{"id":41658,"date":"2023-04-25T12:36:58","date_gmt":"2023-04-25T04:36:58","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41658"},"modified":"2025-09-03T11:45:47","modified_gmt":"2025-09-03T03:45:47","slug":"parmodulin-2-synonyms-ml161-cas423735-93-7-medchemexpressmce%e8%b2%a8%e8%99%9fhy-13965","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=41658","title":{"rendered":"Parmodulin 2 (Synonyms: ML161) | CAS#423735-93-7 MedChemExpress(MCE)\u8ca8\u865fHY-13965"},"content":{"rendered":"

MCE (MedChem Express) –Parmodulin 2 (Synonyms: ML161) <\/span><\/span><\/span><\/span><\/strong><\/span><\/p>\n

MCE\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds(\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs(\u539f\u6599\u85e5)\u53caNatural compounds(\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002<\/p>\n

<\/p>\n

Parmodulin 2 (ML161) \u662f\u86cb\u767d\u9176\u6fc0\u6d3b\u53d7\u9ad4 1 (protease-activated receptor 1, PAR1) \u7684\u8b8a\u69cb\u6291\u5236\u5291(allosteric inhibitor)\uff0cIC50 \u70ba 0.26 \u03bcM\u3002 Parmodulin 2 \u662f\u4e00\u7a2e\u6709\u6548\u7684\u975e\u7af6\u722d\u6027\u6291\u5236\u5291(non-competitive inhibitor )\uff0c\u53ef\u6291\u5236 SFLLRN \u8a98\u5c0e\u7684 P-\u9078\u64c7\u7d20(P-selectin<\/a>\u00a0)\u8868\u9054\uff0c\u5f9e\u800c\u6291\u5236\u9ad4\u5916\u8840\u5c0f\u677f\u805a\u96c6(platelet aggregation )\u548c\u9ad4\u5167\u8840\u5c0f\u677f\u8840\u6813\u5f62\u6210(platelet thrombus formation)\u3002Parmodulin 2\uff08ML161\uff1b10 \u00b5M\uff1b\u6301\u7e8c 30 \u5206\u9418\uff09\u6291\u5236\u5167\u76ae HUVEC \u7d30\u80de\u4e2d\u7684\u4fc3\u708e\u4fe1\u865f(proinflammatory signaling)\u3002Parmodulin 2\uff08ML161\uff1b5 mg\/kg\uff1bIV\uff09\u986f\u8457\u6291\u5236\u8840\u5c0f\u677f\u8840\u6813\u5f62\u6210\uff0cAUC\uff08\u66f2\u7dda\u4e0b\u9762\u7a4d\uff09\u6291\u5236 73%[2]\u3002Parmodulin 2 \u5728\u9ad4\u5167\u6291\u5236\u8840\u5c0f\u677f\u8840\u6813\u5f62\u6210\uff0c\u4e0d\u5ef6\u9577\u51fa\u8840\u6642\u9593\u3002 Parmodulin 2 \u901a\u904e Par1 \u548c \u03b12A \u814e\u4e0a\u817a\u7d20\u80fd\u53d7\u9ad4\u9078\u64c7\u6027\u5730\u6291\u5236\u8840\u5c0f\u677f\u805a\u96c6 [2]\u3002<\/p>\n

Parmodulin 2 (Synonyms: ML161)|\u00a0 CAS#423735-93-7 MedChemExpress(MCE)\u8ca8\u865fHY-13965<\/a><\/span><\/p>\n

