{"id":48454,"date":"2024-01-25T15:27:41","date_gmt":"2024-01-25T07:27:41","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=48454"},"modified":"2025-08-29T18:19:43","modified_gmt":"2025-08-29T10:19:43","slug":"atezolizumab-cas1380723-44-3-mce%e8%b2%a8%e8%99%9fhy-p9904","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=48454","title":{"rendered":"Atezolizumab| CAS#1380723-44-3 MCE\u8ca8\u865fHY-P9904"},"content":{"rendered":"

\u7814\u7a76\u7d1a\u751f\u7269\u76f8\u4f3c\u85e5\u6297\u9ad4(research-grade biosimilar antibodies)<\/span>\u00a0<\/strong><\/span><\/p>\n

MedChemExpress (MCE) \u6291\u5236\u6027\u6297\u9ad4(Inhibitory Antibodies )\u662f\u7814\u7a76\u7d1a\u751f\u7269\u76f8\u4f3c\u85e5\u6297\u9ad4(research-grade biosimilar antibodies)\uff0c\u5177\u6709\u8207\u539f\u59cb\u6cbb\u7642\u6297\u9ad4\u76f8\u540c\u7684\u751f\u7269\u6d3b\u6027\u6210\u5206(bioactive component)\u3002\u751f\u7269\u76f8\u4f3c\u85e5( Biosimilar)\u4f7f\u5f97\u7814\u7a76\u85e5\u7269\u7684\u751f\u7269\u6548\u61c9\u6210\u70ba\u53ef\u80fd\u3002\u9019\u4e9b\u6297\u9ad4\u7279\u7570\u6027\u7d50\u5408\u6a19\u9776\u7d30\u80de\u6216\u86cb\u767d\u8cea\uff0c\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u60e1\u6027\u816b\u7624\u7d30\u80de\u6216\u963b\u65b7\u7279\u5b9a\u7d30\u80de\u53d7\u9ad4\u4f86\u963b\u6b62\u816b\u7624\u751f\u9577\u3002\u6a19\u9776\u86cb\u767d\u5305\u62ecCD20\u3001HER2\u3001EGFR\u3001VEGFR\u3001TNF-\u03b1\u7b49\u3002MCE\u6291\u5236\u6297\u9ad4\u5df2\u5ee3\u6cdb\u61c9\u7528\u65bc\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology )\u548c\u611f\u67d3(infection)\u7b49\u6700\u71b1\u9580\u7684\u7814\u7a76\u9818\u57df\u3002<\/p>\n

MCE \u6291\u5236\u6297\u9ad4(MCE Inhibitory Antibodies)\u662f\u55ae\u682a\u6297\u9ad4 (mAb)\uff0c\u5df2\u5ee3\u6cdb\u61c9\u7528\u65bc\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78( immunology )\u548c\u611f\u67d3(infection)\u7b49\u6700\u71b1\u9580\u7684\u7814\u7a76\u9818\u57df\u3002\u9019\u4e9b\u55ae\u682a\u6297\u9ad4\uff08mAb\uff09\u55ae\u4e00\u7279\u7570\u6027\u5730\u8207\u67d0\u4e9b\u7d30\u80de\u6216\u86cb\u767d\u8cea\u7d50\u5408\uff0c\u5f9e\u800c\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u60e1\u6027\u816b\u7624\u7d30\u80de\uff0c\u4e26\u900f\u904e\u963b\u65b7\u7279\u5b9a\u7684\u7d30\u80de\u53d7\u9ad4\u4f86\u9632\u6b62\u816b\u7624\u751f\u9577\u3002\u5b83\u5011\u53ef\u4ee5\u6291\u5236PD-1\u3001PD-L1\u3001EGFR\u3001VEGFR\u3001TNF-\u03b1 \u6216\u5176\u4ed6\u5728\u75be\u75c5\u4e2d\u7570\u5e38\u6d3b\u8e8d\u7684\u9776\u9ede\uff0c\u4f8b\u5982\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624(non-Hodgkin lymphom)\u3001A \u578b\u8840\u53cb\u75c5( Hemophilia A)\u3001\u814e\u7d30\u80de\u764c(renal cell carcinoma)\u3001\u5e15\u91d1\u68ee\u6c0f\u75c7(Parkinson’s disease)\u548c\u8f49\u79fb\u6027HER2 \u967d\u6027\u4e73\u764c\u764c\u75c7(metastatic HER2-positive breast cancer)\u3002\u4f8b\u5982\uff0c\u900f\u904e\u8207 VEGF \u7d50\u5408\uff0c\u8c9d\u4f10\u55ae\u6297(Bevacizumab )\u53ef\u9632\u6b62 VEGF \u8207\u5176\u53d7\u9ad4\u76f8\u4e92\u4f5c\u7528\uff0c\u5f9e\u800c\u6291\u5236\u65b0\u8840\u7ba1\u751f\u9577(inhibiting new vessel growth)\u3002\u862d\u535a\u5229\u73e0\u55ae\u6297(Lambrolizumab)\u9776\u5411\u6dcb\u5df4\u7d30\u80de\u7684\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1 1 (PD-1) \u53d7\u9ad4\u3002\u900f\u904e\u963b\u6b62\u5176\u914d\u9ad4\uff08PD-L1 \u548c PD-L2\uff09\u7684\u7d50\u5408\uff0cLambrolizumab \u8a98\u5c0e\u6297\u816b\u7624\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n

