{"id":39023,"date":"2023-02-26T13:55:38","date_gmt":"2023-02-26T05:55:38","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=39023"},"modified":"2023-02-27T10:28:57","modified_gmt":"2023-02-27T02:28:57","slug":"39023","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=39023","title":{"rendered":"IHC\u75c5\u7406\u5b78\u6297\u9ad4-PD-L1\/CD274 C\u672b\u7aef\u6297\u9ad4 | IReal antibodies\u8ca8\u865fIR167-643"},"content":{"rendered":"

IHC\/Pathology Antibodies<\/strong>–IReal Biotechnology<\/span><\/span><\/p>\n

IREAL\u63d0\u4f9b\u591a\u7a2e\u9ad8\u8cea\u91cf\u75c5\u7406\u55ae\u591a\u682a\u6297\u9ad4 (IREAL Antibody)\uff0c\u5305\u62ec HER2\u3001EGFR\u3001PD-1\u3001Ki-67\u3001EpCAM\u3001Cytokeratin 7\u00a0\u3001CD3\u3001Fatty Acid Synthase\/FASN\u3001CD44\u3001CD45\u3001SQSTM1\u3001CD62E\/E-selectin\u3001CDX2\u3001GON4L\u3001ST3GAL1\/SIAT4A\u7b49\u591a\u7a2e\u75c5\u7406\u5b78\u8a8d\u8b49\u6297\u9ad4 (Pathology Validated Antibodies)\u3002<\/p>\n

\"\"<\/p>\n

\"HOT\"<\/a>IHC\u75c5\u7406\u5b78\u6297\u9ad4-PD-L1\/CD274 C\u672b\u7aef\u6297\u9ad4 |\u00a0IReal Biotechnology\u8ca8\u865fIR167-643<\/a><\/span><\/span><\/strong><\/span><\/p>\n

IREAL PD-L1\/CD274 C terminal\u75c5\u7406\u5b78\u6297\u9ad4 (Endogenous)\uff0c\u91dd\u5c0d PD-L1 \/ CD274 \u5177\u6709\u5c08\u4e00\u8868\u73fe\uff0c\u53ef\u61c9\u7528\u65bcIHC(Paraffin)\u3001IF(Immunofluorescence)\u3001Western Blot & Immunoprecipitation: Reported in the literature, not verified in house\u5be6\u9a57\uff0c\u7269\u7a2e\u4f86\u6e90\u70baRabbit-IgG\uff0c\u53cd\u61c9\u7269\u7a2e: Human\u3002<\/p>\n

\u75c5\u7406\u5b78\u6297\u9ad4\u7522\u54c1\u4ecb\u7d39:<\/span><\/strong><\/span><\/p>\n