\"\"<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

\"\"<\/p>\n

Parmodulin 2<\/em>\u00a0Chemical Structure<\/span><\/strong><\/span><\/p>\n

CAS No. :\u00a0423735-93-7<\/span><\/strong><\/span><\/p>\n

\"\"<\/p>\n

MedChemexpress (MCE) \u7522\u54c1<\/span><\/h4>\n

MCE (MedChemexpress) \u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\uff0c\u63d0\u4f9b\u7a2e\u985e\u9f4a\u5168\u7684\u5316\u5b78\u53ca\u751f\u5316\u7814\u7a76\u7528\u7522\u54c1\uff0c\u5305\u62ec\u5275\u65b0\u7684\u751f\u547d\u79d1\u5b78\u8a66\u5291\uff0creference compounds (\u6a19\u6e96\u5316\u5408\u7269)\uff0cAPIs (\u539f\u6599\u85e5) \u53caNatural compounds (\u5929\u7136\u5316\u5408\u7269)\u4ee5\u63d0\u4f9b\u5be6\u9a57\u5ba4\u6216\u79d1\u5b78\u7814\u7a76\u4e4b\u7528\uff0cMedChemExpress(MCE)\u7522\u54c150000+ \u7279\u7570\u6027\u6291\u5236\u5291\u3001\u5316\u5408\u7269\u5eab\u3001\u91cd\u7d44\u86cb\u767d\uff0c\u5c08\u6ce8\u65bc\u4fe1\u865f\u901a\u8def\u548c\u75be\u75c5\u7814\u7a76\u9818\u57df\u3002\u5168\u7403\u6587\u737b\u5ee3\u6cdb\u5f15\u7528\uff0c\u8cea\u63a7\u9ad4\u7cfb\u56b4\u683c\uff0c\u54c1\u8cea100%\u3002\u5b98\u7db2\u9023\u7d50<\/span> https:\/\/www.medchemexpress.com<\/a><\/span><\/span><\/p>\n

\u2022Anti-infection<\/a><\/span><\/strong><\/h4>\n

\u2022Antibody-drug Conjugate\/ADC Related<\/a><\/span><\/strong><\/h4>\n

\u2022Apoptosis<\/a><\/span><\/strong><\/h4>\n

\u2022Autophagy<\/a><\/span><\/strong><\/h4>\n

\u2022Cell Cycle\/DNA Damage<\/a><\/span><\/strong><\/h4>\n

\u2022Cytoskeleton<\/a><\/span><\/strong><\/h4>\n

\u2022Epigenetics<\/a><\/span><\/strong><\/h4>\n

\u2022GPCR\/G Protein<\/a><\/span><\/strong><\/h4>\n

\u2022Immunology\/Inflammation<\/a><\/span><\/strong><\/h4>\n

\u2022JAK\/STAT Signaling<\/a>\u2022MAPK\/ERK Pathway<\/a><\/span><\/strong><\/h4>\n

\u2022Membrane Transporter\/Ion Channel<\/a><\/span><\/strong><\/h4>\n

\u2022Metabolic Enzyme\/Protease<\/a><\/span><\/strong><\/h4>\n

\u2022Neuronal Signaling<\/a><\/span><\/strong><\/h4>\n

\u2022NF-\u03baB<\/a><\/span><\/strong><\/h4>\n

\u2022PI3K\/Akt\/mTOR<\/a><\/span><\/strong><\/h4>\n

\u2022PROTAC<\/a><\/span><\/strong><\/h4>\n

\u2022Protein Tyrosine Kinase\/RTK<\/a>\u2022Stem Cell\/Wnt<\/a><\/span><\/strong><\/h4>\n

\u2022TGF-beta\/Smad<\/a><\/span><\/strong><\/h4>\n

\u2022Vitamin D Related<\/a><\/span><\/strong><\/h4>\n

\u2022Others<\/a><\/span><\/strong><\/h4>\n","protected":false},"excerpt":{"rendered":"

MCE (MedChem Express) –Parmodulin 2 (Synonyms: ML […]<\/p>\n","protected":false},"author":3,"featured_media":52860,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5369],"tags":[6867,5652,6866,6869,6865,6868],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41658"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41658"}],"version-history":[{"count":5,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41658\/revisions"}],"predecessor-version":[{"id":52861,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41658\/revisions\/52861"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/52860"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41658"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}