{"id":45539,"date":"2023-08-30T17:42:18","date_gmt":"2023-08-30T09:42:18","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=45539"},"modified":"2025-09-02T14:04:11","modified_gmt":"2025-09-02T06:04:11","slug":"gw6471-cas-880635-03-0-mce%e8%b2%a8%e8%99%9fhy-15372","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=45539","title":{"rendered":"GW6471 | CAS# 880635-03-0 MCE\u8ca8\u865fHY-15372\u00a0"},"content":{"rendered":"

MCE (MedChem Express)<\/span> -GW6471 is a potent PPAR\u03b1<\/a><\/b>\u00a0antagonist<\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

GW6471 | CAS# 880635-03-0 MCE\u8ca8\u865fHY-15372\u00a0<\/strong><\/a><\/span><\/p>\n

GW6471 is a potent PPAR\u03b1<\/a><\/b> antagonist. In a cell-based reporter assay, GW6471 completely inhibits GW409544-induced activation of PPAR\u03b1 with an IC50 of 0.24 \u03bcM[1]. The functional role of PPAR\u03b1 is evaluated on renal cell carcinoma (RCC) cell viability by MTT assay. Both Caki-1 (VHL wild type) and 786-O (VHL mutated) cells are incubated separately with a specific PPAR\u03b1 agonist, WY14,643, or a specific PPAR\u03b1 antagonist, GW6471 at concentrations from 12.5 to 100 \u03bcM for 72 hours, and cell viability is assessed. While WY14,643 either has no affect on, or slightly increased, cell viability, GW6471 significantly and dose-dependently inhibits cell viability (up to approximately 80%) in both cell lines[2].<\/p>\n

\u5728\u57fa\u65bc\u7d30\u80de\u7684\u5831\u544a\u57fa\u56e0\u6aa2\u6e2c( cell-based reporter assay)\u4e2d\uff0cGW6471 \u5b8c\u5168\u6291\u5236 GW409544 \u8a98\u5c0e\u7684 PPAR\u03b1 \u6fc0\u6d3b\uff0cIC50 \u70ba 0.24 \u03bcM[1]\u3002\u901a\u904e MTT \u6e2c\u5b9a\u8a55\u4f30 PPAR\u03b1 \u5c0d\u814e\u7d30\u80de\u764c (RCC) \u7d30\u80de\u6d3b\u529b\u7684\u529f\u80fd\u4f5c\u7528\u3002\u5c07 Caki-1\uff08VHL \u91ce\u751f\u578b\uff09\u548c 786-O\uff08VHL \u7a81\u8b8a\u578b\uff09\u7d30\u80de\u5206\u5225\u8207\u6fc3\u5ea6\u70ba 12.5 \u81f3 100 \u03bcM \u7684\u7279\u5b9a PPAR\u03b1 \u6fc0\u52d5\u5291 WY14,643 \u6216\u7279\u5b9a PPAR\u03b1 \u62ee\u6297\u5291 GW6471 \u5b75\u80b2 72 \u5c0f\u6642\uff0c\u4e26\u8a55\u4f30\u7d30\u80de\u6d3b\u529b\u3002\u96d6\u7136 WY14,643 \u5c0d\u7d30\u80de\u6d3b\u529b\u6c92\u6709\u5f71\u97ff\u6216\u7565\u6709\u589e\u52a0\uff0c\u4f46 GW6471 \u986f\u8457\u4e14\u5291\u91cf\u4f9d\u8cf4\u6027\u5730\u6291\u5236\u5169\u7a2e\u7d30\u80de\u7cfb\u4e2d\u7684\u7d30\u80de\u6d3b\u529b\uff08\u9ad8\u9054\u7d04 80%\uff09[2]\u3002<\/p>\n

<\/p>\n

GW6471<\/em>\u00a0Chemical Structure<\/p>\n

CAS No. :\u00a0880635-03-0<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

30 Publications Citing Use of MCE GW6471<\/span><\/strong><\/span><\/p>\n\n\n\n\n\n\n\n\n
Molecular Weight<\/th>\n\n
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619.67<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Appearance<\/th>\n\n
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Solid<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Formula<\/th>\n\n
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C35<\/sub>H36<\/sub>F3<\/sub>N3<\/sub>O4<\/sub><\/p>\n<\/div>\n<\/td>\n<\/tr>\n

