{"id":41031,"date":"2023-04-13T11:25:44","date_gmt":"2023-04-13T03:25:44","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=41031"},"modified":"2023-04-19T17:41:11","modified_gmt":"2023-04-19T09:41:11","slug":"chop%e6%8a%97%e9%ab%94-chop-antibody%e8%b2%a8%e8%99%9fir129-522-ireal-biotechnology-%e8%89%be%e9%8b%ad%e7%94%9f%e6%8a%80","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=41031","title":{"rendered":"CHOP\u6297\u9ad4 |CHOP antibody\u8ca8\u865fIR129-522 (IReal Biotechnology \u827e\u92ed\u751f\u6280)"},"content":{"rendered":"<p><span style=\"color: #33cccc;\"><strong><span style=\"font-size: 12pt;\"><a href=\"http:\/\/biopioneer.com.tw\/?news=%e3%80%90%e9%85%b5%e7%b4%a0%e5%85%8d%e7%96%ab%e5%88%86%e6%9e%90%e5%84%80%e3%80%91%e8%a7%b8%e6%8e%a7%e8%9e%a2%e5%b9%95%e6%bf%be%e7%89%87%e5%bc%8f-elisa-reader-rayto-rt-6900\"><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/11\/HOT.jpg\" alt=\"HOT\" width=\"50\" height=\"38\" \/><\/a><a style=\"color: #33cccc;\" href=\"http:\/\/biopioneer.com.tw\/?p=41031\">CHOP\u6297\u9ad4 |CHOP antibody\u8ca8\u865fIR129-522 (IReal Biotechnology \u827e\u92ed\u751f\u6280)<\/a><\/span><\/strong><\/span><\/p>\n<p>CHOPantibody (IReal Biotechnology \u827e\u92ed\u751f\u6280,IR129-522)<\/p>\n<p>iReal \u827e\u92b3\u751f\u6280\u7368\u5bb6\u6253\u9020\u51faMonoclonal-like Polyclonal Antibody\uff0c\u514d\u75ab\u539f(Immunogen)\u70ba\u61c9\u7528\u77ed\u93c8\u80dc\u80bd(peptide)\u70ba\u6297\u539f\u8a2d\u8a08\u51fa\u767c\u9ede\uff0c\u6311\u9078\u5404\u86cb\u767d\u6700\u4f73\u7684\u4f4d\u9ede(epitope) \u8fa8\u8b58\u4f4d\u4f86\u8fa8\u8a8d\u76ee\u6a19\u86cb\u767d\uff0ciReal\u00a0\u514d\u75ab\u8840\u6e05\u7d93\u904e\u4e00\u9023\u591a\u6b65\u9a5f\u7684\u7d14\u5316\u904e\u7a0b(Affinity column purified )\uff0c\u53bb\u9664\u6389\u5404\u7a2e\u975e\u5c08\u4e00\u6027\u7684\u86cb\u767d\uff0c\u4ee5\u964d\u4f4e\u6297\u9ad4\u7684\u80cc\u666f\u503c\uff1b\u540c\u6642\u85c9\u7531\u5154\u5b50\u7368\u7279\u7684\u514d\u75ab\u7cfb\u7d71\u6240\u7522\u751f\u7684\u6297\u9ad4\uff0c\u80fd\u5920\u7522\u2f63\u8a31\u591a\u2f7c\u2fcf\u514d\u75ab\u7cfb\u7d71\u4e0d\u80fd\u8b58\u5225\u7684\u6297\u539f\u7684\u6297\u9ad4\u3002\u64c1\u6709\u5404\u5b78\u8853\u55ae\u4f4d\u771f\u5be6\u6578\u64da\u7684\u9a57\u8b49\uff0c\u4e26\u5177\u5099\u81e8\u5e8a\u9a57\u8b49\u898f\u683c\u7684\u6297\u9ad4\u54c1\u8cea\uff0c\u5927\u91cf\u4e14\u73fe\u8ca8\u4f9b\u61c9\u3002<\/p>\n<p><span style=\"color: #808080;\">CHOP antibody\u00a0<\/span>(Endogenous)\uff0c\u91dd\u5c0dCHOP\u5177\u6709\u5c08\u4e00\u8868\u73fe\uff0c\u53ef\u61c9\u7528\u65bcWestern Blot\u3001IF\u3001IHC(Paraffin)\u5be6\u9a57\uff0c\u7269\u7a2e\u4f86\u6e90\u70baRabbit-IgG\uff0c\u53cd\u61c9\u7269\u7a2e: Human\u3002<\/p>\n<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/03\/IREAL-WB\u5be6\u9a57\u64cd\u4f5c\u624b\u518a.pdf\">Weatern Blot\u64cd\u4f5c\u624b\u518a<\/a><\/span><\/p>\n<p>Western Blot 1:500\u20131:1000<br \/>\nImmunofluorescence 1:300\u20131:500<br \/>\nImmunohistochemistry (Paraffin) 1:100-1:200<\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">CHOP\u6297\u9ad4Vimentin antibody\u7522\u54c1\u4ecb\u7d39:<\/span><\/strong><\/span><\/p>\n<p>This gene