{"id":42947,"date":"2023-06-09T15:29:43","date_gmt":"2023-06-09T07:29:43","guid":{"rendered":"https:\/\/biopioneer.com.tw\/?p=42947"},"modified":"2023-06-09T17:14:13","modified_gmt":"2023-06-09T09:14:13","slug":"cd105-%e9%87%8d%e7%b5%84%e8%9b%8b%e7%99%bd-t-b-cell-surface-proteins-bioworld%e8%b2%a8%e8%99%9fncp0171","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=42947","title":{"rendered":"CD105 \u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP0171"},"content":{"rendered":"

CD105 \u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP0171<\/span><\/a><\/span><\/p>\n

CD105\/Endoglin \u662f TGF-\u03b2 \u53d7\u9ad4\u8907\u5408\u7269( TGF-\u03b2 receptor complex)\u7684\u8f14\u52a9\u53d7\u9ad4(auxiliary receptor )\uff0c\u5728\u76f8\u95dc\u4fe1\u865f\u901a\u8def( signaling pathway)\u4e2d\u767c\u63ee\u4f5c\u7528\u3002 CD105\/\u5167\u76ae\u7cd6\u86cb\u767d(CD105\/Endoglin)\u662f\u4e00\u7a2e\u8de8\u819c\u86cb\u767d( transmembrane protein )\uff0c\u4ee5\u4e8c\u786b\u9375\u9023\u63a5(disulfide-linked homodimer)\u7684\u540c\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\u3002\u5b83\u4e3b\u8981\u8868\u9054\u65bc\u8840\u7ba1\u548c\u7d50\u7de0\u7d44\u7e54\u4ee5\u53ca\u5167\u76ae\u7d30\u80de\u548c\u57fa\u8cea\u7d30\u80de\u3002\u64da\u5831\u5c0e\uff0c\u5728\u50b7\u53e3\u7652\u5408(wound healing )\u548c\u816b\u7624\u8840\u7ba1\u5f62\u6210(tumor vascularization)\u904e\u7a0b\u4e2d\uff0c\u4ee5\u53ca\u5728\u708e\u75c7\u7d44\u7e54(inflammatory tissues)\u548c\u767c\u80b2\u4e2d\u7684\u80da\u80ce( developing embryos)\u4e2d\uff0c CD105\/\u5167\u76ae\u7cd6\u86cb\u767d(CD105\/Endoglin)\u8868\u9054\u4e0a\u8abf\u3002\u5df2\u767c\u73fe CD105\/\u5167\u76ae\u7cd6\u86cb\u767d(CD105\/Endoglin)\u7684\u7a81\u8b8a\u662f\u907a\u50b3\u6027\u51fa\u8840\u6027\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7 (hereditary hemorrhagic telangiectasia, HHT) \u7684\u81f4\u75c5\u56e0\u7d20\uff0c\u907a\u50b3\u6027\u51fa\u8840\u6027\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7 (hereditary hemorrhagic telangiectasia, HHT) \u662f\u4e00\u7a2e\u4ee5\u8840\u7ba1\u7d50\u69cb\u7578\u5f62\u70ba\u7279\u5fb5\u7684\u75be\u75c5\u3002\u9019\u7a2e\u86cb\u767d\u8cea\u5c0d\u6b63\u5e38\u548c\u816b\u7624\u8840\u7ba1\u529f\u80fd(tumor vascular function)\u7684\u91cd\u8981\u6027\u4f7f\u5176\u6210\u70ba\u5167\u76ae\u7d30\u80de\u589e\u6b96(endothelial cell proliferatio)\u7684\u826f\u597d\u6a19\u8a8c\u7269\u4ee5\u53ca\u764c\u75c7\u7684\u6f5b\u5728\u6cbb\u7642\u9776\u9ede\u3002<\/p>\n

https:\/\/bioworlde.com\/\u00a0<\/a><\/p>\n

<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Product Name<\/td>\nCD105 Recombinant Protein<\/td>\n<\/tr>\n
Catalog No.<\/td>\nNCP0171<\/td>\n<\/tr>\n
Swiss-Prot<\/td>\nP17813<\/a><\/td>\n<\/tr>\n
Host<\/td>\nE.coli<\/td>\n<\/tr>\n
Tag<\/td>\nHis-tag in C-terminal<\/td>\n<\/tr>\n
Restriction sites<\/td>\nNdeI-XhoI<\/td>\n<\/tr>\n
Background<\/td>\n<\/td>\n<\/tr>\n
Soluble<\/td>\nPBS, 4M Urea, PH7.4<\/td>\n<\/tr>\n
Purification&Purity<\/td>\nTransferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).<\/td>\n<\/tr>\n
Concentration<\/td>\n\u22650.5mg\/ml<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

<\/p>\n

Expression vector :<\/b>
\npet-22b(+)<\/p>\n

BiowMW :<\/b>
\n~62kDa<\/p>\n

Soluble :<\/b>
\nPBS, 4M Urea, PH7.4<\/p>\n

Purification&Purity :<\/b>
\nTransferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).<\/p>\n

Storage&Stability :<\/b>
\nStore at 4\u00b0C short term. Aliquot and store at -20\u00b0C long term. Avoid freeze-thaw cycles.<\/p>\n

Restriction sites :<\/b>
\nNdeI-XhoI<\/p>\n","protected":false},"excerpt":{"rendered":"

CD105 \u91cd\u7d44\u86cb\u767d | T\/B cell surface proteins BioWorld\u8ca8\u865fNCP017 […]<\/p>\n","protected":false},"author":3,"featured_media":31670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5799],"tags":[5822],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42947"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42947"}],"version-history":[{"count":7,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42947\/revisions"}],"predecessor-version":[{"id":42971,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/42947\/revisions\/42971"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/31670"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42947"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}