#8221; MedComm (2020). 2024 May 9;5(5):e553. PMID: 38737469<\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"cite\" class=\"tbar\"><a href=\" http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/08\/1-PMSF-CAS329-98-6-APExBIO\u8ca8\u865fA2587.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/div>\n<div><img decoding=\"async\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/08\/5-PMSF-CAS329-98-6-APExBIO%E8%B2%A8%E8%99%9FA2587.png\" \/><\/div>\n<div class=\"detail-table \">\n<div class=\"detail-box-cont\">\n<p><strong style=\"color: #800000;\"><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.apexbt.com\">https:\/\/www.apexbt.com<\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/APEXBIO-\u7522\u54c1\u6e05\u55ae2025.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%9E%8B%E9%8C%84%E4%B8%8B%E8%BC%89.gif\" alt=\"\u578b\u9304\u4e0b\u8f09\" width=\"150\" height=\"50\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>APExBIO\u7cfb\u5217\u5546\u54c1-&gt;&gt;PMSF CAS#329-98-6 APExBIO Technolog [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":47343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368],"tags":[6867,6878,6866,6869],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52153"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52153"}],"version-history":[{"count":5,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52153\/revisions"}],"predecessor-version":[{"id":52160,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/52153\/revisions\/52160"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/47343"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52153"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}