encodes a member of the CCAAT\/enhancer-binding protein (C\/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C\/EBP members, such as C\/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]<\/p>\n<p>\u8a72\u57fa\u56e0\u7de8\u78bc CCAAT\/\u589e\u5f37\u5b50\u7d50\u5408\u86cb\u767d (C\/EBP) \u8f49\u9304\u56e0\u5b50\u5bb6\u65cf\u7684\u6210\u54e1\u3002\u8a72\u86cb\u767d\u8cea\u901a\u904e\u8207\u5176\u4ed6 C\/EBP \u6210\u54e1\uff08\u5982 C\/EBP \u548c LAP\uff08\u809d\u6fc0\u6d3b\u86cb\u767d\uff09\uff09\u5f62\u6210\u7570\u4e8c\u805a\u9ad4\u4e26\u963b\u6b62\u5176 DNA \u7d50\u5408\u6d3b\u6027\uff0c\u5f9e\u800c\u767c\u63ee\u986f\u6027\u5931\u6d3b\u6291\u88fd\u5291\u7684\u4f5c\u7528\u3002\u8a72\u86cb\u767d\u8cea\u8207\u8102\u80aa\u751f\u6210\u548c\u7d05\u7d30\u80de\u751f\u6210\u6709\u95dc\uff0c\u88ab\u5167\u8cea\u7db2\u61c9\u6fc0\u6fc0\u6d3b\uff0c\u4e26\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u3002\u901a\u904e\u6613\u4f4d\u8a98\u5c0e\u8a72\u57fa\u56e0\u8207 16 \u865f\u67d3\u8272\u9ad4\u4e0a\u7684 FUS \u6216 22 \u865f\u67d3\u8272\u9ad4\u4e0a\u7684 EWSR1 \u878d\u5408\uff0c\u5728\u7c98\u6db2\u6a23\u8102\u80aa\u8089\u7624\u6216\u5c24\u6587\u8089\u7624\u4e2d\u7522\u751f\u5d4c\u5408\u86cb\u767d\u3002\u5df2\u7d93\u9451\u5b9a\u51fa\u7de8\u78bc\u5169\u7a2e\u4e0d\u540c\u9577\u5ea6\u7684\u4e9e\u578b\u7684\u591a\u500b\u9078\u64c7\u6027\u526a\u63a5\u7684\u8f49\u9304\u672c\u8b8a\u9ad4\u3002[\u7531 RefSeq \u63d0\u4f9b\uff0c2010 \u5e74 8 \u6708]<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/04\/CHOP\u6297\u9ad4-CHOP-antibody\u8ca8\u865fIR129-522-IReal-Biotechnology-\u827e\u92ed\u751f\u6280.pdf\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-11-300x97.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df 1_\u5de5\u4f5c\u5340\u57df 1\" width=\"149\" height=\"48\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.irealbio.com\/Upload\/Products\/1662365677_a9f96af9e17a2651d088.jpg\" alt=\"IR129-522 \u6297 CHOP \u6297\u9ad4 WB \u5716\u50cf\" width=\"502\" height=\"276\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u6297 CHOP \u6297\u9ad4 WB \u5716\u50cf(IREAL, #IR129-522)<\/span><\/strong><\/span><\/p>\n<p>\u6240\u6709\u6cf3\u9053\uff1a\u6297 CHOP \u6297\u9ad4 &#8211; 1\/500 \u7a00\u91cb<br \/>\n\u88c2\u89e3\u7269\/\u86cb\u767d\u8cea\uff0c\u6bcf\u6cf3\u9053 50 \u03bcg<br \/>\n\u8a72\u5370\u8de1\u662f\u4f7f\u7528 10% SDS-PAGE \u7522\u751f\u7684\u3002\u51dd\u81a0\u5728 140V \u4e0b\u904b\u884c 50 \u5206\u9418\uff0c\u7136\u5f8c\u5728 18V \u4e0b\u8f49\u79fb\u5230\u785d\u9178\u7e96\u7dad\u7d20\u819c\u4e0a 60 \u5206\u9418\u3002\u7136\u5f8c\u5c07\u819c\u5c01\u9589\u4e00\u5c0f\u6642\uff0c\u7136\u5f8c\u5728 4\u00b0C \u4e0b\u8207 IR129-522 \u4e00\u8d77\u5b75\u80b2\u904e\u591c\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.irealbio.com\/Upload\/Products\/1662365687_b595d5c54a51057efd58.jpg\" alt=\"IR129-522 \u6297 CHOP \u6297\u9ad4 WB \u5716\u50cf\" width=\"546\" height=\"300\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u6297 CHOP \u6297\u9ad4 WB \u5716\u50cf(IREAL, #IR129-522)<\/span><\/strong><\/span><br \/>\n\u6240\u6709\u6cf3\u9053\uff1a\u6297 CHOP \u6297\u9ad4 &#8211; 1\/800 \u7a00\u91cb<br \/>\n\u88c2\u89e3\u7269\/\u86cb\u767d\u8cea\uff0c\u6bcf\u6cf3\u9053 50 \u03bcg<br \/>\n\u8a72\u5370\u8de1\u662f\u4f7f\u7528 10% SDS-PAGE \u7522\u751f\u7684\u3002\u7136\u5f8c\u5c07\u785d\u9178\u7e96\u7dad\u7d20\u819c\u5c01\u9589\u4e00\u5c0f\u6642\uff0c\u7136\u5f8c\u5728 4\u00b0C \u4e0b\u8207 IR129-522 \u4e00\u8d77\u5b75\u80b2\u904e\u591c\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.irealbio.com\/Upload\/Products\/1664244960_89bbcc096e3414a90a04.jpg\" alt=\"IR129-522 \u6297 CHOP \u6297\u9ad4 ICC\/IF \u5716\u50cf\" width=\"338\" height=\"296\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u6297 CHOP \u6297\u9ad4 ICC\/IF \u5716\u50cf(IREAL, #IR129-522)<\/span><\/strong><\/span><br \/>\n\u514d\u75ab\u7192\u5149\uff1a\u7d30\u80de\u5728\u5ba4\u6eab\u4e0b\u7528 4% \u591a\u805a\u7532\u919b\u56fa\u5b9a 10 \u5206\u9418\uff0c\u5728\u5ba4\u6eab\u4e0b\u7528 0.1% NP-40 \u900f\u5316 10 \u5206\u9418\uff0c\u7136\u5f8c\u5728\u5ba4\u6eab\u4e0b\u7528 5% BSA \u5c01\u9589 30 \u5206\u9418\u3002\u5728 1:400 \u548c 4\u00b0C \u4e0b\u7528 IR129-522 \u6297 CHOP \u6297\u9ad4\uff08\u7d05\u8272\uff09\u5c0d\u7d30\u80de\u9032\u884c\u67d3\u8272\u3002DAPI\uff08\u85cd\u8272\uff09\u7528\u4f5c\u6838\u8907\u67d3\u5291\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/www.irealbio.com\/Upload\/Products\/1664244969_29db209211e71d7dc8b2.jpg\" alt=\"IR129-522 \u6297 CHOP \u6297\u9ad4 IHC \u5716\u50cf\" width=\"524\" height=\"288\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">\u6297 CHOP \u6297\u9ad4 IHC \u5716\u50cf(IREAL, #IR129-522)<\/span><\/strong><\/span><\/p>\n<p>\u7528 1\/200 \u7684 IR129-522 \u6a19\u8a18 CHOP \u7684\u77f3\u881f\u5305\u57cb\u4eba\u985e\u764c\u75c7\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u5206\u6790\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/02\/IREAL-IHC%E7%97%85%E7%90%86%E6%8A%97%E9%AB%94.png\" alt=\"\" \/><\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">IHC\/\u75c5\u7406\u5b78\u6297\u9ad4(IHC\/Pathology antibodies)<\/span><\/strong><\/span><\/p>\n<p>Please note that related Positive Control Slides are also available. \u5206\u5b50\u75c5\u7406\u5b78(molecular pathology)\u4e2d\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78(Immunohistochemistry)\u626e\u6f14\u91cd\u8981\u4f5c\u7528\uff1a\u8a3a\u65b7(Diagnosis)\u3001\u9810\u5f8c(Prognosis)\u548c\u9810\u6e2c(Predictive)\u3002 IHC \u6297\u9ad4(IHC antibodies)\u5df2\u88ab\u78ba\u5b9a\u70ba\u7528\u65bc\u798f\u723e\u99ac\u6797\u56fa\u5b9a\u77f3\u881f\u5207\u7247(formalin-fixed paraffin sections)\u514d\u75ab\u7d44\u7e54\u5316\u5b78(immunohistochemistry)\u7684\u6700\u4f73\u8a66\u5291\u3002\u6240\u6709 IHC\/\u75c5\u7406\u5b78\u6297\u9ad4(IHC\/Pathology antibodies)\u50c5\u4f9b\u7814\u7a76\u4f7f\u7528\u3002IHC\/\u75c5\u7406\u5b78\u6297\u9ad4\u5df2\u7d93\u91dd\u5c0d\u4eba\u9ad4\/\u8001\u9f20\/\u5927\u9f20\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u9032\u884c\u4e86\u5ee3\u6cdb\u7684\u6e2c\u8a66\u548c\u9a57\u8b49(Pathology validated)\uff0c\u4e26\u7d93\u904e\u7cbe\u5fc3\u8a2d\u8a08\uff0c\u53ef\u63d0\u4f9b\u4e00\u81f4\u3001\u7279\u7570\u6027\u548c\u654f\u611f\u7684\u67d3\u8272\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">PD-1\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7a0b\u5e8f\u6027\u6b7b\u4ea1 