{"id":42987,"date":"2023-06-09T17:37:51","date_gmt":"2023-06-09T09:37:51","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=42987"},"modified":"2023-06-13T17:34:47","modified_gmt":"2023-06-13T09:34:47","slug":"cd40%e9%87%8d%e7%b5%84%e8%9b%8b%e7%99%bd-t-b-cell-surface-proteins-bioworld%e8%b2%a8%e8%99%9fncp0208","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=42987","title":{"rendered":"CD40\u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP0208"},"content":{"rendered":"

CD40\u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP0208<\/span><\/strong><\/a><\/span><\/p>\n

CD40 Recombinant Protein<\/p>\n

CD40\uff0c\u4e5f\u7a31\u70ba\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u53d7\u9ad4\u8d85\u5bb6\u65cf\u6210\u54e1 5 (tumor necrosis factor receptor superfamily member 5 , TNFRSF5)\uff0c\u662f\u4e00\u7a2e I \u578b\u8de8\u819c\u86cb\u767d(Type I transmembrane protein )\uff0c\u8868\u9054\u65bc B \u7d30\u80de\u8868\u9762\u548c\u514d\u75ab\u7cfb\u7d71\u7684\u5c08\u696d\u6297\u539f\u5448\u905e\u7d30\u80de(professional antigen-presenting cells )\uff0c\u4ee5\u53ca\u5e7e\u7a2e\u975e\u9020\u8840\u7d30\u80de\u985e\u578b(non-hematopoietic cell types)\u548c\u764c\u75c7(cancers)\u3002 CD40 \u8207 CD40 ligand (CD40L\/TNFSF5) \u76f8\u4e92\u4f5c\u7528\uff0cCD40 ligand\u4e3b\u8981\u5728\u6d3b\u5316\u7684 T \u7d30\u80de\u4e0a\u8868\u9054\uff0c\u4f46\u4e5f\u6709\u5831\u5c0e\u5728\u8840\u5c0f\u677f(blood platelets)\u3001\u80a5\u5927\u7d30\u80de(mast cells)\u3001\u55dc\u9e7c\u6027\u7c92\u7d30\u80de(basophils)\u3001NK \u7d30\u80de(NK cells)\u548c B \u7d30\u80de\u4e0a\u8868\u9054\u3002\u5728\u8207 CD40L \u7d50\u5408\u5f8c\uff0cCD40 \u901a\u904e TNF \u53d7\u9ad4( TNF receptor )\u76f8\u95dc\u56e0\u5b50\u548c MAP \u6fc0\u9176\u4fe1\u865f\u901a\u8def(MAP kinase signaling pathways)\u767c\u51fa\u4fe1\u865f\uff0c\u5c0e\u81f4\u591a\u7a2e\u514d\u75ab( immune)\u548c\u708e\u75c7\u53cd\u61c9(inflammatory responses)\uff0c\u5305\u62ec\u6a39\u7a81\u72c0\u7d30\u80de\u6fc0\u6d3b( dendritic cell activation)\u548c\u4ea4\u53c9\u5448\u905e(cross-presentation)\u3001T \u7d30\u80de\u4f9d\u8cf4\u6027\u514d\u75ab\u7403\u86cb\u767d\u985e\u5225\u8f49\u63db(T cell-dependent immunoglobulin class switching)\u3001\u8a18\u61b6 B \u7d30\u80de\u767c\u80b2(memory B cell development)\u548cgerminal center \u5f62\u6210\u3002 CD40\/CD40L \u8ef8\u5c0d\u65bc\u7d30\u80de\u548c\u9ad4\u6db2\u9069\u61c9\u6027\u514d\u75ab(humoral adaptive immunity)\u7684\u555f\u52d5\u548c\u9032\u5c55\u81f3\u95dc\u91cd\u8981\uff0c\u662f\u816b\u7624\u514d\u75ab\u5b78(tumor immunology)\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5(neurodegenerative diseases)\u3001\u8840\u7ba1\u75be\u75c5(vascular diseases)\u548c\u708e\u75c7\u6027\u75be\u75c5( inflammatory disorders)\u7814\u7a76\u4e2d\u7684\u4e00\u500b\u91cd\u8981\u9818\u57df\u3002<\/p>\n

https:\/\/bioworlde.com\/<\/a><\/p>\n

<\/p>\n

 <\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Product Name<\/td>\nCD40 Recombinant Protein<\/td>\n<\/tr>\n
Catalog No.<\/td>\nNCP0208<\/td>\n<\/tr>\n
Swiss-Prot<\/td>\nP25942<\/a><\/td>\n<\/tr>\n
Host<\/td>\nE.coli<\/td>\n<\/tr>\n
Tag<\/td>\nHis-tag in C-terminal<\/td>\n<\/tr>\n
Restriction sites<\/td>\nNdeI-XhoI<\/td>\n<\/tr>\n
Background<\/td>\n<\/td>\n<\/tr>\n
Soluble<\/td>\nPBS, 4M Urea, PH7.4<\/td>\n<\/tr>\n
Purification&Purity<\/td>\nTransferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).<\/td>\n<\/tr>\n
Concentration<\/td>\n\u22650.5mg\/ml<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Product Name :<\/b>
\nCD40 Recombinant Protein<\/p>\n

Swiss-Prot :<\/b>
\nP25942<\/a><\/p>\n

Host :<\/b>
\nE.coli<\/p>\n

Tag :<\/b>
\n\u22650.5mg\/ml<\/p>\n

Soluble :<\/b>
\nPBS, 4M Urea, PH7.4<\/p>\n

Purification&Purity :<\/b>
\nTransferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).<\/p>\n

Storage&Stability :<\/b>
\nStore at 4\u00b0C short term. Aliquot and store at -20\u00b0C long term. Avoid freeze-thaw cycles.<\/p>\n

Expression vector :<\/b>
\npet-22b(+)<\/p>\n

BiowMW :<\/b>
\n~19kDa<\/p>\n","protected":false},"excerpt":{"rendered":"

CD40\u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP0208 […]<\/p>\n","protected":false},"author":3,"featured_media":31670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5799],"tags":[5829],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42987"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42987"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42987\/revisions"}],"predecessor-version":[{"id":42988,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42987\/revisions\/42988"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/31670"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42987"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42987"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42987"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}