{"id":39020,"date":"2023-02-25T17:31:56","date_gmt":"2023-02-25T09:31:56","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=39020"},"modified":"2023-02-27T10:29:11","modified_gmt":"2023-02-27T02:29:11","slug":"ac-yvad-cho-cas-143313-51-3-apexbio%e8%b2%a8%e8%99%9fa8954","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=39020","title":{"rendered":"Ac-YVAD-CHO | CAS# 143313-51-3 APExBIO\u8ca8\u865fA8954"},"content":{"rendered":"<p><span style=\"color: #33cccc;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #33cccc;\" href=\"http:\/\/biopioneer.com.tw\/?p=39020\">Ac-YVAD-CHO | CAS# 143313-51-3 APExBIO\u8ca8\u865fA8954<\/a><\/span><\/strong><\/span><\/p>\n<p>\u767d\u7d30\u80de\u4ecb\u7d20 1\u03b2 \u8f49\u63db\u9176\u9078\u64c7\u6027\u6291\u5236\u5291\uff08ICE\uff1bCaspase-1\uff09<\/p>\n<p><strong><span style=\"font-size: 12pt; color: #800000;\">\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/p>\n<p>Ac-YVAD-CHO \u662f\u4e00\u7a2e\u6709\u6548\u3001\u7279\u7570\u6027\u3001\u53ef\u9006\u7684 caspase-1 \u6291\u5236\u5291\uff0c\u5728 1 \u03bcM \u6fc3\u5ea6\u4e0b\u53ef\u5b8c\u5168\u963b\u65b7 caspase-1 \u6d3b\u6027 (99%) [1]\u3002Caspase-1 \u662f\u4e00\u7a2e\u9032\u5316\u4e0a\u4fdd\u5b88\u7684\u9176\uff0c\u53ef\u86cb\u767d\u6c34\u89e3\u5207\u5272\u5176\u4ed6\u86cb\u767d\u8cea\uff0c\u5176\u6fc0\u6d3b\u5c0e\u81f4\u7d30\u80de\u56e0\u5b50\u3001\u767d\u7d30\u80de\u4ecb\u7d20 1\u03b2 (IL-1\u03b2) \u548c\u767d\u7d30\u80de\u4ecb\u7d20 18 (IL-18) \u7684processing\u548c\u91cb\u653e\uff0c\u4ee5\u53capyroptosis\uff0c\u4e00\u7a2e\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u4ea1\u7684\u5f62\u5f0f(immunogenic form of cell death )[1]\u3002\u5728\u7528 \u03b1-\u6eb6\u8840\u7d20(\u03b1-hemolysin)\u8655\u7406\u7684 THP-1 \u7d30\u80de\u4e2d\uff0cAc-YVAD-CHO \u5728 1 \u03bcM \u6642\u53ef\u6291\u5236\u6eb6\u8840\u7d20\u8a98\u5c0e\u7684 99% \u7684\u6d3b\u6027 [1]\u3002\u5728\u9ec3\u560c\u5464\/\u9ec3\u560c\u5464\u6c27\u5316\u9176 (xanthine\/xanthine-oxidase , X\/XO) \u8655\u7406\u7684\u8868\u9054 G85R \u7684 N2a \u7d30\u80de\u4e2d\uff0c100 \u03bcM \u7684 Ac-YVAD-CHO \u4fdd\u8b77\u8868\u9054 G85R \u7684\u7d30\u80de\u514d\u53d7 X\/XO \u8a98\u5c0e\u7684\u7d30\u80de\u6d3b\u529b\u55aa\u5931\u3001caspase-1 \u88c2\u89e3\u548cIL-1\u03b2\u5206\u6ccc\u589e\u52a0[2]\u3002\u5728\u7532\u82ef\u4e8c\u7570\u6c30\u9178\u916f (TDI) \u66b4\u9732\u7684\u5c0f\u9f20\u4e2d\uff0cAc-YVAD-CHO\uff081 mg\/kg\uff0ci.n.\uff0cq.d.\uff0c\u9023\u7e8c 7 \u5929\uff09\u6709\u6548\u6291\u5236\u6c23\u9053\u9ad8\u53cd\u61c9\u6027 (AHR)\u3001\u6c23\u9053\u5468\u570d\u7684\u6c23\u9053\u708e\u75c7\u548c\u4e0a\u76ae\u676f\u72c0\u7d30\u80de\u589e\u751f\u3002\u6b64\u5916\uff0cAc-YVAD-CHO \u53ef\u986f\u8457\u964d\u4f4e TH1\/TH2 \u7d30\u80de\u7684\u6578\u91cf\uff0c\u4e26\u964d\u4f4e IL-18 \u548c IL-1\u03b2 \u7684\u6c34\u5e73 [3]\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.apexbt.com\/media\/diy\/images\/wb\/A8954_1.jpg\" alt=\"Ac-YVAD-CHO\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.apexbt.com\/media\/diy\/images\/wb\/A8954_2.jpg\" alt=\"Ac-YVAD-CHO\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.apexbt.com\/media\/diy\/images\/wb\/A8954_3.jpg\" alt=\"Ac-YVAD-CHO\" \/><\/p>\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Product Citation<\/span><\/strong><\/span><\/h2>\n<ul>\n<li>1. Jianhua Wang, Lichun Wang, et al. &#8220;Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.&#8221; Int Immunopharmacol. 2021 May;94:107496.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33639565\">PMID:33639565<\/a><\/li>\n<li>2. Chen S, Yao L, et al. &#8220;Blockade of the NLRP3\/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model.&#8221; Toxicol Sci. 2019 Apr 17. pii: kfz099.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31070765\">PMID:31070765<\/a><\/li>\n<\/ul>\n<h2><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\">Chemical Properties<\/span><\/strong><\/span><\/h2>\n<table width=\"1128\">\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A crystalline solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>492.5<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>143313-51-3<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>23<\/sub>H<sub>32<\/sub>N<sub>4<\/sub>O<sub>8<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>Soluble in DMSO<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>(4S,7S,10S,13S)-13-formyl-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/A8954.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>CC(N([C@H](C(N([C@H](C(N([C@H](C(N([C@H](C([H])=O)CC(O)=O)[H])=O)C)[H])=O)C(C)C)[H])=O)CC1=CC=C(C=C1)O)[H])=O<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-size: 12pt;\"><a style=\"color: #800000;\" href=\"http:\/\/www.apexbt.com\/\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/09\/APExBIO_logo-300x65.jpg\" alt=\"APExBIO_logo\" \/><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ac-YVAD-CHO | CAS# 143313-51-3 APExBIO\u8ca8\u865fA8954 \u767d\u7d30\u80de\u4ecb\u7d20 1\u03b2  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":34299,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[5272],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39020"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=39020"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39020\/revisions"}],"predecessor-version":[{"id":39022,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/39020\/revisions\/39022"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34299"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=39020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=39020"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=39020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}