1 (Programmed Death 1, PD-1) \u662f T \u7d30\u80de\u8abf\u7bc0\u5291(T-cell regulators) CD28\/CTLA-4 \u5bb6\u65cf\u7684\u6210\u54e1\uff0c\u5728\u6d3b\u5316\u7684 T \u7d30\u80de\u3001B \u7d30\u80de\u548c\u5de8\u566c\u7d30\u80de\u8868\u9762\u8868\u9054\u70ba\u5171\u53d7\u9ad4(co-receptor)\u3002\u65b0\u7684\u7814\u7a76\u8868\u660e\uff0cPD-1\/PD-L1 \u4fe1\u865f\u901a\u8def\u53ef\u80fd\u8207\u6297\u816b\u7624\u514d\u75ab\u6709\u95dc\uff0c\u56e0\u70ba PD-L1 \u5df2\u88ab\u8b49\u660e\u53ef\u8a98\u5c0e\u6d3b\u5316 T \u7d30\u80de\u51cb\u4ea1(apoptosis)\u6216\u6291\u5236\u7d30\u80de\u6bd2\u6027 T \u7d30\u80de(cytotoxic T cells)\u7684\u6d3b\u6027\u3002\u8207 CD10 \u548c BCL6 \u4e0d\u540c\uff0cPD-1 \u50c5\u7531\u5c11\u6578 B \u7d30\u80de\u8868\u9054\uff0c\u56e0\u6b64\u6297 PD-1 \u53ef\u80fd\u662f\u8840\u7ba1\u514d\u75ab\u6bcd\u7d30\u80de\u6027\u6dcb\u5df4\u7624(angioimmunoblastic lymphoma)\u4e2d\u66f4\u7279\u7570\u548c\u6709\u7528\u7684\u8a3a\u65b7\u6a19\u8a8c\u7269\u3002&gt;&gt;\u00a0<span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/?p=39023\">PD-L1\/CD274 C\u672b\u7aef\u6297\u9ad4<\/a><\/span><\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">CTLA4\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>CD152 \u6297\u539f\uff0c\u4e5f\u7a31\u70ba CTLA4\uff0c\u662f\u4e00\u7a2e\u5c6c\u65bc\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf(immunoglobulin superfamily)\u7684\u5b8c\u6574\u819c\u86cb\u767d\uff0c\u5176\u8868\u9054\u70ba 30 kDa \u55ae\u9ad4(30 kDa monomer)\u6216\u4e8c\u786b\u9375\u9023\u63a5\u7684\u540c\u578b\u4e8c\u805a\u9ad4(disulfide-linked homodimer)\u3002\u5b83\u8207T\u7d30\u80de\u6297\u539fCD28(T cell antigen CD28)\u5177\u6709\u540c\u6e90\u6027\uff0c\u8207CD28\u4e00\u6a23\uff0c\u662fCD80\u548cCD86\u7684\u914d\u9ad4(ligand)\u3002 CTLA-4 \u662f T \u8f14\u52a9\u7d30\u80de\u4e0a\u7684\u4e00\u7a2e\u53d7\u9ad4\uff0c\u53ef\u4f5c\u70ba\u514d\u75ab\u6aa2\u67e5\u9ede(immune checkpoint)\u548c\u514d\u75ab\u53cd\u61c9\u7684\u4e0b\u8abf\u56e0\u5b50\u3002 CTLA-4 \u7684\u7a81\u8b8a\u8207\u8a31\u591a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5(autoimmune diseases)\u6709\u95dc\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">Lp-PLA2\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>Lp-PLA2\uff0c\u4e5f\u7a31\u70ba\u8102\u86cb\u767d\u76f8\u95dc\u78f7\u8102\u9176 A2 (Lipoprotein-associated Phospholipase A2)\u6216\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\u4e59\u9170\u6c34\u89e3\u9176 (platelet-activating factor acetylhydrolase , PAF-AH)\uff0c\u662f\u4e00\u7a2e\u7531\u708e\u75c7\u7d30\u80de(inflammatory cells )\u7522\u751f\u7684\u9176\uff0c\u5176\u529f\u80fd\u662f\u4f7f\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50(platelet-activating factor)\u5931\u6d3b\u548c\u964d\u89e3(degrade)\uff0c\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\u662f\u4e00\u7a2e\u6709\u6548\u7684\u4fc3\u708e\u6027\u78f7\u8102(pro-inflammatory phospholipid)\uff0c\u540c\u6642\u9084\u8ca0\u8cac\u6c34\u89e3\u6c27\u5316\u4fee\u98fe(hydrolyzing oxidatively