\u8a72\u57fa\u56e0\u7de8\u78bc\u4e00\u7a2e\u514d\u75ab\u6291\u5236\u53d7\u9ad4\u914d\u9ad4(immune inhibitory receptor ligand)\uff0c\u7531\u9020\u8840(hematopoietic)\u548c\u975e\u9020\u8840\u7d30\u80de(non-hematopoietic cells)\u8868\u9054\uff0c\u5982 T \u7d30\u80de\u548c B \u7d30\u80de\u4ee5\u53ca\u5404\u7a2e\u985e\u578b\u7684\u816b\u7624\u7d30\u80de(tumor cells)\u3002\u7de8\u78bc\u7684\u86cb\u767d\u8cea\u662f\u4e00\u7a2e I \u578b\u8de8\u819c\u86cb\u767d(type I transmembrane protein)\uff0c\u5177\u6709\u514d\u75ab\u7403\u86cb\u767d V \u6a23(immunoglobulin V-like)\u548c C \u6a23\u7d50\u69cb\u57df(C-like domains)\u3002\u8a72\u914d\u9ad4\u8207\u5176\u53d7\u9ad4\u7684\u76f8\u4e92\u4f5c\u7528\u6291\u5236 T \u7d30\u80de\u6d3b\u5316(T-cell activation)\u548c\u7d30\u80de\u56e0\u5b50\u7522\u751f(cytokine production)\u3002\u5728\u6b63\u5e38\u7d44\u7e54\u611f\u67d3 ( infection)\u6216\u708e\u75c7(inflammation)\u671f\u9593\uff0c\u9019\u7a2e\u76f8\u4e92\u4f5c\u7528\u5c0d\u65bc\u901a\u904e\u7dad\u6301\u514d\u75ab\u53cd\u61c9\u7684\u7a69\u614b(homeostasis)\u4f86\u9810\u9632\u81ea\u8eab\u514d\u75ab(autoimmunity)\u5f88\u91cd\u8981\u3002\u5728\u816b\u7624\u5fae\u74b0\u5883(tumor microenvironments)\u4e2d\uff0c\u9019\u7a2e\u76f8\u4e92\u4f5c\u7528\u901a\u904e\u7d30\u80de\u6bd2\u6027 T \u7d30\u80de\u5931\u6d3b\u70ba\u816b\u7624\u7d30\u80de\u63d0\u4f9b\u514d\u75ab\u9003\u9038(immune escape)\u3002\u8a72\u57fa\u56e0\u5728\u816b\u7624\u7d30\u80de\u4e2d\u7684\u8868\u9054\u88ab\u8a8d\u70ba\u53ef\u9810\u6e2c(prognostic)\u8a31\u591a\u985e\u578b\u7684\u4eba\u985e\u60e1\u6027\u816b\u7624(human malignancies)\uff0c\u5305\u62ec\u7d50\u8178\u764c(colon cancer)\u548c\u814e\u7d30\u80de\u764c(renal cell carcinoma)\u3002\u53ef\u8b8a\u526a\u63a5(Alternative splicing)\u5c0e\u81f4\u591a\u500b\u8f49\u9304\u672c\u8b8a\u9ad4(multiple transcript variants)\u3002 [\u7531 RefSeq \u63d0\u4f9b\uff0c2015 \u5e74 9 \u6708]<\/p>\n

\"\u8a8d\u8b49\u6297\u9ad4_\u5de5\u4f5c\u5340\u57df<\/p>\n

\"IR167-643<\/p>\n

\u00a0\u6297 PD-L1 \u6297\u9ad4 IHC \u5716\u50cf\u00a0<\/span><\/strong><\/span>\u00a0(IREAL\u8ca8\u865fIR167-643)\u00a0<\/span><\/strong><\/h2>\n

\u7528 1\/150 \u7684 IR167-643 \u6a19\u8a18 PD-L1 \/ CD274 \u7684\u77f3\u881f\u5305\u57cb\u4eba\u4e73\u817a\u764c\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u5206\u6790\u3002<\/p>\n

\"IR167-643<\/p>\n

\u6297 PD-L1 \u6297\u9ad4 IHC \u5716\u50cf<\/span><\/strong><\/span>\u00a0(IREAL\u8ca8\u865fIR167-643)\u00a0<\/span><\/strong><\/h2>\n

\u7528 1\/150 \u7684 IR167-643 \u6a19\u8a18 PD-L1 \/ CD274 \u7684\u77f3\u881f\u5305\u57cb\u4eba\u4e73\u817a\u764c\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u5206\u6790\u3002<\/p>\n

\"IR167-643<\/p>\n

\u6297 PD-L1 \u6297\u9ad4 IHC \u5716\u50cf\u00a0<\/span><\/strong><\/span>\u00a0(IREAL\u8ca8\u865fIR167-643)\u00a0<\/span><\/strong><\/h2>\n

\u7528 1\/150 \u7684 IR167-643 \u6a19\u8a18 PD-L1 \/ CD274 \u7684\u77f3\u881f\u5305\u57cb\u4eba\u4e73\u817a\u764c\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u5206\u6790<\/p>\n

\"IR167-643<\/p>\n

\u6297 PD-L1 \u6297\u9ad4 ICC\/IF \u5716\u50cf (IREAL\u8ca8\u865fIR167-643)\u00a0<\/span><\/strong><\/h2>\n

\u7d30\u80de\u5728\u5ba4\u6eab\u4e0b\u7528 4% PFA \u56fa\u5b9a 10 \u5206\u9418\uff0c\u5728\u5ba4\u6eab\u4e0b\u7528 0.1% NP-40 \u6ef2\u900f 10 \u5206\u9418\uff0c\u7136\u5f8c\u5728\u5ba4\u6eab\u4e0b\u7528 5% BSA \u5c01\u9589 30 \u5206\u9418\u3002\u5728 1:200 \u548c 4\u00b0C \u4e0b\u7528 IR167-643 \u6297 PD-L1 \/ CD274 \u6297\u9ad4\uff08\u7d05\u8272\uff09\u67d3\u8272\u3002<\/p>\n