CAS No.<\/th>\n\n
SMILES<\/th>\n\n
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CCC(NC[C@@H](N\/C(C)=C\\C(C1=CC=C(C(F)(F)F)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2)=O<\/p>\n<\/div>\n<\/td>\n<\/tr>\n

Shipping<\/th>\n\n
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Room temperature in continental US; may vary elsewhere.<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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GW6471<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0J Dairy Sci<\/cite>. 2023 Feb 14;S0022-0302(23)00052-8. \u00a0<\/a>[Abstract]<\/b><\/a><\/p>\n

GW6471 significantly reduces the regulatory effects of GINY and DQW on the protein expression levels of PPAR\u03b1, CPT-1a, ACOX1, HO-1, and FASN in HepG2 cells.<\/p>\n<\/div>\n


\nGW6471<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Oxid Med Cell Longev<\/cite>. 2019 Nov 3;2019:7536803. \u00a0<\/a>[Abstract]<\/b><\/a>Cells are treated with PE (50 \u03bcM), zileuton (100 \u03bcM), and GW6471 (10 \u03bcM) for 24 h. \u03b1-Actinin staining (n = 6) results in H9c2 cells.
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\nGW6471<\/strong>\u00a0purchased from MCE. Usage Cited in:\u00a0Oxid Med Cell Longev<\/cite>. 2019 Nov 3;2019:7536803. \u00a0<\/a>[Abstract]<\/b><\/a>The antihypertrophic effects of zileuton ar counteracted by GW6471 as indicated by increased PE-induced hypertrophic marker transcription, cell surface area, and oxidative stress when compared with those in the PE group and PE+ zileuton group.<\/div>\n<\/div>\n