modified)\u7684\u591a\u4e0d\u98fd\u548c\u8102\u80aa\u9178(polyunsaturated fatty acids)\u3002 Lp-PLA2 \u7684\u9176\u4fc3\u4f5c\u7528\u7522\u7269\u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316(atherosclerosis)\u7684\u767c\u5c55\u6709\u95dc\uff0c\u4e26\u8207\u51a0\u5fc3\u75c5(coronary heart disease)\u548c\u4e2d\u98a8(stroke)\u7684\u98a8\u96aa\u589e\u52a0\u5448\u6b63\u76f8\u95dc\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">Muc2\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7c98\u86cb\u767d 2(Mucin 2)\uff0c\u4e5f\u7a31\u70ba MUC2\uff0c\u662f\u4e00\u7a2e\u7de8\u78bc\u7c98\u86cb\u767d\u5bb6\u65cf(mucin protein family)\u6210\u54e1\u7684\u4eba\u985e\u57fa\u56e0\u3002\u7531\u8a72\u57fa\u56e0\u7de8\u78bc\u7684\u86cb\u767d\u8cea\u5f62\u6210\u4fdd\u8b77\u8178\u8154(gut lumen)\u7684\u4e0d\u6eb6\u6027\u7c98\u6db2\u5c4f\u969c\u3002\u5728\u6b63\u5e38\u7d50\u8178(normal colon)\u3001\u4e73\u817a(breast)\u3001\u524d\u5217\u817a(prostate)\u548c\u553e\u6db2\u817a(salivary gland)\u7b49\u4eba\u9ad4\u7d44\u7e54\u4ee5\u53ca\u80c3\u8178\u9053(gastrointestinal)\u3001\u7d50\u8178(colonic)\u3001\u4e73\u817a(breast)\u548c\u524d\u5217\u817a\u816b\u7624(prostate neoplasia)\u4e2d\u6aa2\u6e2c\u5230 MUC2 \u8868\u9054\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">\u7d30\u80de\u89d2\u86cb\u767d 18 (Cytokeratin 18) \u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7d30\u80de\u89d2\u86cb\u767d 18 (Cytokeratin 18, CK 18) \u662f\u4e00\u7a2e 45kDa \u7684\u86cb\u767d\u8cea\uff0c\u5c6c\u65bc\u9178\u6027\u985e\u578b\u7684\u7d30\u80de\u89d2\u86cb\u767d(cytokeratins)\uff0c\u901a\u5e38\u5728\u7c21\u55ae\u7684\u975e\u5206\u5c64\u4e0a\u76ae\u7d30\u80de(non-stratified epithelia)\u4e2d\u8868\u9054\u3002\u7136\u800c\uff0cCK 18 \u4e5f\u5728\u79fb\u884c\u4e0a\u76ae(transitional epithelium)\u7684\u57fa\u5e95\u7d30\u80de\u548c\u8868\u5c64\u7d30\u80de\u4ee5\u53ca\u8907\u96dc\u4e0a\u76ae(complex epithelia)\u7684\u7ba1\u8154\/\u5206\u6ccc\u7d30\u80de(luminal\/secretory cells)\u4e2d\u8868\u9054\u3002 CK 18 \u6297\u9ad4\u5728\u8d77\u6e90\u65bc\u7c21\u55ae\u548c\u817a\u9ad4\u4e0a\u76ae(glandular epithelium)\u7684\u817a\u764c(Adenocarcinomas)\u4ee5\u53ca\u9c57\u72c0\u7d30\u80de\u764c(Squamous Carcinoma)\u7684\u4f4e\u5206\u5316\u816b\u7624\u7d30\u80de\u4e2d\u5448\u967d\u6027\u67d3\u8272\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">MLH1\u75c5\u7406\u5b78\u6297\u9ad4\u00a0<\/span>\u662f\u4e00\u7a2e\u932f\u914d\u4fee\u5fa9\u86cb\u767d(mismatch repair protein)\uff0c\u8207 MSH2\u3001MSH6 \u548c PMS2 \u4e00\u8d77\u53c3\u8207\u7dad\u6301\u907a\u50b3\u4fe1\u606f\u7684\u5b8c\u6574\u6027\u3002\u9019\u7a2e\u86cb\u767d\u8cea\u901a\u5e38\u8207\u907a\u50b3\u6027(hereditary)\u975e\u606f\u8089\u75c5\u6027\u7d50\u76f4\u8178\u764c(non-polyposis colorectal cancer)\u6709\u95dc\uff0c\u56e0\u70ba MLH1 \u57fa\u56e0\u5728\u60a3\u6709\u9019\u7a2e\u764c\u75c7\u7684\u60a3\u8005\u4e2d\u7d93\u5e38\u767c\u751f\u7a81\u8b8a\u3002\u7814\u7a76\u8868\u660e\uff0cMLH1 \u5728\u5927\u90e8\u5206\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\u6027(microsatellite instability)\u4ee5\u53ca\u5b50\u5bae\u5167\u819c\u764c(endometrial)\u548c\u5375\u5de2\u764c(ovarian