\"IR167-643<\/p>\n

\u6297 PD-L1 \u6297\u9ad4 WB\/IP \u5716\u50cf<\/span><\/strong><\/span>\u00a0(IREAL\u8ca8\u865fIR167-643)\u00a0<\/span><\/strong><\/h2>\n

\u5ba2\u6236\u53cd\u994b\uff1a
\n\u7d30\u80de\uff1aMDA-MB-231
\n1Ab\uff1aIR167-643 1-500
\n2Ab\uff1a\u6297\u5154 IgG\uff08\u8f15\u93c8\uff091-3000<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

\"\"<\/p>\n

IHC\/\u75c5\u7406\u5b78\u6297\u9ad4(IHC\/Pathology antibodies)<\/span><\/strong><\/span><\/p>\n

Please note that related Positive Control Slides are also available. \u5206\u5b50\u75c5\u7406\u5b78(molecular pathology)\u4e2d\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78(Immunohistochemistry)\u626e\u6f14\u91cd\u8981\u4f5c\u7528\uff1a\u8a3a\u65b7(Diagnosis)\u3001\u9810\u5f8c(Prognosis)\u548c\u9810\u6e2c(Predictive)\u3002 IHC \u6297\u9ad4(IHC antibodies)\u5df2\u88ab\u78ba\u5b9a\u70ba\u7528\u65bc\u798f\u723e\u99ac\u6797\u56fa\u5b9a\u77f3\u881f\u5207\u7247(formalin-fixed paraffin sections)\u514d\u75ab\u7d44\u7e54\u5316\u5b78(immunohistochemistry)\u7684\u6700\u4f73\u8a66\u5291\u3002\u6240\u6709 IHC\/\u75c5\u7406\u5b78\u6297\u9ad4(IHC\/Pathology antibodies)\u50c5\u4f9b\u7814\u7a76\u4f7f\u7528\u3002IHC\/\u75c5\u7406\u5b78\u6297\u9ad4\u5df2\u7d93\u91dd\u5c0d\u4eba\u9ad4\/\u8001\u9f20\/\u5927\u9f20\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u9032\u884c\u4e86\u5ee3\u6cdb\u7684\u6e2c\u8a66\u548c\u9a57\u8b49(Pathology validated)\uff0c\u4e26\u7d93\u904e\u7cbe\u5fc3\u8a2d\u8a08\uff0c\u53ef\u63d0\u4f9b\u4e00\u81f4\u3001\u7279\u7570\u6027\u548c\u654f\u611f\u7684\u67d3\u8272\u3002<\/p>\n

PD-1\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7a0b\u5e8f\u6027\u6b7b\u4ea1 1 (Programmed Death 1, PD-1) \u662f T \u7d30\u80de\u8abf\u7bc0\u5291(T-cell regulators) CD28\/CTLA-4 \u5bb6\u65cf\u7684\u6210\u54e1\uff0c\u5728\u6d3b\u5316\u7684 T \u7d30\u80de\u3001B \u7d30\u80de\u548c\u5de8\u566c\u7d30\u80de\u8868\u9762\u8868\u9054\u70ba\u5171\u53d7\u9ad4(co-receptor)\u3002\u65b0\u7684\u7814\u7a76\u8868\u660e\uff0cPD-1\/PD-L1 \u4fe1\u865f\u901a\u8def\u53ef\u80fd\u8207\u6297\u816b\u7624\u514d\u75ab\u6709\u95dc\uff0c\u56e0\u70ba PD-L1 \u5df2\u88ab\u8b49\u660e\u53ef\u8a98\u5c0e\u6d3b\u5316 T \u7d30\u80de\u51cb\u4ea1(apoptosis)\u6216\u6291\u5236\u7d30\u80de\u6bd2\u6027 T \u7d30\u80de(cytotoxic T cells)\u7684\u6d3b\u6027\u3002\u8207 CD10 \u548c BCL6 \u4e0d\u540c\uff0cPD-1 \u50c5\u7531\u5c11\u6578 B \u7d30\u80de\u8868\u9054\uff0c\u56e0\u6b64\u6297 PD-1 \u53ef\u80fd\u662f\u8840\u7ba1\u514d\u75ab\u6bcd\u7d30\u80de\u6027\u6dcb\u5df4\u7624(angioimmunoblastic lymphoma)\u4e2d\u66f4\u7279\u7570\u548c\u6709\u7528\u7684\u8a3a\u65b7\u6a19\u8a8c\u7269\u3002>>\u00a0PD-L1\/CD274 C\u672b\u7aef\u6297\u9ad4<\/a><\/span><\/p>\n