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MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5316\u5408\u7269\u54c1\u724c<\/td>\n\u5316\u5408\u7269CAS\u865f<\/td>\n\u5316\u5408\u7269\u540d\u7a31<\/td>\n\u5316\u5408\u7269\u8ca8\u865f<\/td>\n\u5316\u5408\u7269\u4ecb\u7d39<\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#108321-42-2<\/td>\nG-418 disulfat<\/td>\nMCE\u8ca8\u865fHY-17561<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#68528-80-3<\/td>\nDSS Crosslinker (disuccinimidyl suberate)<\/td>\nMCE\u8ca8\u865fHY-W019543<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1380723-44-3<\/td>\nAtezolizumab<\/td>\nMCE\u8ca8\u865fHY-P9904<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1207456-01-6<\/td>\nTalazoparib (BMN-673; LT-673)<\/td>\nMCE\u8ca8\u865fHY-16106<\/span><\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#763113-22-0<\/td>\nOlaparib<\/td>\nMCE\u8ca8\u865fHY-10162<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1382764-52-4<\/td>\nLipidGreen 2\u8102\u8cea\u6210\u50cf\u5c0f\u5206\u5b50\u63a2\u91dd<\/td>\nMCE\u8ca8\u865fHY-D1353<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#103404-75-7<\/td>\nD-\u87a2\u5149\u7d20(D-luciferin) \u6c34\u6eb6\u6027\u9209\u9e7d<\/td>\nMCE\u8ca8\u865fHY-12591<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#15144-35-9<\/td>\nD-\u87a2\u5149\u7d20(D-Luciferin potassium)<\/td>\nMCE\u8ca8\u865fHY-12591B<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#186689-07-6<\/td>\n2-NBDG\u6d3b\u7d30\u80de\u548c\u7d44\u7e54\u8461\u8404\u7cd6\u7684\u651d\u53d6<\/td>\nMCE\u8ca8\u865fHY-116215<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\n<\/td>\nIPTG\u00a0 ( Isopropyl \u03b2-D-thiogalactoside)<\/td>\nMCE\u8ca8\u865fHY-15921<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#10121-91-2<\/td>\n\u81ea\u566c\u6ce1(autophagic vacuoles)\u87a2\u5149\u6a19\u8a8c<\/td>\nMCE\u8ca8\u865fHY-D1027<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#28728-55-4<\/td>\n\u805a\u51dd\u80fa(Polybrene) \u967d\u96e2\u5b50\u805a\u5408\u7269<\/td>\nMCE\u8ca8\u865fHY-112735<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#288250-47-5<\/td>\nY-320 \u514d\u75ab\u8abf\u7bc0\u5291<\/td>\nMCE\u8ca8\u865fHY-15898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#30931-67-0<\/td>\nABTS diammonium salt<\/td>\nMCE\u8ca8\u865fHY-15902<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#16561-29-8<\/td>\nPhorbol 12-myristate 13-acetate, PMA<\/td>\nMCE\u8ca8\u865fHY-18739<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#50-63-5<\/td>\n\u78f7\u9178\u6c2f\u55b9 Chloroquine phosphate<\/td>\nMCE\u8ca8\u865fHY-17589<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9003-11-6<\/td>\nPoloxamer 407<\/td>\nMCE\u8ca8\u865fHY-D1005<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#150347-59-4<\/td>\nCFSE\u87a2\u5149\u67d3\u6599<\/td>\nMCE\u8ca8\u865fHY-D0938<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9025-71-2<\/td>\n\u55ae\u5be7\u9176(Tannase)<\/td>\nMCE\u8ca8\u865fHY-P2877<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 941678-49-5<\/td>\nRuxolitinib<\/td>\nMCE\u8ca8\u865fHY-50856<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#9002-92-0<\/td>\nPolidocanol<\/td>\nMCE\u8ca8\u865fHY-B2106<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#HY-100579<\/td>\nFerrostatin-1 (Synonyms: Fer-1)<\/td>\nMCE\u8ca8\u865f HY-100579<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#154-23-4<\/td>\n\u5152\u8336\u7d20(Catechin)<\/td>\nMCE\u8ca8\u865f HY-N0898<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nFT895\u5f37\u6548\u9078\u64c7\u6027 HDAC11 \u6291\u5236\u5291<\/td>\nMCE\u8ca8\u865f HY-112285<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 5471-63-6<\/td>\n1,3-\u4e8c\u82ef\u57fa\u7570\u82ef\u4e26\u544b\u5583 (DPBF)<\/td>\nMCE\u8ca8\u865f HY-W011664<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 2225728-57-2<\/td>\nAkaLumine hydrochloride<\/td>\nMCE\u8ca8\u865fHY-112641A<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#203115-63-3<\/td>\nWRN \u89e3\u65cb\u9176\u6291\u5236\u5291NSC 617145<\/td>\nMCE\u8ca8\u865f \u00a0HY-110185<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#2244-11-3<\/td>\nAlloxan hydrate<\/td>\nMCE\u8ca8\u865fHY-W017227<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#23491-44-3<\/td>\nHoechst 33258<\/td>\nMCE\u8ca8\u865fHY-15558<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#18883-66-4<\/td>\nStreptozotocin<\/td>\nMCE\u8ca8\u865fHY-13753<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#554435-83-5<\/td>\nDeferasirox (Fe3+ chelate)<\/td>\nMCE\u8ca8\u865f\u00a0HY-16564<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#124-20-9<\/td>\nSpermidine<\/td>\nMCE\u8ca8\u865f\u00a0HY-B1776<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#298-83-9<\/td>\nNBT<\/td>\nMCE\u8ca8\u865fHY-15925<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#298-83-9<\/td>\nBCIP<\/td>\nMCE\u8ca8\u865f HY-15909<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#35013-72-0<\/td>\n\u751f\u7269\u7d20-NHS(Biotin-NHS)<\/td>\nMCE\u8ca8\u865f HY-D0802<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 25988-63-0<\/td>\nPoly-L-lysine hydrobromide<\/td>\nMCE\u8ca8\u865f HY-126437C<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 1898-66-4<\/td>\n\u6297\u6c27\u5316\u5291\u8207\u81ea\u7531\u57fa\u6e05\u9664\u6d3b\u6027\u6e2c\u91cf-DPPH<\/td>\nMCE\u8ca8\u865f HY-112053<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#92214-54-5<\/td>\n12-O-Tiglylphorbol-13-isobutyrate<\/td>\nMCE\u8ca8\u865f HY-107227<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 9001-73-4<\/td>\nPapain<\/td>\nMCE\u8ca8\u865f HY-P1645<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS#1069-66-5<\/td>\nValproic acid sodium<\/td>\nMCE\u8ca8\u865f HY-10585A<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n
MCE(MedChemexpress)<\/td>\nCAS# 1391194-67-4<\/td>\n(2R)-Octyl-\u03b1-hydroxyglutarate<\/td>\nMCE\u8ca8\u865f HY-103641<\/td>\n\u7522\u54c1\u9023\u7d50<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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 <\/p>\n

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