cancers)\u60a3\u8005\u4e2d\u5b58\u5728\u7f3a\u9677\u3002\u7576\u5728 IHC \u9762\u677f\u4e2d\u8207 MSH6\u3001MSH2 \u548c PMS2 \u914d\u5c0d\u6642\uff0c\u6297 MLH1 \u7684\u4f7f\u7528\u5f97\u5230\u512a\u5316\u3002<\/p>\n<p><span style=\"color: #008080; font-size: 12pt;\">HER2\u75c5\u7406\u5b78\u6297\u9ad4:<\/span><\/p>\n<p>HER2\u5728 10-20% \u7684\u4e73\u817a\u764c\u60a3\u8005(breast cancer patients)\u4e2d\u88ab\u8b58\u5225\u51fa\u4f86\u3002 Her2\/Neu (c-erbB-2) \u539f\u764c\u57fa\u56e0(proto-oncogene)\u662f\u4e00\u7a2e\u8de8\u819c\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176(transmembrane receptor tyrosine kinase)\uff0c\u5728\u8a31\u591a\u764c\u75c7\u4e2d\u90fd\u6709\u81e8\u5e8a\u8868\u73fe\u3002 c-erbB-2 \u86cb\u767d\u7684\u904e\u5ea6\u8868\u9054(Overexpression)\u8207\u5c0e\u7ba1\u4e73\u817a\u764c(ductal breast cancer)\u4ee5\u53ca\u80ba\u817a\u764c(pulmonary)\u548c\u80c3\u817a\u764c(gastric adenocarcinomas)\u6709\u95dc\u3002Her2 \u548c p53 \u4e4b\u9593\u7684\u76f8\u95dc\u6027\u4e5f\u5df2\u88ab\u8b49\u660e\uff0c\u56e0\u70ba\u9019\u5169\u7a2e\u86cb\u767d\u7684\u904e\u5ea6\u8868\u9054\u8207\u8180\u80f1\u764c\u65e9\u671f\u4fb5\u8972(early invasion)\u548c\u8f49\u79fb(metastasis)\u6709\u95dc\u3002<\/p>\n<p><span style=\"font-size: 12pt; color: #008080;\">Ki-67\u00a0<\/span>\u662f\u4e00\u7a2e\u6838\u975e\u7d44\u86cb\u767d(nuclear non-histone protein)\uff0c\u5728\u975c\u6b62\u7d30\u80de(quiescent cells)\u4e2d\u4ee5\u4f4e\u6c34\u5e73\u5b58\u5728\uff0c\u4f46\u5728\u589e\u6b96\u7d30\u80de(proliferating cells)\u4e2d\u589e\u52a0\uff0c\u5c24\u5176\u662f\u5728 G2\u3001M \u548c S \u671f\u5f8c\u534a\u671f\u3002\u56e0\u6b64\uff0cKi-67 \u53cd\u61c9\u6027\uff08\u5b9a\u7fa9\u70ba\u901a\u904e IHC \u67d3\u8272\u6e2c\u91cf\u7684\u67d3\u8272\u967d\u6027\u7684\u816b\u7624\u7d30\u80de\u767e\u5206\u6bd4\uff09\u662f\u7d30\u80de\u589e\u6b96(cell proliferation)\u7684\u7279\u7570\u6027\u6838\u6a19\u8a18(nuclear marker )\u3002\u904e\u5ea6\u8868\u9054\u7d93\u5e38\u51fa\u73fe\u5728\u5404\u7a2e\u60e1\u6027\u7d44\u7e54(malignant tissues )\u4e2d\uff0c\u4e26\u4e14\u8207\u60a3\u6709\u795e\u7d93\u5167\u5206\u6ccc\u816b\u7624(neuroendocrine tumor)\u7684\u500b\u9ad4\u7684\u8f03\u5dee\u5b58\u6d3b\u7387\u76f8\u95dc\u3002&gt;&gt;<span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"http:\/\/biopioneer.com.tw\/?p=39025\">IHC\u75c5\u7406\u5b78\u6297\u9ad4-Ki-67\u00a0\u6297\u9ad4<\/a><strong><span style=\"font-size: 12pt;\">\u00a0<\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.irealbio.com\/Upload\/Editor\/u\/c4ca4238a0b923820dcc509a6f75849b\/e8abb21c17f13576949dd00fff6d7bec10fb5fa2.jpg\" alt=\"Better Choice for iReal Clinical-IHC antibody\" \/><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #800080;\"><strong>Exosome \u7814\u7a76\u5de5\u5177\/\u764c\u75c7\u76f8\u95dcExosomal Protein Marker<\/strong><\/span>&#8211;<span style=\"color: #ff9900;\">IReal Biotechnology<\/span><\/span><\/p>\n<p>IREAL\u63d0\u4f9b\u591a\u7a2e\u9ad8\u8cea\u91cf\u5916\u6ccc\u9ad4(exosomes)\u55ae\u591a\u682a\u6297\u9ad4 (IREAL Antibody)\uff0c\u5305\u62ec<span style=\"color: #666699;\"><a style=\"color: #666699;\" href=\"http:\/\/biopioneer.com.tw\/?p=39202\">CD9(#IR300-981)<\/a><\/span>\u3001<span