Atezolizumab| CAS#1380723-44-3 MCE\u8ca8\u865fHY-P9904\u00a0 \u226598.0%<\/span><\/strong><\/a><\/span><\/p>\n

\n
\n

\u00a0(Synonyms: MPDL3280A)<\/p>\n<\/div>\n

\n
Atezolizumab (MPDL3280A) \u662f\u4e00\u7a2e\u91dd\u5c0d\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u9ad4 1 (PD-L1<\/a><\/b>) \u7684\u9078\u64c7\u6027\u4eba\u6e90\u5316\u55ae\u682a\u00a0IgG1<\/a>\u6297\u9ad4\uff0c\u7528\u65bc\u764c\u75c7\u7814\u7a76\u3002Atezolizumab \u640d\u5bb3\u7c92\u7dda\u9ad4(mitochondria )\u529f\u80fd\uff0c\u5c0e\u81f4\u6c27\u5316\u5291(oxidants)\u548c\u6297\u6c27\u5316\u5291(antioxidants.)\u4e4b\u9593\u7684\u4e0d\u5e73\u8861\u3002 Atezolizumab \u900f\u904e\u6d3b\u5316 JNK \u8def\u5f91\u8a98\u5c0e\u9aa8\u8089\u7624\u7d30\u80de(osteosarcoma cells )\u7c92\u7dda\u9ad4\u76f8\u95dc\u51cb\u4ea1\u3002 Atezolizumab\uff0810\u03bcg\/ml\uff1b24\u5c0f\u6642\uff1bHOS\u548c143B\u7d30\u80de\uff09\u8a98\u5c0e\u9aa8\u8089\u7624\u7d30\u80de\u81ea\u566c\u4f5c\u7528(autophagy)[1]\u3002<\/div>\n
<\/div>\n
\u5f15\u7528\u6587\u737b\u00a0<\/a><\/div>\n
<\/div>\n
\u5f15\u7528\u6587\u737b<\/a><\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\n\n\n\n\n\n\n\n\n\n
Molecular Weight<\/th>\n\n
\n

144590.50<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
Appearance<\/th>\n\n
\n

Liquid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Color<\/th>\n\n
\n

Colorless to light yellow<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

SMILES<\/th>\n\n
\n

[Atezolizumab]<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
\n

Shipping with dry ice.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Storage<\/th>\n\n
\n