CTLA4\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>CD152 \u6297\u539f\uff0c\u4e5f\u7a31\u70ba CTLA4\uff0c\u662f\u4e00\u7a2e\u5c6c\u65bc\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf(immunoglobulin superfamily)\u7684\u5b8c\u6574\u819c\u86cb\u767d\uff0c\u5176\u8868\u9054\u70ba 30 kDa \u55ae\u9ad4(30 kDa monomer)\u6216\u4e8c\u786b\u9375\u9023\u63a5\u7684\u540c\u578b\u4e8c\u805a\u9ad4(disulfide-linked homodimer)\u3002\u5b83\u8207T\u7d30\u80de\u6297\u539fCD28(T cell antigen CD28)\u5177\u6709\u540c\u6e90\u6027\uff0c\u8207CD28\u4e00\u6a23\uff0c\u662fCD80\u548cCD86\u7684\u914d\u9ad4(ligand)\u3002 CTLA-4 \u662f T \u8f14\u52a9\u7d30\u80de\u4e0a\u7684\u4e00\u7a2e\u53d7\u9ad4\uff0c\u53ef\u4f5c\u70ba\u514d\u75ab\u6aa2\u67e5\u9ede(immune checkpoint)\u548c\u514d\u75ab\u53cd\u61c9\u7684\u4e0b\u8abf\u56e0\u5b50\u3002 CTLA-4 \u7684\u7a81\u8b8a\u8207\u8a31\u591a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5(autoimmune diseases)\u6709\u95dc\u3002<\/p>\n

Lp-PLA2\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>Lp-PLA2\uff0c\u4e5f\u7a31\u70ba\u8102\u86cb\u767d\u76f8\u95dc\u78f7\u8102\u9176 A2 (Lipoprotein-associated Phospholipase A2)\u6216\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\u4e59\u9170\u6c34\u89e3\u9176 (platelet-activating factor acetylhydrolase , PAF-AH)\uff0c\u662f\u4e00\u7a2e\u7531\u708e\u75c7\u7d30\u80de(inflammatory cells )\u7522\u751f\u7684\u9176\uff0c\u5176\u529f\u80fd\u662f\u4f7f\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50(platelet-activating factor)\u5931\u6d3b\u548c\u964d\u89e3(degrade)\uff0c\u8840\u5c0f\u677f\u6d3b\u5316\u56e0\u5b50\u662f\u4e00\u7a2e\u6709\u6548\u7684\u4fc3\u708e\u6027\u78f7\u8102(pro-inflammatory phospholipid)\uff0c\u540c\u6642\u9084\u8ca0\u8cac\u6c34\u89e3\u6c27\u5316\u4fee\u98fe(hydrolyzing oxidatively modified)\u7684\u591a\u4e0d\u98fd\u548c\u8102\u80aa\u9178(polyunsaturated fatty acids)\u3002 Lp-PLA2 \u7684\u9176\u4fc3\u4f5c\u7528\u7522\u7269\u8207\u52d5\u8108\u7ca5\u6a23\u786c\u5316(atherosclerosis)\u7684\u767c\u5c55\u6709\u95dc\uff0c\u4e26\u8207\u51a0\u5fc3\u75c5(coronary heart disease)\u548c\u4e2d\u98a8(stroke)\u7684\u98a8\u96aa\u589e\u52a0\u5448\u6b63\u76f8\u95dc\u3002<\/p>\n