style=\"color: #666699;\"><a style=\"color: #666699;\" href=\"http:\/\/biopioneer.com.tw\/?p=39550\">CD63(#IR301-983)<\/a><\/span>\u3001<span style=\"color: #666699;\"><a style=\"color: #666699;\" href=\"http:\/\/biopioneer.com.tw\/?p=39573\">CD81(#IR302-986)<\/a><\/span>\u3001<a href=\"http:\/\/biopioneer.com.tw\/?p=39654\">Flotillin-1(#IR304-990)<\/a>\u3001<span style=\"color: #666699;\"><a style=\"color: #666699;\" href=\"http:\/\/biopioneer.com.tw\/?p=39576\">Alix(#IR303-988)<\/a><\/span>\u7b2c\u4e09\u65b9\u9a57\u8b49IHC\/IF\/WB\u6297\u9ad4\u3002\u5916\u6ccc\u9ad4(exosomes)\u53e6\u6709\u63d0\u4f9b\u5957\u7d44\u578b\u5f0f\u7684<span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.irealbio.com\/products\/info\/196\">\u6297\u9ad4Panel\u5957\u7d44<\/a>\u3002<\/span><\/p>\n<p>\u8b58\u5225\u5916\u6ccc\u9ad4(exosomes)\u7684\u6700\u5e38\u898b\u8de8\u819c\u6a19\u8a18\u4f86\u81ea\u56db\u8de8\u819c\u86cb\u767d\u5bb6\u65cf\uff08CD63 \u3001CD81 \u548c CD9\uff09\u3002\u8a72\u5bb6\u65cf\u4e2d\u7684\u86cb\u767d\u8cea\u5177\u6709\u56db\u500b\u8de8\u819c\u5340\u57df\uff0c\u4e26\u4e14\u5b9a\u4f4d\u65bc\u8cea\u819c\u4e2d\u5bcc\u542b\u56db\u8de8\u819c\u86cb\u767d\u7684\u5fae\u57df (\u00a0tetraspanin enriched microdomains, TEM)\u3002\uff08CD63 \u3001CD81 \u3001 CD9\u53caCD82\uff09\u8207\u7c98\u9644\u5206\u5b50(\u00a0adhesion molecules)\u3001\u8de8\u819c\u53d7\u9ad4(\u00a0transmembrane receptors)\u548c\u7d30\u80de\u5167\u4fe1\u865f\u86cb\u767d(intracellular signaling proteins)\u76f8\u95dc\uff0c\u4ee5\u4fc3\u9032\u548c\u8abf\u7bc0\u4fe1\u865f(\u00a0signaling events)\u4e8b\u4ef6\u3002\u9ad8\u8cea\u91cf\u5916\u6ccc\u9ad4(exosomes)\u55ae\u591a\u682a\u6297\u9ad4 (IREAL Antibody)\uff0c\u63d0\u4f9b\u60a8\u66f4\u591aExosome \u7814\u7a76\u5de5\u5177\uff0c\u53ef\u61c9\u7528\u65bcIHC\/IF\/WB\u6297\u9ad4\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/01\/%E7%B6%B2%E7%AB%99%E8%A6%8F%E6%A0%BC%E5%B0%8F%E5%9C%96-%E5%93%81%E7%89%8C%E4%BB%8B%E7%B4%B9_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x120.jpg\" alt=\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716 \u54c1\u724c\u4ecb\u7d39_\u5de5\u4f5c\u5340\u57df 1\" width=\"146\" height=\"60\" \/><\/p>\n<p><span style=\"font-size: 12pt;\"><span style=\"color: #339966;\"><strong>BRAND\/AGENCY\/<\/strong><strong>\u53f0\u7063\u4ee3\u7406\u5546<\/strong><\/span><strong><span style=\"color: #339966;\">\/<\/span><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.irealbio.com\/\">\u00a0<\/a><\/span><\/strong><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.irealbio.com\/\"><strong>IREAL<\/strong><strong>\u827e\u92b3\u53f0\u7063\u4ee3\u7406\u5546<\/strong><\/a><\/span><\/span><\/p>\n<p>IREAL\u827e\u92ed\u5b98\u7db2\u00a0<span style=\"color: #993366;\"><a style=\"color: #993366;\" href=\"https:\/\/www.irealbio.com\/\">https:\/\/www.irealbio.com\/<\/a><\/span><\/p>\n<p>IREAL\u827e\u92ed\u751f\u7269\u79d1\u6280\u63d0\u4f9b\u6642\u4e0b\u71b1\u9580\u7814\u7a76\u9818\u57dfEMT marker\u3001Apoptosis\u3001ER stress\u3001Cell