Please store the product under the recommended conditions in the Certificate of Analysis.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/div>\n<\/div>\n<\/div>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\u5316\u5408\u7269\u54c1\u724c<\/td>\n\u5316\u5408\u7269CAS\u865f<\/td>\n\u5316\u5408\u7269\u540d\u7a31<\/td>\n\u5316\u5408\u7269\u8ca8\u865f<\/td>\n\u5316\u5408\u7269\u4ecb\u7d39<\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1496553<\/a><\/td>\nZolbetuximab (IMAB362) \u4e00\u7a2e\u91dd\u5c0d Claudin-18.2 \u7684\u55ae\u682a\u6297\u9ad4\u3002 Zolbetuximab (IMAB362) \u900f\u904e\u514d\u75ab\u6548\u61c9\u6a5f\u5236\u4ecb\u5c0e Claudin-18.2 \u967d\u6027\u7d30\u80de\u7684\u7279\u7570\u6027\u6bba\u50b7\u3002 Zolbetuximab \u53ef\u7528\u65bc\u80c3\u8178\u9053\u817a\u764c(gastrointestinal adenocarcinomas )\u548c\u80f0\u817a\u816b\u7624( pancreatic tumors)\u7684\u7814\u7a76\u3002<\/td>\nMCE\u8ca8\u865fHY-P99058<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#174722-31-7<\/td>\nRituximab (anti-CD20) \u5229\u59a5\u6614\u55ae\u6297\uff08\u6297 CD20\uff09\u662f\u4e00\u7a2e\u6297 CD20 \u5d4c\u5408\u55ae\u682a\u6297\u9ad4(chimeric monoclonal antibody)\uff0c\u7528\u65bc\u6cbb\u7642\u67d0\u4e9b\u81ea\u9ad4\u514d\u75ab\u75be\u75c5(autoimmune diseases )\u548c\u764c\u75c7\u985e\u578b\u3002<\/td>\nMCE\u8ca8\u865fHY-P9913A<\/td>\n\n