Muc2\u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7c98\u86cb\u767d 2(Mucin 2)\uff0c\u4e5f\u7a31\u70ba MUC2\uff0c\u662f\u4e00\u7a2e\u7de8\u78bc\u7c98\u86cb\u767d\u5bb6\u65cf(mucin protein family)\u6210\u54e1\u7684\u4eba\u985e\u57fa\u56e0\u3002\u7531\u8a72\u57fa\u56e0\u7de8\u78bc\u7684\u86cb\u767d\u8cea\u5f62\u6210\u4fdd\u8b77\u8178\u8154(gut lumen)\u7684\u4e0d\u6eb6\u6027\u7c98\u6db2\u5c4f\u969c\u3002\u5728\u6b63\u5e38\u7d50\u8178(normal colon)\u3001\u4e73\u817a(breast)\u3001\u524d\u5217\u817a(prostate)\u548c\u553e\u6db2\u817a(salivary gland)\u7b49\u4eba\u9ad4\u7d44\u7e54\u4ee5\u53ca\u80c3\u8178\u9053(gastrointestinal)\u3001\u7d50\u8178(colonic)\u3001\u4e73\u817a(breast)\u548c\u524d\u5217\u817a\u816b\u7624(prostate neoplasia)\u4e2d\u6aa2\u6e2c\u5230 MUC2 \u8868\u9054\u3002<\/p>\n

\u7d30\u80de\u89d2\u86cb\u767d 18 (Cytokeratin 18) \u75c5\u7406\u5b78\u6297\u9ad4\uff1a<\/span>\u7d30\u80de\u89d2\u86cb\u767d 18 (Cytokeratin 18, CK 18) \u662f\u4e00\u7a2e 45kDa \u7684\u86cb\u767d\u8cea\uff0c\u5c6c\u65bc\u9178\u6027\u985e\u578b\u7684\u7d30\u80de\u89d2\u86cb\u767d(cytokeratins)\uff0c\u901a\u5e38\u5728\u7c21\u55ae\u7684\u975e\u5206\u5c64\u4e0a\u76ae\u7d30\u80de(non-stratified epithelia)\u4e2d\u8868\u9054\u3002\u7136\u800c\uff0cCK 18 \u4e5f\u5728\u79fb\u884c\u4e0a\u76ae(transitional epithelium)\u7684\u57fa\u5e95\u7d30\u80de\u548c\u8868\u5c64\u7d30\u80de\u4ee5\u53ca\u8907\u96dc\u4e0a\u76ae(complex epithelia)\u7684\u7ba1\u8154\/\u5206\u6ccc\u7d30\u80de(luminal\/secretory cells)\u4e2d\u8868\u9054\u3002 CK 18 \u6297\u9ad4\u5728\u8d77\u6e90\u65bc\u7c21\u55ae\u548c\u817a\u9ad4\u4e0a\u76ae(glandular epithelium)\u7684\u817a\u764c(Adenocarcinomas)\u4ee5\u53ca\u9c57\u72c0\u7d30\u80de\u764c(Squamous Carcinoma)\u7684\u4f4e\u5206\u5316\u816b\u7624\u7d30\u80de\u4e2d\u5448\u967d\u6027\u67d3\u8272\u3002<\/p>\n

MLH1\u75c5\u7406\u5b78\u6297\u9ad4\u00a0<\/span>\u662f\u4e00\u7a2e\u932f\u914d\u4fee\u5fa9\u86cb\u767d(mismatch repair protein)\uff0c\u8207 MSH2\u3001MSH6 \u548c PMS2 \u4e00\u8d77\u53c3\u8207\u7dad\u6301\u907a\u50b3\u4fe1\u606f\u7684\u5b8c\u6574\u6027\u3002\u9019\u7a2e\u86cb\u767d\u8cea\u901a\u5e38\u8207\u907a\u50b3\u6027(hereditary)\u975e\u606f\u8089\u75c5\u6027\u7d50\u76f4\u8178\u764c(non-polyposis colorectal cancer)\u6709\u95dc\uff0c\u56e0\u70ba MLH1 \u57fa\u56e0\u5728\u60a3\u6709\u9019\u7a2e\u764c\u75c7\u7684\u60a3\u8005\u4e2d\u7d93\u5e38\u767c\u751f\u7a81\u8b8a\u3002\u7814\u7a76\u8868\u660e\uff0cMLH1 \u5728\u5927\u90e8\u5206\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\u6027(microsatellite instability)\u4ee5\u53ca\u5b50\u5bae\u5167\u819c\u764c(endometrial)\u548c\u5375\u5de2\u764c(ovarian cancers)\u60a3\u8005\u4e2d\u5b58\u5728\u7f3a\u9677\u3002\u7576\u5728 IHC \u9762\u677f\u4e2d\u8207 MSH6\u3001MSH2 \u548c PMS2 \u914d\u5c0d\u6642\uff0c\u6297 MLH1 \u7684\u4f7f\u7528\u5f97\u5230\u512a\u5316\u3002<\/p>\n