Cycle\u3001Autophagy\u53caNeuroscience\u7b49\u5e38\u7528\u6297\u9ad4\uff0c\u4e26\u63d0\u4f9b\u5ba2\u88fd\u5316\u6297\u9ad4\u670d\u52d9\u5e73\u53f0\u3002iReal\u00a0\u827e\u92ed\u751f\u7269\u79d1\u6280\u63d0\u4f9b\u6642\u4e0b\u71b1\u9580\u7814\u7a76\u9818\u57dfEMT marker\u3001Apoptosis\u3001ER stress\u3001Cell Cycle\u3001Autophagy\u53caNeuroscience\u7b49\u5e38\u7528\u6297\u9ad4\uff0c\u4e26\u63d0\u4f9b\u5ba2\u88fd\u5316\u6297\u9ad4\u670d\u52d9\u5e73\u53f0\u3002iReal \u827e\u92b3\u751f\u6280\u7368\u5bb6\u6253\u9020\u51faMonoclonal-like Polyclonal Antibody\uff0c\u514d\u75ab\u539f(Immunogen)\u70ba\u61c9\u7528\u77ed\u93c8\u80dc\u80bd(peptide)\u70ba\u6297\u539f\u8a2d\u8a08\u51fa\u767c\u9ede\uff0c\u6311\u9078\u5404\u86cb\u767d\u6700\u4f73\u7684\u4f4d\u9ede(epitope) \u8fa8\u8b58\u4f4d\u4f86\u8fa8\u8a8d\u76ee\u6a19\u86cb\u767d\uff0ciReal\u00a0\u514d\u75ab\u8840\u6e05\u7d93\u904e\u4e00\u9023\u591a\u6b65\u9a5f\u7684\u7d14\u5316\u904e\u7a0b(Affinity column purified )\uff0c\u53bb\u9664\u6389\u5404\u7a2e\u975e\u5c08\u4e00\u6027\u7684\u86cb\u767d\uff0c\u4ee5\u964d\u4f4e\u6297\u9ad4\u7684\u80cc\u666f\u503c\uff1b\u540c\u6642\u85c9\u7531\u5154\u5b50\u7368\u7279\u7684\u514d\u75ab\u7cfb\u7d71\u6240\u7522\u751f\u7684\u6297\u9ad4\uff0c\u80fd\u5920\u7522\u2f63\u8a31\u591a\u2f7c\u2fcf\u514d\u75ab\u7cfb\u7d71\u4e0d\u80fd\u8b58\u5225\u7684\u6297\u539f\u7684\u6297\u9ad4\u3002\u64c1\u6709\u5404\u5b78\u8853\u55ae\u4f4d\u771f\u5be6\u6578\u64da\u7684\u9a57\u8b49\uff0c\u4e26\u5177\u5099\u81e8\u5e8a\u9a57\u8b49\u898f\u683c\u7684\u6297\u9ad4\u54c1\u8cea\uff0c\u5927\u91cf\u4e14\u73fe\u8ca8\u4f9b\u61c9IHC\/IF\/WB\u6297\u9ad4\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2023\/02\/IREAL%E8%89%BE%E9%8A%B3%E5%85%8D%E7%96%AB%E6%9F%93%E8%89%B2%E6%8A%97%E9%AB%94-%E5%A4%AA%E9%BC%8E%E7%94%9F%E6%8A%80_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x300.jpg\" alt=\"IREAL\u827e\u92b3\u514d\u75ab\u67d3\u8272\u6297\u9ad4-\u592a\u9f0e\u751f\u6280_\u5de5\u4f5c\u5340\u57df 1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%9E%8B%E9%8C%84%E4%B8%8B%E8%BC%89.gif\" alt=\"\u578b\u9304\u4e0b\u8f09\" width=\"150\" height=\"50\" \/><\/p>\n<p><a href=\"http:\/\/biopioneer.com.tw\/?news=%E3%80%90yihder-lab-20%E5%85%AC%E5%8D%87%E6%81%86%E6%BA%AB%E5%BE%AA%E7%92%B0%E6%B0%B4%E6%A7%BD%E3%80%91%E6%B0%B4%E6%B5%B4%E6%A7%BDwaterbath-%E8%B2%A8%E8%99%9Fbh-230d-yihder\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2023\/02\/%E7%8E%BB%E7%89%87%E5%85%A8%E6%99%AF%E6%8E%83%E7%9E%84%E6%9C%8D%E5%8B%99.jpg\" alt=\"\" width=\"963\" height=\"324\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CHOP\u6297\u9ad4 |CHOP antibody\u8ca8\u865fIR129-522 (IReal Biotechnology \u827e [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":38534,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5264],"tags":[5584],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41031"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41031"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41031\/revisions"}],"predecessor-version":[{"id":41054,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/41031\/revisions\/41054"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/38534"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41031"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}