\u7522\u54c1\u9023\u7d50<\/span><\/a><\/p>\n

 <\/td>\n<\/tr>\n

MCE(MedChemexpress)<\/td>\nCAS#216974-75-3<\/td>\nBevacizumab (PBS)\u662f\u4e00\u7a2e\u4eba\u6e90\u5316\u00a0IgG1\u00a0\u55ae\u682a\u6297\u9ad4\uff0c\u4ee5\u9ad8\u89aa\u548c\u529b\u7279\u7570\u6027\u7d50\u5408\u6240\u6709 \u00a0VEGF-A\u4e9e\u578b\u3002\u8c9d\u4f10\u73e0\u55ae\u6297(Bevacizumab)\u662f\u4e00\u7a2e\u4eba\u6e90\u5316\u55ae\u682a\u6297\u9ad4\uff0c\u4ee5\u9ad8\u89aa\u548c\u529b\u7279\u7570\u6027\u7d50\u5408\u6240\u6709 VEGF-A \u4e9e\u578b\uff0c\u4e26\u6291\u5236\u5176\u8207 VEGFR-1 \u548c VEGFR-2 \u7684\u76f8\u4e92\u4f5c\u7528[1]<\/td>\nMCE\u8ca8\u865fHY-P9906A<\/td>\n\u7522\u54c1\u9023\u7d50<\/span><\/a><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#180288-69-1<\/td>\n\u66f2\u59a5\u73e0\u55ae\u6297(Trastuzumab)\u662f\u4e00\u7a2e\u4eba\u6e90\u5316 IgG1 \u55ae\u682a\u6297\u9ad4\uff0c\u9069\u7528\u65bc HER2 \u904e\u5ea6\u8868\u73fe\u7684\u4fb5\u8972\u6027\u4e73\u764c\u60a3\u8005(invasive breast cancers)\u3002\u66f2\u59a5\u73e0\u55ae\u6297(Trastuzumab)\u5177\u6709 HER2 \u967d\u6027\u8f49\u79fb\u6027\u4e73\u764c(HER2 Positive Metastatic Breast\u00a0Cancer<\/a> )\u548c HER2 \u967d\u6027\u80c3\u764c(HER2 Positive Gastric\u00a0Cancer<\/a> )\u7814\u7a76\u7684\u6f5b\u529b\u3002<\/td>\nMCE\u8ca8\u865fHY-P9907<\/td>\n\u7522\u54c1\u9023\u7d50<\/span><\/a><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1374853-91-4<\/td>\nPembrolizumab (MK-3475) \u53ef\u6291\u5236\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1 1 (programmed cell death 1, PD-1) \u53d7\u9ad4\uff0c\u7528\u65bc\u764c\u75c7\u514d\u75ab\u6cbb\u7642(cancer immunotherapy<\/a>)\u3002Pembrolizumab (MK-3475)
\nPembrolizumab (MK-3475)\u589e\u52a0\u7d30\u80de\u6fc0\u7d20 IFN-\u03b3(cytokines IFN-\u03b3)\u3001TNF-\u03b1 \u7684\u5206\u6ccc\u4ee5\u53ca A549 \u7d30\u80de(\u4eba\u985e\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7d30\u80de\u682a, A549) \u7684\u51cb\u4ea1\u7d30\u80de\u6b7b\u4ea1[2]\u3002 Pembrolizumab \u53ef\u6539\u5584\u03b1ROR1-CAR T \u4ecb\u5c0e\u7684\u7d30\u80de\u6bd2\u6027\uff0c\u4e26\u900f\u904e\u963b\u65b7\u03b1ROR1-CAR T \u7d30\u80de\u4e2d\u7684PD-1::PD-L1 \u76f8\u4e92\u4f5c\u7528\u4f86\u6e1b\u5c11\u5171\u57f9\u990a\u7684\u03b1ROR1-CAR T \u548cA549 \u7d30\u80de(\u4eba\u985e\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7d30\u80de\u682a, A549) \u4e2d\u7684\u816b\u7624\u767c\u751f[2]\u3002<\/td>\n		MCE\u8ca8\u865fHY-P9902<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#946414-94-4<\/td>\nNivolumab \u662f\u4e00\u7a2e\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u9ad4 1 (PD-1) \u963b\u65b7\u6027\u4eba\u985e IgG4 \u6297\u9ad4\uff0c\u7528\u65bc\u6cbb\u7642\u665a\u671f\uff08\u8f49\u79fb\u6027\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c(non-small cell lung cancer)\u3002<\/td>\nMCE\u8ca8\u865fHY-P9903<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1190264-60-8<\/td>\nDupilumab (REGN-668) \u662f\u4e00\u7a2e\u91dd\u5c0dIL-4 receptor<\/a>\u00a0<\/b>\u03b1 (IL-4R\u03b1) \u7684\u5168\u4eba\u6e90\u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u6291\u5236IL-4<\/a><\/b>\u00a0 \u548c\u00a0IL-13<\/a><\/b>\u8a0a\u865f\u50b3\u5c0e\uff0c\u986f\u8457\u6539\u5584\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u7570\u4f4d\u6027\u76ae\u819a\u708e\u3002<\/td>\nMCE\u8ca8\u865fHY-P9926<\/td>\n\u7522\u54c1\u9023\u7d50<\/span><\/a><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#656247-17-5<\/td>\nNintedanib (BIBF 1120) \u662f\u4e00\u7a2e\u6709\u6548\u7684\u4e09\u91cd\u8840\u7ba1\u6fc0\u9176\u6291\u5236\u5291(Triple angiokinase inhibitor)<\/td>\nMCE\u8ca8\u865fHY-50904<\/td>\n\u7522\u54c1\u9023\u7d50<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7814\u7a76\u7d1a\u751f\u7269\u76f8\u4f3c\u85e5\u6297\u9ad4(research-grade biosimilar antibodies)\u00a0 MedCh […]<\/p>\n","protected":false},"author":3,"featured_media":52093,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[6535,6867,6866,6869,6865,6868],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48454"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=48454"}],"version-history":[{"count":5,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48454\/revisions"}],"predecessor-version":[{"id":52653,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/48454\/revisions\/52653"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52093"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=48454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=48454"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=48454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}