HER2\u75c5\u7406\u5b78\u6297\u9ad4:<\/span><\/p>\n

HER2\u5728 10-20% \u7684\u4e73\u817a\u764c\u60a3\u8005(breast cancer patients)\u4e2d\u88ab\u8b58\u5225\u51fa\u4f86\u3002 Her2\/Neu (c-erbB-2) \u539f\u764c\u57fa\u56e0(proto-oncogene)\u662f\u4e00\u7a2e\u8de8\u819c\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176(transmembrane receptor tyrosine kinase)\uff0c\u5728\u8a31\u591a\u764c\u75c7\u4e2d\u90fd\u6709\u81e8\u5e8a\u8868\u73fe\u3002 c-erbB-2 \u86cb\u767d\u7684\u904e\u5ea6\u8868\u9054(Overexpression)\u8207\u5c0e\u7ba1\u4e73\u817a\u764c(ductal breast cancer)\u4ee5\u53ca\u80ba\u817a\u764c(pulmonary)\u548c\u80c3\u817a\u764c(gastric adenocarcinomas)\u6709\u95dc\u3002Her2 \u548c p53 \u4e4b\u9593\u7684\u76f8\u95dc\u6027\u4e5f\u5df2\u88ab\u8b49\u660e\uff0c\u56e0\u70ba\u9019\u5169\u7a2e\u86cb\u767d\u7684\u904e\u5ea6\u8868\u9054\u8207\u8180\u80f1\u764c\u65e9\u671f\u4fb5\u8972(early invasion)\u548c\u8f49\u79fb(metastasis)\u6709\u95dc\u3002<\/p>\n

Ki-67\u00a0<\/span>\u662f\u4e00\u7a2e\u6838\u975e\u7d44\u86cb\u767d(nuclear non-histone protein)\uff0c\u5728\u975c\u6b62\u7d30\u80de(quiescent cells)\u4e2d\u4ee5\u4f4e\u6c34\u5e73\u5b58\u5728\uff0c\u4f46\u5728\u589e\u6b96\u7d30\u80de(proliferating cells)\u4e2d\u589e\u52a0\uff0c\u5c24\u5176\u662f\u5728 G2\u3001M \u548c S \u671f\u5f8c\u534a\u671f\u3002\u56e0\u6b64\uff0cKi-67 \u53cd\u61c9\u6027\uff08\u5b9a\u7fa9\u70ba\u901a\u904e IHC \u67d3\u8272\u6e2c\u91cf\u7684\u67d3\u8272\u967d\u6027\u7684\u816b\u7624\u7d30\u80de\u767e\u5206\u6bd4\uff09\u662f\u7d30\u80de\u589e\u6b96(cell proliferation)\u7684\u7279\u7570\u6027\u6838\u6a19\u8a18(nuclear marker )\u3002\u904e\u5ea6\u8868\u9054\u7d93\u5e38\u51fa\u73fe\u5728\u5404\u7a2e\u60e1\u6027\u7d44\u7e54(malignant tissues )\u4e2d\uff0c\u4e26\u4e14\u8207\u60a3\u6709\u795e\u7d93\u5167\u5206\u6ccc\u816b\u7624(neuroendocrine tumor)\u7684\u500b\u9ad4\u7684\u8f03\u5dee\u5b58\u6d3b\u7387\u76f8\u95dc\u3002>>IHC\u75c5\u7406\u5b78\u6297\u9ad4-Ki-67\u00a0\u6297\u9ad4<\/a>\u00a0<\/span><\/strong><\/span><\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716<\/p>\n

BRAND\/AGENCY\/<\/strong>\u53f0\u7063\u4ee3\u7406\u5546<\/strong><\/span>\/<\/span>\u00a0<\/a><\/span><\/strong>IREAL<\/strong>\u827e\u92b3\u53f0\u7063\u4ee3\u7406\u5546<\/strong><\/a><\/span><\/span><\/p>\n

IREAL\u827e\u92ed\u5b98\u7db2 https:\/\/www.irealbio.com\/<\/a><\/span><\/p>\n

IREAL\u827e\u92ed\u751f\u7269\u79d1\u6280\u63d0\u4f9b\u6642\u4e0b\u71b1\u9580\u7814\u7a76\u9818\u57dfEMT marker\u3001Apoptosis\u3001ER stress\u3001Cell Cycle\u3001Autophagy\u53caNeuroscience\u7b49\u5e38\u7528\u6297\u9ad4\uff0c\u4e26\u63d0\u4f9b\u5ba2\u88fd\u5316\u6297\u9ad4\u670d\u52d9\u5e73\u53f0<\/p>\n

\"IREAL\u827e\u92b3\u514d\u75ab\u67d3\u8272\u6297\u9ad4-\u592a\u9f0e\u751f\u6280_\u5de5\u4f5c\u5340\u57df<\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
IR205-742<\/td>\np63<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR350-950<\/td>\nTTF-1 \/ NKX2-1 \/ Thyroid Transcription Factor<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IHC<\/td>\n<\/tr>\n
IR351-953<\/td>\nCDX2<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IHC<\/td>\n<\/tr>\n
IR297-2<\/td>\nST3GAL1 \/ SIAT4A<\/td>\nCancer Biomarker \/ Sialylation<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IRM309<\/td>\nc-Myc antibody [PK-9]<\/td>\nCancer oncology<\/td>\nMouse<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IRM013<\/td>\nGLI1, monoclonal antibody [23A]<\/td>\nCancer \/ EMT<\/td>\nMouse<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR291-959<\/td>\nIRF4 \/ MUM1<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR290-956<\/td>\nYAP1<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR219-807<\/td>\nMET \/ C-MET \/ HGFR<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR212-1<\/td>\nKI-67<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR212-772<\/td>\nKI-67 \/ MKI67<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IRQ6001<\/td>\nKi67 [SP6] Rab-monoclonal<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR222-861<\/td>\nPan-Cytokeratin, Pan-CK<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC, FC<\/td>\n<\/tr>\n
IR226-865<\/td>\nCytokeratin 5\/6, CK5\/6<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR228-868<\/td>\nCytokeratin 7, CK7<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR235-880<\/td>\nCytokeratin 14\/17, CK14\/17<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR236-890<\/td>\nCytokeratin 18\/19, CK18\/19<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR238-892<\/td>\nCytokeratin 20, CK20<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR229-871<\/td>\nCytokeratin 8, CK8<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR227-867<\/td>\nCytokeratin 7\/8, CK7\/8<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IHC<\/td>\n<\/tr>\n
IR223-862<\/td>\nCytokeratin 8\/18, CK8\/18<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IHC<\/td>\n<\/tr>\n
IR237-891<\/td>\nCytokeratin 8\/18\/19, CK8\/18\/19<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IHC<\/td>\n<\/tr>\n
IRCP005<\/td>\nGON4L<\/td>\nCancer Biomarker<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR218-1<\/td>\nEpCAM \/ CD326 (Intracellular domain)<\/td>\nCancer Biomarker \/ EMT \/ CSC<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR218-3<\/td>\nEpCAM \/ CD326 (Extracellular domain)<\/td>\nCancer Biomarker \/ EMT \/ CSC<\/td>\nRabbit<\/td>\nH<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR208-752<\/td>\nCD44<\/td>\nCancer Stem Cell (CSC)<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n
IR30-78<\/td>\nCD133 \/ Prominin-1 (IHC only), Extracellular<\/td>\nCancer Stem Cell (CSC)<\/td>\nRabbit<\/td>\nH<\/td>\nIHC<\/td>\n<\/tr>\n
IR30-79<\/td>\nCD133 \/ Prominin-1\u00a0 (Intracellular domain)<\/td>\nCancer Stem Cell (CSC)<\/td>\nRabbit<\/td>\nH,M,R<\/td>\nWB, IF, IHC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

IHC\/Pathology Antibodies–IReal Biotechnology IREA […]<\/p>\n","protected":false},"author":3,"featured_media":38534,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5264,1],"tags":[5271],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39023"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39023"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39023\/revisions"}],"predecessor-version":[{"id":39100,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39023\/revisions\/39100"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/38534"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39023"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}